Statistics in Medicine

© John Wiley & Sons, Ltd.

Cover image for Vol. 31 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

EDITORS: Ralph D'Agostino, Vern Farewell, Joel Greenhouse and Louise Ryan

Impact Factor: 2.328

ISI Journal Citation Reports © Ranking: 2010: 4/22 (Medical Informatics); 8/110 (Statistics & Probability); 11/37 (Mathematical & Computational Biology); 42/140 (Public Environmental & Occupational Health); 44/106 (Medicine Research & Experimental)

Online ISSN: 1097-0258

  1. Research Articles

    1. Classification accuracy and cut point selection

      Xinhua Liu

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4509

  2. Special Issue Papers

    1. General joint frailty model for recurrent event data with a dependent terminal event: Application to follicular lymphoma data

      Yassin Mazroui, Simone Mathoulin-Pelissier, Pierre Soubeyran and Virginie Rondeau

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4479

  3. Research Articles

    1. A nonparametric test for equality of survival medians

      Mohammad H. Rahbar, Zhongxue Chen, Sangchoon Jeon, Joseph C. Gardiner and Jing Ning

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.5309

    2. Predictive power to assist phase 3 go/no go decision based on phase 2 data on a different endpoint

      Shengyan Hong and Li Shi

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4476

    3. Identifying representative trees from ensembles

      Mousumi Banerjee, Ying Ding and Anne-Michelle Noone

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4492

    4. Multilevel latent variable models for global health-related quality of life assessment

      Annette Kifley, Gillian Z. Heller, Ken J. Beath, David Bulger, Jun Ma and Val Gebski

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4455

    5. A pathway analysis method for genome-wide association studies

      Babak Shahbaba, Catherine M. Shachaf and Zhaoxia Yu

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4477

    6. A mixed non-homogeneous hidden Markov model for categorical data, with application to alcohol consumption

      Antonello Maruotti and Roberto Rocci

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4478

    7. On the covariance of two correlated log-odds ratios

      Pantelis G. Bagos

      Article first published online: 3 FEB 2012 | DOI: 10.1002/sim.4474

    8. Estimating net survival: the importance of allowing for informative censoring

      Coraline Danieli, Laurent Remontet, Nadine Bossard, Laurent Roche and Aurélien Belot

      Article first published online: 26 JAN 2012 | DOI: 10.1002/sim.4464

  4. Special Issue Papers

    1. Hierarchical Bayesian formulations for selecting variables in regression models

      Veronika Rockova, Emmanuel Lesaffre, Jolanda Luime and Bob Löwenberg

      Article first published online: 25 JAN 2012 | DOI: 10.1002/sim.4439

  5. Research Articles

    1. The analysis of binary longitudinal data with time-dependent covariates

      Matthew W. Guerra, Justine Shults, Jay Amsterdam and Thomas Ten-Have

      Article first published online: 13 JAN 2012 | DOI: 10.1002/sim.4465

    2. Mixed effect Poisson log-linear models for clinical and epidemiological sleep hypnogram data

      Bruce J. Swihart, Brian S. Caffo, Ciprian M. Crainiceanu and Naresh M. Punjabi

      Article first published online: 13 JAN 2012 | DOI: 10.1002/sim.4457

    3. Bayesian approach to predicting cancer incidence for an area without cancer registration by using cancer incidence data from nearby areas

      Ramon Clèries, Josepa Ribes, Maria Buxo, Alberto Ameijide, Rafael Marcos-Gragera, Jaume Galceran, José Miguel Martínez and Yutaka Yasui

      Article first published online: 11 JAN 2012 | DOI: 10.1002/sim.4463

    4. A two-stage Bayesian design for co-development of new drugs and companion diagnostics

      Stella Wanjugu Karuri and Richard Simon

      Article first published online: 11 JAN 2012 | DOI: 10.1002/sim.4462

  6. Special Issue Papers

    1. The basic theory, diagnostic, and therapeutic system of traditional Chinese medicine and the challenges they bring to statistics

      Jingqing Hu and Baoyan Liu

      Article first published online: 11 JAN 2012 | DOI: 10.1002/sim.4409

  7. Research Articles

    1. Detecting case–control expression quantitative trait loci using locally most powerful or maximin robust rank tests

      Ao Yuan, Jinfeng Xu, Qingqi Yue and Gang Zheng

      Article first published online: 15 DEC 2011 | DOI: 10.1002/sim.4461

  8. Special Issue Papers

    1. Performance of binary markers for censored failure time outcome: nonparametric approach based on proportions

      Laura Antolini and Maria Grazia Valsecchi

      Article first published online: 12 DEC 2011 | DOI: 10.1002/sim.4443

    2. How to deal with double partial verification when evaluating two index tests in relation to a reference test?

      Nan van Geloven, Kimiko A. Broeze, Brent C. Opmeer, Ben Willem Mol and Aeilko H. Zwinderman

      Article first published online: 12 DEC 2011 | DOI: 10.1002/sim.4440

  9. Research Articles

    1. Preserving the allocation ratio at every allocation with biased coin randomization and minimization in studies with unequal allocation

      Olga M. Kuznetsova and Yevgen Tymofyeyev

      Article first published online: 12 DEC 2011 | DOI: 10.1002/sim.4447

    2. Bayesian-adjusted R2 for the meta-analytic evaluation of surrogate time-to-event endpoints in clinical trials

      Lindsay Anne Renfro, Qian Shi, Daniel J. Sargent and Bradley P. Carlin

      Article first published online: 9 DEC 2011 | DOI: 10.1002/sim.4416

  10. Special Issue Papers

    1. Sufficient dimension reduction for longitudinally measured predictors

      Ruth M. Pfeiffer, Liliana Forzani and Efstathia Bura

      Article first published online: 9 DEC 2011 | DOI: 10.1002/sim.4437

    2. Data processing and analysis in real-world traditional Chinese medicine clinical data: challenges and approaches

      Baoyan Liu, Xuezhong Zhou, Yinhui Wang, Jingqing Hu, Liyun He, Runshun Zhang, Shibo Chen and Yufeng Guo

      Article first published online: 9 DEC 2011 | DOI: 10.1002/sim.4417

  11. Research Articles

    1. Global hypothesis testing for high-dimensional repeated measures outcomes

      Yueh-Yun Chi, Matthew Gribbin, Yvonne Lamers, Jesse F. Gregory III and Keith E. Muller

      Article first published online: 9 DEC 2011 | DOI: 10.1002/sim.4435

  12. Special Issue Papers

    1. A Bayesian order-restricted model for hormonal dynamics during menstrual cycles of healthy women

      Anindya Roy, Michelle Danaher, Sunni L. Mumford and Zhen Chen

      Article first published online: 7 DEC 2011 | DOI: 10.1002/sim.4419

  13. Research Articles

    1. Estimating incidence rates using exact or interval-censored data with an application to hospital-acquired infections

      Lisha Deng, Peter J. Diggle and John Cheesbrough

      Article first published online: 7 DEC 2011 | DOI: 10.1002/sim.4418

  14. Special Issue Papers

    1. Comparison of alternative models for linking drug exposure with adverse effects

      Michal Abrahamowicz, Marie-Eve Beauchamp and Marie-Pierre Sylvestre

      Article first published online: 17 NOV 2011 | DOI: 10.1002/sim.4343

  15. Research Articles

    1. Outcome-dependent sampling for longitudinal binary response data based on a time-varying auxiliary variable

      Jonathan S. Schildcrout, Sunni L. Mumford, Zhen Chen, Patrick J. Heagerty and Paul J. Rathouz

      Article first published online: 16 NOV 2011 | DOI: 10.1002/sim.4359

  16. Special Issue Papers

    1. Interpretability and importance of functionals in competing risks and multistate models

      Per Kragh Andersen and Niels Keiding

      Article first published online: 14 NOV 2011 | DOI: 10.1002/sim.4385

    2. Towards power and sample size calculations for the comparison of two groups of patients with item response theory models

      Jean-Benoit Hardouin, Sarah Amri, Mohand-Larbi Feddag and Véronique Sébille

      Article first published online: 8 NOV 2011 | DOI: 10.1002/sim.4387

  17. Research Articles

    1. Spatial scan statistics with overdispersion

      Tonglin Zhang, Zuoyi Zhang and Ge Lin

      Article first published online: 3 NOV 2011 | DOI: 10.1002/sim.4404

    2. Optimal sample sizes for phase II clinical trials and pilot studies

      Nigel Stallard

      Article first published online: 3 NOV 2011 | DOI: 10.1002/sim.4357

    3. Local sparse bump hunting reveals molecular heterogeneity of colon tumors

      Jean-Eudes Dazard, J. Sunil Rao and Sanford Markowitz

      Article first published online: 3 NOV 2011 | DOI: 10.1002/sim.4389

  18. Special Issue Papers

    1. An evaluation of penalised survival methods for developing prognostic models with rare events

      G. Ambler, S. Seaman and R. Z. Omar

      Article first published online: 14 OCT 2011 | DOI: 10.1002/sim.4371

    2. A two-stage mixed-effects model approach for gene-set analyses in candidate gene studies

      Roula Tsonaka, Annette H. M. van der Helm-van Mil and Jeanine J. Houwing-Duistermaat

      Article first published online: 14 OCT 2011 | DOI: 10.1002/sim.4370

    3. Estimating the number of true discoveries in genome-wide association studies

      Woojoo Lee, A. Gusnanto, A. Salim, P. Magnusson, Xueling Sim, E.S. Tai and Y. Pawitan

      Article first published online: 11 OCT 2011 | DOI: 10.1002/sim.4391

    4. Sensitivity analysis for interactions under unmeasured confounding

      Tyler J. VanderWeele, Bhramar Mukherjee and Jinbo Chen

      Article first published online: 4 OCT 2011 | DOI: 10.1002/sim.4354

    5. Non-compartmental estimation of pharmacokinetic parameters for flexible sampling designs

      Thomas Jaki and Martin J. Wolfsegger

      Article first published online: 3 OCT 2011 | DOI: 10.1002/sim.4386

    6. Design evaluation and optimisation in crossover pharmacokinetic studies analysed by nonlinear mixed effects models

      Thu Thuy Nguyen, Caroline Bazzoli and France Mentré

      Article first published online: 3 OCT 2011 | DOI: 10.1002/sim.4390

    7. Syndrome evaluation in traditional Chinese medicine using second-order latent variable model (page 00)

      Yang Li, Danhui Yi, Huiyun Zhang and Yichen Qin

      Article first published online: 3 OCT 2011 | DOI: 10.1002/sim.4335

    8. Competing risks and the clinical community: irrelevance or ignorance?

      Michael T. Koller, Heike Raatz, Ewout W. Steyerberg and Marcel Wolbers

      Article first published online: 23 SEP 2011 | DOI: 10.1002/sim.4384

  19. Research Articles

    1. Logistic regression analysis of biomarker data subject to pooling and dichotomization

      Z. Zhang, A. Liu, R.H.  Lyles and B. Mukherjee

      Article first published online: 23 SEP 2011 | DOI: 10.1002/sim.4367

  20. Special Issue Papers

    1. Optimum threshold estimation based on cost function in a multistate diagnostic setting

      Konstantina Skaltsa, Lluís Jover, David Fuster and Josep Lluís Carrasco

      Article first published online: 21 SEP 2011 | DOI: 10.1002/sim.4369

    2. Considerations on what constitutes a ‘qualified statistician’ in regulatory guidelines

      Christoph Gerlinger, Lutz Edler, Tim Friede, Meinhard Kieser, Christos T Nakas, Martin Schumacher, Jørgen Seldrup and Norbert Victor

      Article first published online: 21 SEP 2011 | DOI: 10.1002/sim.4345

    3. Bayesian adaptive clinical trials: a dream for statisticians only?

      Sylvie Chevret

      Article first published online: 9 SEP 2011 | DOI: 10.1002/sim.4363

    4. Identifying influential observations in Bayesian models by using Markov chain Monte Carlo

      Dan Jackson, Ian R. White and James Carpenter

      Article first published online: 8 SEP 2011 | DOI: 10.1002/sim.4356

    5. Estimation and testing based on data subject to measurement errors: from parametric to non-parametric likelihood methods

      Albert Vexler, Wan-Min Tsai and Yaakov Malinovsky

      Article first published online: 29 JUL 2011 | DOI: 10.1002/sim.4304

    6. Random effects models for assessing diagnostic accuracy of traditional Chinese doctors in absence of a gold standard

      Zheyu Wang and Xiao-Hua Zhou

      Article first published online: 31 MAY 2011 | DOI: 10.1002/sim.4275

  21. Research Articles

    1. A simulation study of predictive ability measures in a survival model I: Explained variation measures

      Babak Choodari-Oskooei, Patrick Royston and Mahesh K. B. Parmar

      Article first published online: 26 APR 2011 | DOI: 10.1002/sim.4242

  22. Special Issue Papers

    1. Discovering herbal functional groups of traditional Chinese medicine

      Ping He, Ke Deng, Zhihai Liu, Delin Liu, Jun S. Liu and Zhi Geng

      Article first published online: 17 MAR 2011 | DOI: 10.1002/sim.4146

    2. Generalized propensity score for estimating the average treatment effect of multiple treatments

      Ping Feng, Xiao-Hua Zhou, Qing-Ming Zou, Ming-Yu Fan and Xiao-Song Li

      Article first published online: 24 FEB 2011 | DOI: 10.1002/sim.4168

    3. Evaluating traditional Chinese medicine using modern clinical trial design and statistical methodology: Application to a randomized controlled acupuncture trial

      Lixing Lao, Yi Huang, Chiguang Feng, Brian M. Berman and Ming T. Tan

      Article first published online: 23 FEB 2011 | DOI: 10.1002/sim.4003

    4. Issues of design and statistical analysis in controlled clinical acupuncture trials: An analysis of English-language reports from Western journals

      Ping Shuai, Xiao-Hua Zhou, Lixing Lao and Xiaosong Li

      Article first published online: 22 FEB 2011 | DOI: 10.1002/sim.4034

    5. Variable selection using the optimal ROC curve: An application to a traditional Chinese medicine study on osteoporosis disease

      X. H. Zhou, B. Chen, Y. M. Xie, F. Tian, H. Liu and X. Liang

      Article first published online: 3 FEB 2011 | DOI: 10.1002/sim.3980

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