Biotechnology and Bioengineering

Cover image for Vol. 112 Issue 6

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Douglas S. Clark

Impact Factor: 4.164

ISI Journal Citation Reports © Ranking: 2013: 26/165 (Biotechnology & Applied Microbiology)

Online ISSN: 1097-0290

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  1. 1 - 58
  1. Articles

    1. Secondary anchor targeted cell release

      Ali Ansari, Felipe T. Lee-Montiel, Jenny Amos and P.I. Imoukhuede

      Accepted manuscript online: 22 MAY 2015 06:16PM EST | DOI: 10.1002/bit.25648

  2. Communications to the Editor

    1. A comprehensive evaluation of public genomic references for mapping RNA-Seq data from Chinese hamster ovary cells

      Huong Le, Chun Chen and Chetan T. Goudar

      Accepted manuscript online: 22 MAY 2015 06:16PM EST | DOI: 10.1002/bit.25649

  3. Articles

    1. miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality

      Simon Fischer, Albert Jesuran Paul, Andreas Wagner, Sven Mathias, Melanie Geiss, Franziska Schandock, Martin Domnowski, Jörg Zimmermann, René Handrick, Friedemann Hesse and Kerstin Otte

      Accepted manuscript online: 21 MAY 2015 05:46PM EST | DOI: 10.1002/bit.25626

    2. Enhanced enterovirus 71 virus-like particle yield from a new baculovirus design

      Shih-Yeh Lin, Chia-Tsui Yeh, Wan-Hua Li, Cheng-Ping Yu, Wen-Chin Lin, Jyh-Yuan Yang, Hsueh-Ling Wu and Yu-Chen Hu

      Accepted manuscript online: 21 MAY 2015 05:46PM EST | DOI: 10.1002/bit.25625

  4. Reviews

    1. The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk based management for their control

      Daniel G. Bracewell, Richard Francis and C. Mark Smales

      Accepted manuscript online: 21 MAY 2015 05:46PM EST | DOI: 10.1002/bit.25628

  5. Commentaries

  6. Articles

    1. Evaluating endoglucanase Cel7B-lignin interaction mechanisms and kinetics using quartz crystal microgravimetry

      Katherine A. Pfeiffer, Hagit Sorek, Christine Roche, Kathryn Strobel, Harvey W. Blanch and Douglas S. Clark

      Accepted manuscript online: 20 MAY 2015 05:29PM EST | DOI: 10.1002/bit.25657

    2. A flexible toolbox to study protein-assisted metalloenzyme assembly in vitro

      Johannes Schiffels and Thorsten Selmer

      Accepted manuscript online: 20 MAY 2015 05:29PM EST | DOI: 10.1002/bit.25658

    3. Liver sinusoid on a chip: Long-term layered co-culture of primary rat hepatocytes and endothelial cells in microfluidic platforms

      Young Bok (Abraham) Kang, Temitope R. Sodunke, Jason Lamontagne, Joseph Cirillo, Caroline Rajiv, Michael J. Bouchard and Moses Noh

      Accepted manuscript online: 20 MAY 2015 05:29PM EST | DOI: 10.1002/bit.25659

    4. Microfluidic wound model for studying the behaviours of Pseudomonas aeruginosa in polymicrobial biofilms

      Evan Wright, Suresh Neethirajan and Xuan Weng

      Accepted manuscript online: 20 MAY 2015 05:27PM EST | DOI: 10.1002/bit.25651

    5. Multi-omic profiling of EPO-producing Chinese hamster ovary cell panel reveals metabolic adaptation to heterologous protein production

      Daniel Ley, Ali Kazemi Seresht, Mikael Engmark, Oliviera Magdenoska, Kristian Fog Nielsen, Helene Faustrup Kildegaard and Mikael Rørdam Andersen

      Accepted manuscript online: 20 MAY 2015 05:27PM EST | DOI: 10.1002/bit.25652

    6. Type III secretion as a generalizable strategy for the production of full-length biopolymer-forming proteins

      Anum Azam, Cheng Li, Kevin J. Metcalf and Danielle Tullman-Ercek

      Accepted manuscript online: 20 MAY 2015 05:27PM EST | DOI: 10.1002/bit.25656

  7. Reviews

    1. Hyperthermia approaches for enhanced delivery of nanomedicines to solid tumors

      Nick Frazier and Hamidreza Ghandehari

      Accepted manuscript online: 20 MAY 2015 05:27PM EST | DOI: 10.1002/bit.25653

  8. Mini-Reviews

    1. Silks as scaffolds for skin reconstruction

      Kerstin Reimers, Christina Liebsch, Christine Radtke, Jörn W. Kuhbier and Peter M. Vogt

      Accepted manuscript online: 20 MAY 2015 05:26PM EST | DOI: 10.1002/bit.25654

  9. Articles

    1. High-throughput micro-scale cultivations and chromatography modeling: Powerful tools for integrated process development

      Pascal Baumann, Tobias Hahn and Jürgen Hubbuch

      Accepted manuscript online: 18 MAY 2015 11:01AM EST | DOI: 10.1002/bit.25630

    2. Persistent enhancement of bacterial motility increases tumor penetration

      Dana N. Thornlow, Emily L. Brackett, Jonathan M. Gigas, Nele Van Dessel and Neil S. Forbes

      Accepted manuscript online: 14 MAY 2015 05:58PM EST | DOI: 10.1002/bit.25645

    3. Characterization of intrinsic variability in time-series metabolomic data of cultured mammalian cells

      Huong Le, Matthew Jerums and Chetan T. Goudar

      Accepted manuscript online: 14 MAY 2015 05:57PM EST | DOI: 10.1002/bit.25646

  10. Reviews

    1. Enzymatic cell disruption of microalgae biomass in biorefinery processes

      Marie Demuez, Ahmed Mahdy, Elia Tomás-Pejó, Cristina González-Fernández and Mercedes Ballesteros

      Accepted manuscript online: 14 MAY 2015 05:56PM EST | DOI: 10.1002/bit.25644

  11. Articles

    1. Unveiling of novel regio-selective fatty acid double bond hydratases from Lactobacillus acidophilus involved in the selective oxyfunctionalization of mono- and di-hydroxy fatty acids

      Kyoung-Rok Kim, Hye-Jin Oh, Chul-Soon Park, Seung-Hye Hong, Ji-Young Park and Deok-Kun Oh

      Accepted manuscript online: 7 MAY 2015 05:40PM EST | DOI: 10.1002/bit.25643

    2. High-rate volatile fatty acid (VFA) production by a granular sludge process at low pH

      J. Tamis, B.M. Joosse, M.C.M. van Loosdrecht and R. Kleerebezem

      Accepted manuscript online: 6 MAY 2015 05:04PM EST | DOI: 10.1002/bit.25640

    3. Development of robust antibody purification by optimizing protein-A chromatography in combination with precipitation methodologies

      Srinivas Chollangi, Ray Parker, Nripen Singh, Yi Li, Mike Borys and Zhengjian Li

      Accepted manuscript online: 6 MAY 2015 05:04PM EST | DOI: 10.1002/bit.25639

    4. Investigation of protein selectivity in multimodal chromatography using in silico designed Fab fragment variants

      Hanne Sophie Karkov, Berit Olsen Krogh, James Woo, Siddharth Parimal, Haleh Ahmadian and Steven M. Cramer

      Accepted manuscript online: 6 MAY 2015 05:03PM EST | DOI: 10.1002/bit.25642

    5. Dissolved carbon dioxide determines the productivity of a recombinant hemagglutinin component of an influenza vaccine produced by insect cells

      Jamal Meghrous, Nikolai Khramtsov, Barry C. Buckland, Manon M.J. Cox, Laura A. Palomares and Indresh K. Srivastava

      Accepted manuscript online: 5 MAY 2015 06:06PM EST | DOI: 10.1002/bit.25634

    6. Characterization and mitigation of nitrous oxide (N2O) emissions from partial and full-nitrification BNR processes based on post-anoxic aeration control

      Ariane Coelho Brotto, Huosheng Li, Muriel Dumit, Jordi Gabarro, Jesús Colprim, Sudhir Murthy and Kartik Chandran

      Accepted manuscript online: 5 MAY 2015 06:06PM EST | DOI: 10.1002/bit.25635

    7. Efficient production of free fatty acids from soybean meal carbohydrates

      Dan Wang, Chandresh Thakker, Ping Liu, George N. Bennett and Ka-Yiu San

      Accepted manuscript online: 5 MAY 2015 06:05PM EST | DOI: 10.1002/bit.25633

    8. High-throughput sequencing reveals adaptation-induced mutations in pentose-fermenting strains of Zymomonas mobilis

      Kori L. Dunn and Christopher V. Rao

      Accepted manuscript online: 5 MAY 2015 05:58PM EST | DOI: 10.1002/bit.25631

  12. Communications to the Editor

    1. Rapid and marker-free Cas9/CRISPR refactoring yields equivalent xylose-utilization performance in yeast

      Ching-Sung Tsai, In Iok Kong, Anastashia Lesmana, Gyver Million, Guo-Chang Zhang, Soo Rin Kim and Yong-Su Jin

      Accepted manuscript online: 5 MAY 2015 05:57PM EST | DOI: 10.1002/bit.25632

  13. Articles

    1. The induction of pro-angiogenic processes within a collagen scaffold via exogenous estradiol and endometrial epithelial cells

      Jacquelyn C. Pence, Kathryn B. H. Clancy and Brendan A. C. Harley

      Accepted manuscript online: 5 MAY 2015 05:57PM EST | DOI: 10.1002/bit.25622

    2. CRISPR-Cas targeted plasmid integration into mammalian cells via non-homologous end joining

      Ravichandra Bachu, Iñigo Bergareche and Lawrence A. Chasin

      Accepted manuscript online: 5 MAY 2015 05:57PM EST | DOI: 10.1002/bit.25629

    3. UV-C mediated rapid carotenoid induction and settling performance of Dunaliella salina and Haematococcus pluvialis

      Kalpesh K Sharma, Faruq Ahmed, Peer M Schenk and Yan Li

      Accepted manuscript online: 22 APR 2015 01:06AM EST | DOI: 10.1002/bit.25621

  14. Systems Biotechnology

    1. A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

      Yuzhou Fan, Ioscani Jimenez Del Val, Christian Müller, Anne Mathilde Lund, Jette Wagtberg Sen, Søren Kofoed Rasmussen, Cleo Kontoravdi, Deniz Baycin-Hizal, Michael J. Betenbaugh, Dietmar Weilguny and Mikael Rørdam Andersen

      Accepted manuscript online: 20 APR 2015 08:48PM EST | DOI: 10.1002/bit.25620

  15. Biocatalysis, Protein Engineering and Nanobiotechnology

    1. Ionic Liquid Activated Bacillus subtilis Lipase A Variants Through Cooperative Surface Substitutions

      Jing Zhao, Ning Jia, Karl-Erich Jaeger, Marco Bocola and Ulrich Schwaneberg

      Accepted manuscript online: 20 APR 2015 04:25PM EST | DOI: 10.1002/bit.25617

  16. Cellular and Metabolic Engineering

    1. Enforced ATP futile cycling increases specific productivity and yield of anaerobic lactate production in Escherichia coli

      Oliver Hädicke, Katja Bettenbrock and Steffen Klamt

      Accepted manuscript online: 20 APR 2015 04:24PM EST | DOI: 10.1002/bit.25623

  17. Bioprocess Engineering and Supporting Technologies

    1. Interlinked population balance and cybernetic models for the simultaneous saccharification and fermentation of natural polymers

      Yong Kuen Ho, Pankaj Doshi, Hak Koon Yeoh and Gek Cheng Ngoh

      Accepted manuscript online: 20 APR 2015 04:21PM EST | DOI: 10.1002/bit.25616

  18. Articles

    1. Metabolic engineering of Clostridium tyrobutyricum for n-butanol production through co-utilization of glucose and xylose

      Le Yu, Mengmeng Xu, I-Ching Tang and Shang-Tian Yang

      Accepted manuscript online: 20 APR 2015 06:51AM EST | DOI: 10.1002/bit.25613

    2. Assessing microbial competition in a hydrogen-based membrane biofilm reactor (MBfR) using multidimensional modeling

      Kelly J. Martin, Cristian Picioreanu and Robert Nerenberg

      Accepted manuscript online: 8 APR 2015 05:46PM EST | DOI: 10.1002/bit.25607

    3. The role of electron donors generated from UV photolysis for accelerating pyridine biodegradation

      Yingxia Tang, Yongming Zhang, Ning Yan, Rui Liu and Bruce E. Rittmann

      Accepted manuscript online: 8 APR 2015 05:45PM EST | DOI: 10.1002/bit.25605

    4. Co-culturing Chlorella minutissima with Escherichia coli can increase neutral lipid production and improve biodiesel quality

      Brendan T. Higgins, John M. Labavitch and Jean S. VanderGheynst

      Accepted manuscript online: 8 APR 2015 05:45PM EST | DOI: 10.1002/bit.25609

    5. The role of micronutrients and strategies for optimized continual glycerol production from carbon dioxide by Dunaliella tertiolecta

      Yvonne Chow, Wang Yung Tu, David Wang, Daphne H.P. Ng and Yuan Kun Lee

      Accepted manuscript online: 8 APR 2015 05:44PM EST | DOI: 10.1002/bit.25608

    6. Temporal characterization of protein production levels from baculovirus vectors coding for GFP and RFP genes under non-conventional promoter control

      Steve George, Altamash M Jauhar, Jennifer Mackenzie, Sascha Kieβlich and Marc G Aucoin

      Accepted manuscript online: 7 APR 2015 10:24AM EST | DOI: 10.1002/bit.25600

    7. Effects of phosphate limitation on soluble microbial products and microbial community structure in semi-continuous Synechocystis-based photobioreactors

      Alexander S. Zevin, Taekgul Nam, Bruce Rittmann and Rosa Krajmalnik-Brown

      Accepted manuscript online: 7 APR 2015 10:23AM EST | DOI: 10.1002/bit.25602

    8. Optimization and automation of an end-to-end high throughput microscale transient protein production process

      Aaron B. Bos, Peng Luan, Dorothea Reilly, Peter D. Harms and Athena W. Wong

      Accepted manuscript online: 7 APR 2015 10:22AM EST | DOI: 10.1002/bit.25601

    9. Engineered microstructure granules for tailored drug release rate

      Min-Ho Hong, Heon-Jin Choi, Yeong-Mu Ko and Yong-Keun Lee

      Accepted manuscript online: 7 APR 2015 10:18AM EST | DOI: 10.1002/bit.25595

    10. Engineering protein folding and translocation improves heterologous protein secretion in Saccharomyces cerevisiae

      Hongting Tang, Xiaoming Bao, Yu Shen, Meihui Song, Shenhuan Wang, Chenqiang Wang and Jin Hou

      Accepted manuscript online: 7 APR 2015 10:17AM EST | DOI: 10.1002/bit.25596

  19. Tissue Engineering and Delivery Systems

    1. Fibrin Gels Engineered with Pro-Angiogenic Growth Factors Promote Engraftment of Pancreatic Islets in Extrahepatic Sites in Mice

      Mejdi Najjar, Vita Manzoli, Chiara Villa, Mikaël M. Martino, R. Damaris Molano, Yvan Torrente, Antonello Pileggi, Luca Inverardi, Camillo Ricordi, Jeffrey A. Hubbell and Alice A. Tomei

      Accepted manuscript online: 18 MAR 2015 03:01PM EST | DOI: 10.1002/bit.25589

  20. Bioprocess Engineering and Supporting Technologies

    1. Reduction of invasive bacteria in ethanol fermentations using bacteriophages

      Thomas O. Worley-Morse, Marc A. Deshusses and Claudia K. Gunsch

      Accepted manuscript online: 18 MAR 2015 03:01PM EST | DOI: 10.1002/bit.25586

  21. Biofuels and Environmental Biotechnology

    1. Consolidated bioprocessing of starchy substrates into ethanol by industrial Saccharomyces cerevisiae strains secreting fungal amylases

      L Favaro, MJ Viktor, SH Rose, M Viljoen-Bloom, WH van Zyl, M Basaglia, L Cagnin and S Casella

      Accepted manuscript online: 18 MAR 2015 03:00PM EST | DOI: 10.1002/bit.25591

  22. Biocatalysis, Protein Engineering, and Nanobiotechnology

    1. Coupling limonene formation and oxyfunctionalization by mixed-culture resting cell fermentation

      Christian Willrodt, Anna Hoschek, Bruno Bühler, Andreas Schmid and Mattijs K. Julsing

      Accepted manuscript online: 18 MAR 2015 03:00PM EST | DOI: 10.1002/bit.25592

  23. Tissue Engineering and Delivery Systems

    1. Initial Design and Physical Characterization of a Polymeric Device for Osmosis-Driven Delayed Burst Delivery of Vaccines

      Ferry PW Melchels, Ingo Fehr, Annika S Reitz, Urip Dunker, Kenneth W Beagley, Tim R Dargaville and Dietmar W Hutmacher

      Accepted manuscript online: 18 MAR 2015 03:00PM EST | DOI: 10.1002/bit.25593

  24. Articles

    1. Genetically expanded cell-free protein synthesis using endogenous pyrrolysyl orthogonal translation system

      Yonatan Chemla, Eden Ozer, Orr Schlesinger, Vincent Noireaux and Lital Alfonta

      Accepted manuscript online: 5 MAR 2015 06:21AM EST | DOI: 10.1002/bit.25587

    2. Bioprocessing analysis of Pyrococcus furiosus strains engineered for CO2-based 3-hydroxypropionate production

      Aaron B. Hawkins, Hong Lian, Benjamin M. Zeldes, Andrew J. Loder, Gina L. Lipscomb, Gerrit J. Schut, Matthew W. Keller, Michael W.W. Adams and Robert M. Kelly

      Accepted manuscript online: 5 MAR 2015 06:17AM EST | DOI: 10.1002/bit.25584

    3. High throughput screening of particle conditioning operations: II. Evaluation of scale-up heuristics with prokaryotically expressed polysaccharide vaccines

      Aaron Noyes, Ben Huffman, Alex Berrill, Nick Merchant, Ranga Godavarti, Nigel Titchener-Hooker, Jonathan Coffman, Khurram Sunasara and Tarit Mukhopadhyay

      Accepted manuscript online: 28 FEB 2015 03:42AM EST | DOI: 10.1002/bit.25580

    4. Bacteriophage therapy for membrane biofouling in membrane bioreactors and antibiotic-resistant bacterial biofilms

      Ananda Shankar Bhattacharjee, Jeong Dong Choi, Amir Mohaghegh Motlagh, Sachiyo T. Mukherji and Ramesh Goel

      Accepted manuscript online: 28 FEB 2015 03:39AM EST | DOI: 10.1002/bit.25574

  25. Tissue Engineering and Delivery Systems

  26. Cellular and Metabolic Engineering

    1. Development of an in vivo glucosylation platform by coupling production to growth: Production of phenolic glucosides by a glycosyltransferase of Vitis vinifera

      Frederik De Bruyn, Brecht De Paepe, Jo Maertens, Joeri Beauprez, Pieter De Cocker, Stein Mincke, Christian Stevens and Marjan De Mey

      Accepted manuscript online: 27 FEB 2015 04:43PM EST | DOI: 10.1002/bit.25570

  27. Engineering Science of Biological Systems

    1. MiRNA mimic screen for improved expression of functional neurotensin receptor from HEK 293 cells

      Su Xiao, Yu-Chi Chen, Michael J. Betenbaugh, Scott E. Martin and Joseph Shiloach

      Accepted manuscript online: 10 FEB 2015 02:53PM EST | DOI: 10.1002/bit.25567

  28. Articles

    1. Highly efficient production of rare sugars D-psicose and L-tagatose by two engineered D-tagatose epimerases

      Andreas Bosshart, Nina Wagner, Lei Lei, Sven Panke and Matthias Bechtold

      Accepted manuscript online: 23 JAN 2015 05:51AM EST | DOI: 10.1002/bit.25547

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