The impact of HIV infection and antiretroviral therapy on the predicted risk of Down syndrome
Thomas G. Charlton, Jamie M. Franklin, Melanie Douglas, Charlotte E. Short, Ian Mills, Rachel Smith, Amanda Clarke, John Smith, Pat A. Tookey, Mario Cortina-Borja and Graham P. Taylor
Article first published online: 28 NOV 2013 | DOI: 10.1002/pd.4267
What's already known about this topic?
- Increases in human chorionic gonadotrophin and α-fetoprotein and decreases in unconjugated estriol have been reported in HIV-positive pregnant women
- This may impact the interpretation of biochemical Down syndrome screening tests
What does this study add?
- When based on biochemical assays, pregnant women with untreated HIV infection receive final Down syndrome risk reports significantly higher than matched HIV-uninfected controls.
- There is no increase risk of Down syndrome in HIV-infected women in the UK.
- The HIV status of all pregnant women should be known prior to interpretation of Down syndrome risk (based on second trimester triple test) and invasive diagnostics.