Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area
Zhiwei Liu, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L. Vaughan, Hans-Olov Adami, Guangwu Huang, Yi Zeng, Yi-Xin Zeng and Weimin Ye
Version of Record online: 27 FEB 2017 | DOI: 10.1002/cncr.30643
In this population-based case-control study of 2499 cases of nasopharyngeal carcinoma and 2576 controls, the excess risk appears to be higher for a maternal than a paternal history and slightly stronger for a sibling compared with a parental history and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of nasopharyngeal carcinoma up to age 74 years is reported to be 3.7%, whereas that among relatives of controls is 0.9%.