Developmental Dynamics

Virtual Issues

Click here to see the virtual issue of free review articles.

Mouse Molecular Genetics

Since the early years of the 20th century, the mouse has served as the premier model organism for investigating the genetic basis of vertebrate development, physiology and disease. Almost since the beginning, Developmental Dynamics (then the American Journal of Anatomy) has provided an important avenue for researchers to publish findings covering all facets of mouse biology. A 1922 article by Edgar Allen on the mouse oestrus cycle laid the foundation for his discovery of estrogen, while an article two years later by H.J. Bagg and C.C. Little reported on the hereditary effects of irradiation. Since then, Developmental Dynamics has published more than 1000 papers on mouse biology and genetics. The articles assembled in this virtual issue have been selected from the last three years of Developmental Dynamics publications. Each uses molecular genetics to address fundamental questions concerning embryonic development.

Hes1 is required for the development of the superior cervical ganglion of sympathetic trunk and the carotid body
Yoko Kameda, Takayoshi Saitoh, Noriko Nemoto, Tokio Katoh and Sachiko Iseki

sl1 and Ldb Co-regulators of transcription are essential early determinants of mouse limb development
Ginat Narkis, Itai Tzchori, Tsadok Cohen, Alex Holtz, Eric Wier and Heiner Westphal

Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development
Tien T. Le, Kevin W. Conley, Timothy J. Mead, Sheldon Rowan, Katherine E. Yutzey and Nadean L. Brown

Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice
Zhijie Xiao, Jaakko Patrakka, Masatoshi Nukui, Lijun Chi, Dadi Niu, Christer Betsholtz, Timo Pikkarainen, Seppo Vainio and Karl Tryggvason

Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3
Yasuaki Mohri, Kazunori Oyama, Atsushi Akamatsu, Shigeki Kato and Katsuhiko Nishimori

Autotaxin is required for the cranial neural tube closure and establishment of the midbrain–hindbrain boundary during mouse development
Seiichi Koike, Yoshifumi Yutoh, Kazuko Keino-Masu, Sumihare Noji, Masayuki Masu and Hideyo Ohuchi

Translocon-associated protein subunit Trap-γ/Ssr3 is required for vascular network formation in the mouse placenta
Yasuka L. Yamaguchi, Satomi S. Tanaka, Naoko Oshima, Hiroshi Kiyonari, Makoto Asashima and Ryuichi Nishinakamura

Gpr177/mouse Wntless is essential for Wnt-mediated craniofacial and brain development
Jiang Fu, Hsiao-Man Ivy Yu, Takamitsu Maruyama, Anthony J. Mirando and Wei Hsu

GPR56 is essential for testis development and male fertility in mice
Guangchun Chen, Liquan Yang, Shahinoor Begum and Lei Xu

Loss of Lhx1 activity impacts on the localization of primordial germ cells in the mouse
Satomi S. Tanaka, Yasuka L. Yamaguchi, Kirsten A. Steiner, Toru Nakano, Ryuichi Nishinakamura, Kin Ming Kwan, Richard R. Behringer and Patrick P.L. Tam

Beyond the closed suture in apert syndrome mouse models: Evidence of primary effects of FGFR2 signaling on facial shape at birth
Neus Martínez-Abadías, Christopher Percival, Kristina Aldridge, Cheryl A. Hill, Timothy Ryan, Satama Sirivunnabood, Yingli Wang, Ethylin Wang Jabs and Joan T. Richtsmeier

Mice lacking the orphan receptor ror1 have distinct skeletal abnormalities and are growth retarded
Natalia Lyashenko, Martina Weissenböck, Amnon Sharir, Reinhold G. Erben, Yasuhiro Minami and Christine Hartmann

Embryonic and not maternal trisomy causes developmental attenuation in the Ts65Dn mouse model for Down syndrome
Joshua D. Blazek, Cherie N. Billingsley, Abby Newbauer and Randall J. Roper

Brain phenotypes in two FGFR2 mouse models for Apert syndrome
Kristina Aldridge, Cheryl A. Hill, Jordan R. Austin, Christopher Percival, Neus Martinez-Abadias, Thomas Neuberger, Yingli Wang, Ethylin Wang Jabs and Joan T. Richtsmeier

Role of bone morphogenetic proteins on cochlear hair cell formation: Analyses of Noggin and Bmp2 mutant mice
Chan Ho Hwang, Dayong Guo, Marie A. Harris, Omar Howard, Yuji Mishina, Lin Gan, Stephen E. Harris and Doris K. Wu

Developmental Dynamics Reviews Virtual Issue

Published: 25 May 2009

Introduction: You can find other Developmental Dynamics Reviews here.

Polarity and cell fate specification in the control of Caenorhabditis elgegans gastrulation
Monica R. Rohrschneider, Jeremy Nance

The RCAS retroviral expression system in the study of skeletal development
Christopher T. Gordon, Felicity A. Rodda, Peter G. Farle

Biological functions of the low and high molecular weigh protein isoforms of fibrolast growth factor -2 in cardiovascular development and disease
Siyun Liao, Janet Bodmer, Daniel Pietras, Mohamad Azhar, Tom Doetscham, Jo El. J. Schultz

Pleiotropic function of FGF-4: Its role in development and stem cells
Nobuyoshi Kosaka, Hiromi Sakamoto, Masaaki Terada, Takahiro Ochiya

Extracellular interactome of the FGF receptor-ligand system: Complexities and the relative simplicity of the worm
Urszula M. Polanska, David G. Fernig, Tarja Kinnuen

Morphogenesis of the node and notochord: The cellular basis for the establishment and maintenance of left-right asymmetry in the mouse
Jeffrey D. Lee, Kathryn V. Anderson

Fluid dynamics of nodal flow and left-right patterning in development
Julyan H.E. Cartwright, Nicolas Piro, Oreste Piro, Idan Tuval

Calcium signalling: A common thread in vertebrate left-right axis development
Adam Langenbacher, Jau-Nian Chen

The development and evolution of left-right asymmetry in invertebrates: Lessons from Drosophilia and snails
Takashi Okumura, Hiroki Utsuno, Junpei Kuroda, Edmund Gittenberger, Takahiro Asami, Kenji Matsuno

MAP3Ks as central regulators of cell fate during development
Evisabel A. Craig, Mark V. Stevens, Richard R. Vaillancourt, Todd D. Camenisch

Development of the corneal stroma, and the collagen-proteoglycan associations that help define its structure and function
Andrew J. Quantock, Robert D. Young

Heparan sulphate proteoglycans: A GAGle of skeletal-hematopoietic regulators
Kathryn D. Rodgers, James D. San Antonio, Olena Jacenko

Palatal seam disintegration: To die or not to die? That is no longer the question
Ali Nawshad

Reprogramming multipotent tumor cells with the embryonic neural crest microenvironment
Jennifer C. Kasemeier-Kulesa, Jessica M. Teddy, Lynne-Marie Postovit, Elisabeth A. Seftor, Richard E.B. Seftor, Mary J.C. Hendrix, Paul M. Kulesa

Embryonic chick corneal epithelium: A model system for exploring cell-matrix interactions
Kathy K.H. Svoboda, Donald A. Fishman, Marion K. Gordon