Cancer

Cover image for Vol. 120 Issue 15

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Fadlo R. Khuri, MD

Impact Factor: 4.901

ISI Journal Citation Reports © Ranking: 2013: 38/202 (Oncology)

Online ISSN: 1097-0142

Associated Title(s): Cancer Cytopathology, CA: A Cancer Journal for Clinicians

VIEW

  1. 1 - 100
  2. 101 - 154
  1. Original Articles

    1. Discipline

      Pediatric Oncology
      Reirradiation of recurrent medulloblastoma

      Cynthia Wetmore, Danielle Herington, Tong Lin, Arzu Onar-Thomas, Amar Gajjar and Thomas E. Merchant

      Article first published online: 30 JUL 2014 | DOI: 10.1002/cncr.28907

      Patients with recurrent medulloblastoma (MB) have a dismal prognosis and no standard curative therapy. The use of radiotherapy as a component of salvage therapy for relapsed MB may prolong survival of both standard and high-risk patients.

    2. Supportive Care
      Electroacupuncture for fatigue, sleep, and psychological distress in breast cancer patients with aromatase inhibitor-related arthralgia: A randomized trial

      Jun J. Mao, John T. Farrar, Deborah Bruner, Jarcy Zee, Marjorie Bowman, Christina Seluzicki, Angela DeMichele and Sharon X. Xie

      Article first published online: 30 JUL 2014 | DOI: 10.1002/cncr.28917

      In this randomized controlled trial among breast cancer patients who experience arthralgia related to aromatase, electroacupuncture produces significant improvements in fatigue, anxiety, and depression, whereas sham acupuncture improves only depression compared with usual care.

    3. Outcomes Research
      Lifestyle and metabolic syndrome in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study

      Webb A. Smith, Chenghong Li, Kerri A. Nottage, Daniel A. Mulrooney, Gregory T. Armstrong, Jennifer Q. Lanctot, Wassim Chemaitilly, Joseph H. Laver, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson and Kirsten K. Ness

      Article first published online: 28 JUL 2014 | DOI: 10.1002/cncr.28670

      Survivors of childhood cancer are at an increased risk of developing metabolic syndrome, which may be reduced with lifestyle modifications. Adherence to a heart-healthy lifestyle is associated with a lower risk of metabolic syndrome among survivors of childhood cancer.

  2. Editorials

    1. Quality lung cancer screening protects quality of life: No harm, no foul

      Jamie S. Ostroff

      Article first published online: 25 JUL 2014 | DOI: 10.1002/cncr.28835

      This ancillary paper from the NLST dataset examines the impact of undergoing LDCT for early detection of lung cancer on health related quality of life and state anxiety assessed at 1 and 6 months following lung screening. Outcomes are compared by screening results. Overall, the findings provide reassurance that undergoing lung cancer screening in the context of a well-designed screening and follow-up protocol poses little or no psychological harm or quality of life impairment to screening participants.

  3. Original Articles

    1. Discipline

      Quality of Life
      You have full text access to this OnlineOpen article
      Impact of lung cancer screening results on participant health-related quality of life and state anxiety in the National Lung Screening Trial

      Ilana F. Gareen, Fenghai Duan, Erin M. Greco, Bradley S. Snyder, Phillip M. Boiselle, Elyse R. Park, Dennis Fryback and Constantine Gatsonis

      Article first published online: 25 JUL 2014 | DOI: 10.1002/cncr.28833

      In a large multi-center lung screening trial, participants receiving a false positive or significant incidental finding screen result experienced no significant difference in health related quality of life or state anxiety at 1 or at 6 months after screening relative to those receiving a negative result.

    2. Epidemiology
      Expected population impacts of discontinued prostate-specific antigen screening

      Roman Gulati, Alex Tsodikov, Ruth Etzioni, Rachel A. Hunter-Merrill, John L. Gore, Angela B. Mariotto and Matthew R. Cooperberg

      Article first published online: 25 JUL 2014 | DOI: 10.1002/cncr.28932

      Recently revised clinical guidelines in the United States recommend against prostate-specific antigen screening. Using 2 models of prostate cancer natural history and survival benefit of screening, the authors report that stopping screening for all men may result in many avoidable cancer deaths, but continued screening for men aged <70 years could prevent a majority of avoidable cancer deaths while dramatically reducing overdiagnoses.

    3. Disease Site

      Head and Neck Disease
      You have full text access to this OnlineOpen article
      A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes

      Arif N. Ali, Jeffrey M. Switchenko, Sungjin Kim, Jeanne Kowalski, Mark W. El-Deiry and Jonathan J. Beitler

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cncr.28901

      A statistical model has been developed that predicts the most likely head and neck site of origin from a cervical “unknown primary” tumor based on epidemiologic and lymph node data derived from the Surveillance, Epidemiology, and End Results database. This model allows for the statistical localization of the most likely tumor site of origin to aid in high-resolution tissue sampling by surgeons searching for a pathologic site diagnosis or radiation field treatment decisions by radiation oncologists.

    4. Discipline

      Radiation Oncology
      Radiotherapy for benign head and neck paragangliomas: A 45-year experience

      Philip Gilbo, Christopher G. Morris, Robert J. Amdur, John W. Werning, Peter T. Dziegielewski, Jessica Kirwan and William M. Mendenhall

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cncr.28923

      Fractionated radiotherapy for head and neck paragangliomas is a safe and efficacious treatment that is associated with a high probability of cure and a low incidence of morbidity. Observation is suitable for asymptomatic patients who are elderly and infirm and have a limited life expectancy.

  4. Correspondence

  5. Review Articles

    1. MYC-associated and double-hit lymphomas: A review of pathobiology, prognosis, and therapeutic approaches

      Adam M. Petrich, Chadi Nabhan and Sonali M. Smith

      Article first published online: 24 JUL 2014 | DOI: 10.1002/cncr.28899

      The co-presence of MYC and BCL2, termed double hit lymphomas, occurs in up to one-third of diffuse large B-cell lymphomas via immunohistochemistry and has a very poor prognosis. There is limited data on clinical management, but increased awareness of this entity will help define criteria for future clinical trial development.

  6. Original Articles

    1. Discipline

      Clinical Trials
      Effect of total dose and fraction size on survival of patients with locally recurrent nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: A phase 2, single-center, randomized controlled trial

      Yun-ming Tian, Chong Zhao, Ying Guo, Ying Huang, Shao-Min Huang, Xiao-Wu Deng, Cheng-Guang Lin, Tai-xiang Lu and Fei Han

      Article first published online: 23 JUL 2014 | DOI: 10.1002/cncr.28934

      Appropriately decreasing the total dose and increasing fraction size in patients with nasopharyngeal carcinoma being treated with radiotherapy can achieve local control rates similar to those achieved with a higher dose. Furthermore, it can improve overall survival by significantly reducing the incidence of severe late complications including mucosal necrosis and massive hemorrhage.

  7. Review Articles

    1. Complications of pelvic radiation in patients treated for gynecologic malignancies

      Akila N. Viswanathan, Larissa J. Lee, Jairam R. Eswara, Neil S. Horowitz, Panagiotis A. Konstantinopoulos, Kristina L. Mirabeau-Beale, Brent S. Rose, Arvind G. von Keudell and Jennifer Y. Wo

      Article first published online: 23 JUL 2014 | DOI: 10.1002/cncr.28849

      Modern radiotherapy techniques, including highly conformal radiation and image-guided conformal brachytherapy, may reduce the risk of radiation-related side effects. The management of side effects, including surgical and chemotherapeutic implications, is discussed.

    2. Management of patients with HER2-positive metastatic breast cancer: Is there an optimal sequence of HER2-directed approaches?

      Amelia B. Zelnak and Kari B. Wisinski

      Article first published online: 23 JUL 2014 | DOI: 10.1002/cncr.28815

      The successful development of therapies targeting the human epidermal growth factor receptor 2 (HER2) has altered the natural progression of disease among patients with HER2-positive metastatic breast cancer. This review focuses on the HER2-directed agents currently available in clinical practice and the literature regarding the optimal sequencing of these agents.

  8. Editorials

    1. Overtreatment of men with early-stage prostate cancer and limited life expectancy

      Matthew R. Danzig and James M. McKiernan

      Article first published online: 17 JUL 2014 | DOI: 10.1002/cncr.28927

      The accompanying article by Daskivich et al explores with rigorous methodology the issue of the overtreatment of men with early stage prostate cancer and limited life expectancy. Particular attention should be paid to the finding of the predominance of radiotherapy in this group, which should not be considered a benign alternative to surgery given the evidence for long-term morbidity after this treatment.

  9. Original Articles

    1. Disease Site

      Genitourinary Disease
      Variation in treatment associated with life expectancy in a population-based cohort of men with early-stage prostate cancer

      Timothy J. Daskivich, Julie Lai, Andrew W. Dick, Claude M. Setodji, Janet M. Hanley, Mark S. Litwin, Christopher Saigal and on behalf of the Urologic Diseases in America Project

      Article first published online: 17 JUL 2014 | DOI: 10.1002/cncr.28926

      This retrospective study characterizes treatment patterns for early stage prostate cancer according to life expectancy in a population-based cohort of US men. Men aged <80 years at diagnosis who have a life expectancy less than 10 years often receive aggressive treatment (mostly radiation therapy) for low-risk and intermediate-risk prostate cancer.

    2. Hematologic Malignancies
      Augmented Berlin-Frankfurt-Münster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL)

      Michael E. Rytting, Deborah A. Thomas, Susan M. O'Brien, Farhad Ravandi-Kashani, Elias J. Jabbour, Anna R. Franklin, Tapan M. Kadia, Naveen Pemmaraju, Naval G. Daver, Alessandra Ferrajoli, Guillermo Garcia-Manero, Marina Y. Konopleva, Jorge E. Cortes, Gautham Borthakur, Rebecca Garris, Maria Cardenas-Turanzas, Kurt Schroeder, Jeffrey L. Jorgensen, Steven M. Kornblau and Hagop M. Kantarjian

      Article first published online: 17 JUL 2014 | DOI: 10.1002/cncr.28930

      Retrospective analysis indicates that pediatric-based therapy for ALL is superior to adult-type therapy. This single institution retrospective comparison shows that the two approaches may yield similar outcomes in this patient population.

    3. Discipline

      Outcomes Research
      Coronary artery disease detected by coronary computed tomography angiography in adult survivors of childhood Hodgkin lymphoma

      Daniel A. Mulrooney, Sara E. Nunnery, Gregory T. Armstrong, Kirsten K. Ness, Deokumar Srivastava, F. Daniel Donovan, Beth A. Kurt, Monika L. Metzger, Matthew J. Krasin, Vijaya Joshi, Jean-Bernard Durand, Leslie L. Robison, Melissa M. Hudson and Scott D. Flamm

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28925

      In the current study, coronary computed tomography angiography identified a significant percentage of survivors of childhood Hodgkin lymphoma with subclinical coronary artery disease. This noninvasive imaging technique may help clinicians to identify those patients who might benefit from lifestyle and/or medication interventions and those for whom lower levels of monitoring may be appropriate.

  10. Correspondence

    1. Cervical cancer: Is the wall crumbling?

      Laeeq Malik and Alex V. Mejia

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28916

    2. A brick in the wall

      Angelica Nogueira-Rodrigues and Carlos G. Ferreira

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28918

  11. Original Articles

    1. Discipline

      Pediatric Oncology
      You have full text access to this OnlineOpen article
      Cancer incidence patterns among children and adolescents in Taiwan from 1995 to 2009: A population-based study

      Giun-Yi Hung, Jiun-Lin Horng, Yu-Sheng Lee, Hsiu-Ju Yen, Chao-Chun Chen and Chih-Ying Lee

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28903

      The authors examine cancer incidence patterns in children and adolescents based on a national, population-based cancer registry of 12,315 individuals in Taiwan from 1995 to 2009. The high rates of malignant hepatic tumors and germ cell neoplasms in Taiwan suggest variations in background risk factors.

  12. Review Articles

    1. Subtyping of triple-negative breast cancer: Implications for therapy

      Vandana G. Abramson, Brian D. Lehmann, Tarah J. Ballinger and Jennifer A. Pietenpol

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28914

      Triple-negative breast cancer (TNBC) is an aggressive disease with limited treatment options and no approved targeted therapies. This review outlines the current knowledge about TNBC and strategies being explored to specifically target this disease.

  13. Original Articles

    1. Disease Site

      Gynecologic Oncology
      Loss of LKB1 in high-grade endometrial carcinoma: LKB1 is a novel transcriptional target of p53

      Ngai Na Co, David Iglesias, Joseph Celestino, Suet Y. Kwan, Samuel C. Mok, Rosemarie Schmandt and Karen H. Lu

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28854

      This is the first report that LKB1 is a transcriptional target of p53, and provides the first evidence that loss of wild-type p53 protein may contribute to the loss of LKB1 in high-grade EEC.

    2. Hepatobiliary Disease
      Risk prediction of hepatocellular carcinoma in patients with cirrhosis: The ADRESS-HCC risk model

      Jennifer A. Flemming, Ju Dong Yang, Eric Vittinghoff, W. Ray Kim and Norah A. Terrault

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28832

      All patients with cirrhosis are at risk of developing hepatocellular carcinoma (HCC), but this risk is not uniform in a heterogeneous population of patients with cirrhosis. The ADRESS-HCC risk model is a useful clinical tool to estimate the risk of HCC in an individual patient with cirrhosis.

    3. Gastrointestinal Disease
      Dual blockade of epidermal growth factor receptor and insulin-like growth factor receptor–1 signaling in metastatic pancreatic cancer: Phase Ib and randomized phase II trial of gemcitabine, erlotinib, and cixutumumab versus gemcitabine plus erlotinib (SWOG S0727)

      Philip A. Philip, Bryan Goldman, Ramesh K. Ramanathan, Heinz-Josef Lenz, Andrew M. Lowy, Robert P. Whitehead, Takeru Wakatsuki, Syma Iqbal, Rakesh Gaur, Jacqueline K. Benedetti and Charles D. Blanke

      Article first published online: 16 JUL 2014 | DOI: 10.1002/cncr.28744

      Simultaneous targeting of the IGF-1R and EGFR signaling pathways for more ffective downstream inhibition of proliferation and survival did not improve outcomes in patients with metastatic pancreatic adenocarcinoma. Patient selection using biomarkers that would predict pathway inhibition is necessary for future studies using targeted agents.

    4. Head and Neck Disease
      Trends and variations in the use of adjuvant therapy for patients with head and neck cancer

      Michelle M. Chen, Sanziana A. Roman, Wendell G. Yarbrough, Barbara A. Burtness, Julie A. Sosa and Benjamin L. Judson

      Article first published online: 15 JUL 2014 | DOI: 10.1002/cncr.28870

      Approximately one-quarter of patients are not receiving National Comprehensive Cancer Network guideline-directed adjuvant therapy. Patient-level and hospital-level factors are associated with variation in the receipt of adjuvant therapy.

    5. Gastrointestinal Disease
      Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304)

      Cornelia M. Ulrich, Cathryn Rankin, Adetunji T. Toriola, Karen W. Makar, Özge Altug-Teber, Jacqueline K. Benedetti, Rebecca S. Holmes, Stephen R. Smalley, Charles D. Blanke and Heinz-Josef Lenz

      Article first published online: 15 JUL 2014 | DOI: 10.1002/cncr.28830

      There were no statistically significant associations noted between 8 functionally significant polymorphisms in 6 genes (MTHFR [C667T, A1298C], SLC191A [G80A], SHMT1 [C1420T], DHFR [Del19bp], TS 1494del, and TSER) involved in folate metabolism and overall survival, disease-free survival, and toxicity in the overall analyses. Nevertheless, there was a trend toward worse disease-free survival and reduced hematological and gastrointestinal toxicities among patients with variant alleles in MTHFR C677T, SLC19A1 G80A, and TSER, respectively.

    6. Discipline

      Psychosocial Oncology
      Pain experiences among a population-based cohort of current, former, and never regular smokers with lung and colorectal cancer

      Adam Gonzalez, Sandra Japuntich, Nancy L. Keating, Robert Wallace, Yulei He, Joanna M. Streck and Elyse R. Park

      Article first published online: 15 JUL 2014 | DOI: 10.1002/cncr.28893

      This large population-based cohort study examined the relations between smoking and pain experiences among patients with lung and colorectal cancer. Results suggest that lung and colorectal cancer patients who smoke report greater pain experiences.

    7. Radiation Oncology
      Does adjuvant radiotherapy benefit patients with diffuse-type gastric cancer? Results from the Surveillance, Epidemiology, and End Results database

      Alexander M. Stessin, Cristina Sison, Allie Schwartz, John Ng, Clifford K.S. Chao and Baoqing Li

      Article first published online: 15 JUL 2014 | DOI: 10.1002/cncr.28913

      The current Surveillance, Epidemiology, and End Results analysis demonstrated a significant survival benefit for adjuvant radiotherapy among patients with diffuse-type gastric cancer. The standard treatment will likely remain controversial until evidence becomes available from phase 3 randomized trials exclusively for diffuse-type gastric cancer.

    8. Clinical Trials
      FCR and bevacizumab treatment in patients with relapsed chronic lymphocytic leukemia

      Preetesh Jain, Hun Ju Lee, Wei Qiao, William Wierda, Ohad Benjamini, Jan Burger, Alessandra Ferrajoli, Zeev Estrov, Hagop Kantarjian, Michael Keating and Susan O'Brien

      Article first published online: 15 JUL 2014 | DOI: 10.1002/cncr.28910

      1) The combination of bevacizumab, an antiangiogenic monoclonal antibody, with chemotherapy has improved outcomes in some solid tumors, but its relevance in leukemia is unclear. 2) We have demonstrated that the addition of bevacizumab to standard FCR chemoimmunotherapy in patients with relapsed chronic lymphocytic leukemia does not improve patient outcomes.

    9. Epidemiology
      Increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States

      Franklin L. Chien, Stephen M. Schwartz and Rebecca H. Johnson

      Article first published online: 14 JUL 2014 | DOI: 10.1002/cncr.28684

      There has been a recent, substantial increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States. Similar trends are not observed in non-Hispanic whites.

  14. Correspondence

    1. External validation of a model to predict locoregional failure after radical cystectomy

      Michael Froehner, Vladimir Novotny, Manfred P. Wirth, Sabine Brookman-May, Atiqullah Aziz and Matthias May

      Article first published online: 12 JUL 2014 | DOI: 10.1002/cncr.28876

  15. Original Articles

    1. Disease Site

      Soft Tissue and Bone Sarcoma
      Prognostic factors and impact of adjuvant treatments on local and metastatic relapse of soft-tissue sarcoma patients in the competing risks setting

      Antoine Italiano, Axel Le Cesne, Jean Mendiboure, Jean-Yves Blay, Sophie Piperno-Neumann, Christine Chevreau, Corinne Delcambre, Nicolas Penel, Philippe Terrier, Dominique Ranchere-Vince, Marick Lae, Sophie Le Guellec, Jean-Jacques Michels, Yves Marie Robin, Carine Bellera and Sylvie Bonvalot

      Article first published online: 10 JUL 2014 | DOI: 10.1002/cncr.28885

      In the setting of competing risks, tumor biology reflected by histological grade is a crucial predictor of local relapse of soft-tissue sarcomas, whereas tumor depth and size have poor if any influence. Grade could also predict the benefit of adjuvant chemotherapy in patients with soft-tissue sarcoma.

  16. Erratum

    1. You have free access to this content
  17. Review Articles

    1. Surgery for primary hyperparathyroidism

      Glenda G. Callender and Robert Udelsman

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cncr.28891

      Primary hyperparathyroidism is a complex disease process that requires careful diagnosis and thoughtful medical and surgical management. The surgical management of patients with persistent or recurrent disease, inherited primary hyperparathyroidism syndromes, and parathyroid carcinoma is particularly challenging. High-quality imaging and reliable intraoperative adjuncts are critical to success.

  18. Original Articles

    1. Disease Site

      Head and Neck Disease
      Cytology and human papillomavirus testing on cytobrushing samples from patients with head and neck squamous cell carcinoma

      Maria Gabriella Donà, Massimo Giuliani, Amina Vocaturo, Giuseppe Spriano, Barbara Pichi, Francesca Rollo, Livia Ronchetti, Renato Covello, Edoardo Pescarmona and Maria Benevolo

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cncr.28909

      Cytobrushing provides adequate material both for morphology and the evaluation of human papillomavirus (HPV) infection. HPV testing on cytobrushing provides reliable information regarding the HPV status of patients with head and neck squamous cell carcinoma.

    2. Genitourinary Disease
      Substance use disorder and its effects on outcomes in men with advanced-stage prostate cancer

      Sumedha Chhatre, David S. Metzger, S. Bruce Malkowicz, George Woody and Ravishankar Jayadevappa

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cncr.28861

      The intersection of advanced prostate cancer and substance use disorder appears to adversely affect outcomes. Thus, incorporating substance use screening and treatments into prostate cancer care guidelines and care coordination is desirable.

  19. Review Articles

    1. The biologic effects of cigarette smoke on cancer cells

      Samantha L. Sobus and Graham W. Warren

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cncr.28904

      Although the 2014 Surgeon General's Report The Health Consequences of Smoking—50 Years of Progress concluded that smoking causes adverse outcomes and increases cancer-specific mortality, there is relatively little information on the biologic effects of cigarette smoke on cancer cells. This review summarizes the known effects of active cigarette smoke exposure on cancer cell biology linking cigarette smoke exposure to a prosurvival cancer cell phenotype.

  20. Original Articles

    1. Discipline

      Supportive Care
      Phase III double-blind, placebo-controlled study of gabapentin for the prevention of delayed chemotherapy-induced nausea and vomiting in patients receiving highly emetogenic chemotherapy, NCCTG N08C3 (Alliance)

      Debra L. Barton, Gita Thanarajasingam, Jeff A. Sloan, Brent Diekmann, Jyotsna Fuloria, Lisa A. Kottschade, Alan P. Lyss, Anthony J. Jaslowski, Miroslaw A. Mazurczak, Scott C. Blair, Shelby Terstriep and Charles L. Loprinzi

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cncr.28892

      In this study, gabapentin did not significantly improve delayed nausea and vomiting; however, patients were satisfied with the overall control of their nausea and vomiting. The use of a 5HT3 RA and dexamethasone provided good control of nausea and vomiting for most patients.

    2. Epidemiology
      Colorectal cancer mortality among Hispanics in California: Differences by neighborhood socioeconomic status and nativity

      Li Tao, Uri Ladabaum, Scarlett Lin Gomez and Iona Cheng

      Article first published online: 9 JUL 2014 | DOI: 10.1002/cncr.28837

      Neighborhood socioeconomic status demonstrates unrecognized differential effects on colorectal cancer mortality between US-born and foreign-born Hispanics, which may be explained by immigration-related factors. The current study provides important insights on further migrant studies among the growing population of Hispanics in the United States.

    3. Disease Site

      Genitourinary Disease
      Simple prognostic score for metastatic castration-resistant prostate cancer with incorporation of neutrophil-to-lymphocyte ratio

      Arnoud J. Templeton, Carmel Pezaro, Aurelius Omlin, Mairéad G. McNamara, Raya Leibowitz-Amit, Francisco E. Vera-Badillo, Gerhardt Attard, Johann S. de Bono, Ian F. Tannock and Eitan Amir

      Article first published online: 3 JUL 2014 | DOI: 10.1002/cncr.28890

      A high neutrophil-to-lymphocyte ratio (NLR) is a marker of host inflammation, indicating poor prognosis in many solid tumors including castration-resistant prostate cancer (CRPC). Incorporation of NLR in a simple risk score improves prognostic accuracy for chemotherapy-naive men with CRPC.

  21. Editorial

    1. Cancer-related inflammation: An emerging prognostic domain in metastatic castration-resistant prostate carcinoma

      David J. Pinato

      Article first published online: 3 JUL 2014 | DOI: 10.1002/cncr.28889

      The neutrophil-to-lymphocyte ratio effectively integrates into a novel prognostic model for castration-resistant prostate cancer according to the study by Templeton et al. Systemic inflammation may provide novel insight into the pathophysiology of the disease as well as new targets for therapy and useful surrogates to optimize clinical management.

  22. Original Articles

    1. Disease Site

      Soft Tissue and Bone Sarcoma
      Outcome of advanced, unresectable conventional central chondrosarcoma

      Annemiek M. van Maldegem, Hans Gelderblom, Emanuela Palmerini, Sander D. Dijkstra, Marco Gambarotti, Pietro Ruggieri, Remi A. Nout, Michiel A. J. van de Sande, Cristina Ferrari, Stefano Ferrari, Judith V. M. G. Bovée and Piero Picci

      Article first published online: 3 JUL 2014 | DOI: 10.1002/cncr.28845

      This study sets the standard for overall survival for both locally advanced and metastatic, unresectable conventional central chondrosarcoma. The data indicate that chemotherapy in patients with unresectable chondrosarcoma may increase survival and that radiotherapy provides a survival advantage.

  23. Editorial

    1. Advanced conventional chondrosarcomas: Time to revisit treatments and clinical research for what is not an indolent disease

      Antoine Italiano

      Article first published online: 3 JUL 2014 | DOI: 10.1002/cncr.28842

      Medical and surgical oncologists involved in the management of patients with sarcoma know well that the management of those with recurrent chondrosarcoma is quite challenging. In light of the currently available data, anthracycline-based chemotherapy and radiotherapy represent reasonable options for chondrosarcoma patients not eligible to a clinical trial with good performance status and who have unresectable metastatic or locally advanced disease, respectively.

    2. Translational immunotherapeutics: Chemoimmunotherapy for malignant pleural mesothelioma

      Prasad S. Adusumilli

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cncr.28883

      Recent data indicate that chemotherapy treats cancer, at least in part, by facilitating an immune response to the tumor. The study results outlined in this issue highlight the potential benefits in devising an optimal strategy for integrating new immune-based therapies into the standard of care for various cancers.

  24. Original Articles

    1. Disease Site

      Chest and Lung Disease
      Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen 125

      Raffit Hassan, Elad Sharon, Anish Thomas, Jingli Zhang, Alexander Ling, Markku Miettinen, Robert J. Kreitman, Seth M. Steinberg, Kevin Hollevoet and Ira Pastan

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cncr.28875

      In this first clinical evaluation of the combination of an immunotoxin with chemotherapy, SS1P, an antimesothelin immunotoxin, was combined with pemetrexed and cisplatin in chemotherapy-naive patients who had advanced malignant pleural mesothelioma. The results from this phase 1 trial demonstrate that SS1P and chemotherapy can be safely combined with no overlapping toxicity. In addition, the objective tumor response rate for the combination is higher than expected with chemotherapy alone and provides a strong rationale for a randomized trial to confirm this finding.

    2. Discipline

      Outcomes Research
      Health-related empowerment in cancer: Validity of scales from the Health Education Impact Questionnaire

      Elizabeth Maunsell, Sophie Lauzier, Jennifer Brunet, Sylvie Pelletier, Richard H. Osborne and H. Sharon Campbell

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cncr.28847

      The current results support the validity of 5 Health Education Impact Questionnaire (heiQ) scales (Social integration and support, Health service navigation, Constructive attitudes and approaches, Skill and technique acquisition, and Emotional distress) as generic measures of health-related empowerment in the cancer setting. These scales could fill an important gap in the measures currently available to evaluate the proximal effects of support interventions.See also pages 000-000 and 000, this issue.

    3. Indicators for evaluating cancer organizations' support services: Performance and associations with empowerment

      Sophie Lauzier, H. Sharon Campbell, Patricia M. Livingston and Elizabeth Maunsell

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cncr.28846

      In this validation study, the authors found that 16 indicators used by 2 national cancer organizations (the Canadian Cancer Society and the Cancer Council Victoria, Australia) to evaluate their information and support services did capture health-related empowerment. These indicators could contribute to determining whether services offered by community-based cancer organizations are reaching one of their important goals: namely, patient empowerment.

  25. Editorials

    1. How should we “empower” cancer patients?

      Judith S. Kaur

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cncr.28852

      Validated measures of empowerment for cancer patients will be very useful for program interventions. In this editorial, the author reviews the 2 articles in this issue that used the Health Education Information Questionnaire and suggests other important populations to study.

  26. Original Articles

    1. Disease Site

      Chest and Lung Disease
      Exercise-induced lung cancer regression: Mechanistic findings from a mouse model

      Kristin A. Higgins, Dongkyoo Park, Gee Young Lee, Walter J. Curran and Xingming Deng

      Article first published online: 2 JUL 2014 | DOI: 10.1002/cncr.28878

      This study demonstrates that daily cardiovascular exercise reduces lung tumor growth in mice, and tumor apoptosis is increased. Exercise should therefore be further explored as a potential anti-cancer therapy.

    2. Gastrointestinal Disease
      Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer

      Yongfu Shao, Meng Ye, Xiaoming Jiang, Weiliang Sun, Xiaoyun Ding, Zhong Liu, Guoliang Ye, Xinjun Zhang, Bingxiu Xiao and Junming Guo

      Article first published online: 1 JUL 2014 | DOI: 10.1002/cncr.28882

      Long noncoding RNAs (lncRNAs) stably exist in gastric juice and can be detected using real-time quantitative reverse transcription-polymerase chain reaction analysis. Some lncRNAs, such as AA174084 in gastric juice, can be used as biomarkers for the detection of gastric cancer with satisfactory specificity and sensitivity.

    3. Melanoma
      The nature and management of metastatic melanoma after progression on BRAF inhibitors: Effects of extended BRAF inhibition

      Matthew M. K. Chan, Lauren E. Haydu, Alexander M. Menzies, Mary W. F. Azer, Oliver Klein, Megan Lyle, Arthur Clements, Alexander Guminski, Richard F. Kefford and Georgina V. Long

      Article first published online: 1 JUL 2014 | DOI: 10.1002/cncr.28851

      This study demonstrates that in patients treated with BRAF inhibitors for metastatic melanoma, one-third progressed in isolated tumor sites, most progressed in existing extracranial sites and intracranial progression alone is uncommon. The BRAF inhibitors dabrafenib and vemurafenib are associated with an overall survival benefit when continued beyond disease progression even after adjusting for potential prognostic factors at progression.

    4. Discipline

      Radiation Oncology
      Postmastectomy radiation therapy for T3N0: A SEER analysis

      Matthew E. Johnson, Elizabeth A. Handorf, Jeffrey M. Martin and Shelly B. Hayes

      Article first published online: 1 JUL 2014 | DOI: 10.1002/cncr.28865

      Postmastectomy radiation therapy is associated with significant improvements in overall and cause-specific survival in patients with T3N0M0 breast cancers treated with modified radical mastectomy from 2000 to 2010 in the SEER database. Postmastectomy radiation therapy should be strongly considered for patients who have T3N0M0 tumors

    5. Translational Research
      Noninvasive radiofrequency treatment effect on mitochondria in pancreatic cancer cells

      Steven A. Curley, Flavio Palalon, Xiaolin Lu and Nadezhda V. Koshkina

      Article first published online: 1 JUL 2014 | DOI: 10.1002/cncr.28895

      Anticancer efficacy of innovative non-invasive method of cancer treatment based on the use of electromagnetic radiofrequency fields (RF) treatment had been reported in our previous studies, however its mechanism of action remains poorly understood. Here we demonstrated the ability of RF treatment to affect mitochondria in cancer cells.

    6. Disparities Research
      Disparities in perceived unmet need for supportive services among patients with lung cancer in the Cancer Care Outcomes Research and Surveillance Consortium

      Dolly A. John, Ichiro Kawachi, Christopher S. Lathan and John Z. Ayanian

      Article first published online: 1 JUL 2014 | DOI: 10.1002/cncr.28801

      Among US patients with lung cancer, approximately 1 in 10 patients experienced an unmet need for supportive services, with US-born black and foreign-born Latino and Asian/Pacific Islander patients disproportionately affected even after controlling for health care access and other factors. Patients with an unmet need for services were more likely to perceive worse quality of health care compared with their counterparts without any unmet need.

    7. Disease Site

      Soft Tissue and Bone Sarcoma
      Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma

      Qing Zhang, Julianne Ubago, Li Li, Haiyang Guo, Yugang Liu, Wenan Qiang, J. Julie Kim, Beihua Kong and Jian-Jun Wei

      Article first published online: 1 JUL 2014 | DOI: 10.1002/cncr.28900

      Six types of USMT have different gene mutation fingerprints. ALM shared many genetic and molecular alterations with LMS. Our findings suggest that ALM may be a precursor lesion of LMS or has similar genetic changes in its early stage.

  27. Review Articles

    1. Surgical management of noncolorectal cancer liver metastases

      Andrew J. Page, Matthew J. Weiss and Timothy M. Pawlik

      Article first published online: 26 JUN 2014 | DOI: 10.1002/cncr.28743

      This review focuses on emerging data for the resection of noncolorectal metastatic disease to the liver, with a focus on indications for surgical resection. Specifically, we review the current data on the surgical management of nonneuroendocrine and neuroendocrine tumors metastatic to the liver.

  28. Editorials

    1. Mind the gap: Efficacy versus effectiveness and pivotal prostate cancer clinical trial demographics

      Matthew D. Galsky and William K. Oh

      Article first published online: 25 JUN 2014 | DOI: 10.1002/cncr.28808

      Large randomized prostate cancer clinical trials over the past 20 years have under-represented racial minorities. It will be critical in the future to ensure that the patients enrolled in trials are representative of the general population, so that clinicians can provide optimal therapy for patients.

  29. Original Articles

    1. Discipline

      Disparities Research
      Under-representation of racial minorities in prostate cancer studies submitted to the US Food and Drug Administration to support potential marketing approval, 1993-2013

      Michel D. Wissing, Paul G. Kluetz, Yang-Min Ning, Jonca Bull, Christine Merenda, Anthony J. Murgo and Richard Pazdur

      Article first published online: 25 JUN 2014 | DOI: 10.1002/cncr.28809

      Over the past 20 years, little improvement has been observed in the enrollment of racial minorities to key prostate cancer clinical trials submitted to the US Food and Drug Administration. With increased global enrollment, drug developers should aim to recruit a patient population that resembles the racial demographics of the patient population to which drug use will be generalized upon approval.

    2. Epidemiology
      Breast reconstruction after mastectomy among Department of Defense beneficiaries by race

      Lindsey R. Enewold, Katherine A. McGlynn, Shelia H. Zahm, Jill Poudrier, William F. Anderson, Craig D. Shriver and Kangmin Zhu

      Article first published online: 25 JUN 2014 | DOI: 10.1002/cncr.28806

      The receipt of reconstruction did not vary by race within this equal-access health system, indicating that the racial disparities reported in previous studies may have been due in part to variations in health care access.

    3. Genetic and intermediate phenotypic susceptibility markers of gastric cancer in Hispanic Americans: A case-control study

      Yuhui Sun, Jian Gu, Jaffer A. Ajani, David W. Chang, Xifeng Wu and John R. Stroehlein

      Article first published online: 24 JUN 2014 | DOI: 10.1002/cncr.28792

      This is the first epidemiological study to examine the association of single nucleotide polymorphisms, leukocyte mitochondrial DNA copy number, and leukocyte telomere length with the risk of gastric cancer (GC) among Hispanics. The results indicate that reference single nucleotide polymorphism rs2294008 in the PSCA gene and leukocyte mitochondrial DNA copy numbers are associated significantly with the risk of GC, but leukocyte telomere length is not, suggesting that GC among Hispanics has both common and distinct biology compared with GC among other ethnic groups.

  30. Correspondence

  31. Original Articles

    1. Discipline

      Outcomes Research
      Impact of Medicare Part D on out-of-pocket drug costs and medical use for patients with cancer

      Sheetal M. Kircher, Michael E. Johansen, Halla S. Nimeiri, Caroline R. Richardson and Matthew M. Davis

      Article first published online: 24 JUN 2014 | DOI: 10.1002/cncr.28898

      Medicare D has reduced out-of-pocket prescription drug costs and outpatient visits for seniors with cancer beyond trends observed for younger patients with no major impact noted on use of other medical services.

    2. Racial disparities in urologist visits among elderly men with prostate cancer: A cohort analysis of patient-related and county of residence-related factors

      Eberechukwu Onukwugha, Phillip Osteen, Jinani Jayasekera, C. Daniel Mullins, Christine A. Mair and Arif Hussain

      Article first published online: 24 JUN 2014 | DOI: 10.1002/cncr.28894

      The current study investigated novel social environment factors including crime, housing, and household characteristics. The results indicate that social environment characteristics and their relationship with urologist visits differed between African American and white men.

  32. Erratum

    1. You have free access to this content
  33. Original Articles

    1. Discipline

      Psychosocial Oncology
      Suicidal ideation in prostate cancer survivors: Understanding the role of physical and psychological health outcomes

      Christopher J. Recklitis, Eric S. Zhou, Eric K. Zwemer, Jim C. Hu and Philip W. Kantoff

      Article first published online: 24 JUN 2014 | DOI: 10.1002/cncr.28880

      The results of the current study indicate that a significant percentage of prostate cancer survivors report recent suicidal ideation and, more importantly, demonstrate that both physical disability and prostate-associated symptoms are strongly associated with suicide ideation. These are novel findings that have important implications for both clinical care and outcomes research.

  34. Erratum

    1. You have free access to this content
  35. Original Articles

    1. Discipline

      Medical Oncology
      Genomic testing in cancer: Patient knowledge, attitudes, and expectations

      Phillip S. Blanchette, Anna Spreafico, Fiona A. Miller, Kelvin Chan, Jessica Bytautas, Steve Kang, Philippe L. Bedard, Andrea Eisen, Larissa Potanina, Jack Holland, Suzanne Kamel-Reid, John D. McPherson, Albiruni R. Razak and Lillian L. Siu

      Article first published online: 24 JUN 2014 | DOI: 10.1002/cncr.28807

      Patients with advanced cancer have a positive attitude toward genomic cancer testing and its potential to improve cancer care. Further education is needed to support patients interested in genomic cancer testing.

    2. Outcomes Research
      The effect of care setting in the delivery of high-value colon cancer care

      Christine M. Veenstra, Andrew J. Epstein, Kaijun Liao, Arden M. Morris, Craig E. Pollack and Katrina A. Armstrong

      Article first published online: 20 JUN 2014 | DOI: 10.1002/cncr.28874

      Treatment by a provider affiliated with an academic medical center was associated with improved overall survival for patients with stage IV colon cancer. For most patients, costs at academic medical centers were not significantly different from costs at nonacademic medical centers.

    3. Psychosocial Oncology
      The development of a financial toxicity patient-reported outcome in cancer: The COST measure

      Jonas A. de Souza, Bonnie J. Yap, Fay J. Hlubocky, Kristen Wroblewski, Mark J. Ratain, David Cella and Christopher K. Daugherty

      Article first published online: 20 JUN 2014 | DOI: 10.1002/cncr.28814

      There is no patient-reported outcome measure that specifically describes the financial distress experienced by cancer patients. The authors describe the development of a novel, 11-item financial measure in 155 patients with advanced cancer.

  36. Review Articles

    1. PET/CT imaging in cancer: Current applications and future directions

      Michael D. Farwell, Daniel A. Pryma and David A. Mankoff

      Article first published online: 19 JUN 2014 | DOI: 10.1002/cncr.28860

      PET/CT is an established imaging technique for cancer detection, and plays an important role in oncologic clinical practice. Although FDG is the most widely utilized radiotracer for PET imaging, this review also discusses many new radiotracers that are increasingly being used to help determine a patient's prognosis, make decisions regarding treatment planning, and evaluate treatment response.

  37. Original Articles

    1. Discipline

      Radiation Oncology
      Highly effective treatment of skull base chordoma with carbon ion irradiation using a raster scan technique in 155 patients: First long-term results

      Matthias Uhl, Matthias Mattke, Thomas Welzel, Falk Roeder, Jan Oelmann, Gregor Habl, Alexandra Jensen, Malte Ellerbrock, Oliver Jäkel, Thomas Haberer, Klaus Herfarth and Jürgen Debus

      Article first published online: 19 JUN 2014 | DOI: 10.1002/cncr.28877

      Carbon ion therapy is a safe and effective treatment for skull base chordoma, resulting in high local control and overall survival rates.

    2. Epidemiology
      You have full text access to this OnlineOpen article
      Interferon-γ–induced inflammatory markers and the risk of cancer: The Hordaland Health Study

      Hui Zuo, Grethe S. Tell, Stein E. Vollset, Per M. Ueland, Ottar Nygård, Øivind Midttun, Klaus Meyer, Arve Ulvik and Simone J.P.M. Eussen

      Article first published online: 19 JUN 2014 | DOI: 10.1002/cncr.28869

      Interferon-γ (IFN-γ)–induced inflammatory markers were associated with an increased cancer risk in a cohort of 6594 adults followed for a median of 12 years, revealing evidence for the role of IFN-γ induced inflammation in human carcinogenesis.

  38. Review Articles

    1. The MAPK pathway across different malignancies: A new perspective

      Mauricio Burotto, Victoria L. Chiou, Jung-Min Lee and Elise C. Kohn

      Article first published online: 19 JUN 2014 | DOI: 10.1002/cncr.28864

      Oncogenic driver mutations and hyperactivation of the classical mitogen-activated protein kinase/extracellular signal-regulating kinase (MAPK/ERK) pathway leads to abnormal proliferation in multiple human cancers. However, normal and malignant cell MAPK/ERK activation and effects are tissue and context dependent.

  39. Original Articles

    1. Discipline

      Disparities Research
      Early adoption of the human papillomavirus vaccine among Hispanic adolescent males in the United States

      Paul L. Reiter, Noel T. Brewer, Melissa B. Gilkey, Mira L. Katz, Electra D. Paskett and Jennifer S. Smith

      Article first published online: 19 JUN 2014 | DOI: 10.1002/cncr.28871

      Human papillomavirus vaccination among Hispanic adolescent males is modest but has increased substantially in recent years. Several variables are key determinants of vaccination among this population.

  40. Review Articles

    1. Medical management of metastatic medullary thyroid cancer

      Jessica E. Maxwell, Scott K. Sherman, Thomas M. O'Dorisio and James R. Howe

      Article first published online: 18 JUN 2014 | DOI: 10.1002/cncr.28858

      Despite significant progress in our understanding of the molecular basis of medullary thyroid cancer, the treatment of patients with metastatic disease remains problematic. In this article, the authors review the evolution of medical therapy for medullary thyroid cancer from the early 1970s to the present.

  41. Editorials

    1. Sarcoma after 5 years of progression-free survival: Lessons from the French Sarcoma Group

      Edwin Choy

      Article first published online: 18 JUN 2014 | DOI: 10.1002/cncr.28834

      Because sarcomas are rare (1% of all adult solid malignancies) and encompass a heterogeneous group of tumors (> 50 subtypes), information regarding late recurrences for patients with resected soft tissue sarcomas, although recognized to occur, is not well defined. Details concerning late recurrences, such as the frequencies, risk factors, and relative rates between tumor subtypes, depend on the existence of a large, well-annotated, multiinstitutional, accurate database that spans several decades of clinical experience. The French Sarcoma Group has assembled such a database, and they report with accuracy and detail what happens to patients with sarcoma after they survive for > 5 years. Recognition that a significant percentage of long-term survivors of sarcoma are still at risk of developing late disease recurrence can be paired with the growing awareness that they are also at risk of a shortened lifespan and increased cardiovascular and psychological morbidity to highlight a critical role for long-term specialty follow-up.

  42. Original Articles

    1. Disease Site

      Soft Tissue and Bone Sarcoma
      Long-term recurrence of soft tissue sarcomas: Prognostic factors and implications for prolonged follow-up

      Maud Toulmonde, Axel Le Cesne, Jean Mendiboure, Jean-Yves Blay, Sophie Piperno-Neumann, Christine Chevreau, Corinne Delcambre, Nicolas Penel, Philippe Terrier, Dominique Ranchère-Vince, Marick Lae, Sophie Le Guellec, Jean-Jacques Michels, Yves-Marie Robin, Carine Bellera and Antoine Italiano

      Article first published online: 18 JUN 2014 | DOI: 10.1002/cncr.28836

      The incidence of late disease recurrence is unknown and to the authors' knowledge no prognostic factors for late events have been characterized in patients with soft tissue sarcomas. The results of the current study emphasize the critical role of long-term follow-up to detect late local recurrence in patients with retroperitoneal or very large soft tissue sarcomas, and late metastatic recurrence in patients with high-grade disease. The data from the current study suggest, however, that the prolonged follow-up of patients with grade 1 disease is not needed.

  43. Review Articles

    1. Oncolytic polio virotherapy of cancer

      Michael C. Brown, Elena Y. Dobrikova, Mikhail I. Dobrikov, Ross W. Walton, Sarah L. Gemberling, Smita K. Nair, Annick Desjardins, John H. Sampson, Henry S. Friedman, Allan H. Friedman, Douglas S. Tyler, Darell D. Bigner and Matthias Gromeier

      Article first published online: 17 JUN 2014 | DOI: 10.1002/cncr.28862

      Oncolytic poliovirus immunotherapy is demonstrating early promise in phase 1 clinical trials against recurrent glioblastoma. Clinical use of oncolytic polioviruses is supported by uniquely suitable target tropism, safety and tumor specificity, tumor cytotoxicity, robust viral cytotoxicity in the presence of innate defenses and pre-existing neutralizing antibodies, and immunogenicity.

  44. Original Articles

    1. Disease Site

      Breast Disease
      You have full text access to this OnlineOpen article
      Assessing the discordance rate between local and central HER2 testing in women with locally determined HER2-negative breast cancer

      Peter A. Kaufman, Kenneth J. Bloom, Howard Burris, Julie R. Gralow, Musa Mayer, Mark Pegram, Hope S. Rugo, Sandra M. Swain, Denise A. Yardley, Miu Chau, Deepa Lalla, Bongin Yoo, Melissa G. Brammer and Charles L. Vogel

      Article first published online: 13 JUN 2014 | DOI: 10.1002/cncr.28710

      Breast tumor samples from patients in the VIRGO observational cohort study originally determined to be negative for HER2 (human epidermal growth factor receptor 2) were retested using both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) (n = 552); of these, 22 (4%) were found to be HER2-positive. Eighteen samples were initially assessed with a single test, and 15 of these were determined to be HER2-positive with the testing methodology (IHC or FISH) not performed initially. These results highlight the value of using multiple tests to assess HER2 status to ensure patients do not forgo potentially efficacious therapy.

  45. Commentary

    1. Failure of researchers, reviewers, editors, and the media to understand flaws in cancer screening studies: Application to an article in Cancer

      Donald A. Berry

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28795

      Evidence from randomized trials makes it clear that mammographic screening is an important option for women who are truly and fully informed about its benefits and risks. Promoting the benefits of screening based on misleading and flawed publications weakens its scientific basis and confuses the public.

  46. Editorials

    1. Breast cancer screening: Time for rational discourse

      Otis W. Brawley and Ruth M. O'Regan

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28788

      Breast cancer screening has limitations, but most of the evidence demonstrates that it saves lives. Women still should be encouraged to have screening mammograms but also should be made aware of their limitations.

  47. Commentary

    1. The 20-year effort to reduce access to mammography screening: Historical facts dispute a commentary in Cancer

      Daniel B. Kopans, Matthew L. Webb and Blake Cady

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28791

      Scientifically unsupported arguments have made their way into the literature and continue to confuse the public and their physicians with regard to the value of mammography screening. The long history of misinformation that has developed in the effort to reduce access to screening is addressed along with the issues raised concerning the authors' recent article in this journal.

  48. Original Articles

    1. Discipline

      Medical Oncology
      Activation of nuclear factor κB pathway and downstream targets survivin and livin by SHARPIN contributes to the progression and metastasis of prostate cancer

      Yiming Zhang, Hai Huang, Huimin Zhou, Tao Du, Lexiang Zeng, Yi Cao, Jieqing Chen, Yiming Lai, Jin Li, Ganping Wang and Zhenghui Guo

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28796

      SHANK-associated RH domain interacting protein, a newly found oncogenic protein, contributes to prostate cancer progression via a cancer-associated nuclear factor κB pathway. It may represent a novel therapeutic target for the treatment of advanced prostate cancer that is resistant to chemotherapy.

    2. Disease Site

      Soft Tissue and Bone Sarcoma
      Retrospective cohort study evaluating the impact of intraperitoneal morcellation on outcomes of localized uterine leiomyosarcoma

      Suzanne George, Constance Barysauskas, César Serrano, Titilope Oduyebo, Jose A. Rauh-Hain, Marcela G. Del Carmen, George D. Demetri and Michael G. Muto

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28844

      Intraperitoneal morcellation of uterine leiomyosarcoma is associated with worsened outcomes in women with localized uterine leiomyosarcoma. Because there are no reliable preoperative techniques to distinguish uterine leiomyosarcoma from benign leiomyoma, all efforts to minimize intraperitoneal uterine morcellation should be considered.

  49. Editorials

    1. Uterine sarcoma dissemination during myomectomy: If not “acceptable collateral damage,” is it possible to mitigate the risk?

      Ian R. Judson and Aisha B. Miah

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28841

      Uterine sarcomas are rare, but benign leiomyomas (fibroids) are extremely common and frequently require surgery: either hysterectomy or myomectomy. A rare but potentially devastating consequence of myomectomy is inadvertent incomplete resection of a uterine sarcoma, resulting in tumor dissemination and a worse prognosis. The authors discuss the acceptable level of risk and how such a risk could be mitigated.

  50. Original Articles

    1. Disease Site

      Gastrointestinal Disease
      Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer

      CheeKian Tham, MinHoe Chew, Richie Soong, JitFong Lim, MeiKim Ang, ChoongLeong Tang, Yi Zhao, Simon Y. K. Ong and Yanqun Liu

      Article first published online: 12 JUN 2014 | DOI: 10.1002/cncr.28802

      High methylation levels of TAC1 in serum at 6-month follow-up, and SEPT9 at 1-year follow-up were independent predictors for tumor recurrence and unfavorable cancer-specific survival. More importantly, TAC1 at 6-month follow-up and SEPT9 at 1-year follow-up exhibited earlier detection of potential recurrences compared with concurrent serum carcinoembryonic antigen, suggesting the potential for recurrence monitoring.

    2. Discipline

      Radiation Oncology
      Low rates of adjuvant radiation in patients with nonmetastatic prostate cancer with high-risk pathologic features

      Anusha Kalbasi, Samuel Swisher-McClure, Nandita Mitra, Robert Sunderland, Marc C. Smaldone, Robert G. Uzzo and Justin E. Bekelman

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cncr.28856

      Although 2013 guidelines advocate that all patients with prostate cancer with high-risk features after surgery should be offered adjuvant radiation, data from the National Cancer Database indicate the rates of adjuvant radiation remain low and unchanged. These data also demonstrate that patients treated at high-volume surgical facilities are less likely to receive adjuvant radiation, irrespective of other factors including margin status.

  51. Original Article

    1. Disease Site

      Gynecologic Oncology
      Effects of metformin on endometrial cancer cell growth in vivo: A preoperative prospective trial

      Akira Mitsuhashi, Takako Kiyokawa, Yasunori Sato and Makio Shozu

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cncr.28853

      The results of the current study demonstrated that an antidiabetic dose of metformin inhibits endometrial cancer cell growth in vivo. Preoperative metformin use caused significant decreases in circulating humoral factors in patients with endometrial cancer.

  52. Original Articles

    1. Discipline

      Diagnostic Imaging
      Multiparametric magnetic resonance imaging outperforms the Prostate Cancer Prevention Trial risk calculator in predicting clinically significant prostate cancer

      Simpa S. Salami, Manish A. Vira, Baris Turkbey, Mathew Fakhoury, Oksana Yaskiv, Robert Villani, Eran Ben-Levi and Ardeshir R. Rastinehad

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cncr.28790

      Multiparametric magnetic resonance imaging of the prostate outperforms the Prostate Cancer Prevention Trial risk calculator in predicting clinically significant prostate cancer. This imaging modality represents an improved paradigm for identifying which men at risk of prostate cancer should be referred for biopsy.

    2. Epidemiology
      Temporal trends in population-based death rates associated with chronic liver disease and liver cancer in the United States over the last 30 years

      Yuhree Kim, Aslam Ejaz, Amit Tayal, Gaya Spolverato, John F. P. Bridges, Robert A. Anders and Timothy M. Pawlik

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cncr.28843

      A comprehensive approach that involves primary and secondary prevention, access to treatment, and funding for liver-related research is needed to address the high death rates associated with chronic liver disease and liver cancer in the United States.

  53. Editorials

    1. Multiparametric MRI for prostate cancer: Seeing is believing

      Christopher A. Warlick

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cncr.28787

      Salami and colleagues present an evaluation of multiparametric magnetic resonance imaging (MRI) combined with MRI/ultrasound fusion prostate biopsies compared with the Prostate Cancer Prevention Trial High-Grade nomogram to predict the presence of clinically significant disease in a largely referral-based population of men. Their report echoes a growing chorus of studies suggesting the ability of MRI and image-guided biopsies to improve the identification of men with clinically significant disease.

  54. Original Articles

    1. Disease Site

      Hematologic Malignancies
      Comorbidities predict worse prognosis in patients with primary myelofibrosis

      Kate J. Newberry, Kiran Naqvi, Khanh T. Nguyen, Marylou Cardenas-Turanzas, Maria Florencia Tanaka, Sherry Pierce and Srdan Verstovsek

      Article first published online: 10 JUN 2014 | DOI: 10.1002/cncr.28857

      Comorbidities are prevalent in patients with primary myelofibrosis and have a significant, independent negative impact on survival. The assessment of comorbidities is particularly important in younger patients with primary myelofibrosis and those with good performance status.

    2. Discipline

      Radiation Oncology
      Management of the lymph node-positive neck in the patient with human papillomavirus-associated oropharyngeal cancer

      Adam S. Garden, Gary B. Gunn, Amy Hessel, Beth M. Beadle, Salmaan Ahmed, Adel K. El-Naggar, Clifton D. Fuller, Lauren A. Byers, Jack Phan, Steven J. Frank, William H. Morrison, Merill S. Kies, David I. Rosenthal and Erich M. Sturgis

      Article first published online: 4 JUN 2014 | DOI: 10.1002/cncr.28831

      A total of 401 lymph node-positive patients with human papillomavirus-associated oropharyngeal cancer were managed with (chemo)radiation, with neck dissection reserved only for those patients with suspicion of residual disease after therapy. Eighty patients underwent neck dissection, and 21 had a positive specimen. The lymph node recurrence rate was 8%, and treatment factors were not found to be associated with recurrence. This further supports a policy of individualization of neck dissection after radiotherapy in the patient with human papillomavirus-associated oropharyngeal cancer.

  55. Correspondence

  56. Original Articles

    1. Disease Site

      Endocrine Disease
      TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA

      Na Wang, Tiantian Liu, Anastasios Sofiadis, C. Christofer Juhlin, Jan Zedenius, Anders Höög, Catharina Larsson and Dawei Xu

      Article first published online: 4 JUN 2014 | DOI: 10.1002/cncr.28800

      TERT promoter mutation occurs as an early genetic event in follicular thyroid adenoma (FTA) and atypical FTA; TERT promoter mutation activates telomerase in FTA or atypical FTA without malignant features.

    2. Discipline

      Supportive Care
      Factors associated with high burden in caregivers of older adults with cancer

      Tina Hsu, Matthew Loscalzo, Rupal Ramani, Stephen Forman, Leslie Popplewell, Karen Clark, Vani Katheria, Tao Feng, Rex Strowbridge, Redmond Rinehart, Dan Smith, Keith Matthews, Jeff Dillehunt and Arti Hurria

      Article first published online: 4 JUN 2014 | DOI: 10.1002/cncr.28765

      Caregiver burden is common among individuals who care for older adults with cancer. High burden is more likely in caregivers of older adults who are employed and who care for individuals who require increased assistance.

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