Rapid Communications in Mass Spectrometry
© John Wiley & Sons, Ltd.
Impact Factor: 2.509
ISI Journal Citation Reports © Ranking: 2012: 13/43 (Spectroscopy); 28/75 (Chemistry Analytical); 34/75 (BIOCHEMICAL RESEARCH METHODS)
Online ISSN: 1097-0231
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Rapid Communications in Mass Spectrometry is a journal whose aim is the rapid publication of original research results and ideas on all aspects of the science of gas-phase ions; it covers all the associated scientific disciplines. There is no formal limit on paper length ("rapid" is not synonymous with "brief"), but papers should be of a length that is commensurate with the importance and complexity of the results being reported. Contributions may be theoretical or practical in nature; they may deal with methods, techniques and applications, or with the interpretation of results; they may cover any area in science that depends directly on measurements made upon gaseous ions or that is associated with such measurements.
In general, submissions that use conventional MS, GC/MS or LC/MS methods to catalogue or screen for components of extracts including Traditional Chinese Medicines are discouraged, except where the authors can clearly demonstrate that their contribution represents a significant extension of the capabilities or applications of mass spectrometry or new understanding of ion chemistry and related disciplines. In addition, articles reporting Stable Isotope analyses may only be published if they express novelty or significant developments in SI methodology.
Description of compounds under study. The molecular structures of chemical compounds (e.g. small molecules and pharmaceuticals) used to carry out the studies have to be fully disclosed in the paper and/or its supporting information or should be readily available without infringements or restriction.
Related work under consideration for publication. Rapid Communications in Mass Spectrometry is dedicated to publishing original contributions that are not being considered for publication in another journal or have not been published before. It is the responsibility of the corresponding author to inform the Editor of any related work currently under review and to cite the relevant contribution in the manuscript at the time of submission. The authors must also indicate if the work described in the manuscript has been the subject of prior presentation including conferences, workshops or other public dissemination media. If the related work is accepted, submitted, or in preparation, the authors must provide a copy of the manuscript as “Supporting Information for Review Only”. The authors will be able to update the status of the related work at a later time during the revision process or at the galley proof stage.
Hypothesized ion fragmentation mechanisms and fragment ion structures.
Papers that are mainly devoted to fragmentation mechanisms, structural elucidation techniques and any other study involving hypothesized ion structures, must provide a level of experimental and possibly computational evidence that justifies the amount of speculative discussion. See Rapid Commun. Mass Spec. 2010; 24: 3499-3500.
Protein identification by mass spectrometry.
Papers that describe identifications of proteins based on mass spectrometric data must ensure that these meet the criteria described by G.K. Taylor and D.R. Goodlett in Rapid Commun. Mass Spec. 2005; 19: 3420.
Rapid Communications in Mass Spectrometry operates an online submission and peer review system that allows authors to submit articles online and track their progress via a web interface. Please read the remainder of these instructions to authors and then click http://mc.manuscriptcentral.com/RCM to navigate to the Rapid Communications in Mass Spectrometry online submission site. IMPORTANT: Please check whether you already have an account in the system before trying to create a new one. If you have reviewed or authored for the journal in the past year it is likely that you will have had an account created.
All papers must be submitted via the online system.
File types. Preferred formats for the text and tables of your manuscript are .doc, .docx, .rtf, .ppt, .xls. Figures may be provided in .tiff or .eps format. Rapid Communications in Mass Spectrometry no longer accepts LaTeX files and cannot accept .pdfs as source files. Main document and Image files must be supplied in one of the preferred document formats.
Upload your manuscript files. At this stage, further source files do not need to be uploaded.
Editable source files must be uploaded at this stage. Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate figure files.
Supporting Information can be a useful way for an author to include important but ancillary information with the online version of an article. Examples of Supporting Information include additional tables, data sets, figures, movie files, audio clips, 3D structures, and other related nonessential multimedia files. Supporting Information should be cited within the article text, and a descriptive legend should be included. It is published as supplied by the author, and a proof is not made available prior to publication; for these reasons, authors should provide any Supporting Information in the desired final format.
For further information on recommended file types and requirements for submission, please visit: http://authorservices.wiley.com/bauthor/suppinfo.asp
OnlineOpen is available to authors of primary research articles who wish to make their article available to non-subscribers on publication, or whose funding agency requires grantees to archive the final version of their article. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers upon publication via Wiley Online Library, as well as deposited in the funding agency's preferred archive. For the full list of terms and conditions, see http://wileyonlinelibrary.com/onlineopen#OnlineOpen_Terms.
Any authors wishing to send their paper OnlineOpen will be required to complete the payment form available from our website at: https://authorservices.wiley.com/bauthor/onlineopen_order.asp
Prior to acceptance there is no requirement to inform an Editorial Office that you intend to publish your paper OnlineOpen if you do not wish to. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.
If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.
For authors signing the copyright transfer agreement
If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:
CTA Terms and Conditions http://authorservices.wiley.com/bauthor/faqs_copyright.asp
For authors choosing OnlineOpen
If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):
Creative Commons Attribution License OAA
Creative Commons Attribution Non-Commercial License OAA
Creative Commons Attribution Non-Commercial -NoDerivs License OAA
To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services http://authorservices.wiley.com/bauthor/faqs_copyright.asp and visit http://www.wileyopenaccess.com/details/content/12f25db4c87/Copyright--License.html.
If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit: http://www.wiley.com/go/funderstatement.
Papers must be in English. Oxford English Dictionary or American spelling is acceptable, provided usage is consistent within the manuscript. In the past RCM has sought to assist authors whose first language is not English by editing the text prior to sending the paper for review, and repeating the process for the revised version if accepted for publication. However, the growth in the number of manuscripts submitted to RCM has meant that this feature is no longer sustainable. In future, manuscripts that are written in English that is ambiguous or incomprehensible, in the opinion of the Editor, will be returned to the authors with a request to resubmit once the language issues have been improved. This policy does not imply that all papers must be written in "perfect" English, whatever that may mean. Rather, the criterion will require that the intended meaning of the authors must be clearly understandable, i.e., not obscured by language problems, by referees who have agreed to review the paper.
Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. A list of independent suppliers of editing services can be found at http://authorservices.wiley.com/bauthor/english_language.asp. Japanese authors can also find a list of local English improvement services at http://www.wiley.co.jp/journals/editcontribute.html. All services are paid for and arranged by the author, and use of one of these services does not guarantee acceptance or preference for publication.
Research articles have no formal limits on length. Please see “How to write a paper for RCM” (http://onlinelibrary.wiley.com/doi/10.1002/RCM.6314/pdf) for guidance on composing research articles together with the following formats published by the journal.
Letters to the editor. A letter to the editor provides a point of view, a critique, or a re-analysis of an article previously published in RCM that highlights novel aspects of this earlier research. A Letter typically contains no more than about 2000 words, sometimes accompanied by 1-2 figures or tables in support of the discussion.
Perspectives. A Perspective is a lightly referenced scholarly opinion piece about current or future directions in a field. A Perspective can serve to assess the science directly concerned with a particular topic or report on relevant issues that may arise from the discipline (for example, policy, effects on society, regulatory issues and controversies). Perspectives that address interdisciplinary research areas or experimental results with significance to a broader audience are of particular interest to the Editors. The Perspective should be accompanied by an abstract and generally contain less than 50 references. Perspectives will be subject to screening for appropriateness and accuracy but will not undergo the traditional peer review model.
Protocols describe in detail innovative experimental procedures for mass spectrometry. These may comprise of procedures for novel sample preparation methods, chemical labelling techniques for enhanced detection by mass spectrometry, clever or more efficient data acquisition routines, intelligent software tools for data extraction or mining, etc. Protocols follow the regular article format and there are no restrictions on page length.
Manuscript style. Use a standard font of the 12-point type: Times, Helvetica, or Courier is preferred. It is not necessary to double-line space your manuscript.
Tables must be on separate pages after the reference list, and not be incorporated into the main text. Figures should be uploaded as separate figure files.
- During the submission process you must enter
1) the full title
2) the short title of up to 70 characters
3) names and affiliations of all authors and
4) the full address, including email, telephone and fax of the author who is to check the proofs.
- Include the name(s) of any sponsor(s) of the research contained in the paper, along with grant number(s).
- Enter an abstract of up to 500 words for all articles (other than Letters to the Editor which requires no abstract). Please see the guidance below on acceptable abstract writing for RCM
- Keywords. Authors should prepare no more than 5 keywords for their manuscript.
RCM now publishes abstracts in a compound form please see below instructions regarding their composition:
Anatomy of the compound abstract
RATIONALE This introduction must convey the significance of the research and consist of 2–3 sentences (approximately 50 words) describing the importance of the study to a broad, non-expert audience. Authors may consider the following questions in the composition of their rationale: What is the problem? Why is the research important?What significance does it have to the immediate scientific community or to society as a whole?
METHODS A succinct description of the specialized processes, techniques and mass spectrometry instrumentation used in the study (maximum of 75 words). For example, the ionization technique and the type of mass spectrometer used will be of particular importance to other mass spectrometrists.
RESULTS Up to 75 words describing the outcome of the study. This should include the most importantexperimental findings. For example, for a classical analytical assay figures of merit and validation data should be summarized. A structural elucidation study may list important new compounds, proposed dissociation mechanisms and associated data such as accurate mass measurements and measurement uncertainties. For proteomics and metabolomics it is important to give the number of significant features, ion suppression effects, newly discovered biomarker molecules, etc
CONCLUSIONS One or two sentences (approximately 50 words) to explain the significance of the results and the conclusions drawn. The conclusions may also answer a question that was outlined in the Rationale section, and/or provide implications of the described research or examples for further applications. These conclusions should be understandable by a broad non-specialist specific audience.
RATIONALE: Melamine has been implicated in the death of numerous pets. In early 2007, melamine was fed to hogs intended for human consumption and contaminated meat products were sold to the public. In order to assist assessment of the potential health risk, it was essential to quickly develop an analytical method for detecting melamine, which is described in this study
METHODS: Melamine was extracted from porcine muscle tissue and extracts cleaned up by solid-phase extraction. Separation was achieved via liquid chromatography, and mass spectrometry analysis was conducted by electro-spray ionization triple-quadrupole mass spectrometry in the multiple reaction monitoring mode using a stable isotope- labeled internal standard.
RESULTS: A five point calibration curve ranging from 50 to 2000 ng/mL of melamine in solvent was used to establish instrument response. The method was validated by analysis of seven replicate porcine muscle tissue samples fortified with 10 ng/g of melamine. The mean recovery for the seven replicates was 83% with 6.5% relative standard deviation and the calculated method detection limit was 1.7 ng/g.
CONCLUSIONS: A quantitative method was rapidly developed for the detection of melamine in edible hog tissue. Data generated provided crucial information to the USDA and FDA in conducting a safety and risk assessment of melamine. This interim assessment indicated that melamine residues in edible tissues of animals inadvertently exposed to melamine are unlikely to pose a human health risk.
Authors must ensure that they format their references in the following style:
References should be cited in the text by numbers in square parentheses (superscript) after the punctuation. They should then be listed at the end of the paper in the order in which they appear in the text in the following format:
 P.J. Weaver, A.M.-F. Laures, J.-C. Wolff. Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer. Rapid. Commun. Mass Spectrom. 2007, 21, 2451.
Examples for Books
 K. Schmidt-Rohr, H.W. Spiess. Multidimensional Solid-State NMR and Polymers. Academic Press, London, 1994.
 V. Sklenar, in NMR Applications in Biopolymers, (Eds: J.W. Finley, S. J. Schmidt, A. S. Serianni). Plenum, New York, 1990, pp. 63-70.
Journal titles should be italicized and abbreviated in accordance with the “Chemical Abstracts Service Source Index” (CASSI; no commas appear in the journal names).
Link to EndNotetemplate.
To include the DOI in a citation to an article, simply append it to the reference as in the following example:
 P.J. Weaver, A.M.-F. Laures, J.-C. Wolff. Investigation of the advanced functionalities of a hybrid quadrupole orthogonal acceleration time-of-flight mass spectrometer. Rapid. Commun. Mass Spectrom. 2007, DOI: 10.1002/RCM.21464.
To link to an article from the author’s homepage, take the DOI (digital object identifier) and append it to "http://dx.doi.org/" as per following example:
DOI 10.1002/RCM.20941, becomes http://dx.doi.org/10.1002/RCM.20941.
Upload each figure as a separate file in either .tiff or .eps format, with the figure number and the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be of a reasonable size that would still be clearly legible upon reduction, and consistent within each figure and set of figures. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All illustrations must be supplied at the correct resolution:
- Black and white and colour photos - 300 dpi
- Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum
- Combinations of photos and drawings (black and white and colour) - 500 dpi
Tables should be part of the the main document and should be placed after the references. If the table is created in excel the file should be uploaded separately.
Chemical structures should be prepared in ChemDraw either 80mm (one column) or 175mm (two column) widths. However, the one-column format should be used whenever possible as this allows greater flexibility in the layout of the manuscript. Use the following settings:
|Drawing settings||Text settings|
|bond spacing||18% of length||size||12 pt|
|fixed length||17 pt|
|bond width||2 pt||Preferences|
|line width||0.75 pt||units||points|
|margin width||2 pt||tolerances||5 pixels|
|hash spacing||2.6 pt|
|bold width||2.6 pt|
Authors using different structural drawing programs should choose settings consistent with those above. Compound numbers should be bold, but not atom labels or captions.
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Where colour illustrations are supplied they may be reproduced online in colour at no cost to the author, if they are required to be printed in colour the cost will be charged to the author.
A single analytical technique, or a type of instrument, is abbreviated without hyphens. Thus, TOFMS, FTICRMS.
The IUPAP unit u is used for the relative molecular mass of an ion or molecule of uniquely specified isotopic composition, e.g., 12C6 1H3 35Cl2 37Cl1 16O1, relative to the standard 12C = 12 u. The u is not a unit of mass-to-charge ratio.
The Dalton (Da) is a unit of mass normally used for the molecular weight (natural isotope-averaged molecular mass), or often for the integral mass number (the molecular mass calculated from the atomic masses of the constituent atoms that have been rounded off to the nearest integer, thus H = 1, O = 16, Cl = 35 or 37, etc.) of a molecule. The Da is thus derived from the u (see above), sometimes together with natural isotopic abundances determined on planet Earth. However, use of the Da in place of the u has become commonplace in the mass spectrometry literature, and is acceptable in RCM. The Da is not a unit of mass-to-charge ratio.
The "atomic mass unit", abbreviated "amu", is an archaic unit for relative molecular or atomic mass based on the old 16O standard now replaced by 12C. Its use is strongly discouraged, and in any event the amu is not a unit of mass-to-charge ratio.
Mass spectrometers measure mass-to-charge ratio, symbolized by m/z , where m is relative molecular mass (e.g., in u) and z is the electrical charge measured in units of the absolute value of the charge on an electron. An m/z value can in principle be a positive or negative number (via z ) though usually the context makes clear whether the ion is positively or negatively charged and no sign need be given. Mass-to-charge ratio ( m/z ) is usually regarded as a dimensionless quantity even though the " m " is measured in "u". However, in view of more recent developments of ionisation techniques that produce abundant multiply charged ions, it is frequently necessary when describing a mass spectrum to discuss the spacings between peaks corresponding to multiply-charged ions not necessarily bearing the same charge. For this reason the Thomson (Th) may be used for such purposes as a unit of mass-to-charge ratio although it is not currently approved by IUPAP or IUPAC. See Cooks RG, Rockwood AL, Rapid Commun. Mass Spectrom. 1991; 5: 93. The use of the abbreviation Da/e is not acceptable.
The term “accurate mass” refers to mass spectrometric determinations of relative molecular mass (in u) to within a sufficient number of significant digits that uncertainties are in the parts-per-million (ppm) range or less, and thus imply higher levels of both accuracy and precision.
The mass of a neutral fragment lost in a fragmentation reaction can be given in u or Da.
Capital letters are used for Litre (L), Torr, Barr. Figures, Schemes and Tables should be referred to using a capital letter. Thus, Figure 1, Table 2 (not, e.g. fig.1). Parts of a Figure should be indicated by (a), (b), etc., both on the Figure itself and in the caption.
Protonated or deprotonated molecules are often observed in mass spectra. They are not protonated or deprotonated ions and should not be referred to as such. Symbols such as [M H] , [M–H]–, [M Na], etc., are appropriate and unambiguous. The use of the term "pseudo-molecular ion" is strongly discouraged as it is not sufficiently specific, and in any case the meaning of "pseudo" in this context is entirely unclear.
Ionic and other species should be enclosed in square brackets and the charge given as a superscript. Thus, [M]2 , [M–H]–, [C3H6O]. The presence of an odd electron may be indicated when necessary as in M·.
Note to NIH Grantees. Pursuant to NIH mandate, Wiley Blackwell will post the accepted version of contributions authored by NIH grant-holders to PubMedCentral upon acceptance. This accepted version will be made publicly available 12 months after publication. For further information, see www.wiley.com/go/nihmandate.
For accepted manuscripts the publisher will supply proofs to the submitting author prior to publication. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, preferably within two days of receipt, will minimise the risk of the paper being held over to a later issue.
Free access to the final PDF offprint or your article will be available via Author Services only. Please therefore sign up for Author Services if you would like to access your article PDF offprint and enjoy the many other benefits the service offers. There is no page charge to authors.
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