Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time
Julia Feichtinger, Inmaculada Hernández, Christoph Fischer, Michael Hanscho, Norbert Auer, Matthias Hackl, Vaibhav Jadhav, Martina Baumann, Peter M. Krempl, Christian Schmidl, Matthias Farlik, Michael Schuster, Angelika Merkel, Andreas Sommer, Simon Heath, Daniel Rico, Christoph Bock, Gerhard G. Thallinger and Nicole Borth
Version of Record online: 29 APR 2016 | DOI: 10.1002/bit.25990
Six closely related CHO cell lines were studied for their genome and epigenome modifications in response to evolutionary pressures and over time. Full genome and DNA methylation data including analyses for SNPs, InDels, translocations and other structural variants, full genome DNA methylation patterns, and detailed data on histone modifications during a batch culture are presented in a web database at cho-epigenome.boku.ac.at/.