Cancer

Cover image for Vol. 121 Issue 7

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Fadlo R. Khuri, MD

Impact Factor: 4.901

ISI Journal Citation Reports © Ranking: 2013: 38/203 (Oncology)

Online ISSN: 1097-0142

Associated Title(s): Cancer Cytopathology, CA: A Cancer Journal for Clinicians

VIEW

  1. 1 - 100
  2. 101 - 158
  1. In Memoriam

    1. You have free access to this content
      Meir Wetzler, MD

      Razelle Kurzrock, Zeev Estrov, Moshe Talpaz and Hagop M. Kantarjian

      Article first published online: 1 APR 2015 | DOI: 10.1002/cncr.29391

  2. Original Articles

    1. Discipline

      Pediatric Oncology
      Renal function in survivors of nonsyndromic Wilms tumor treated with unilateral radical nephrectomy

      Rodrigo B. Interiano, Noel Delos Santos, Sujuan Huang, Deo Kumar Srivastava, Leslie L. Robison, Melissa M. Hudson, Daniel M. Green and Andrew M. Davidoff

      Article first published online: 1 APR 2015 | DOI: 10.1002/cncr.29373

      Partial nephrectomy is occasionally considered for patients with unilateral Wilms tumor to avoid the theoretical complication of renal insufficiency. In the current study, the authors evaluate the prevalence of hypertension and impaired renal function in long-term survivors of nonsyndromic unilateral Wilms tumor who were treated without nephrotoxic chemotherapy or ionizing radiation and report that <7% of patients had hypertension and <3% had significant renal dysfunction at a median follow-up of nearly 20 years after unilateral radical nephrectomy.

    2. Clinical Trials
      Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study

      Renata Pasqualini, Randall E. Millikan, Dawn R. Christianson, Marina Cardó-Vila, Wouter H. P. Driessen, Ricardo J. Giordano, Amin Hajitou, Anh G. Hoang, Sijin Wen, Kirstin F. Barnhart, Wallace B. Baze, Valerie D. Marcott, David H. Hawke, Kim-Anh Do, Nora M. Navone, Eleni Efstathiou, Patricia Troncoso, Roy R. Lobb, Christopher J. Logothetis and Wadih Arap

      Article first published online: 1 APR 2015 | DOI: 10.1002/cncr.29344

      The authors report on the development of a new ligand-directed peptidomimetic (termed bone metastasis-targeting peptidomimetic-11) for interleukin-11 receptor-based human vascular targeting, including the translation from preclinical studies to a first-in-class, first-in-man clinical trial in patients with metastatic, castrate-resistant prostate cancer.

  3. Editorial

    1. Addressing apoptosis to tumor zip codes

      Zachery R. Reichert and Maha HA. Hussain

      Article first published online: 1 APR 2015 | DOI: 10.1002/cncr.29346

      In the current issue of Cancer, Pasqualini and colleagues report on a study in which they target prostatic tumor vasculature signatures with an apoptosis-inducing, peptidomimetic drug. The authors of this editorial place this vascular-targeting discovery into a broader clinical context while focusing on opportunities and challenges in implementing it further.

  4. Retraction

    1. You have free access to this content
      Retraction

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncr.29342

      This article corrects:
  5. Original Articles

    1. Discipline

      Disparities Research
      Rural-urban disparities in incidence and outcomes of neuroendocrine tumors: A population-based analysis of 6271 cases

      Julie Hallet, Calvin H. L. Law, Paul J. Karanicolas, Refik Saskin, Ning Liu and Simron Singh

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncr.29338

      Neuroendocrine tumors are more commonly diagnosed and portend a worse prognosis in rural areas versus urban areas despite similar patterns of advanced stages at presentation. This may be related to a different biology (highlighted by increased distant recurrence in rural areas) and partly to geography and socioeconomic status variations that affect health care access and delivery.

    2. Translational Research
      Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer

      Hideaki Kinugasa, Kazuhiro Nouso, Koji Miyahara, Yuki Morimoto, Chihiro Dohi, Koichiro Tsutsumi, Hironari Kato, Takehiro Matsubara, Hiroyuki Okada and Kazuhide Yamamoto

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncr.29364

      In the current study, K-ras mutations were detected in cell-free serum circulating tumor DNA in 62.6% of patients with pancreatic cancer using digital polymerase chain reaction. The G12V mutation, which is one type of K-ras mutation in circulating tumor DNA, was associated with a poor prognosis.

    3. Clinical Trials
      Phase 2 study of MK-2206, an allosteric inhibitor of AKT, as second-line therapy for advanced gastric and gastroesophageal junction cancer: A SWOG cooperative group trial (S1005)

      Ramesh K. Ramanathan, Shannon L. McDonough, Hagen F. Kennecke, Syma Iqbal, Joaquina C. Baranda, Tara E. Seery, Howard J. Lim, Aram F. Hezel, Gina M. Vaccaro and Charles D. Blanke

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncr.29363

      MK-2206 is well tolerated in patients with gastric/gastroesophageal junction cancers, and there is some evidence of activity, but overall survival (5.1 months) is less than anticipated (6.5 months).

    4. Disease Site

      Head and Neck Disease
      Genome-wide association study identifies common genetic variants associated with salivary gland carcinoma and its subtypes

      Li Xu, Hongwei Tang, Diane W. Chen, Adel K. El-Naggar, Peng Wei and Erich M. Sturgis

      Article first published online: 30 MAR 2015 | DOI: 10.1002/cncr.29381

      Salivary gland carcinomas are a rare malignancy with unknown etiology. In the current study, the authors perform a genome-wide association analysis of salivary gland carcinomas and identify a panel of coding single-nucleotide polymorphisms associated with the risk of salivary gland carcinoma and its mucoepidermoid carcinoma subtype.

  6. Commentary

    1. You have free access to this content
      Society of Gynecologic Oncology recommendations for the prevention of ovarian cancer

      Joan L. Walker, C. Bethan Powell, Lee-may Chen, Jeanne Carter, Victoria L. Bae Jump, Lynn P. Parker, Mark E. Borowsky and Randall K. Gibb

      Article first published online: 27 MAR 2015 | DOI: 10.1002/cncr.29321

      Death from ovarian cancer could theoretically be reduced with feasible interventions for all women and with the identification of high-risk women for genetic testing and risk-reducing salpingo-oophorectomy. Women and their physicians should consider oral contraceptives for prevention, opportunistic salpingectomy for sterilization at the completion of childbearing, and salpingectomy at the time of hysterectomy.

    2. You have free access to this content
      Ovarian cancer prevention: Time for primetime?

      Otis W. Brawley

      Article first published online: 27 MAR 2015 | DOI: 10.1002/cncr.29347

      In this issue of Cancer, members of the Society of Gynecologic Oncology review the etiology of ovarian cancer and present the society's recommendations for the prevention of the disease. They call for a concerted effort to identify women at high risk who are most likely to benefit from cancer chemotherapy or surgical prevention.

  7. Editorial

    1. You have free access to this content
      Time to divest from tobacco-funded research

      Fadlo R. Khuri and Suresh S. Ramalingam

      Article first published online: 26 MAR 2015 | DOI: 10.1002/cncr.29361

      In this editorial, the Editor-in-Chief and Section Editor for Chest and Lung Disease explain why Cancer will no longer consider any work that is funded directly or indirectly from tobacco companies or their subsidiaries.

  8. Original Articles

    1. Disease Site

      Hematologic Malignancies
      Final results of a phase 2 trial of clofarabine and low-dose cytarabine alternating with decitabine in older patients with newly diagnosed acute myeloid leukemia

      Tapan M. Kadia, Stefan Faderl, Farhad Ravandi, Elias Jabbour, Guillermo Garcia-Manero, Gautam Borthakur, Alessandra Ferrajoli, Marina Konopleva, Jan Burger, Xuelin Huang, Xuemei Wang, Sherry Pierce, Mark Brandt, Jennie Feliu, Jorge Cortes and Hagop Kantarjian

      Article first published online: 25 MAR 2015 | DOI: 10.1002/cncr.29367

      A prolonged, low-intensity regimen for older patients with acute myeloid leukemia provides high remission rates with low toxicity and long relapse-free survival.

    2. Genitourinary Disease
      Long-term impact of androgen-deprivation therapy on physical function and quality of life

      Shabbir M. H. Alibhai, Henriette Breunis, Narhari Timilshina, Gary Naglie, Ian Tannock, Murray Krahn, Padraig Warde, Neil E. Fleshner, Sarah Duff Canning and George Tomlinson

      Article first published online: 24 MAR 2015 | DOI: 10.1002/cncr.29355

      In men with nonmetastatic prostate cancer, androgen-deprivation therapy is associated with declines in physical function (endurance, upper extremity strength, and lower extremity function) and quality of life over 1 year that persist or decline with 2 additional years of use.

    3. Discipline

      Clinical Trials
      Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma

      Ruth Seggewiss-Bernhardt, Ralf C. Bargou, Yeow Tee Goh, A. Keith Stewart, Andrew Spencer, Adrian Alegre, Joan Bladé, Oliver G. Ottmann, Cristina Fernandez-Ibarra, Hong Lu, Scott Pain, Mikhail Akimov and Swaminathan Padmanabhan Iyer

      Article first published online: 24 MAR 2015 | DOI: 10.1002/cncr.29339

      A promising cancer target in multiple myeloma is overexpressed heat shock protein 90, which is crucial in buffering the high levels of proteotoxic stress characteristic of this disease. This phase 1/1B trial shows disease stabilization with the small molecule heat shock protein 90 inhibitor NVP-AUY922 with or without bortezomib in patients with relapsed or refractory multiple myeloma. Increased therapeutic success should be reachable by mutual inhibition of survival feedback loops (eg, additional heat shock protein 70 inhibition).

    4. Disparities Research
      You have full text access to this OnlineOpen article
      Health system delay and its effect on clinical stage of breast cancer: Multicenter study

      Karla Unger-Saldaña, Alfonso Miranda, Gelasio Zarco-Espinosa, Fernando Mainero-Ratchelous, Enrique Bargalló-Rocha and Jesús Miguel Lázaro-León

      Article first published online: 24 MAR 2015 | DOI: 10.1002/cncr.29331

      Both patient delays and provider delays are associated with higher probabilities of patients starting cancer treatment with advanced-stage disease. Research aimed at identifying specific access barriers to medical services is much needed to guide the design of tailored health policies, especially in developing countries.

    5. Disease Site

      Breast Disease
      The evolving role of adjuvant radiotherapy for elderly women with early-stage breast cancer

      Charles E. Rutter, Nataniel H. Lester-Coll, Brandon R. Mancini, Christopher D. Corso, Henry S. Park, Debra N. Yeboa, Cary P. Gross and Suzanne B. Evans

      Article first published online: 24 MAR 2015 | DOI: 10.1002/cncr.29377

      The current study analyzes the ongoing national response to the Cancer and Leukemia Group B (CALGB) 9343 trial, including reduction in the use of radiotherapy (RT), adoption of hypofractionated RT, and the use of an RT boost to the lumpectomy cavity. Continued decreases in RT use and boost RT to the lumpectomy cavity after the presentation of mature trial data reflect the gradual integration of randomized evidence.

  9. Editorial

    1. What health care system delays reveal about inequalities in breast cancer medicine and global health

      Kristin Bright

      Article first published online: 24 MAR 2015 | DOI: 10.1002/cncr.29333

      Health care system delays have an impact on clinical breast cancer stage and may be associated with disparities in outcomes. To evaluate the interaction of individual, organizational, and sociopolitical factors that affect system delays and to address the associated health disparities, understanding is needed regarding how providers, patients, and researchers conceptualize delays.

  10. Original Articles

    1. Discipline

      Epidemiology
      Dietary intake of fish, polyunsaturated fatty acids, and survival after breast cancer: A population-based follow-up study on Long Island, New York

      Nikhil K. Khankari, Patrick T. Bradshaw, Susan E. Steck, Ka He, Andrew F. Olshan, Jing Shen, Jiyoung Ahn, Yu Chen, Habibul Ahsan, Mary Beth Terry, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella and Marilie D. Gammon

      Article first published online: 24 MAR 2015 | DOI: 10.1002/cncr.29329

      All-cause mortality was reduced by 16% to 34% among women with breast cancer who reported a high intake of fish and long-chain ω-3 polyunsaturated fatty acids. Therefore, pending additional replication, long-chain ω-3 polyunsaturated fatty acid intake from fish and other dietary sources may provide a potential strategy for improving survival after a diagnosis of breast cancer.

    2. Psychosocial Oncology
      Long-term psychological benefits of cognitive-behavioral stress management for women with breast cancer: 11-year follow-up of a randomized controlled trial

      Jamie M. Stagl, Laura C. Bouchard, Suzanne C. Lechner, Bonnie B. Blomberg, Lisa M. Gudenkauf, Devika R. Jutagir, Stefan Glück, Robert P. Derhagopian, Charles S. Carver and Michael H. Antoni

      Article first published online: 23 MAR 2015 | DOI: 10.1002/cncr.29076

      Women in a randomized controlled trial receiving cognitive-behavioral stress management (CBSM) after surgery for early-stage breast cancer are evaluated at an 8- to 15-year follow-up (median, 11 years). Women in the CBSM group report fewer depressive symptoms and better quality of life than a control group up to 15 years later.

    3. Disease Site

      Head and Neck Disease
      Surgical salvage improves overall survival for patients with HPV-positive and HPV-negative recurrent locoregional and distant metastatic oropharyngeal cancer

      Theresa Guo, Jesse R. Qualliotine, Patrick K. Ha, Joseph A. Califano, Young Kim, John R. Saunders, Ray G. Blanco, Gypsyamber D'Souza, Zhe Zhang, Christine H. Chung, Ana Kiess, Christine G. Gourin, Wayne Koch, Jeremy D. Richmon, Nishant Agrawal, David W. Eisele and Carole Fakhry

      Article first published online: 17 MAR 2015 | DOI: 10.1002/cncr.29323

      To the authors' knowledge, few clinical data currently are available regarding the clinical behavior and treatment of recurrent oropharyngeal cancer, particularly distant metastatic disease, within the context of human papillomavirus tumor status. In this retrospective analysis, surgical salvage is associated with prolonged overall survival for patients with recurrent locoregional and distant metastatic oropharyngeal cancer, independent of human papillomavirus tumor status.

    4. Discipline

      Medical Oncology
      Differences in the survival of patients with recurrent versus de novo metastatic KRAS-mutant and EGFR-mutant lung adenocarcinomas

      Helena A. Yu, Camelia S. Sima, Matthew D. Hellmann, Jarushka Naidoo, Natalie Busby, Katherine Rodriguez, Gregory J. Riely and Mark G. Kris

      Article first published online: 17 MAR 2015 | DOI: 10.1002/cncr.29313

      Stage of disease at the time of the initial diagnosis is associated with survival from the time of diagnosis of metastatic disease in specific molecular subsets of lung cancer. Stage at diagnosis should be accounted for in prospective studies among patients with metastatic lung cancer.

    5. Disparities Research
      Patient characteristics associated with the level of patient-reported care coordination among male patients with colorectal cancer in the Veterans Affairs healthcare system

      George L. Jackson, Leah L. Zullig, Sean M. Phelan, Dawn Provenzale, Joan M. Griffin, Steven B. Clauser, David A. Haggstrom, Rahul M. Jindal and Michelle van Ryn

      Article first published online: 17 MAR 2015 | DOI: 10.1002/cncr.29341

      The current study sought to determine whether patient characteristics, including race/ethnicity, were associated with patient-reported care coordination among patients with colorectal cancer who were treated in the Veterans Affairs health care system. Patients with CRC who are treated in the Veterans Affairs system report high levels of care coordination, and there appears to be no racial/ethnic disparity in reported coordination.

    6. Epidemiology
      Breast cancer risk after full-term pregnancies among African women from Nigeria, Cameroon, and Uganda

      Dominique Sighoko, Temidayo Ogundiran, Adeyinka Ademola, Clement Adebamowo, Lin Chen, Stella Odedina, Imaria Anetor, Paul Ndom, Antony Gakwaya, Oladosu Ojengbede, Dezheng Huo and Olufunmilayo I. Olopade

      Article first published online: 17 MAR 2015 | DOI: 10.1002/cncr.29305

      There is no transient increase in breast cancer risk after a full-term pregnancy among African women. The protection conferred by pregnancy occurs immediately after the first full-term pregnancy regardless of the age at that pregnancy and the number of pregnancies.

    7. Disease Site

      Head and Neck Disease
      Correlation of gene methylation in surgical margin imprints with locoregional recurrence in head and neck squamous cell carcinoma

      Masamichi Hayashi, Gaosong Wu, Jong-Lyel Roh, Xiaofei Chang, Xiufeng Li, Julie Ahn, Marla Goldsmith, Zubair Khan, Justin Bishop, Zhe Zhang, Xian Chong Zhou, Jeremy Richmon, Nishant Agrawal and Wayne M. Koch

      Article first published online: 13 MAR 2015 | DOI: 10.1002/cncr.29303

      The results from this study reveal that combinations of 2 methylated genes in histologically negative, deep surgical margins are significantly associated with a poor prognosis in a cohort of prospectively collected patients with head and neck squamous cell carcinoma (n = 73). Among 41 patients who have tumors with methylation of both EDNRB and HOXA9, no locoregional recurrences are observed within 2 years when margins are negative for these markers.

  11. Editorial

    1. Molecular margin of surgical resections—Where do we go from here?

      Li Mao and David Clark

      Article first published online: 13 MAR 2015 | DOI: 10.1002/cncr.29299

      The molecular surgical margin may provide a more accurate and objective assessment, which may improve current clinical practice for patients with head and neck squamous cell carcinoma. However, more work is needed to develop clinically applicable assays.

  12. Communication

    1. You have full text access to this OnlineOpen article
      Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018

      Reinier G. S. Meester, Chyke A. Doubeni, Ann G. Zauber, S. Luuk Goede, Theodore R. Levin, Douglas A. Corley, Ahmedin Jemal and Iris Lansdorp-Vogelaar

      Article first published online: 12 MAR 2015 | DOI: 10.1002/cncr.29336

      Achieving the National Colorectal Cancer Roundtable target of an 80% colorectal cancer screening rate by 2018 may decrease disease incidence rates in the United States by 22% and mortality rates by 33%. This translates to 280,000 avoided new cancer cases and 200,000 avoided cancer deaths through 2030.

  13. Editorial

    1. Can we achieve an 80% screening rate for colorectal cancer by 2018 in the United States?

      Electra D. Paskett and Fadlo R. Khuri

      Article first published online: 12 MAR 2015 | DOI: 10.1002/cncr.29335

      The best way to reach the goal of 80% adherence to screening for colorectal cancer is through a national multilevel initiative that includes policy makers, community organizations, and payors, as well as health care organizations, health care practitioners, and the public, as was done in the state of Delaware. The challenge is to convince other states and the United States as a whole to adopt Delaware's strategy. We offer the challenge–who will accept?

  14. Original Articles

    1. Disease Site

      Breast Disease
      Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: A multi-institutional study

      Ines Vaz-Luis, Melissa E. Hughes, Angel M. Cronin, Hope S. Rugo, Stephen B. Edge, Beverly Moy, Richard L. Theriault, Michael J. Hassett, Eric P. Winer and Nancy U. Lin

      Article first published online: 10 MAR 2015 | DOI: 10.1002/cncr.29310

      Adjuvant chemotherapy use among patients with stage I breast cancer has changed significantly over time. There has been an intensification of treatment and an increase in the use of taxane-based regimens, with a reduction in concomitant anthracycline-based regimens. Striking institutional variations reflect a lack of certainty regarding the optimal regimens for these patients.

    2. Discipline

      Epidemiology
      Incidence of secondary malignancies among patients with Waldenström macroglobulinemia: An analysis of the SEER database

      Jorge J. Castillo, Adam J. Olszewski, Zachary R. Hunter, Sandra Kanan, Kirsten Meid and Steven P. Treon

      Article first published online: 10 MAR 2015 | DOI: 10.1002/cncr.29334

      With Surveillance, Epidemiology, and End Results 13 data (1992-2011), standardized incidence ratios are calculated for secondary malignancies in patients with Waldenström macroglobulinemia versus the general population. Patients with Waldenström macroglobulinemia have a 49% higher risk of developing secondary malignancies. The risk is significantly increased for cancers of the lungs, urinary tract, and thyroid; melanoma; lymphoma; and acute leukemia. The standardized incidence ratio for secondary malignancies in patients with Waldenström macroglobulinemia is increased, regardless of age, sex, race, or year of diagnosis.

    3. Disease Site

      Endocrine Disease
      Aromatase inhibitors, tamoxifen, and endometrial cancer in breast cancer survivors

      Rowan T. Chlebowski, Joanne E. Schottinger, Jiaxiao Shi, Joanie Chung and Reina Haque

      Article first published online: 10 MAR 2015 | DOI: 10.1002/cncr.29332

      In a community-based health plan, endometrial cancer incidence is lower among women who receive an aromatase inhibitor versus tamoxifen. In addition, aromatase inhibitors may mitigate the incidence of tamoxifen-associated endometrial cancer.

    4. Discipline

      Epidemiology
      A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh

      Wei Jie Seow, Wen-Chi Pan, Molly L. Kile, Lin Tong, Andrea A. Baccarelli, Quazi Quamruzzaman, Mahmuder Rahman, Golam Mostofa, Muhammad Rakibuz-Zaman, Muhammad Kibriya, Habibul Ahsan, Xihong Lin and David C. Christiani

      Article first published online: 10 MAR 2015 | DOI: 10.1002/cncr.29291

    5. Familial clustering of breast and prostate cancer and risk of postmenopausal breast cancer in the Women's Health Initiative Study

      Jennifer L. Beebe-Dimmer, Cecilia Yee, Michele L. Cote, Nancie Petrucelli, Nynikka Palmer, Cathryn Bock, Dorothy Lane, Ilir Agalliu, Marcia L. Stefanick and Michael S. Simon

      Article first published online: 9 MAR 2015 | DOI: 10.1002/cncr.29075

      A family history of prostate cancer among first-degree relatives increases one's risk for breast cancer diagnosed after the age of 50 years. Information on one's family cancer history is critical for risk assessment and may influence decisions about screening for early detection.

    6. Cancer stage at diagnosis in patients infected with the human immunodeficiency virus and transplant recipients

      Meredith S. Shiels, Glenn Copeland, Marc T. Goodman, Janna Harrell, Charles F. Lynch, Karen Pawlish, Ruth M. Pfeiffer and Eric A. Engels

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29324

      Bladder cancer and melanoma are more likely to be diagnosed at an advanced stage in both individuals infected with the human immunodeficiency virus and transplant recipients, thereby suggesting a role for immunosuppression in their progression. Some common cancers are shifted toward later stages in human immunodeficiency virus-infected individuals and earlier stages in transplant recipients, which is consistent with differences in medical surveillance noted in these populations.

    7. Clinical Trials
      Yoga and meditation for menopausal symptoms in breast cancer survivors—A randomized controlled trial

      Holger Cramer, Sybille Rabsilber, Romy Lauche, Sherko Kümmel and Gustav Dobos

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29330

      The authors evaluate the effects of a 12-week traditional Hatha yoga and meditation intervention. Among breast cancer survivors, yoga combined with meditation seems to be a safe and effective intervention for menopausal symptoms.

    8. Medical Oncology
      Three-arm, randomized, phase 2 study of carboplatin and paclitaxel in combination with cetuximab, cixutumumab, or both for advanced nonsmall cell lung cancer (NSCLC) patients who will not receive bevacizumab-based therapy: An Eastern Cooperative Oncology Group (ECOG) study (E4508)

      Nasser H. Hanna, Suzanne E. Dahlberg, Jill M. Kolesar, Charu Aggarwal, Fred R. Hirsch, Suresh S. Ramalingam and Joan H. Schiller

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29308

      Preclinical evidence supports the clinical investigation of inhibitors to the insulin-like growth factor receptor and the epidermal growth factor receptor either alone or combined in patients with nonsmall cell lung cancer. However, based on the apparent lack of efficacy and excessive premature deaths, the current results do not support the continued investigation of carboplatin, paclitaxel, and cixutumumab alone or in combination with cetuximab for patients with advanced nonsmall cell lung cancer.

    9. Epidemiology
      Genetic variants in noncoding PIWI-interacting RNA and colorectal cancer risk

      Haiyan Chu, Liping Xia, Xiaonan Qiu, Dongying Gu, Linjun Zhu, Jing Jin, Gaoyun Hui, Qiuhan Hua, Mulong Du, Na Tong, Jinfei Chen, Zhengdong Zhang and Meilin Wang

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29314

      The PIWI-interacting RNA 015551 reference single nucleotide polymorphism rs11776042, which is located in the long noncoding RNA LNC00964-3, may decrease the risk of colorectal cancer, and the expression level of this interacting RNA has a positive correlation with that of LNC00964-3.

    10. Disease Site

      Hematologic Malignancies
      Improvements in the early death rate among 9380 patients with acute myeloid leukemia after initial therapy: A SEER database analysis

      Mary-Elizabeth M. Percival, Li Tao, Bruno C. Medeiros and Christina A. Clarke

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29319

      Early death in patients aged ≤ 65 years with acute myeloid leukemia has declined significantly over time from 18.7% for patients diagnosed between 1973 and 1977 to 5.8% for patients diagnosed between 2008 and 2010. Simultaneously, the median overall survival improved significantly from 6 months for those diagnosed between 1973 and 1977 to 23 months for those diagnosed between 2008 and 2010.

  15. Correspondence

    1. Reply to discrepant results for smoking and cessation among electronic cigarette users

      Sarah P. Borderud, Yuelin Li, Jack E. Burkhalter, Christine E. Sheffer and Jamie S. Ostroff

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29306

    2. Discrepant results for smoking and cessation among electronic cigarette users

      Brad Rodu, Nantaporn Plurphanswat and Carl V. Phillips

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29307

  16. Original Articles

    1. Disease Site

      Gastrointestinal Disease
      Management patterns and predictors of mortality among US patients with cancer hospitalized for malignant bowel obstruction

      Olatunji B. Alese, Sungjin Kim, Zhengjia Chen, Taofeek K. Owonikoko and Bassel F. El-Rayes

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29297

      Malignant bowel obstruction is a common cause of death in hospitalized patients with advanced cancer. The current study characterizes predictors of survival and the influence of treatment modality in these patients.

    2. Hematologic Malignancies
      Very low utility of surveillance imaging in early-stage classic Hodgkin lymphoma treated with a combination of doxorubicin, bleomycin, vinblastine, and dacarbazine and radiation therapy

      Neetha Gandikota, Sidonie Hartridge-Lambert, Jocelyn C. Migliacci, Joachim Yahalom, Carol S. Portlock and Heiko Schöder

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29277

      Routine surveillance imaging can be safely omitted in early-stage classic Hodgkin lymphoma with a complete positron emission tomography response after a combination of doxorubicin, bleomycin, vinblastine, and dacarbazine and radiotherapy.

    3. Discipline

      Epidemiology
      Early estimates of SEER cancer incidence for 2012: Approaches, opportunities, and cautions for obtaining preliminary estimates of cancer incidence

      Denise Riedel Lewis, Huann-Sheng Chen, Douglas N. Midthune, Kathleen A. Cronin, Martin F. Krapcho and Eric J. Feuer

      Article first published online: 4 MAR 2015 | DOI: 10.1002/cncr.29304

      Surveillance, Epidemiology, and End Results (SEER) data submissions from November and February are evaluated to make decisions about the possibility of earlier data release. Although earlier release of SEER data is possible, considerations and cautions are presented for interpreting rates and trends from earlier data.

    4. Disease Site

      Neuro-Oncology
      Cognitive predictors of understanding treatment decisions in patients with newly diagnosed brain metastasis

      Adam Gerstenecker, Karen Meneses, Kevin Duff, John B. Fiveash, Daniel C. Marson and Kristen L. Triebel

      Article first published online: 3 MAR 2015 | DOI: 10.1002/cncr.29326

      The ability to understand treatment decisions is highly influenced by cognition in patients with brain metastasis. Using only two cognitive variables, actuarial equations can be constructed to screen for patients with brain metastasis who are in need of a more comprehensive evaluation of their medical decision-making capacity.

    5. Discipline

      Epidemiology
      Cancer during pregnancy and the postpartum period: A population-based study

      Therese M.-L. Andersson, Anna L. V. Johansson, Irma Fredriksson and Mats Lambe

      Article first published online: 3 MAR 2015 | DOI: 10.1002/cncr.29325

      Fewer cancers than expected are found during pregnancy, a finding that cannot be explained entirely by delayed diagnosis.

  17. Erratum

    1. You have free access to this content
  18. Original Articles

    1. Discipline

      Disparities Research
      Treatment decisional regret among men with prostate cancer: Racial differences and influential factors in the North Carolina Health Access and Prostate Cancer Treatment Project (HCaP-NC)

      Bonny B. Morris, Laura Farnan, Lixin Song, Elizabeth L. Addington, Ronald C. Chen, Matthew E. Nielsen, Merle Mishel, James L. Mohler and Jeannette T. Bensen

      Article first published online: 3 MAR 2015 | DOI: 10.1002/cncr.29309

      In an analysis of 348 African American men and 446 Caucasian American men with prostate cancer, prostate cancer treatment decisional regret is present and persistent well beyond initial diagnosis and treatment. Younger African Americans are more likely to report regret, and regret is negatively associated with satisfaction in understanding of the potential side effects of treatment and treatment effect on the spousal relationship.

    2. Disease Site

      Head and Neck Disease
      Methylation status of HPV16 E2-binding sites classifies subtypes of HPV-associated oropharyngeal cancers

      Miriam Reuschenbach, Christian U. Huebbers, Elena-Sophie Prigge, Justo Lorenzo Bermejo, Martin S. Kalteis, Simon F. Preuss, Inga M.C. Seuthe, Jutta Kolligs, Ernst-Jan M. Speel, Nadine Olthof, Bernd Kremer, Steffen Wagner, Jens P. Klussmann, Svetlana Vinokurova and Magnus von Knebel Doeberitz

      Article first published online: 2 MAR 2015 | DOI: 10.1002/cncr.29315

      The methylation status of regulatory regions in the human papillomavirus (HPV) genome (E2-binding sites) is associated with the viral physical status and might explain deregulated viral oncogene expression in the presence of E2. Furthermore, the methylation status could be of prognostic significance among patients with HPV-associated oropharyngeal squamous cell cancers.

    3. Genitourinary Disease
      Circulating vitamin D, vitamin D–related genetic variation, and risk of fatal prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium

      Irene M. Shui, Alison M. Mondul, Sara Lindström, Konstantinos K. Tsilidis, Ruth C. Travis, Travis Gerke, Demetrius Albanes, Lorelei A. Mucci, Edward Giovannucci, Peter Kraft and for the Breast and Prostate Cancer Cohort Consortium Group

      Article first published online: 2 MAR 2015 | DOI: 10.1002/cncr.29320

      Because of the high prevalence of prostate cancer (PCa) and the wide international variation in vitamin D status, identifying causal links between the two could have a large public health impact. Few studies have addressed the risk of fatal PCa. In this study, a convincing association is not observed between circulating 25-hydroxyvitamin D (25(OH)D) or single-nucleotide polymorphisms (SNPs) in key vitamin D–related genes and fatal PCa. However, interactions between biologically relevant SNPs and circulating 25(OH)D with respect to fatal PCa may deserve further investigation.

  19. Review Articles

    1. The RET oncogene in papillary thyroid carcinoma

      Jason D. Prescott and Martha A. Zeiger

      Article first published online: 2 MAR 2015 | DOI: 10.1002/cncr.29044

      The rearranged in transformation/papillary thyroid carcinoma (RET/PTC) fusion proteins play a key oncogenic role in the development of some papillary thyroid carcinomas. For this reason, the elucidation and subsequent targeting of mechanisms whereby such proteins mediate their oncogenic effects remains an important area of research.

  20. Original Articles

    1. Discipline

      Pediatric Oncology
      Osteochondroma in long-term survivors of high-risk neuroblastoma

      Brian H. Kushner, Stephen S. Roberts, Danielle N. Friedman, Deborah Kuk, Irina Ostrovnaya, Shakeel Modak, Kim Kramer, Ellen M. Basu and Nai-Kong V. Cheung

      Article first published online: 27 FEB 2015 | DOI: 10.1002/cncr.29316

      Osteochondromas in long-term survivors of neuroblastoma should be expected because these benign growths can occur within or outside radiation fields and these patients undergo radiologic studies over the course of years. A pathogenic role for chemotherapy, anti-GD2 monoclonal antibodies, or isotretinoin remains speculative.

  21. Review Articles

    1. Inflammation-induced activation of the indoleamine 2,3-dioxygenase pathway: Relevance to cancer-related fatigue

      Sangmi Kim, Brian J. Miller, Michael E. Stefanek and Andrew H. Miller

      Article first published online: 27 FEB 2015 | DOI: 10.1002/cncr.29302

      This review examines the increasing data that implicate the indoleamine 2,3-dioxygenase pathway in the etiology of cancer-related fatigue, and it explores potential translational implications for novel treatments for cancer-related fatigue.

  22. Original Article

    1. Disease Site

      Hematologic Malignancies
      Identification of geographic clustering and regions spared by cutaneous T-cell lymphoma in Texas using 2 distinct cancer registries

      Ivan V. Litvinov, Michael T. Tetzlaff, Elham Rahme, Youssef Habel, David R. Risser, Pamela Gangar, Michelle A. Jennings, Kevin Pehr, Victor G. Prieto, Denis Sasseville and Madeleine Duvic

      Article first published online: 27 FEB 2015 | DOI: 10.1002/cncr.29301

      To the authors' knowledge, the current study is the first to document the existence of geographic clustering as well as areas spared by cutaneous T-cell lymphoma in Texas. The results strongly argue for the existence of an external trigger for this malignancy.

  23. Original Articles

    1. Discipline

      Epidemiology
      Validity of anthropometric measurements for characterizing obesity among adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study

      Robyn E. Karlage, Carmen L. Wilson, Nan Zhang, Sue Kaste, Daniel M. Green, Gregory T. Armstrong, Leslie L. Robison, Wassim Chemaitilly, Deo Kumar Srivastava, Melissa M. Hudson and Kirsten K. Ness

      Article first published online: 27 FEB 2015 | DOI: 10.1002/cncr.29300

      Skinfold measurements and waist-to-height ratios are valid and easily administered alternatives to the body mass index for the classification of body composition abnormalities in childhood cancer survivors. Clinicians should be aware of the risk of false-negative misclassification of obesity when they are using the body mass index in this population. Those exposed to cranial radiation are at particular risk.

    2. Outcomes Research
      Treatment-related toxicities in older adults with head and neck cancer: A population-based analysis

      Caitriona B. O'Neill, Shrujal S. Baxi, Coral L. Atoria, James P. O'Neill, Martin C. Henman, Eric J. Sherman, Nancy Y. Lee, David G. Pfister and Elena B. Elkin

      Article first published online: 27 FEB 2015 | DOI: 10.1002/cncr.29262

      In older patients, the rates of acute toxicities and feeding tube use in patients receiving chemotherapy and radiation therapy can potentially be considerable. It is possible that for certain older patients, the potential benefit of adding chemotherapy to radiation therapy does not outweigh the harms of this combined-modality therapy.

    3. Disease Site

      Gastrointestinal Disease
      Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer

      Abdul K. Siraj, Sarita Prabhakaran, Prashant Bavi, Rong Bu, Shaham Beg, Mohsen Al Hazmi, Maha Al-Rasheed, Mohammed Al-Assiri, Rami Sairafi, Fouad Al-Dayel, Nasser Al-Sanea, Shahab Uddin and Khawla S. Al-Kuraya

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29288

      This comprehensive study will help in implementing a universal screening/reflex testing strategy for Lynch syndrome in a clinical setting among patients with colorectal cancer in Saudi Arabia and in conducting a national screening program benefitting both patients and their relatives.

  24. Correspondence

    1. Reply to Wilms tumor and breast cancer

      Norman E. Breslow, Susan M. Peterson and Daniel M. Green

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29278

  25. Original Articles

    1. Disease Site

      Head and Neck Disease
      Increasing diagnosis of subclinical thyroid cancers leads to spurious improvements in survival rates

      Allen S. Ho, Louise Davies, Iain J. Nixon, Frank L. Palmer, Laura Y. Wang, Snehal G. Patel, Ian Ganly, Richard J. Wong, R. Michael Tuttle and Luc G. T. Morris

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29289

      Modern medical practices now uncover previously undiagnosed small thyroid cancers and artificially improve survival rates but leave mortality rates unchanged. Relying on survival data to measure success in treating thyroid cancer unnecessarily reinforces aggressive diagnostic and therapeutic practices.

  26. Correspondence

    1. Wilms tumor and breast cancer

      Steven Lehrer and Kenneth E. Rosenzweig

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29279

    2. Reply to Wilms tumor and breast cancer

      Jennifer B. Dean and Jeffrey S. Dome

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29281

  27. Original Articles

    1. Discipline

      Outcomes Research
      Reference values of the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being: A report from the American Cancer Society's studies of cancer survivors

      Alexis R. Munoz, John M. Salsman, Kevin D. Stein and David Cella

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29286

      The current study provides reference values from a representative sample of the US adult cancer survivor population. These data will aid researchers and clinicians with interpreting the magnitude and meaning of their own findings on the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being; The 12-item Spiritual Well-Being Scale (FACIT-Sp-12) measure and allow for comparisons of scores across groups in trials.

    2. Symptom Control and Palliative Care
      Automated pain intervention for underserved minority women with breast cancer

      Karen O. Anderson, Guadalupe R. Palos, Tito R. Mendoza, Charles S. Cleeland, Kai-Ping Liao, Michael J. Fisch, Araceli Garcia-Gonzalez, Alyssa G. Rieber, L. Arlene Nazario, Vicente Valero, Karin M. Hahn, Cheryl L. Person and Richard Payne

      Article first published online: 24 FEB 2015 | DOI: 10.1002/cncr.29204

  28. Editorial

    1. A review of incidence and relevant risk factors in genitourinary malignancies

      Marie B. Tobin and Gary D. Steinberg

      Article first published online: 17 FEB 2015 | DOI: 10.1002/cncr.29273

      In the current issue of Cancer, Klaassen et al have identified an increased risk of suicide in 4 of 5 genitourinary malignancies, with an especially high risk noted in patients with bladder and kidney cancer. This study identified older age, male sex, single/widowed/divorced status, white race, aggressive disease, and increased surgical intervention as risk factors for increased suicide risk in patients with genitourinary malignancies.

  29. Original Articles

    1. Discipline

      Psychosocial Oncology
      Factors associated with suicide in patients with genitourinary malignancies

      Zachary Klaassen, Rita P. Jen, John M. DiBianco, Lael Reinstatler, Qiang Li, Rabii Madi, Ronald W. Lewis, Arthur M. Smith, Durwood E. Neal Jr, Kelvin A. Moses and Martha K. Terris

      Article first published online: 17 FEB 2015 | DOI: 10.1002/cncr.29274

      Suicide in patients with genitourinary malignancies, particularly those with bladder, kidney, and prostate cancer, poses a public health dilemma. Clinicians should be aware of risk factors for suicide in these patients, especially among men, the elderly, and those with aggressive disease.

    2. Translational Research
      Genetic variations in angiopoietin and pericyte pathways and clinical outcome in patients with resected colorectal liver metastases

      Stefan Stremitzer, Wu Zhang, Dongyun Yang, Yan Ning, Sebastian Stintzing, Ana Sebio, Yu Sunakawa, Shinichi Yamauchi, Satoshi Matsusaka, Rita El-Khoueiry, Judith Stift, Friedrich Wrba, Thomas Gruenberger and Heinz-Josef Lenz

      Article first published online: 17 FEB 2015 | DOI: 10.1002/cncr.29259

      Variations in genes involved in angiopoietin and pericyte pathways that may become escape mechanisms under antivascular endothelial growth factor-targeted therapy are investigated in a unique cohort of patients with resectable colorectal liver metastases who received perioperative bevacizumab-based chemotherapy and underwent liver resection in curative intent. Genetic variants in RALBP1, PDGFB, and ANGPT2 were associated with response, recurrence-free survival, overall survival, and the probability of achieving a cure and may serve as predictive and/or prognostic biomarkers in patients who are treated using a multidisciplinary approach.

  30. Review Article

    1. New oral small molecules in the treatment of chronic lymphocytic leukemia

      Nicole Lamanna

      Article first published online: 17 FEB 2015 | DOI: 10.1002/cncr.29130

      There has been a dramatic change in therapy for chronic lymphocytic leukemia over the last 20 years. The current study provides a review of some of the new small molecule inhibitors being used in the treatment of patients with chronic lymphocytic leukemia, with a focus on the B-cell receptor signaling-associated kinases (Bruton tyrosine kinase, phosphatidylinositol 3-kinase, and spleen tyrosine kinase) as well as inhibition of Bcl-2.

  31. Editorial

    1. Genetic variants and response to cancer treatments

      Janindra Warusavitarne, Justin Stebbing and Omar Faiz

      Article first published online: 17 FEB 2015 | DOI: 10.1002/cncr.29257

      The authors discuss new findings that single nucleotide polymorphisms in genes associated with off-target effects of antiangiogenesis agents have a bearing on clinical outcomes. This, in turn, reveals potential new targets for drug development.

  32. Original Articles

    1. Discipline

      Quality of Life
      Cancer treatments and their side effects are associated with aggravation of insomnia: Results of a longitudinal study

      Josée Savard, Hans Ivers, Marie-Hélène Savard and Charles M. Morin

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29244

      This study showed that cancer treatments are associated with increased insomnia, an effect that is mediated by somatic symptoms. It emphasizes the importance of managing appropriately treatment side effects in order to prevent the occurrence and aggravation of insomnia in this population.

    2. Disease Site

      Gastrointestinal Disease
      Predicting early mortality in resectable pancreatic adenocarcinoma: A cohort study

      Davendra P.S. Sohal, Shiva Shrotriya, Kate Tullio Glass, Robert J. Pelley, Michael J. McNamara, Bassam Estfan, Marc Shapiro, Jane Wey, Sricharan Chalikonda, Gareth Morris-Stiff, R. Matthew Walsh and Alok A. Khorana

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29298

      Baseline patient-related clinical and laboratory parameters can predict high mortality after surgical resection in patients with pancreatic adenocarcinoma. Patients undergoing routine clinical care can be identified early through this approach.

    3. Hematologic Malignancies
      Disease characteristics, patterns of care, and survival in very elderly patients with diffuse large B-cell lymphoma

      Jessica N. Williams, Ashish Rai, Joseph Lipscomb, Jean L. Koff, Loretta J. Nastoupil and Christopher R. Flowers

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29290

      Treatment with the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for >4 cycles appears to yield optimal survival among patients with diffuse large B-cell lymphoma who are aged >80 years, even after controlling for comorbid diseases, performance status, and Ann Arbor stage of disease. Use of the regimen of rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) for >4 cycles also appears to be an effective treatment for patients in this age group with Ann Arbor stage III/IV disease.

    4. Discipline

      Outcomes Research
      Residential racial segregation and mortality among black, white, and Hispanic urban breast cancer patients in Texas, 1995 to 2009

      Sandi L. Pruitt, Simon J. Craddock Lee, Jasmin A. Tiro, Lei Xuan, John M. Ruiz and Stephen Inrig

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29282

      Residential racial segregation is adversely associated with mortality among urban women with breast cancer in Texas, does not explain the main effect of race/ethnicity on mortality after adjustment for tumor, patient, and neighborhood covariates, and its effects may differ by patient race/ethnicity.

    5. Disease Site

      Melanoma
      Sentinel lymph node biopsy is indicated for patients with thick clinically lymph node-negative melanoma

      Maki Yamamoto, Kate J. Fisher, Joyce Y. Wong, Jonathan M. Koscso, Monique A. Konstantinovic, Nicholas Govsyeyev, Jane L. Messina, Amod A. Sarnaik, C. Wayne Cruse, Ricardo J. Gonzalez, Vernon K. Sondak and Jonathan S. Zager

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29239

      Sentinel lymph node biopsy is indicated for the staging of patients with clinically lymph node-negative melanoma of intermediate thickness, but its use is controversial in patients with thick melanoma. The results of the current study indicate that sentinel lymph node biopsy in patients with thick melanoma appears to have prognostic value in determining overall, disease-specific, and recurrence-free survival.

    6. Discipline

      Psychosocial Oncology
      When do we need to care about the caregiver? Supportive care needs, anxiety, and depression among informal caregivers of patients with cancer and cancer survivors

      Halina Sklenarova, Arne Krümpelmann, Markus W. Haun, Hans-Christoph Friederich, Johannes Huber, Michael Thomas, Eva C. Winkler, Wolfgang Herzog and Mechthild Hartmann

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29223

      This study introduces a family perspective to cancer. It describes that caregivers' emotional well-being is also significantly affected and presents detailed information on their needs for support.

  33. Editorial

    1. The time is now: Assessing and addressing the needs of cancer caregivers

      Teresa L. Deshields and Allison J. Applebaum

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29226

      Informal caregivers are essential to the current system of delivery for cancer care, yet research indicates that these caregivers are distressed and endorse many unmet needs. Further research is needed to identify how to best address the supportive care needs of this population.

  34. Original Articles

    1. Discipline

      Symptom Control and Palliative Care
      Patient beliefs that chemotherapy may be curative and care received at the end of life among patients with metastatic lung and colorectal cancer

      Jennifer W. Mack, Anne Walling, Sydney Dy, Anna Liza M. Antonio, John Adams, Nancy L. Keating and Diana Tisnado

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29250

      An understanding of the purpose of chemotherapy for incurable cancer is a critical aspect of informed consent. Patients with advanced cancer who are well informed about chemotherapy's goals receive late-life chemotherapy at rates similar to those for other patients, but they are more likely to enroll in hospice before death. This suggests important care outcomes beyond chemotherapy use.

  35. Correspondence

    1. Progression-free survival: Does a correlation with survival justify its role as a surrogate clinical endpoint?

      Susan Halabi, Brian I. Rini, Bernard Escudier, Walter M. Stadler and Eric J. Small

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29252

  36. Review Article

    1. Improving access to novel agents for childhood leukemia

      Weili Sun, Paul S. Gaynon, Richard Sposto and Alan S. Wayne

      Article first published online: 11 FEB 2015 | DOI: 10.1002/cncr.29267

      The complex biology and aggressive nature of childhood leukemia, coupled with the relatively small patient population available for study, pose specific challenges to the development of new therapies. In this review, the authors discuss strategies and initiatives designed to improve access to new agents and early phase clinical trials for pediatric leukemia.

  37. Correspondence

  38. Original Articles

    1. Discipline

      Clinical Trials
      Phase 1b study of the mammalian target of rapamycin inhibitor sirolimus in combination with nanoparticle albumin–bound paclitaxel in patients with advanced solid tumors

      Maysa M. Abu-Khalaf, Megan A. Baumgart, Scott N. Gettinger, Indukala Doddamane, David P. Tuck, Shihe Hou, Nianhang Chen, Catherine Sullivan, Kimberly Lezon-Geyda, Daniel Zelterman, Christos Hatzis, Hari Deshpande, Michael P. Digiovanna, Masoud Azodi, Peter E. Schwartz and Lyndsay N. Harris

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29254

      Sirolimus shows an acceptable safety profile and promising activity at a weekly dose of 40 mg with nab-paclitaxel (100 mg/m2), with better responses seen in patients with a higher posttreatment AKT score and an early reduction in [18F]fludeoxyglucose activity.

    2. Epidemiology
      The past, present, and future of cancer incidence in the United States: 1975 through 2020

      Hannah K. Weir, Trevor D. Thompson, Ashwini Soman, Bjørn Møller and Steven Leadbetter

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29258

      Between 2010 and 2020, the cancer incidence rates/risk is predicted to stabilize for much of the US population. However, we expect the number of cancer cases to increase substantially. A greater emphasis on primary prevention and early detection is needed to counter the effect of an aging and growing population on the burden of cancer.

    3. Statin use and risk of pancreatic cancer: Results from a large, clinic-based case-control study

      Evan J. Walker, Andrew H. Ko, Elizabeth A. Holly and Paige M. Bracci

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29256

      The association between statin use and pancreatic cancer risk is poorly understood. In this large case-control study, statin use is associated with a decreased risk of pancreatic cancer in men, and the duration of use is inversely associated with risk.

    4. Pediatric Oncology
      Predictors of colorectal cancer surveillance among survivors of childhood cancer treated with radiation: A report from the Childhood Cancer Survivor Study

      Casey L. Daniel, Connie L. Kohler, Kayla L. Stratton, Kevin C. Oeffinger, Wendy M. Leisenring, John W. Waterbor, Kimberly F. Whelan, Gregory T. Armstrong, Tara O. Henderson, Kevin R. Krull, Leslie L. Robison and Paul C. Nathan

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29265

      Less than 30% of childhood cancer survivors in the current study cohort who were considered to be at an increased risk of colorectal cancer were screened as recommended. Educational interventions targeted at survivors and their primary care physicians are needed to increase awareness of survivors' increased risk of colorectal cancer due to radiation exposure and appropriate surveillance.

    5. Disease Site

      Hematologic Malignancies
      Unrelated cord blood compared with haploidentical grafts in patients with hematological malignancies

      Jean El-Cheikh, Roberto Crocchiolo, Sabine Furst, Stefania Bramanti, Barbara Sarina, Angela Granata, Andrea Vai, Claude Lemarie, Catherine Faucher, Bilal Mohty, Samia Harbi, Reda Bouabdallah, Norbert Vey, Armando Santoro, Christian Chabannon, Luca Castagna and Didier Blaise

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29271

      Alternative donors, such as unrelated umbilical cord blood and related haploidentical donors, are more and more frequently searched for and used for patients who are candidates for allogeneic hematopoietic stem cell transplantation but are without a suitable related or unrelated donor. In the current study, comparison of umbilical cord blood and haploidentical donor grafts suggests that, for patients with high-risk hematological diseases without a related or unrelated donor, haploidentical transplants are a promising alternative option that deserves further investigation.

  39. Erratum

    1. You have free access to this content
    2. You have free access to this content
  40. Original Articles

    1. Disease Site

      Chest and Lung Disease
      Personalizing annual lung cancer screening for patients with chronic obstructive pulmonary disease: A decision analysis

      Kathryn P. Lowry, G. Scott Gazelle, Michael E. Gilmore, Colden Johanson, Vidit Munshi, Sung Eun Choi, Angela C. Tramontano, Chung Yin Kong and Pamela M. McMahon

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29225

      A microsimulation model was used to evaluate the health benefits of hypothetical lung cancer screening programs targeting individuals with chronic obstructive pulmonary disease compared with programs with eligibility based on smoking history alone. Programs incorporating lower pack-year thresholds for individuals with COPD achieved the highest life expectancy per number of screens.

  41. Review Articles

    1. Infertility in reproductive-age female cancer survivors

      Jennifer M. Levine, Joanne Frankel Kelvin, Gwendolyn P. Quinn and Clarisa R. Gracia

      Article first published online: 3 FEB 2015 | DOI: 10.1002/cncr.29181

      This review summarizes risks for infertility in reproductive-age females with cancer, presents options for fertility preservation, addresses psychosocial issues, raises ethical issues, and outlines considerations for developing an institutional fertility preservation program.

  42. Original Articles

    1. Discipline

      Clinical Trials
      A phase 1 study of cetuximab and lapatinib in patients with advanced solid tumor malignancies

      John F. Deeken, Hongkun Wang, Deepa Subramaniam, Aiwu Ruth He, Jimmy Hwang, John L. Marshall, Christina E. Urso, Yiru Wang, Corinne Ramos, Kenneth Steadman and Michael J. Pishvaian

      Article first published online: 29 JAN 2015 | DOI: 10.1002/cncr.29224

      Acquired resistance to anti-EGFR monoclonal antibody therapy may be caused by EGFR-ErbB2 dimer formation in tumor cells. The authors conduct this phase 1 trial combining cetuximab and lapatinib to determine the recommended dose and safety of combining dual EGFR and ErbB2 therapies.

  43. Correspondence

    1. Critical evaluation of the scientific content in clinical practice guidelines

      Andres Cervantes, George Pentheroudakis and Dirk Arnold

      Article first published online: 29 JAN 2015 | DOI: 10.1002/cncr.29261

  44. Original Articles

    1. Discipline

      Outcomes Research
      Cost effectiveness of proton versus photon radiation therapy with respect to the risk of growth hormone deficiency in children

      Raymond Mailhot Vega, Jane Kim, Abby Hollander, Jona Hattangadi-Gluth, Jeff Michalski, Nancy J. Tarbell, Torunn I. Yock, Marc Bussiere and Shannon M. MacDonald

      Article first published online: 29 JAN 2015 | DOI: 10.1002/cncr.29209

      Although proton therapy is costly, it may sometimes be cost effective compared with traditional photon therapy, especially when treating pediatric tumors. The authors present data regarding strategy favorability between proton versus photon radiotherapy for pediatric brain tumors and analyze the cost effectiveness and the risk and cost of growth hormone deficiency with specific dose comparisons between modalities.

    2. Disease Site

      Head and Neck Disease
      Randomized trial comparing surgery and adjuvant radiotherapy versus concurrent chemoradiotherapy in patients with advanced, nonmetastatic squamous cell carcinoma of the head and neck: 10-year update and subset analysis

      N. Gopalakrishna Iyer, Daniel S.W. Tan, Veronique KM Tan, Weining Wang, Jacqueline Hwang, Ngian-Chye Tan, Ranjiv Sivanandan, Hiang-Khoon Tan, Wan Teck Lim, Mei-Kim Ang, Joseph Wee, Khee-Chee Soo and Eng Huat Tan

      Article first published online: 29 JAN 2015 | DOI: 10.1002/cncr.29251

      The 10-year update of a trial comparing concurrent chemotherapy and radiotherapy with surgery and adjuvant radiotherapy in patients with stage III/IV nonmetastatic head and neck squamous cell carcinoma is presented. Subset analysis demonstrates that surgery with adjuvant radiotherapy is superior to concurrent chemotherapy and radiotherapy in patients with advanced resectable squamous cell carcinoma arising from the oral cavity and maxillary sinus.

    3. Gastrointestinal Disease
      Variation in hospital treatment patterns for metastatic colorectal cancer

      Robert W. Krell, Scott E. Regenbogen and Sandra L. Wong

      Article first published online: 29 JAN 2015 | DOI: 10.1002/cncr.29253

      Wide variation in hospital treatment patterns for patients with metastatic colorectal cancer has been stable over time. It appears that much of the approach for the treatment of metastatic colorectal cancer depends on the hospital in which the patient presents.

  45. Commentary

    1. Downstage migration after neoadjuvant chemoradiotherapy for rectal cancer: The reverse of the Will Rogers phenomenon?

      Emmanouil Fokas, Torsten Liersch, Rainer Fietkau, Werner Hohenberger, Clemens Hess, Heinz Becker, Rolf Sauer, Christian Wittekind and Claus Rödel

      Article first published online: 21 JAN 2015 | DOI: 10.1002/cncr.29260

      Although downstaging after neoadjuvant treatment is increasingly used as a prognostic factor and surrogate endpoint in clinical trials, the current study directly questions its value after preoperative treatment when assessing treatment efficacy.

  46. Original Articles

    1. Discipline

      Clinical Trials
      Paclitaxel/carboplatin with or without belinostat as empiric first-line treatment for patients with carcinoma of unknown primary site: A randomized, phase 2 trial

      John D. Hainsworth, Gedske Daugaard, Thierry Lesimple, Gerdt Hübner, F. Anthony Greco, Michael J. Stahl, Christian Meyer Zum Büschenfelde, Djelila Allouache, Nicolas Penel, Poul Knoblauch and Karim S. Fizazi

      Article first published online: 21 JAN 2015 | DOI: 10.1002/cncr.29229

      The addition of belinostat to combined paclitaxel and carboplatin does not improve the progression-free survival of patients with carcinoma of unknown primary site who receive first-line therapy, although patients who receive belinostat have a higher investigator-assessed response rate.

    2. Disease Site

      Gastrointestinal Disease
      You have full text access to this OnlineOpen article
      Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer

      Bo Yang, Lin Cao, Jiaen Liu, Yanjie Xu, Gillian Milne, Wanhei Chan, Steven D. Heys, Colin D. McCaig and Jin Pu

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncr.29235

      The level of chloride channel accessory 1 expression may be a potential predictor of prognosis in primary human colorectal cancer. Low expression of chloride channel accessory 1 predicts disease recurrence and lower survival, and this has implications for the selection of patients most likely to need and benefit from adjuvant chemotherapy.

    3. Discipline

      Medical Oncology
      Comparison of oncology drug approval between Health Canada and the US Food and Drug Administration

      Doreen A. Ezeife, Tony H. Truong, Daniel Y. C. Heng, Sylvie Bourque, Stephen A. Welch and Patricia A. Tang

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncr.29246

      The drug approval timeline, from regulatory agency submission to approval, is 3 months shorter for the US Food and Drug Administration than for Health Canada. The median time from Health Canada approval to the placement of a drug on a provincial formulary is 16.7 months.

    4. Disease Site

      Breast Disease
      Trends in breast biopsy pathology diagnoses among women undergoing mammography in the United States: A report from the Breast Cancer Surveillance Consortium

      Kimberly H. Allison, Linn A. Abraham, Donald L. Weaver, Anna N. A. Tosteson, Heidi D. Nelson, Tracy Onega, Berta M. Geller, Karla Kerlikowske, Patricia A. Carney, Laura E. Ichikawa, Diana S. M. Buist and Joann G. Elmore

      Article first published online: 20 JAN 2015 | DOI: 10.1002/cncr.29199

      Based on diagnostic results of breast biopsies from the BCSC from women undergoing mammography between 1996 and 2008, the frequencies of biopsy after screening mammography did not change over time, whereas diagnoses of DCIS and invasive cancer increased, suggesting more targeted use of biopsy. Among biopsies following mammography, women with dense breasts or family history of breast cancer were more likely to have high-risk lesions or invasive cancer.

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