Cancer

Cover image for Vol. 123 Issue S11

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Fadlo R. Khuri, MD

Impact Factor: 5.649

ISI Journal Citation Reports © Ranking: 2015: 26/213 (Oncology)

Online ISSN: 1097-0142

Associated Title(s): Cancer Cytopathology, CA: A Cancer Journal for Clinicians

  1. Erratum

    1. You have free access to this content
  2. Original Articles

    1. Disease Site

      Gastrointestinal Disease
      Contribution of patient, physician, and environmental factors to demographic and health variation in colonoscopy follow-up for abnormal colorectal cancer screening test results

      Melissa R. Partin, Amy A. Gravely, James F. Burgess Jr, David A. Haggstrom, Sarah E. Lillie, David B. Nelson, Sean M. Nugent, Aasma Shaukat, Shahnaz Sultan, Louise C. Walter and Diana J. Burgess

      Version of Record online: 11 MAY 2017 | DOI: 10.1002/cncr.30765

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      In the Veterans Health Administration, blacks are more likely to receive colonoscopy follow-up for positive fecal occult blood test/fecal immunochemical test results than whites, and follow-up rates decline with advancing age and comorbidity burden. Patient behaviors (refusal, private sector colonoscopy use) and physician behaviors (inappropriate screening) explain race variation in follow-up rates and contribute to age and comorbidity variation.

  3. Commentary

    1. Clinical trial enrollment of adolescents and young adults with sarcoma

      Lara E. Davis, Katherine A. Janeway, Aaron R. Weiss, Yen-Lin E. Chen, Thomas J. Scharschmidt, Mark Krailo, Julia L. Glade Bender, Lisa M. Kopp, Shreyaskumar R. Patel, Gary K. Schwartz, L. Elise Horvath, Douglas S. Hawkins, Meredith K. Chuk, Denise K. Reinke, Richard G. Gorlick and R. Lor Randall

      Version of Record online: 11 MAY 2017 | DOI: 10.1002/cncr.30757

      A focused effort to include the underrepresented and understudied adolescent and young adult population in current and future sarcoma clinical trials is overdue. Increased enrollment of adolescents and young adults in sarcoma trials across cooperative groups will produce more meaningful results that better represent the disease's biology, epidemiology, and treatment environment.

  4. Original Articles

    1. Discipline

      Pediatric Oncology
      Palmar-plantar erythrodysesthesia syndrome following treatment with high-dose methotrexate or high-dose cytarabine

      Seth E. Karol, Wenjian Yang, Colton Smith, Cheng Cheng, Clinton F. Stewart, Sharyn D. Baker, John T. Sandlund, Jeffrey E. Rubnitz, Michael W. Bishop, Alberto S. Pappo, Sima Jeha, Ching-Hon Pui and Mary V. Relling

      Version of Record online: 11 MAY 2017 | DOI: 10.1002/cncr.30762

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      Palmar-plantar erythrodysesthesia syndrome is rare after high-dose cytarabine or methotrexate and occurs in just 1.3% of patients receiving them. Among pediatric patients, older age is associated with an increased risk of developing palmar-plantar erythrodysesthesia syndrome.

  5. Review Articles

    1. Soft tissue sarcoma nomograms and their incorporation into practice

      Dario Callegaro, Rosalba Miceli, Luigi Mariani, Chandrajit P. Raut and Alessandro Gronchi

      Version of Record online: 10 MAY 2017 | DOI: 10.1002/cncr.30721

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      Nomograms for soft tissue sarcoma offer more patient-specific prognosis prediction. Within this heterogeneous family of tumors, the tailored prediction of patient prognosis through statistical models improves the clinician's capabilities.

  6. Original Articles

    1. Disease Site

      Head and Neck Disease
      Hepatitis B virus screening and reactivation and management of patients with nasopharyngeal carcinoma: A large-scale, big-data intelligence platform–based analysis from an endemic area

      Jia-Wei Lv, Yu-Pei Chen, Xiao-Dan Huang, Guan-Qun Zhou, Lei Chen, Wen-Fei Li, Ling-Long Tang, Yan-Ping Mao, Ying Guo, Rui-Hua Xu, Jun Ma and Ying Sun

      Version of Record online: 10 MAY 2017 | DOI: 10.1002/cncr.30775

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      Data regarding hepatitis B virus screening and reactivation and the clinical management of nasopharyngeal carcinoma patients with hepatitis B virus infections are lacking. This study clarifies the risk of hepatitis B virus reactivation with different regimens, systematically investigates the benefit of hepatitis B virus screening and antiviral prophylaxis, and identifies the risk factors associated with reactivation in patients with nasopharyngeal carcinoma.

    2. Gastrointestinal Disease
      North Central Cancer Treatment Group N0543 (Alliance): A phase 2 trial of pharmacogenetic-based dosing of irinotecan, oxaliplatin, and capecitabine as first-line therapy for patients with advanced small bowel adenocarcinoma

      Robert R. McWilliams, Nathan R. Foster, Michelle R. Mahoney, Thomas C. Smyrk, Joseph A. Murray, Matthew M. Ames, L. Elise Horvath, Daniel J. Schneider, Timothy J. Hobday, Aminah Jatoi, Jeffrey P. Meyers and Matthew P. Goetz

      Version of Record online: 10 MAY 2017 | DOI: 10.1002/cncr.30766

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      Dosing with irinotecan, oxaliplatin, and capecitabine in patients with small bowel adenocarcinoma appears to be tolerable, and substantial antitumor activity is noted in the current study. By dosing with a pharmacogenomic-based regimen, the authors observe reasonable rates of toxicity and signs of activity in tumor response rates.

    3. Hematologic Malignancies
      Comprehensive analysis of cutaneous T-cell lymphoma (CTCL) incidence and mortality in Canada reveals changing trends and geographic clustering for this malignancy

      Feras M. Ghazawi, Elena Netchiporouk, Elham Rahme, Matthew Tsang, Linda Moreau, Steven Glassman, Nathalie Provost, Martin Gilbert, Sara-Elizabeth Jean, Kevin Pehr, Denis Sasseville and Ivan V. Litvinov

      Version of Record online: 10 MAY 2017 | DOI: 10.1002/cncr.30758

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      Cutaneous T-cell lymphoma demonstrates nonrandom distribution with case clustering in industrial areas of Canada and spares cities with a low industrial presence. These findings argue for the existence of a potentially preventable external trigger for this rare skin cancer.

    4. Gastrointestinal Disease
      Outcomes for patients with locally advanced pancreatic adenocarcinoma treated with stereotactic body radiation therapy versus conventionally fractionated radiation

      Jim Zhong, Kirtesh Patel, Jeffrey Switchenko, Richard J. Cassidy, William A. Hall, Theresa Gillespie, Pretesh R. Patel, David Kooby and Jerome Landry

      Version of Record online: 10 MAY 2017 | DOI: 10.1002/cncr.30706

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      According to a propensity-matched comparison of 988 patients with locally advanced pancreatic cancer in the National Cancer Data Base, the use of stereotactic body radiation therapy is significantly associated with better overall survival in comparison with conventionally fractionated radiation. In a subset analysis, there is no subset of patients for whom conventionally fractionated radiation is favored.

    5. Gynecologic Oncology
      Somatic mutation profiles of clear cell endometrial tumors revealed by whole exome and targeted gene sequencing

      Matthieu Le Gallo, Meghan L. Rudd, Mary Ellen Urick, Nancy F. Hansen, Suiyuan Zhang, NISC Comparative Sequencing Program, Fred Lozy, Dennis C. Sgroi, August Vidal Bel, Xavier Matias-Guiu, Russell R. Broaddus, Karen H. Lu, Douglas A. Levine, David G. Mutch, Paul J. Goodfellow, Helga B. Salvesen, James C. Mullikin and Daphne W. Bell

      Version of Record online: 9 MAY 2017 | DOI: 10.1002/cncr.30745

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      The objective of this study was to search exome-wide for novel somatically mutated genes in clear cell endometrial cancers (ECs) and to assess the mutational spectrum of known and candidate driver genes in this tumor type. Our findings demonstrate the molecular similarities of some clear cell ECs to serous and endometrioid ECs, and implicate TAF1 as a novel candidate clear cell EC driver gene.

  7. Editorial

    1. Genetic landscape of clear cell endometrial cancer and the era of precision medicine

      Gloria S. Huang and Alessandro D. Santin

      Version of Record online: 9 MAY 2017 | DOI: 10.1002/cncr.30743

      The increased understanding of the genetic landscape of clear cell endometrial cancer should guide the development of precision medicine strategies to improve survival. See also pages 000-000.

  8. Original Articles

    1. Discipline

      Disparities Research
      County-level cumulative environmental quality associated with cancer incidence

      Jyotsna S. Jagai, Lynne C. Messer, Kristen M. Rappazzo, Christine L. Gray, Shannon C. Grabich and Danelle T. Lobdell

      Version of Record online: 8 MAY 2017 | DOI: 10.1002/cncr.30709

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      County-level cumulative environmental exposures are positively associated with all-site cancer incidence rates, indicating a potential increase in cancer incidence with decreasing environmental quality. Research focusing on single environmental exposures in cancer development may not address the broader environmental context in which cancers develop.

  9. Editorial

    1. Impact of the environment on cancer: Seeing the forest for the trees

      Scarlett Lin Gomez, Salma Shariff-Marco, Iona Cheng and Peggy Reynolds

      Version of Record online: 8 MAY 2017 | DOI: 10.1002/cncr.30711

      The study by Jagai et al. is a valuable resource for researchers to focus on better understanding associations between environmental quality and cancer incidence, as well as for policy makers to target specific regions and environmental factors within those regions to reduce the burden of cancer in the United States. This study also demonstrates the value of environmental geospatial data, a key tool that provides the empirical scientific evidence base to allow scientists to identify disease-contributing factors and identify vulnerable communities. See also pages 000-000.

  10. Original Articles

    1. Discipline

      Psychosocial Oncology
      Cancer as a stressful life event: Perceptions of children with cancer and their peers

      Katianne M. Howard Sharp, Jennifer J. Lindwall, Victoria W. Willard, Alanna M. Long, Karen M. Martin-Elbahesh and Sean Phipps

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30741

      Children may not view their cancer experience as their most stressful life event. The diagnosis of childhood cancer is more appropriately viewed as a manageable stressor, rather than a major trauma.

    2. Disease Site

      Gynecologic Oncology
      Cost-effectiveness of human papillomavirus vaccination for adolescent girls in Punjab state: Implications for India's universal immunization program

      Shankar Prinja, Pankaj Bahuguna, Dharmjeet Singh Faujdar, Gaurav Jyani, Radhika Srinivasan, Sushmita Ghoshal, Vanita Suri, Mini P. Singh and Rajesh Kumar

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30734

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      Introduction of the human papillomavirus vaccination for adolescent girls is being considered in the Punjab state of India. However, evidence regarding its cost-effectiveness is sought by policy makers when making this decision. The results of the current study indicate that human papillomavirus vaccination is a very cost-effective strategy for Punjab state, and is likely to be cost-effective for other Indian states.

    3. Discipline

      Medical Oncology
      Phase 1/2 study of rilotumumab (AMG 102), a hepatocyte growth factor inhibitor, and erlotinib in patients with advanced non–small cell lung cancer

      Ahmad A. Tarhini, Imran Rafique, Theofanis Floros, Phu Tran, William E. Gooding, Liza C. Villaruz, Timothy F. Burns, David M. Friedland, Daniel P. Petro, Mariya Farooqui, Jose Gomez-Garcia, Autumn Gaither-Davis, Sanja Dacic, Athanassios Argiris, Mark A Socinski, Laura P. Stabile and Jill M. Siegfried

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30717

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      Combined rilotumumab and erlotinib has an acceptable safety profile and a disease control rate that meets prespecified criteria for success in patients with advanced non–small cell lung cancer who have wild-type epidermal growth factor receptor tumors compared with previously published reports for erlotinib alone. High circulating levels of neuregulin-1 may indicate sensitivity to this combination. See related editorial on pages 000–000, this issue.

  11. Editorial

    1. The persistent promise of combining HGF/MET and EGFR inhibition in non-small cell lung cancer

      Jody C. Chuang and Joel W. Neal

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30718

      Hepatocyte growth factor/mesenchymal-epidermal transition factor (MET) dysregulation is a viable target in non-small cell lung cancer, both alone and potentially in combination with epidermal growth factor receptor inhibition. Future trials involving epidermal growth factor receptor and MET inhibitors should focus on more selected patient populations and include relevant biomarker studies. See referenced original article on pages 000-000, this issue.

  12. Original Articles

    1. Discipline

      Outcomes Research
      Hispanics have the lowest stem cell transplant utilization rate for autologous hematopoietic cell transplantation for multiple myeloma in the United States: A CIBMTR report

      Jeffrey R. Schriber, Parameswaran N. Hari, Kwang Woo Ahn, Mingwei Fei, Luciano J. Costa, Mohamad A. Kharfan-Dabaja, Miguel Angel-Diaz, Robert P. Gale, Siddharatha Ganguly, Saulius K. Girnius, Shahrukh Hashmi, Attaphol Pawarode, David H. Vesole, Peter H. Wiernik, Baldeep M. Wirk, David I. Marks, Taiga Nishihori, Richard F. Olsson, Saad Z. Usmani, Tomer M. Mark, Yago L. Nieto and Anita D'Souza

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30747

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      The results from this investigation of the stem cell transplantation utilization rate across race/ethnicity in the United States indicate that, although the rate is increasing, it remains low and is significantly lower among Hispanics followed by non-Hispanic blacks compared with non-Hispanic whites. Race/ethnicity does not impact transplantation outcomes but remains a barrier to clinical care; and efforts are warranted to increase the use of transplantation for eligible patients who have multiple myeloma, with emphasis on groups that underuse transplantation. See also pages 000-000.

    2. Psychosocial Oncology
      The association of demoralization with mental disorders and suicidal ideation in patients with cancer

      Sigrun Vehling, David W. Kissane, Christopher Lo, Heide Glaesmer, Tim J. Hartung, Gary Rodin and Anja Mehnert

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30749

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      Clinically relevant demoralization frequently occurs independently of a mental disorder in patients with cancer and has a unique contribution to suicidal ideation. Demoralization is a useful concept to identify profiles of psychological distress symptoms amenable to interventions improving psychological well-being in patients with cancer.

    3. Disease Site

      Genitourinary Disease
      Impact of travel distance to the treatment facility on overall mortality in US patients with prostate cancer

      Malte W. Vetterlein, Björn Löppenberg, Patrick Karabon, Deepansh Dalela, Tarun Jindal, Akshay Sood, Felix K.-H. Chun, Quoc-Dien Trinh, Mani Menon and Firas Abdollah

      Version of Record online: 4 MAY 2017 | DOI: 10.1002/cncr.30744

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      Men who travel long distances to obtain treatment for prostate cancer have an overall survival benefit, but this benefit is not consistent in all subgroups of patients. The overall benefit might be explained by the trend in centralization of care. However, even if the travel burden is overcome, adverse outcomes are still significantly influenced by baseline socioeconomic and facility-specific factors.

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