Developmental Dynamics

Cover image for Vol. 245 Issue 6

Edited By: Parker B. Antin

Impact Factor: 2.376

ISI Journal Citation Reports © Ranking: 2014: 4/21 (Anatomy & Morphology); 28/41 (Developmental Biology)

Online ISSN: 1097-0177

Meet the Editors


Parker Antin, PhD, is professor of Cellular and Molecular Medicine in the School of Medicine, and Associate Dean for Research in the College of Agriculture and Life Sciences at the University of Arizona. His laboratory studies lineage diversification and morphogenesis during vertebrate embryo development. Current research is focused on understanding how epithelial-mesenchymal transition is regulated during avian gastrulation, and regulatory pathways governing early stages of heart development. He also directs the GEISHA (gallus expression in situ hybridization analysis) database project, a repository of in situ hybridization gene expression information and associated metadata for the chicken embryo.
Areas of Expertise: Gastrulation, cardiovascular development, lineage diversification, bioinformatics.
Additional information about Parker Antin's lab can be found at:
http://mcrp.med.arizona.edu/html/parkerantin/index.html


Gary Schoenwolf, PhD, is the Distinguished Professor of Neurobiology and Anatomy, and an Adjunct Professor of Pediatrics at the University of Utah. The Schoenwolf laboratory addresses the general question of how intercellular and intracellular signaling results in the generation of pattern during vertebrate embryogenesis. Although we work on a number of diverse organ rudiments and developmental events using multiple experimental organisms, our current work is focused on normal and abnormal development of the inner ear. Our research combines molecular, cellular, embryological, transgenic, imaging, and in vitro and in vivo approaches. This work is relevant for understanding birth defects, cancer, and aging.
Areas of Expertise: Development, morphogenesis, inner ear, patterning, signaling, BMPs, FGFs, and SHH.
Additional information about Gary Schoenwolf's lab can be found at:
http://www.neuro.utah.edu/labs/schoenwolf/schoenwolf_lab.html


Nadean L. Brown, PhD, is Associate Professor in the Department of Cell Biology and Human Anatomy in the School of Medicine at the University of California, Davis. Her research is directed at understanding the molecular mechanisms regulating formation of the mammalian lens and retina, using mouse models to investigate the genetic pathways underlying lens and retinal tissue formation during embryogenesis. A current focus is on understanding how lens progenitor cells stop dividing and turn into fiber cells, and how retinal progenitor cells choose to become one type of neuron, although multiple fates are available to them. Her long-term goal is to better understand congenital eye diseases and ultimately inform stem cell therapies to correct vision loss.
Areas of Expertise: Neural development, mammalian developmental genetics, ocular development, ocular disease, Notch signaling mechanisms.
Additional information about Nadean Brown's lab can be found at:
https://basicscience.ucdmc.ucdavis.edu/Brown_Lab/


Suzanne L. (Suzi) Mansour, PhD, is Professor of Human Genetics at the University of Utah. Her research is concerned with understanding the genetic mechanisms underpinning normal development and function of the ear, which mediates the sensations of hearing and balance. One focus is the roles and regulation of the genes coding for Fibroblast Growth Factor (FGF) signaling components in mouse ear development. These signals control many different aspects of ear development, including the initial induction, specification and shaping of the ear primordium, as well as later processes of sensory and supporting cell differentiation. A second related focus is the roles of Fgf3 and Fgf10 in development of the heart. Congenital heart defects occur in approximately 1% of all births and many of the most common abnormalities are seen in mice with genetically engineered disturbances of FGF signaling pathways.
Areas of Expertise: Inner ear development, Morphogenesis, FGF signaling, Heart development.
Additional information about Suzi's lab can be found at:
http://www.genetics.utah.edu/index.php/hg-faculty/81-human-genetics/hg-faculty/108-faculty-mansour


Takashi Mikawa, PhD, is the Camilla and George D. Smith Distinguished Professor in Science and Medicine, Investigator in the Cardiovascular Research Institute, and Professor of Anatomy at the University of California, San Francisco. His laboratory investigates non-steady state reactions that orchestrate the differentiation and integration of many cell type during organogenesis. The main focus of the lab has been to uncover specific reactions that define cell fate decision, cell size and shape, body axis formation, and faithful delivery of parental genomes to all daughter cells during organ formation. Areas of Expertise: Morphogenesis, Body axis formation, Cell-to-cell communication, Cell architecture regulation, Cell fate diversification, Coupling of biophysical forces and biochemical reactions.
Areas of Expertise: Morphogenesis, Body axis formation, Cell-to-cell communication, Cell architecture regulation, Cell fate diversification, Coupling of biophysical forces and biochemical reactions.
Additional information about Takashi's research is available at:
http://bms.ucsf.edu/directory/faculty/takashi-mikawa-phd


David M. Ornitz, MD, PhD, is Alumni Endowed Professor in the Department of Developmental Biology at Washington University School of Medicine. His research uses molecular, genetic and biochemical approaches to study the regulation of cell growth, development and response to injury, in the mouse. Current studies are examining FGFs, FGF receptors and a variety of other interacting signaling pathways (hedgehog, Wnt, BMP, TGFb, VEGF) in the mouse embryo and in adult mice, with a focus on inner ear, skeletal, cardiovascular and pulmonary development and physiology. Using knockout and conditional knockout technology the Ornitz laboratory has constructed FGF and FGF receptor mutants with defects in these and other organ systems. Mutant mice are being studied as genetic and developmental model systems for mesodermal and epithelial patterning, organogenesis, tissue repair, and cancer.
Areas of Expertise: Skeletal development, Lung development, Heart/vascular development, Inner ear development.
Additional information about Dave’s research is available at:
http://ornitzlab.wustl.edu/


Marian Ros, MD, PhD, is Professor at the Instituto de Biomedicina y Biotecnología de Cantabria, CSIC-Universidad de Cantabria in Santander (SPAIN). The goal of her research is to understand the molecular basis of morphogenesis: how the formation of a particular form or structure is genetically and molecularly controlled during vertebrate development. This goal includes understanding the origin of the developmental defects that lead to human malformations. Her group predominantly uses the developing limb as a model system and is currently investigating the role of Hox and Gli3 genes in controlling digit number, crosstalk between differing signaling pathways during limb development, proximo-distal axis formation, and the function of Hox genes in endochondral ossification. Her work has also contributed to the understanding of left-right axis formation.
Areas of Expertise: Limb patterning, morphogenesis, cell signaling, Hox genes.
Additional information about Marian's research is available at:
http://www.unican.es/ibbtecold/Investigacion/Grupo+Biodes.htm


Koji Tamura, PhD, is Professor of Developmental Biology and Neurosciences at the Tohoku University Graduate School of Life Sciences in Sendai, Japan. His research interests are in understanding the molecular and cellular mechanisms underlying organ morphogenesis and diversity in vertebrates, and mechanisms of organ regeneration. Each organ has a characteristic shape that is required for its proper function. During development, the structure of an organ is produced by intrinsic and genetic programs in the embryo. A primary goal is to elucidate the developmental programs and the subsequent behavior of cells and tissues that generate the distinct morphology of organs, and how these developmental programs are modified during evolution to produce morphological diversity. Koji’s lab is also investigating the mechanisms of organ regeneration. Although appropriate morphogenesis is essential to regenerate functional replica of lost organs, little attention has been paid to this in recent regeneration studies such as studies on stem cell biology.
Areas of Expertise:Vertebrate organ development and regeneration, diversity and evolution of organ morphology, limb morphogenesis.
Additional information about Koji’s research is available at:
http://www.biology.tohoku.ac.jp/lab-www/tamlab/english/research_e.html


Frans Tax, PhD, is Professor of Molecular and Cellular Biology at the University of Arizona. His main research interest is elucidating general molecular mechanisms used by plants to specify and maintain cell fates, including the fates of stem cells and their descendants. Both experimental manipulations and forward genetic screens implicate intercellular signaling in these processes. Studying receptors is one way to further dissect the role of the signaling-based molecular mechanisms. To dissect signaling events that take place during development, we analyze the phenotypes of plants mutant for individual or multiple receptors. We have identified key roles for specific receptors during radial patterning in early embryogenesis, during the formation of lateral roots, in the formation of fruit organs from stem cells within the fruit, in the development of vascular tissues, and in the process of cell elongation.
Areas of Expertise:Stem cells in plants, intercellular signaling, plant hormones, receptor kinase function and signaling pathways.
Additional information about Frans’ research is available at:
http://mcb2.arizona.edu/tax/


Paul Trainor, PhD, is an Investigator at the Stowers Institute for Medical Research and Adjunct Professor in Anatomy and Cell Biology at the University of Kansas Medical Center. Research in the Trainor laboratory centers on neural crest cell development, evolution and disease. Neural crest cells are a multipotent migratory cell population that gives rise to an astonishing array of tissues during vertebrate development. Neural crest cells have been integral to vertebrate evolution, particularly with respect to jaw formation and craniofacial development but also to numerous organs throughout the body. Malformations and syndromes that arise due to defects in neural crest cell development are collectively called neurocristopathies. The Trainor lab seeks to understand the mechanisms that regulate neural crest cell formation, migration, survival and differentiation and apply this basic knowledge to better understand vertebrate evolution and the etiology and pathogenesis of birth defects as well as potentially develop therapeutic avenues for their prevention.
Areas of Expertise: Neural crest cells, craniofacial morphogenesis, cell lineage and fate, organogenesis, mouse genetics and development.
Additional information about Paul Trainor’s lab can be found at:
http://research.stowers.org/trainorlab/index.html


H. Joseph Yost, PhD, is Vice Chairman for Basic Science Research, Department of Pediatrics; Professor of Neurobiology and Anatomy; and Adjunct Professor of Pediatrics at the University of Utah. The goal of Joe’s research is to understand the genes, molecules and developmental mechanisms that regulate the assignment of different cell identities in functionally appropriate positions in the developing vertebrate embryo, and to utilize this knowledge for the advancement of human medicine. His lab is a founder and leader in the field of vertebrate left-right axis formation, identifying major cell-cell signaling pathways that control cilia function, cell migration and downstream pathways. Another focus of his lab is cardiac development, using genome-wide approaches to elucidate the gene regulatory networks that control heart development in zebrafish. Recent studies of heparin sulfate proteoglycans has led to the glycocode hypothesis, in which specific sulfation patterns on cell surface glycosaminoglycans control and provide specificity to cell-cell signaling decisions.
Areas of Expertise:Cardiovascular development, Left-Right patterning, cilia, proteoglycans, zebrafish, Xenopus, genetics.
Additional information about Joe’s research is available at:
http://yost.genetics.utah.edu


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