Clinical and genetic determinants of ovarian metastases from colorectal cancer
Karuna Ganesh, Ronak H. Shah, Efsevia Vakiani, Garrett M. Nash, Hugh P. Skottowe, Rona Yaeger, Andrea Cercek, Anne Lincoln, Christina Tran, Neil H. Segal, Diane L. Reidy, Anna Varghese, Andrew S. Epstein, Yukio Sonoda, Dennis Chi, Jose Guillem, Larissa Temple, Philip Paty, Jaclyn Hechtman, Jinru Shia, Martin Weiser, Julio Garcia Aguilar, Nancy Kemeny, Michael F. Berger, Leonard Saltz and Zsofia K. Stadler
Version of Record online: 22 NOV 2016 | DOI: 10.1002/cncr.30424
The results of this large retrospective study of patients with ovarian metastases from colorectal cancer demonstrate that patients who undergo complete surgical resection of all macroscopic metastatic disease have a better prognosis than those who undergo incomplete surgical resection. In addition, the authors identify tumor mutations specifically associated with ovarian metastases and with poor survival, thus laying the foundation for future genetic risk stratification of candidates for oophorectomy.