Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors
Anja Rudolph, Roger L. Milne, Thérèse Truong, Julia A. Knight, Petra Seibold, Dieter Flesch-Janys, Sabine Behrens, Ursula Eilber, Manjeet K. Bolla, Qin Wang, Joe Dennis, Alison M. Dunning, Mitul Shah, Hannah R. Munday, Hatef Darabi, Mikael Eriksson, Judith S. Brand, Janet Olson, Celine M. Vachon, Emily Hallberg, J. Esteban Castelao, Angel Carracedo, Maria Torres, Jingmei Li, Keith Humphreys, Emilie Cordina-Duverger, Florence Menegaux, Henrik Flyger, Børge G. Nordestgaard, Sune F. Nielsen, Betul T. Yesilyurt, Giuseppe Floris, Karin Leunen, Ellen G. Engelhardt, Annegien Broeks, Emiel J. Rutgers, Gord Glendon, Anna Marie Mulligan, Simon Cross, Malcolm Reed, Anna Gonzalez-Neira, José Ignacio Arias Perez, Elena Provenzano, Carmel Apicella, Melissa C. Southey, Amanda Spurdle, kConFab Investigators, AOCS Group, Lothar Häberle, Matthias W. Beckmann, Arif B. Ekici, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Catriona McLean, Laura Baglietto, Stephen J. Chanock, Jolanta Lissowska, Mark E. Sherman, Thomas Brüning, Ute Hamann, Yon-Dschun Ko, Nick Orr, Minouk Schoemaker, Alan Ashworth, Veli-Matti Kosma, Vesa Kataja, Jaana M. Hartikainen, Arto Mannermaa, Anthony Swerdlow, GENICA-Network, Graham G. Giles, Hermann Brenner, Peter A. Fasching, Georgia Chenevix-Trench, John Hopper, Javier Benítez, Angela Cox, Irene L. Andrulis, Diether Lambrechts, Manuela Gago-Dominguez, Fergus Couch, Kamila Czene, Stig E. Bojesen, Doug F. Easton, Marjanka K. Schmidt, Pascal Guénel, Per Hall, Paul D. P. Pharoah, Montserrat Garcia-Closas and Jenny Chang-Claude
Article first published online: 23 SEP 2014 | DOI: 10.1002/ijc.29188
The recent discovery of 47 susceptibility loci associated with all or estrogen receptor-negative breast cancer provided new opportunities for genetic risk prediction but it remained unclear how exposure levels of environmental (non-genetic) risk factors influenced the risk assessment. In this gene-environment study, the international team examined interactions between the single nucleotide polymorphisms and 13 established environmental risk factors including parity, height and alcohol consumption. Notably, relative risks of breast cancer associated with the susceptibility loci were not strongly modified by environmental risk factors, a finding that, if confirmed, has important implications for the risk assessment in breast cancer.