Risk factors for metachronous colorectal cancer following a primary colorectal cancer: A prospective cohort study
Harindra Jayasekara, Jeanette C. Reece, Daniel D. Buchanan, Christophe Rosty, S. Ghazaleh Dashti, Driss Ait Ouakrim, Ingrid M. Winship, Finlay A. Macrae, Alex Boussioutas, Graham G. Giles, Dennis J. Ahnen, Jan Lowery, Graham Casey, Robert W. Haile, Steven Gallinger, Loic Le Marchand, Polly A. Newcomb, Noralane M. Lindor, John L. Hopper, Susan Parry, Mark A. Jenkins and Aung Ko Win
Version of Record online: 9 MAY 2016 | DOI: 10.1002/ijc.30153
Individuals diagnosed with a colorectal cancer (CRC) are at increased risk of developing a metachronous CRC (a new primary CRC) in the remaining part of the large bowel later in life. Routine stratification of individuals based on their risk for metachronous CRC would allow prevention by surveillance colonoscopy to become cost-effective. In this prospective cohort study, location of the initial CRC in the proximal colon and presence of a synchronous CRC were associated with an increased risk of metachronous CRC, highlighting their importance when deciding on the intensity of surveillance colonoscopy. There was no evidence for associations between lifestyle and female reproductive factors and metachronous CRC risk.