Fam60A plays a role for production stabilities of recombinant CHO cell lines
Anett Ritter, Sandro Nuciforo, Axel Schulze, Mevion Oertli, Tatjana Rauschert, Bernd Voedisch, Sabine Geisse, Thomas Jostock and Holger Laux
Version of Record online: 22 SEP 2016 | DOI: 10.1002/bit.26181
Ritter and coauthors provide primary evidence that the FAM60A protein plays a key role in production stability of CHO cell lines. Knock-out of the gene Fam60A, which is located within the telomeric region of the small chromosome 8 in CHO-K1a cells, increases the percentage of stable clones after long-term cultivation. This highlights that Fam60a is a relevant gene for cell line engineering approaches to increase production stability in recombinant cell lines.