Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer
Katharina Nimptsch, Krasimira Aleksandrova, Heiner Boeing, Jürgen Janke, Young-Ae Lee, Mazda Jenab, So Yeon Kong, Konstantinos K. Tsilidis, Elisabete Weiderpass, Bas H. Bueno-De-Mesquita, Peter D. Siersema, Eugène H.J.M. Jansen, Antonia Trichopoulou, Anne Tjønneland, Anja Olsen, Chunsen Wu, Kim Overvad, Marie-Christine Boutron-Ruault, Antoine Racine, Heinz Freisling, Verena Katzke, Rudolf Kaaks, Pagona Lagiou, Dimitrios Trichopoulos, Gianluca Severi, Alessio Naccarati, Amalia Mattiello, Domenico Palli, Sara Grioni, Rosario Tumino, Petra H. Peeters, Ingrid Ljuslinder, Hanna Nyström, Jenny Brändstedt, María-José Sánchez, Aurelio Barricarte Gurrea, Catalina Bonet Bonet, María-Dolores Chirlaque, Miren Dorronsoro, José Ramón Quirós, Ruth C. Travis, Kay-Tee Khaw, Nick Wareham, Elio Riboli, Marc J. Gunter and Tobias Pischon
Article first published online: 5 FEB 2015 | DOI: 10.1002/ijc.29448
Fetuin-A is a liver protein associated with insulin resistance, but with no defined role yet in colorectal cancer. In this prospective study, the authors uncover a modest linear association between fetuin-A levels and higher risk of colorectal cancer, but this was only observed in male participants. In addition, no association was observed between fetuin-A variants and colorectal cancer risk in a Mendelian randomization analysis, arguing against a direct role of fetuin-A in colorectal carcinogenesis.