A randomized phase 2 study comparing EC or CMF versus nab-paclitaxel plus capecitabine as adjuvant chemotherapy for nonfrail elderly patients with moderate to high-risk early breast cancer (ICE II-GBG 52)
Gunter von Minckwitz, Bettina Conrad, Toralf Reimer, Thomas Decker, Holger Eidtmann, Wolfgang Eiermann, John Hackmann, Volker Möbus, Frederik Marmé, Jochem Potenberg, Elmar Stickeler, Eike Simon, Christoph Thomssen, Jens Huober, Carsten Denkert, Joachim Alfer, Christian Jackisch, Valentina Nekljudova, Nicole Burchardi, Sibylle Loibl and for the German Breast Group Investigators
Article first published online: 25 JUN 2015 | DOI: 10.1002/cncr.29506
The results of the ICE II (Investigational Chemotherapy for Elderly patients trial II) trial demonstrated that nonfrail elderly patients with moderate or high-risk breast cancer can be treated with taxane-based polychemotherapy. However, compound-specific toxicities appear to lower relative dose intensity and therefore potential survival benefits.