Area postrema undergoes dynamic postnatal changes in mice and humans
Hamza Numan Gokozan, Faisal Baig, Sarah Corcoran, Fay Patsy Catacutan, Patrick Edwin Gygli, Ana C. Takakura, Thiago S. Moreira, Catherine Czeisler and José J. Otero
Accepted manuscript online: 24 SEP 2015 04:33AM EST | DOI: 10.1002/cne.23903
The area postrema is a major integrator of the autonomic nervous system (ANS). At birth, mammals show ANS immaturity resulting in generalized dysautonomia. Here, Gokozan et al. by combining modern and traditional neuroanatomical tools demonstrate that the development of the area postrema dynamically changes during postnatal development in mice and humans. These changes include a significant increase in size and increase in the innervation during the post-natal epoch. The graphical abstract above illustrates the increase in area postrema size and in synaptic vessicles derived from PHOX2B-derived neurons that we identified in this work.