High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans
Leonard Lipovich, Zhuo-Cheng Hou, Hui Jia, Christopher Sinkler, Michael McGowen, Kirstin N. Sterner, Amy Weckle, Amara B. Sugalski, Lenore Pipes, Domenico L. Gatti, Christopher E. Mason, Chet C. Sherwood, Patrick R. Hof, Christopher W. Kuzawa, Lawrence I. Grossman, Morris Goodman and Derek E. Wildman
Article first published online: 20 AUG 2015 | DOI: 10.1002/cne.23843
Using next-generation RNA sequencing of a Gorilla planum temporale (red dot), with transcript-to-genome alignments, the authors demonstrate different sequences of orthologous human and gorilla brain messenger RNA and protein molecules. These distinctions relate to the genomic basis of phenotypic differences among hominids, heralding a new era of comparative molecular morphology.