Journal of Comparative Neurology
© Wiley Periodicals, Inc.
Edited By: PATRICK R. HOF
Impact Factor: 3.331
ISI Journal Citation Reports © Ranking: 2015: 7/160 (Zoology); 91/256 (Neurosciences)
Online ISSN: 1096-9861
- JCN Antibody Database
- The Fine Structure of the Aging Brain
- Neurosciences on the Internet
- The World Wide Web Virtual Library: Neuroscience (Bioscience)
Societies and Professional Organizations
- American Association of Anatomists
- Association of Neuroscience Departments and Programs
- European Neuroscience Association
- International Brain Research Organization
- Society for Neuroscience
Clicking on the link below will allow you to download an Excel spreadsheet in which we have collected information on the antibodies used for immunohistochemistry by papers published in JCN from 2006 to present. It is organized alphabetically by the common name used for the antibody by the authors of the paper. Occasionally, different antibodies against the same target molecule may be listed under slightly different names. We recommend that the reader scan the list for alternate names for the target molecule that is to be identified. The list indicates which papers in JCN have used a particular antibody; more information on the antibodies can be found in those papers. The list will be updated every 4-6 months.
As of May, 2011, we have added a new feature to the Database. The Neuroscience Information Framework (http://www.neuinfo.org/) is systematically cataloguing antibodies, and we are cooperating with them, as our database on papers that characterize antibodies is the most extensive documentation available. They have provided their registry number (Antibody ID from NIF), and a link to the text for that antibody in their registry. They have also added the PubMed ID numbers for all of our papers for each antibody, which will make it easier for users of both their database and ours to look up the original JCN papers in PubMed.
The reason for presenting this list is that JCN has had a policy since 2006 on requiring rigorous characterization for all antibodies that are used in our papers (see our editorial on this subject). The antibodies on the list have in (nearly*) all cases been described and characterized adequately according to these guidelines, at least for the purpose for which the antibody was used in that paper. Note that using an antibody for a different purpose may require a more rigorous characterization; this can be determined only on a case by case basis, however. Nevertheless, if you are looking for an antibody to identify a particular target immunohistochemically, this list is a good place to begin your search. We suggest you then look up the paper in which the antibody was used, to make sure that it will meet your needs and to verify its characterization. (The characterization of antibodies in JCN papers often goes well beyond the material published by the manufacturer, so that examining this information before you order an antibody can be very useful.) While we do not guarantee that these antibodies will identify only the intended target (that is a function of the actual experiment and controls), this is the most carefully verified list of antibodies that we are aware of, and we wanted to share this resource with our readers and authors.
*This policy is enforced by our editors, who are humans and occasionally do make errors, and let through an occasional antibody with insufficient information. We apologize to users who encounter these rare events. However, our goal is to avoid such errors, and hence if you do use one of these antibodies in your own work, we will insist on appropriate characterization in any future papers.
The Fine Structure of the Aging Brain
Alan Peters and his colleague, Claire Folger, have provided the neuroscience community with an extraordinary resource, The Fine Structure of the Aging Brain. As pointed out in the Editorial by Peters and Folger, this resource resides on a website containing 18 chapters of the highest quality electron micrographs available to be downloaded. This unique resource is an invaluable companion to the landmark book commonly referred to by all students of cerebral cortex as “Peters, Palay, and Webster ”, which contains electron micrographs of unparalleled quality accompanied by an extensive text that describes every element of cortical circuitry illuminated by high resolution electron microscopy. The first edition of Peters, Palay and Webster was published when I was a graduate student in 1976, and as evidenced by my extensive notes in the margins, it served as my authoritative source on the synaptic organization of cerebral cortex for many years. There has never been anything like Peters, Palay, and Webster - until now - with the publication of this stunning material illustrating the fine structure of neocortex of the aged rhesus monkey brain.
Alan Peters is unquestionably the world’s leading authority on the synaptic and cellular basis of age-related cognitive decline. In a sense, Alan created this area of research when he launched his Program Project Grant from the National Institute on Aging, number PO1 AG000001, designating it as the first research grant ever awarded by NIA. All of us currently working in this arena owe a great debt to Alan, who not only had the insight to pursue such studies in the nonhuman primate, but also set standards for quality that still drive the field. It is also fitting that this wonderful resource reside within the purview of The Journal of Comparative Neurology, a journal that we can be assured will maintain the website and build on this resource with the utmost care and respect for the material.
Thank you to both Alan and JCN for seeing this project through to fruition and making it freely available to students of cerebral cortex and aging for generations to come.
John H. Morrison
Dean of Basic Sciences and the Graduate School of Biological Sciences
Professor, Fishberg Department of Neuroscience and Friedman Brain Institute
Icahn School of Medicine at Mount Sinai
New York, NY 10029