Cancer

Cover image for Vol. 123 Issue 13

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Fadlo R. Khuri, MD

Impact Factor: 5.997

ISI Journal Citation Reports © Ranking: 2016: 35/217 (Oncology)

Online ISSN: 1097-0142

Associated Title(s): Cancer Cytopathology, CA: A Cancer Journal for Clinicians

VIEW

  1. 1 - 100
  2. 101 - 155
  1. Original Articles

    1. Discipline

      Outcomes Research
      Comparing outcomes of matched related donor and matched unrelated donor hematopoietic cell transplants in adults with B-Cell acute lymphoblastic leukemia

      Eric Segal, Michael Martens, Hai-Lin Wang, Ruta Brazauskas, Daniel Weisdorf, Brenda M. Sandmaier, H. Jean Khoury, Marcos de Lima and Wael Saber

      Version of Record online: 27 APR 2017 | DOI: 10.1002/cncr.30737

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      In this study, the outcomes of post–hematopoietic cell transplantation using matched related donors, 8/8 human leukocyte antigen–matched unrelated donors, and 7/8 unrelated donors are compared for adults with acute lymphoblastic leukemia. Patient-, disease-, and transplant-related variables that can further modify the association between the donor source and the posttransplant outcomes are identified. Because of their comparable outcomes, 8/8 unrelated donor transplants are a suitable alternative to matched related donor transplants, whereas 7/8 unrelated donor transplants are associated with poorer overall survival.

    2. Disease Site

      Head and Neck Disease
      Triple-modality treatment in patients with advanced stage tonsil cancer

      Dylan F. Roden, David Schreiber and Babak Givi

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30728

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      Upfront surgery allows for the intensification of adjuvant therapy(s) based on surgical pathology. Triple-modality therapy (surgery followed by concurrent chemoradiation) may have a survival benefit in a subset of patients with advanced stage cancer of the tonsil.

    3. Discipline

      Epidemiology
      Breast cancer stage variation and survival in association with insurance status and sociodemographic factors in US women 18 to 64 years old

      Christine D. Hsu, Xiaoyan Wang, David V. Habif Jr., Cynthia X. Ma and Kimberly J. Johnson

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30722

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      Using the Surveillance, Epidemiology, and End Results 18 registries database, this study examines associations between health insurance status and demographic variables and breast cancer diagnosis stage and survival for women diagnosed between the ages of 18 and 64 years. Women who have Medicaid or no insurance, women who are unmarried, and women who are black are more likely to have higher stage diagnoses and to die of their disease.

    4. Disease Site

      Soft Tissue and Bone Sarcoma
      Immunotherapy with single agent nivolumab for advanced leiomyosarcoma of the uterus: Results of a phase 2 study

      Eytan Ben-Ami, Constance M. Barysauskas, Sarah Solomon, Kadija Tahlil, Rita Malley, Melissa Hohos, Kathleen Polson, Margaret Loucks, Mariano Severgnini, Tara Patel, Amy Cunningham, Scott J. Rodig, F. Stephen Hodi, Jeffrey A. Morgan, Priscilla Merriam, Andrew J. Wagner, Geoffrey Shapiro and Suzanne George

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30738

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      Although this study reveals a lack of benefit for single-agent nivolumab in an unselected cohort of women, it has stimulated further investigations of novel combinations of immunotherapy in sarcoma patients. The results of this study will help guide patients and providers away from the use of nivolumab for off-label use in this patient population in an era of significant health care costs.

    5. Discipline

      Pediatric Oncology
      Improved outcomes after successful implementation of a pediatric early warning system (PEWS) in a resource-limited pediatric oncology hospital

      Asya Agulnik, Lupe Nataly Mora Robles, Peter W. Forbes, Doris Judith Soberanis Vasquez, Ricardo Mack, Federico Antillon-Klussmann, Monica Kleinman and Carlos Rodriguez-Galindo

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30664

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      This study describes the successful implementation of a pediatric early warning system (PEWS) in a resource-limited pediatric oncology hospital, resulting in a decrease in inpatient clinical deterioration events and pediatric intensive care unit utilization. The results of this study demonstrate that PEWS is a feasible and effective quality improvement measure to improve care for children with cancer in hospitals with limited resources.

  2. Review Articles

    1. Regulations and policies regarding e-cigarettes

      Leila F. Barraza, Kim E. Weidenaar, Livia T. Cook, Andrea R. Logue and Michael T. Halpern

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30725

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      The use of electronic cigarettes is a growing public health concern, because the ingredients of these products, their potential health impacts on users, and their “secondhand smoke” exposures to nonsmokers are uncertain. This review highlights available data regarding the safety and public health impact of electronic cigarettes and details the current status of US regulations and policies affecting their sale and use.

  3. Original Articles

    1. Discipline

      Disparities Research
      Lay health educators and print materials for the promotion of colorectal cancer screening among Korean Americans: A randomized comparative effectiveness study

      Angela M. Jo, Tung T. Nguyen, Susan Stewart, Min J. Sung, Ginny Gildengorin, Janice Y. Tsoh, Elisa K. Tong, Penny Lo, Charlene Cuaresma, Angela Sy, Hy Lam, Ching Wong, Matthew Jeong, Moon S. Chen Jr and Marjorie Kagawa-Singer

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30568

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      Herein, the authors conduct a 2-arm cluster randomized controlled trial comparing a brochure with a brochure plus a lay health educator outreach program in increasing colorectal cancer screening among Korean Americans among whom a large percentage lack health care access. Compared with a brochure, lay health educator outreach yields a greater increase in knowledge but results in similar increases in colorectal cancer screening, suggesting that more work is needed to appropriately address logistical and system barriers in this community.

    2. Clinical Trials
      Phase 1 dose-escalation study of mirvetuximab soravtansine (IMGN853), a folate receptor α-targeting antibody-drug conjugate, in patients with solid tumors

      Kathleen N. Moore, Hossein Borghaei, David M. O'Malley, Woondong Jeong, Shelly M. Seward, Todd M. Bauer, Raymond P. Perez, Ursula A. Matulonis, Kelli L. Running, Xiaoyan Zhang, Jose F. Ponte, Rodrigo Ruiz-Soto and Michael J. Birrer

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30736

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      Mirvetuximab soravtansine (IMGN853) is an antibody-drug conjugate that targets folate receptor α for tumor-directed delivery of the maytansinoid DM4, a potent microtubule-disrupting agent. In this phase 1 study in patients with advanced solid tumors, IMGN853 is tolerable with manageable toxicities, and treatment is associated with encouraging signs of clinical activity, particularly in patients with epithelial ovarian cancer.

    3. Epidemiology
      Thyroid cancer incidence among Asian immigrants to Ontario, Canada: a population-based cohort study

      Baiju R. Shah, Rebecca Griffiths and Stephen F. Hall

      Version of Record online: 25 APR 2017 | DOI: 10.1002/cncr.30746

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      Immigrants from Southeast and East Asia have markedly higher thyroid cancer incidence than nonimmigrants. Immigrants from the Philippines, South Korea, and China are at particularly elevated risk.

    4. Disease Site

      Genitourinary Disease
      You have full text access to this OnlineOpen article
      Decipher test impacts decision making among patients considering adjuvant and salvage treatment after radical prostatectomy: Interim results from the Multicenter Prospective PRO-IMPACT study

      John L. Gore, Marguerite du Plessis, María Santiago-Jiménez, Kasra Yousefi, Darby J. S. Thompson, Lawrence Karsh, Brian R. Lane, Michael Franks, David Y. T. Chen, Mark Bandyk, Fernando J. Bianco Jr, Gordon Brown, William Clark, Adam S. Kibel, Hyung L. Kim, William Lowrance, Murugesan Manoharan, Paul Maroni, Scott Perrapato, Paul Sieber, Edouard J. Trabulsi, Robert Waterhouse, Elai Davicioni, Yair Lotan and Daniel W. Lin

      Version of Record online: 19 APR 2017 | DOI: 10.1002/cncr.30665

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      Use of the Decipher test appears to result in a change in treatment decision making in a substantial percentage of men with prostate cancer who are considering adjuvant or salvage radiotherapy after radical prostatectomy. Decisional effectiveness improves for both patients and providers with use of the Decipher test.

    5. Discipline

      Symptom Control and Palliative Care
      Association between aggressive care and bereaved families’ evaluation of end-of-life care for veterans with non-small cell lung cancer who died in Veterans Affairs facilities

      Mary Ersek, Susan C. Miller, Todd H. Wagner, Joshua M. Thorpe, Dawn Smith, Cari R. Levy, Risha Gidwani, Katherine Faricy-Anderson, Karl A. Lorenz, Bruce Kinosian and Vincent Mor

      Version of Record online: 17 APR 2017 | DOI: 10.1002/cncr.30700

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      In the current study, the authors examine the association between episodes of aggressive care within the last 30 days of life and families’ evaluations of end-of-life care in patients with non-small cell lung cancer. The results demonstrate that when patients experience at least 1 episode of aggressive care, bereaved families rate care lower than when patients do not receive any aggressive care, although these associations appear to be moderated by whether the patients die in an inpatient hospice/palliative care unit.

    6. Disease Site

      Hematologic Malignancies
      Immune responses and long-term disease recurrence status after telomerase-based dendritic cell immunotherapy in patients with acute myeloid leukemia

      Hanna J. Khoury, Robert H. Collins Jr, William Blum, Patrick S. Stiff, Laurence Elias, Jane S. Lebkowski, Anita Reddy, Kevin P. Nishimoto, Debasish Sen, Edward D. Wirth III, Casey C. Case and John F. DiPersio

      Version of Record online: 14 APR 2017 | DOI: 10.1002/cncr.30696

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      The administration of telomerase-pulsed dendritic cells leads to antitelomerase T-cell responses in patients with intermediate-risk and high-risk acute myeloid leukemia. Approximately 58% of patients with acute myeloid leukemia were found to remain free of disease recurrence with a median follow-up of 52 months, thereby suggesting possible favorable recurrence-free survival.

    7. Discipline

      Epidemiology
      Cancer incidence profile in sub-Saharan African-born blacks in the United States: Similarities and differences with US-born non-Hispanic blacks

      Genet A. Medhanie, Stacey A. Fedewa, Hibret Adissu, Carol E. DeSantis, Rebecca L. Siegel and Ahmedin Jemal

      Version of Record online: 13 APR 2017 | DOI: 10.1002/cncr.30701

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      The cancer incidence profile of African-born blacks is different from that of US-born blacks and varies by countries (region) of origin. Compared with US-born blacks, African-born blacks have significantly higher proportional incidence ratios for infection-related cancers (liver, stomach, and Kaposi sarcoma) and blood cancers (leukemia and non-Hodgkin lymphoma), whereas they have lower proportional incidence ratios for smoking-related cancers (lung, lip and oral cavity, larynx, and urinary bladder).

    8. Disease Site

      Breast Disease
      Treatment experiences of Latinas after diagnosis of breast cancer

      Steven J. Katz, Lauren P. Wallner, Paul H. Abrahamse, Nancy K. Janz, Kathryn A. Martinez, Dean A. Shumway, Ann S. Hamilton, Kevin C. Ward, Kenneth A. Resnicow and Sarah T. Hawley

      Version of Record online: 11 APR 2017 | DOI: 10.1002/cncr.30702

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      There is little disparity in breast cancer treatment communication and decision making experiences as reported by Latinas with low acculturation versus other groups. However, the approach taken by Latina patients with low acculturation with regard to treatment decision making represents an important challenge to health care providers.

    9. Hematologic Malignancies
      Efficacy and feasibility of sorafenib as a maintenance agent after allogeneic hematopoietic stem cell transplantation for Fms-like tyrosine kinase 3-mutated acute myeloid leukemia

      Giorgia Battipaglia, Annalisa Ruggeri, Radwan Massoud, Jean El Cheikh, Matthieu Jestin, Ahmad Antar, Syed Osman Ahmed, Walid Rasheed, Marwan Shaheen, Ramdane Belhocine, Eolia Brissot, Remy Dulery, Sandra Eder, Federica Giannotti, Francoise Isnard, Simona Lapusan, Marie-Therese Rubio, Anne Vekhoff, Mahmoud Aljurf, Ollivier Legrand, Mohamad Mohty and Ali Bazarbachi

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30680

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      Sorafenib has shown encouraging results in patients with Fms-like tyrosine kinase 3 (FLT3)-positive acute myeloid leukemia. When used as a maintenance agent after allogeneic stem cell transplantation, sorafenib is safe and efficacious and allows long-term disease control.

    10. Discipline

      Complementary Medicine
      Mindfulness practice reduces cortisol blunting during chemotherapy: A randomized controlled study of colorectal cancer patients

      David S. Black, Cheng Peng, Alix G. Sleight, Nathalie Nguyen, Heinz-Josef Lenz and Jane C. Figueiredo

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30698

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      Cortisol blunting in cancer patients is predictive of adverse health outcomes and reduced survival. Our findings show that mindfulness practice may increase acute cortisol reactivity as a counter to the cortisol blunting that is often observed in cancer patients, specifically during chemotherapy infusions.

    11. Disease Site

      Hematologic Malignancies
      Characteristics and outcomes of older patients with secondary acute myeloid leukemia according to treatment approach

      Prajwal Chaitanya Boddu, Hagop M. Kantarjian, Farhad Ravandi, Guillermo Garcia-Manero, Srdan Verstovsek, Elias J. Jabbour, Koichi Takahashi, Kapil Bhalla, Marina Konopleva, Courtney D. DiNardo, Maro Ohanian, Naveen Pemmaraju, Nitin Jain, Sherry Pierce, William G. Wierda, Jorge E. Cortes and Tapan M. Kadia

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30704

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      Lower intensity (ie, low-dose cytarabine–based and hypomethylating agent–based) approaches are associated with lower early mortality and improved overall survival in comparison with intensive regimens in older patients with secondary acute myeloid leukemia. CPX-351 is not statistically associated with superior median survival in comparison with lower intensity therapy approaches to secondary acute myeloid leukemia.

    12. Discipline

      Pediatric Oncology
      Contribution of the TP53 R337H mutation to the cancer burden in southern Brazil: Insights from the study of 55 families of children with adrenocortical tumors

      Maria J. Mastellaro, Ana L. Seidinger, Guolian Kang, Renata Abrahão, Eliana C. M. Miranda, Stanley B. Pounds, Izilda A. Cardinalli, Simone S. Aguiar, Bonald C. Figueiredo, Carlos Rodriguez-Galindo, Silvia R. Brandalise, José A. Yunes, Antônio de A. Barros-Filho and Raul C. Ribeiro

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30703

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      Presymptomatic individuals who carry the germline tumor protein 53 (TP53) R337H mutation, which encodes a p53 mutant with partial loss of function (a low-penetrance mutant), have an increased lifetime risk of developing cancer. However, age at diagnosis, family history, and cancer types differ between those who carry the germline R337H mutation versus the TP53 DNA-binding domain mutation (classic Li-Fraumeni syndrome), and these differences have implications for genetic counseling and surveillance of carriers of TP53 R337H and possibly other low-penetrance mutant alleles.

    13. Disease Site

      Breast Disease
      The role of postmastectomy radiotherapy in women with pathologic T3N0M0 breast cancer

      Richard J. Cassidy, Yuan Liu, Shannon T. Kahn, Naresh K. Jegadeesh, Xi Liu, Preeti D. Subhedar, Cletus A. Arciero, Theresa W. Gillespie and Mylin A. Torres

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30675

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      There is conflicting evidence regarding the usefulness of postmastectomy radiotherapy among women with pT3N0M0 breast cancer. In this analysis of the National Cancer Data Base of women with pT3N0M0 breast cancer, postmastectomy radiotherapy is associated with improved overall survival, regardless of tumor size, surgical margin status, and receipt of systemic therapy. This finding is confirmed on multivariable analysis, interaction effect testing, and propensity score matched analysis.

    14. Discipline

      Pediatric Oncology
      Three sides to a story: Child, parent, and nurse perspectives on the child's experience during hematopoietic stem cell transplantation

      Christina K. Ullrich, Angie Mae Rodday, Kristin M. Bingen, Mary Jo Kupst, Sunita K. Patel, Karen L. Syrjala, Lynnette L. Harris, Christopher J. Recklitis, Grace Chang, Eva C. Guinan, Norma Terrin, Hocine Tighiouart, Sean Phipps and Susan K. Parsons

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30723

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      An assessment of the experience of children undergoing hematopoietic stem cell transplantation via multiple raters (child, parent, and nurse) is highly feasible and reveals that their perspectives differ by various factors and change over time. Taken together, different raters' viewpoints deepen the understanding of the child's transplant experience.

    15. Epidemiology
      Effect of depression before breast cancer diagnosis on mortality among postmenopausal women

      Xiaoyun Liang, Karen L. Margolis, Michael Hendryx, Katherine Reeves, Sylvia Wassertheil-Smoller, Julie Weitlauf, Suzanne C. Danhauer, Rowan T. Chlebowski, Bette Caan, Lihong Qi, Dorothy Lane, Sayeh Lavasani and Juhua Luo

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30688

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      Women with newly developed depression before the diagnosis of breast cancer have a modestly but significantly increased risk for death from any cause and for death from breast cancer if they are diagnosed at a late stage. The results also highlight the importance of prevention efforts to supporting mental health and preventing the initial emergence of depression among older women.

    16. Disease Site

      Hematologic Malignancies
      You have full text access to this OnlineOpen article
      Overall survival with ponatinib versus allogeneic stem cell transplantation in Philadelphia chromosome-positive leukemias with the T315I mutation

      Franck E. Nicolini, Grzegorz W. Basak, Dong-Wook Kim, Eduardo Olavarria, Javier Pinilla-Ibarz, Jane F. Apperley, Timothy Hughes, Dietger Niederwieser, Michael J. Mauro, Charles Chuah, Andreas Hochhaus, Giovanni Martinelli, Maral DerSarkissian, Mei Sheng Duh, Lisa J. McGarry, Hagop M. Kantarjian and Jorge E. Cortes

      Version of Record online: 7 APR 2017 | DOI: 10.1002/cncr.30558

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      In patients who have chronic-phase chronic myeloid leukemia (CML) with the Philadelphia chromosome threonine to isoleucine mutation at codon 315, single-agent ponatinib is associated with significantly longer overall survival compared with allogenic stem cell transplantation. In those who have accelerated-phase CML, blast-crisis CML, and Philadelphia chromosome-positive acute lymphoblastic leukemia with the T315I mutation, single-agent ponatinib is associated with similar or shorter overall survival compared with stem cell transplantation.

    17. Discipline

      Epidemiology
      Perioperative chemotherapy versus postoperative chemoradiotherapy in patients with resectable gastric/gastroesophageal junction adenocarcinomas: A survival analysis of 5058 patients

      Timothy L. Fitzgerald, Jimmy T. Efird, Nelly Bellamy, Suzanne M. Russo, Charulata Jindal, Catalina Mosquera, Elizabeth G. Holliday and Tithi Biswas

      Version of Record online: 6 APR 2017 | DOI: 10.1002/cncr.30692

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      A total of 5058 patients with resected, clinical American Joint Committee on Cancer TNM stage II and stage III adenocarcinomas of the stomach or gastroesophageal junction diagnosed from 2004 through 2013 were identified from the National Cancer Data Base. Patients treated with perioperative chemotherapy appear to survive significantly longer compared with those receiving postoperative chemoradiotherapy (P<.0001).

    18. Disease Site

      Breast Disease
      Relative effectiveness of adjuvant chemotherapy for invasive lobular compared with invasive ductal carcinoma of the breast

      Schelomo Marmor, Jane Yuet Ching Hui, Jing Li Huang, Scott Kizy, Heather Beckwith, Anne H. Blaes, Natasha M. Rueth and Todd M. Tuttle

      Version of Record online: 5 APR 2017 | DOI: 10.1002/cncr.30699

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      In this population-based study, although adjuvant chemotherapy significantly reduces the risk of breast cancer recurrence and death in women with stage I/II invasive ductal carcinoma, a similar survival benefit is not observed for those with estrogen receptor-positive, human epidermal growth factor 2-negative, stage I/II invasive lobular carcinoma.

    19. Discipline

      Radiation Oncology
      The impact of the omission or inadequate dosing of radiotherapy in extranodal natural killer T-cell lymphoma, nasal type, in the United States

      John A. Vargo, Arisha Patel, Scott M. Glaser, Goundappa K. Balasubramani, Rafic J. Farah, Stanley M. Marks and Sushil Beriwal

      Version of Record online: 5 APR 2017 | DOI: 10.1002/cncr.30697

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      In this hospital-based registry analysis, two-thirds of 642 patients are reported to have received treatment discordant with the recommendations of clinical practice guidelines. Highlighting the importance of the increased adoption of evidence-based guidelines, this study demonstrates that both the omission of radiotherapy and a suboptimal dose of radiotherapy are negatively associated with overall survival in a propensity score–adjusted multivariate analysis.

    20. Psychosocial Oncology
      Effects of patient-centered communication on anxiety, negative affect, and trust in the physician in delivering a cancer diagnosis: A randomized, experimental study

      Jelena Zwingmann, Walter F. Baile, Johann W. Schmier, Jürg Bernhard and Monika Keller

      Version of Record online: 5 APR 2017 | DOI: 10.1002/cncr.30694

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      Patient-centered communication makes a difference in patients' experience, insofar that they report feeling less anxious and more trustful of the oncologist. Video exposure appears to be a valuable method for investigating the impact of a physician's communication style during critical encounters.

    21. Disease Site

      Head and Neck Disease
      A comprehensive comparative analysis of treatment modalities for sinonasal malignancies

      Tyler P. Robin, Bernard L. Jones, Oren M. Gordon, Andy Phan, Diana Abbott, Jessica D. McDermott, Julie A. Goddard, David Raben, Ryan M. Lanning and Sana D. Karam

      Version of Record online: 3 APR 2017 | DOI: 10.1002/cncr.30686

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      In the current large cancer registry study, multimodality therapy appears to be associated with improved overall survival in patients with sinonasal cancers. This finding emphasizes the importance of shared multidisciplinary decision making in the management of these complex patients.

    22. Discipline

      Disparities Research
      Serum 25-hydroxyvitamin D, vitamin D binding protein, and prostate cancer risk in black men

      Tracy M. Layne, Stephanie J. Weinstein, Barry I. Graubard, Xiaomei Ma, Susan T. Mayne and Demetrius Albanes

      Version of Record online: 3 APR 2017 | DOI: 10.1002/cncr.30634

      Little is known about the relationship between vitamin D status and prostate cancer risk in black men. This study suggests that higher vitamin D binding protein is associated with lower prostate cancer risk in black men independent of 25-hydroxyvitamin D status.

    23. Outcomes Research
      Tumor volume doubling time of pulmonary metastases predicts overall survival and can guide the initiation of multikinase inhibitor therapy in patients with metastatic, follicular cell-derived thyroid carcinoma

      Mona M. Sabra, Eric J. Sherman and R. Michael Tuttle

      Version of Record online: 3 APR 2017 | DOI: 10.1002/cncr.30690

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      The average tumor volume doubling time (midDT) of lung metastases from follicular cell-derived thyroid cancer is an accessible, easily calculated, and reliable prognostic indicator of overall survival in patients with metastatic differentiated thyroid cancer. Unlike thyroglobulin doubling time, the midDT can be used to properly select patients with progressive, metastatic, radioactive iodine-refractory thyroid cancer who are likely to derive a survival benefit from multikinase inhibitor therapy.

    24. Disease Site

      Neuro-Oncology
      High-dose chemotherapy with thiotepa, busulfan, and cyclophosphamide and autologous stem cell transplantation for patients with primary central nervous system lymphoma in first complete remission

      Zachariah DeFilipp, Shuli Li, Areej El-Jawahri, Philippe Armand, Lakshmi Nayak, Nancy Wang, Tracy T. Batchelor and Yi-Bin Chen

      Version of Record online: 3 APR 2017 | DOI: 10.1002/cncr.30695

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      To the authors’ knowledge, the optimal approach to consolidative therapy for patients with primary central nervous system lymphoma in first complete remission has yet to be determined. In the current study, the authors report that autologous stem cell transplantation with a central nervous system-directed conditioning regimen of thiotepa, busulfan, and cyclophosphamide appears to be associated with promising disease control and an acceptable toxicity profile.

    25. Discipline

      Pediatric Oncology
      Prognostic disclosures over time: Parental preferences and physician practices

      Bryan A. Sisk, Tammy I. Kang and Jennifer W. Mack

      Version of Record online: 3 APR 2017 | DOI: 10.1002/cncr.30716

      The majority of parents of children with cancer report wanting detailed, longitudinal prognostic conversations during the year after diagnosis, and almost no parents prefer to receive less prognostic information. Longitudinal prognostic disclosure can help rather than hurt parents.

    26. Medical Oncology
      Clinical features of Bim deletion polymorphism and its relation with crizotinib primary resistance in Chinese patients with ALK/ROS1 fusion-positive non-small cell lung cancer

      Limin Zhang, Tao Jiang, Xuefei Li, Yan Wang, Chao Zhao, Sha Zhao, Lei Xi, Shijia Zhang, Xiaozhen Liu, Yijun Jia, Hui Yang, Jinpeng Shi, Chunxia Su, Shengxiang Ren and Caicun Zhou

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/cncr.30677

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      The results of the current study suggest that the B-cell chronic lymphocytic leukemia/lymphoma (Bcl-2)-like 11 (BCL2L11) (Bim) deletion polymorphism is associated with a poor objective response rate and shorter progression-free survival in patients with anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer who are treated with crizotinib. The Bim deletion polymorphism appears to be an independent predictive factor of shorter progression-free survival among patients with ALK-positive non-small cell lung cancer who are treated with crizotinib.

    27. Disease Site

      Gastrointestinal Disease
      Management of stage III colon cancer in the elderly: Practice patterns and outcomes in the general population

      Shaila J. Merchant, Sulaiman Nanji, Kelly Brennan, Safiya Karim, Sunil V. Patel, James J. Biagi and Christopher M. Booth

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/cncr.30691

      This article describes the utilization of and outcomes associated with adjuvant chemotherapy among elderly patients (≥70 years) with resected stage III colon cancer. Adjuvant chemotherapy is delivered to 48% of elderly patients in routine practice and is associated with improved outcomes.

    28. Chest and Lung Disease
      7-year follow-up after stereotactic ablative radiotherapy for patients with stage I non-small cell lung cancer: Results of a phase 2 clinical trial

      Bing Sun, Eric D. Brooks, Ritsuko U. Komaki, Zhongxing Liao, Melenda D. Jeter, Mary F. McAleer, Pamela K. Allen, Peter A. Balter, James D. Welsh, Michael S O'Reilly, Daniel Gomez, Stephen M. Hahn, Jack A. Roth, Reza J. Mehran, John V. Heymach and Joe Y. Chang

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/cncr.30693

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      To the authors' knowledge, the current prospective study is the first to investigate stereotactic ablative radiotherapy for patients with early-stage non-small cell lung cancer and presents the longest follow-up at 7 years. The results demonstrate outstanding overall survival, with locoregional and distant disease control rates for stereotactic ablative radiotherapy that are comparable to those for surgery but with lower toxicity. Close surveillance and aggressive salvage treatment are crucial because many patients with recurrent disease and a second primary malignancy are highly curable.

    29. Discipline

      Quality of Life
      You have full text access to this OnlineOpen article
      Quality of life with cediranib in relapsed ovarian cancer: The ICON6 phase 3 randomized clinical trial

      Dan P. Stark, Adrian Cook, Julia M. Brown, Michael D. Brundage, Andrew C. Embleton, Richard S. Kaplan, Fharat A. Raja, Ann Marie W. Swart, Galina Velikova, Wendi Qian and Jonathan A. Ledermann

      Version of Record online: 24 MAR 2017 | DOI: 10.1002/cncr.30657

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      The ICON6 randomized controlled trial shows a significant progression-free survival benefit with the use of cediranib, and this article shows no corresponding detriment to the quality of life. Prolonged cancer control, with quality of life maintained, suggests a role for cediranib in the treatment of relapsed ovarian cancer.

    30. Disease Site

      Melanoma
      A phase 2 trial of dasatinib in patients with locally advanced or stage IV mucosal, acral, or vulvovaginal melanoma: A trial of the ECOG-ACRIN Cancer Research Group (E2607)

      Kevin Kalinsky, Sandra Lee, Krista M. Rubin, Donald P. Lawrence, Anthony J. Iafrarte, Darell R. Borger, Kim A. Margolin, Mario M. Leitao Jr, Ahmad A. Tarhini, Henry B. Koon, Andrew L. Pecora, Anthony J. Jaslowski, Gary I. Cohen, Timothy M. Kuzel, Christopher D. Lao and John M. Kirkwood

      Version of Record online: 23 MAR 2017 | DOI: 10.1002/cncr.30663

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      In this multicenter, cooperative-group, 2-stage, single-arm clinical trial, 7 of 73 evaluable patients (9.6%) with mucosal, acral, vulvovaginal, or chronically sun-damaged melanoma achieved a partial response (wild-type KIT, 3 of 42; KIT mutation, 4 of 25; and unknown KIT status, 0 of 6). The dasatinib response rate among KIT-mutant melanoma patients is lower than anticipated.

    31. Breast Disease
      Are there patients with T1 to T2, lymph node-negative breast cancer who are “high-risk” for locoregional disease recurrence?

      Anita Mamtani, Sujata Patil, Michelle M. Stempel and Monica Morrow

      Version of Record online: 23 MAR 2017 | DOI: 10.1002/cncr.30658

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      Among 657 patients with T1 to T2N0 breast cancer with ≥ 1 high-risk features (age < 40 years, lymphovascular invasion, high grade, multifocality/multicentricity, and a central/medial tumor location) who were treated with mastectomy without postmastectomy radiotherapy, the locoregional disease recurrence rate is 4.7%. Tumor size and receipt of systemic therapy are predictive (hazard ratios of 1.7 and 0.40, respectively), but no high-risk features appear to confer an increased risk of locoregional disease recurrence either independently or together.

    32. Discipline

      Clinical Trials
      Insurance denials for cancer clinical trial participation after the Affordable Care Act mandate

      Christine B. Mackay, Kaitlyn R. Antonelli, Suanna S. Bruinooge, Jarron M. Saint Onge and Shellie D. Ellis

      Version of Record online: 23 MAR 2017 | DOI: 10.1002/cncr.30689

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      Insurance denials for participation in adult cancer clinical trials continue despite the Affordable Care Act's clinical trial policy. Both academic and community research sites have experienced insurance denials and delays as barriers to patient enrollment.

    33. Disease Site

      Hematologic Malignancies
      Long-term outcome after a treosulfan-based conditioning regimen for patients with acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

      Arnon Nagler, Myriam Labopin, Dietrich Beelen, Fabio Ciceri, Liisa Volin, Avichai Shimoni, Roberto Foá, Noel Milpied, Jacopo Peccatori, Emmanuelle Polge, Audrey Mailhol, Mohamad Mohty and Bipin N. Savani

      Version of Record online: 22 MAR 2017 | DOI: 10.1002/cncr.30646

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      A treosulfan-based conditioning regimen provides acceptable long-term survival with a low risk of early organ toxicity and acute graft-versus-host disease. The objective of future studies should be to compare treosulfan with the currently available ablative regimens and to define the best treosulfan combinations.

    34. Cytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogenic stem cell transplantation using reduced intensity conditioning

      Orhan Kemal Yucel, Rima M. Saliba, Gabriella Rondon, Sairah Ahmed, Amin Alousi, Qaiser Bashir, Stefan O. Ciurea, Uday Popat, Isa Khouri, David Marin, Katy Rezvani, Partow Kebriaei, Elizabeth J. Shpall, Richard E. Champlin and Betül Oran

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/cncr.30632

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      Outcome data in older myelodysplastic syndrome (MDS) patients with allogeneic stem cell transplantation is limited, hence we investigated the outcomes in this population with the use of reduced intensity conditioning. Survival after hematopoietic stem cell transplantation (HSCT) depends on cytogenetics and hematopoietic cell transplantation–comorbidity index in older MDS patients, and decisions to proceed with HSCT should take these factors into account.

    35. Discipline

      Radiation Oncology
      The prognostic value of extranodal extension in human papillomavirus-associated oropharyngeal squamous cell carcinoma

      Yi An, Henry S. Park, Jacqueline R. Kelly, John M. Stahl, Wendell G. Yarbrough, Barbara A. Burtness, Joseph N. Contessa, Roy H. Decker, Matthew Koshy and Zain A. Husain

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/cncr.30598

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      The presence of extranodal extension in patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma is correlated with inferior survival. However, adjuvant chemoradiation, compared with adjuvant radiotherapy alone, in a subgroup of patients with extranodal extension does not produce a detectable benefit.

    36. Disease Site

      Breast Disease
      Survival benefit needed to undergo chemotherapy: Patient and physician preferences

      Ines Vaz-Luis, Anne O'Neill, Karen Sepucha, Kathy D. Miller, Emily Baker, Chau T. Dang, Donald W. Northfelt, Eric P. Winer, George W. Sledge, Bryan Schneider and Ann H. Partridge

      Version of Record online: 21 MAR 2017 | DOI: 10.1002/cncr.30671

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      Among patients who receive contemporary adjuvant chemotherapy, there is substantial variation in preferences regarding survival benefit worth undergoing adjuvant chemotherapy. Engaging patients preferences regarding risks/benefits of treatment is critical in patient-centered medical decision making and care.

    37. Discipline

      Psychosocial Oncology
      Cancer in adolescents and young adults: Who remains at risk of poor social functioning over time?

      Olga Husson, Bradley J. Zebrack, Christine Aguilar, Brandon Hayes-Lattin and Steve Cole

      Version of Record online: 20 MAR 2017 | DOI: 10.1002/cncr.30656

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      Nearly one-third of adolescent and young adult patients with cancer remain at risk of poor social functioning 24 months after their primary diagnosis. Reducing physical symptoms and psychological distress and enhancing social support by intervention during the period after treatment may potentially help these young survivors to better reintegrate into society.

    38. Outcomes Research
      The early adoption of intensity-modulated radiotherapy and stereotactic body radiation treatment among older Medicare beneficiaries with prostate cancer

      Bruce L. Jacobs, Jonathan G. Yabes, Samia H. Lopa, Dwight E. Heron, Chung-Chou H. Chang, Florian R. Schroeck, Justin E. Bekelman, Jeremy M Kahn, Joel B. Nelson and Amber E. Barnato

      Version of Record online: 16 MAR 2017 | DOI: 10.1002/cncr.30574

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      There is a stark contrast in the adoption rates of intensity-modulated radiotherapy and stereotactic body radiation treatment for prostate cancer at the time of their introduction. Further investigation of the nonclinical factors associated with this difference is warranted.

    39. Safety and Quality
      Variation in the use of advanced imaging at the time of breast cancer diagnosis in a statewide registry

      N. Lynn Henry, Thomas M. Braun, Tara M. Breslin, David H. Gorski, Samuel M. Silver and Jennifer J. Griggs

      Version of Record online: 16 MAR 2017 | DOI: 10.1002/cncr.30674

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      Use of advanced imaging at the time of diagnosis of stage 0-IIA breast cancer decreased between 2008 and 2015 in a large statewide collaborative and remained stable for stage IIB disease. This decrease in testing over time resulted in a cost savings, especially for patients with stage I disease.

    40. Disease Site

      Genitourinary Disease
      Economic evaluation of nivolumab as a second-line treatment for advanced renal cell carcinoma from US and Chinese perspectives

      Xiao Min Wan, Liu Bao Peng, Jin An Ma and Yuan Jian Li

      Version of Record online: 16 MAR 2017 | DOI: 10.1002/cncr.30666

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      In the United States, nivolumab is unlikely to be a high-value treatment for metastatic renal cell carcinoma at the current price, and a price reduction appears to be justified. When the drug is approved in China, value-based prices for the cost of nivolumab will be $7.90 and $9.70/mg for the country and Beijing City, respectively.

    41. Discipline

      Clinical Trials
      Optimal dose of rabbit thymoglobulin in conditioning regimens for unmanipulated, haploidentical, hematopoietic stem cell transplantation: Long-term outcomes of a prospective randomized trial

      Ying-Jun Chang, Yu Wang, Xiao-Dong Mo, Xiao-Hui Zhang, Lan-Ping Xu, Chen-Hua Yan, Huan Chen, Yu-Hong Chen, Yao Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Kai-Yan Liu and Xiao-Jun Huang

      Version of Record online: 16 MAR 2017 | DOI: 10.1002/cncr.30540

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      Considerable progress has been made in unmanipulated haploidentical hematopoietic stem cell transplantation with an antithymocyte globulin (ATG)-based conditioning regimen. The findings of the current study suggest that ATG at a dose of 10 mg/kg is associated with better prevention of graft-versus-host disease and superior graft-versus-host disease-free/recurrence-free survival, but an increased rate of infection-related deaths. The optimal dose of ATG in the setting of unmanipulated haploidentical hematopoietic stem cell transplantation should be investigated further.

    42. Disease Site

      Hematologic Malignancies
      [18F]-FDG PET/CT in the staging and management of indolent lymphoma: A prospective multicenter PET registry study

      Ur Metser, Jill Dudebout, Tara Baetz, David C. Hodgson, Deanna L. Langer, Pamela MacCrostie, Victor Mak and Noam Tau

      Version of Record online: 13 MAR 2017 | DOI: 10.1002/cncr.30672

      Positron emission tomography/computed tomography (PET/CT) has a significant impact on staging and management in patients with apparent limited stage indolent lymphoma who are being considered for curative radiotherapy. PET/CT should be routinely incorporated into the workup of these patients.

    43. Breast Disease
      Using the National Cancer Data Base for quality evaluation to assess adherence to treatment guidelines for nonmetastatic inflammatory breast cancer

      Heather Y. Lin, Isabelle Bedrosian, Gildy V. Babiera, Simona F. Shaitelman, Henry M. Kuerer, Wendy A. Woodward, Naoto T. Ueno and Yu Shen

      Version of Record online: 13 MAR 2017 | DOI: 10.1002/cncr.30660

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      Facility-level rather than patient-level factors appear to contribute disproportionately to the underuse of trimodality therapy among patients with nonmetastatic inflammatory breast cancer. To improve treatment guideline adherence for these patients, it is critical to identify the specific facility-level factors associated with the underuse of trimodality therapy.

    44. Discipline

      Survivorship
      Posttreatment trajectories of physical activity in breast cancer survivors

      Alexander R. Lucas, Beverly J. Levine and Nancy E. Avis

      Version of Record online: 8 MAR 2017 | DOI: 10.1002/cncr.30641

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      Without intervention, a large number of breast cancer survivors remain physically inactive after treatment. This group of survivors has a higher body mass index and lower physical functioning and less vitality compared with more active survivors.

    45. Psychosocial Oncology
      Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome

      Diana D. Shi, David P. Yuppa, Trevor Dutton, Lauren K. Brais, Sarah L. Minden, Ilana M. Braun, Matthew H. Kulke, Jennifer A. Chan and Fremonta L. Meyer

      Version of Record online: 7 MAR 2017 | DOI: 10.1002/cncr.30633

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      In the current study, the authors report that <10% of patients with neuroendocrine tumors with known carcinoid syndrome experience worsened carcinoid symptoms after the initiation of serotonergic medications. Serotonergic medications appear to be safe options for the treatment of symptoms of depression and anxiety in the majority of patients with neuroendocrine tumors and carcinoid syndrome.

    46. Disease Site

      Head and Neck Disease
      Adherence to National Comprehensive Cancer Network guidelines for time to initiation of postoperative radiation therapy for patients with head and neck cancer

      Evan M. Graboyes, Elizabeth Garrett-Mayer, Anand K. Sharma, Eric J. Lentsch and Terry A. Day

      Version of Record online: 27 FEB 2017 | DOI: 10.1002/cncr.30651

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      In a review of the National Cancer Data Base, more than 50% of patients with head and neck squamous cell carcinoma who undergo surgery and postoperative radiation therapy receive care that does not adhere to National Comprehensive Cancer Network guidelines with regard to initiating postoperative radiation therapy within 6 weeks of surgery. Sociodemographic, oncologic, treatment, and hospital factors are all associated with failure to receive guideline-directed care and should be explored in future studies.

    47. Discipline

      Epidemiology
      Quantification of familial risk of nasopharyngeal carcinoma in a high-incidence area

      Zhiwei Liu, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Liming Liang, Ingemar Ernberg, Thomas L. Vaughan, Hans-Olov Adami, Guangwu Huang, Yi Zeng, Yi-Xin Zeng and Weimin Ye

      Version of Record online: 27 FEB 2017 | DOI: 10.1002/cncr.30643

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      In this population-based case-control study of 2499 cases of nasopharyngeal carcinoma and 2576 controls, the excess risk appears to be higher for a maternal than a paternal history and slightly stronger for a sibling compared with a parental history and for a sororal than a fraternal history. Among relatives of cases, the cumulative risk of nasopharyngeal carcinoma up to age 74 years is reported to be 3.7%, whereas that among relatives of controls is 0.9%.

    48. Clinical Trials
      Epstein-Barr virus-specific adoptive immunotherapy for recurrent, metastatic nasopharyngeal carcinoma

      Julian Huang, Mark Fogg, Lori J. Wirth, Heather Daley, Jerome Ritz, Marshall R. Posner, Fred C. Wang and Jochen H. Lorch

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/cncr.30541

      Early-stage and intermediate stage nasopharyngeal cancer generally carry a good prognosis, but for patients with recurrent, metastatic disease, treatment options are limited. A phase 1/2 study evaluating the efficacy of Epstein-Barr virus-stimulated cytotoxic T-lymphocyte immunotherapy demonstrates the potential for a durable response, but further research is necessary to increase the efficacy of this immunotherapy in the population of patients with incurable nasopharyngeal cancer.

    49. Disease Site

      Breast Disease
      Breast cancer prevention strategies in lobular carcinoma in situ: A decision analysis

      Stephanie M. Wong, Natasha K. Stout, Rinaa S. Punglia, Ipshita Prakash, Yasuaki Sagara and Mehra Golshan

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/cncr.30644

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      Women diagnosed with lobular carcinoma in situ have a 3-fold to 10-fold increased risk of developing invasive breast cancer. In this analysis, a Markov simulation model is used to evaluate the overall and quality-adjusted life expectancies and survival differences offered by active surveillance, risk-reducing chemoprevention, and bilateral prophylactic mastectomy, with results suggesting that prevention strategies only modestly affect overall survival in patients with lobular carcinoma in situ, whereas chemoprevention remains the preferred management strategy for optimizing invasive disease-free survival while prolonging quality-adjusted life expectancy.

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