Generalizability of established prostate cancer risk variants in men of African ancestry
Ying Han, Lisa B. Signorello, Sara S. Strom, Rick A. Kittles, Benjamin A. Rybicki, Janet L. Stanford, Phyllis J. Goodman, Sonja I. Berndt, John Carpten, Graham Casey, Lisa Chu, David V. Conti, Kristin A. Rand, W. Ryan Diver, Anselm J.M. Hennis, Esther M. John, Adam S. Kibel, Eric A. Klein, Suzanne Kolb, Loic Le Marchand, M. Cristina Leske, Adam B. Murphy, Christine Neslund-Dudas, Jong Y. Park, Curtis Pettaway, Timothy R. Rebbeck, Susan M. Gapstur, S. Lilly Zheng, Suh-Yuh Wu, John S. Witte, Jianfeng Xu, William Isaacs, Sue A. Ingles, Ann Hsing, The PRACTICAL Consortium, The ELLIPSE GAME-ON Consortium, Douglas F. Easton, Rosalind A. Eeles, Fredrick R. Schumacher, Stephen Chanock, Barbara Nemesure, William J. Blot, Daniel O. Stram, Brian E. Henderson and Christopher A. Haiman
Article first published online: 15 JUL 2014 | DOI: 10.1002/ijc.29066
While genome-wide association studies have identified more than 80 risk variants for prostate cancer, the generalizability of the variants in non-European and non-Asian populations needs to be understood before these loci can be used widely in risk modeling. Here, in the largest study to date, the vast majority of established variants also contributed to prostate cancer risk in men of African ancestry, with a subset of variants proving informative for risk modeling in this population. Further genomic characterization is needed to understand the contribution of the loci to risk in this population, which may be influenced by linkage disequilibrium patterns.