Biotechnology and Bioengineering

Cover image for Vol. 113 Issue 8

Edited By: Douglas S. Clark

Impact Factor: 4.243

ISI Journal Citation Reports © Ranking: 2015: 24/161 (Biotechnology & Applied Microbiology)

Online ISSN: 1097-0290

B&B Reviews

Biotechnology and Bioengineering Reviews

Since 2010, Editor-in-Chief Douglas S. Clark instituted our Board of Review Editors to identify scientific experts to provide critical and relevant Reviews and Mini-Reviews to our readership. All of our Reviews and Mini-Reviews published over the last three years are captured below.

 Board of Review Editors
William Bentley
University of Maryland
College Park, Maryland

James Bryers
University of Washington
Seattle, Washington

Michael J. Betenbaugh
Johns Hopkins University
Baltimore, Maryland

Lonnie Shea
University of Michigan
Ann Arbor, Michigan

Andrew Zydney
Pennsylvania State University
University Park, Pennsylvania


Advances in affinity ligand-functionalized nanomaterials for biomagnetic separation
Conor Fields, Peng Li, James J. O'Mahony and Gil U. Lee

The use of ‘Omics technology to rationally improve industrial mammalian cell line performance
Amanda M. Lewis, Nicholas R. Abu-Absi, Michael C. Borys and Zheng Jian Li

Recent therapeutic approaches for spinal cord injury
Andrea Raspa, Raffaele Pugliese, Mahboubeh Maleki and Fabrizio Gelain

Application of gas diffusion electrodes in bioelectrochemical syntheses and energy conversion
Angelika E.W. Horst, Klaus-Michael Mangold and Dirk Holtmann

Continuous downstream processing for high value biological products: A Review
Andrew Zydney

Combatting bacterial persister cells
Thomas Wood

Transforming exoelectrogens for biotechnology using synthetic biology
Michaela A. TerAvest and Caroline M. Ajo-Franklin

Clarification technologies for monoclonal antibody manufacturing processes: Current state and future perspectives
Nripen Singh, Abhiram Arunkumar, Srinivas Chollangi, Zhijun George Tan, Michael Borys and Zheng Jian Li

Fibrous proteins: At the crossroads of genetic engineering and biotechnological applications
Sezin Yigit, Nina Dinjaski and David L. Kaplan

Current and future prospects for CRISPR-based tools in bacteria
Michelle L. Luo, Ryan T. Leenay and Chase L. Beisel

Scaffold and scaffold-free self-assembled systems in regenerative medicine
Dilip Thomas, Diana Gaspar, Anna Sorushanova, Gesmi Milcovich, Kyriakos Spanoudes, Anne Maria Mullen, Timothy O'Brien, Abhay Pandit and Dimitrios I. Zeugolis

Industrial systems biology and its impact on synthetic biology of yeast cell factories
Eugene Fletcher, Anastasia Krivoruchko and Jens Nielsen

Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices
Shang Song and Shuvo Roy


Modeling of plant in vitro cultures: Overview and estimation of biotechnological processes
Rüdiger W. Maschke, Katja Geipel and Thomas Bley

Natural and engineered production of taxadiene with taxadiene synthase
Sameh Soliman and Yi Tang

Oxidative phosphorylation revisited
Sunil Nath and John Villadsen

Improved virus purification processes for vaccines and gene therapy
Piergiuseppe Nestola, Cristina Peixoto, Ricardo R. J. S Silva, Paula M. Alves, José P. B. Mota and Manuel J. T. Carrondo

Microtubule-based nanomaterials: Exploiting nature's dynamic biopolymers
George D. Bachand, Erik D. Spoerke and Mark J. Stevens

Challenges and opportunities for microalgae-mediated CO2 capture and biorefinery
Jyoti R. Seth and Pramod P. Wangikar

Bioengineering strategies to generate artificial protein complexes
Heejae Kim, Ka-Hei Siu, Maryam Raeeszadeh-Sarmazdeh, Qing Sun, Qi Chen and Wilfred Chen

The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk-based management for their control
Daniel G. Bracewell, Richard Francis and C. Mark Smales

Enzymatic cell disruption of microalgae biomass in biorefinery processes
Marie Demuez, Ahmed Mahdy, Elia Tomás-Pejó, Cristina González-Fernández and Mercedes Ballesteros

Hyperthermia approaches for enhanced delivery of nanomedicines to solid tumors
Nick Frazier and Hamidreza Ghandehari

Silks as scaffolds for skin reconstruction
Kerstin Reimers, Christina Liebsch, Christine Radtke, Jörn W. Kuhbier and Peter M. Vogt


Expanding the scope of site-specific recombinases for genetic and metabolic engineering
Thomas Gaj, Shannon J. Sirk and Carlos F. Barbas III

Materials-based strategies for multi-enzyme immobilization and co-localization: A review
Feng Jia, Balaji Narasimhan, Surya Mallapragada

Bioengineering virus-like particles as vaccines
Linda H.L. Lua; Natalie K. Connors; Frank Sainsbury; Yap P. Chuan; Nani Wibowo; Anton P.J. Middelberg

Nanocomposite hydrogels for biomedical applications
Akhilesh K. Gaharwar; Nicholas A. Peppas; Ali Khademhosseini

Lipase-catalyzed process for biodiesel production: Protein engineering and lipase production
Hyun Tae Hwang, Feng Qi, Chongli Yuan, Xuebing Zhao, Doraiswami Ramkrishna, Dehua Liu and Arvind Varma

Systems metabolic engineering design: Fatty acid production as an emerging case study
Ting Wei Tee, Anupam Chowdhury, Costas D. Maranas and Jacqueline V. Shanks

Recent advances in engineering proteins for biocatalysis
Ye Li and Patrick C. Cirino

Anaerobic gut fungi: Advances in isolation, culture, and cellulolytic enzyme discovery for biofuel production
Charles H. Haitjema, Kevin V. Solomon, John K. Henske, Michael K. Theodorou and Michelle A. O'Malley

Co-opting biology to deliver drugs
Parisa Yousefpour and Ashutosh Chilkoti

Recent advances in the understanding of biological implications and modulation methodologies of monoclonal antibody N-linked high mannose glycans
Helen H. Shi and Chetan T. Goudar

Regulation mechanisms in mixed and pure culture microbial fermentation
Robert D. Hoelzle, Bernardino Virdis and Damien J. Batstone

Host cell protein testing by ELISAs and the use of orthogonal methods
Judith Zhu-Shimoni, Christopher Yu, Julie Nishihara, Robert M. Wong, Feny Gunawan, Margaret Lin, Denise Krawitz, Peter Liu, Wendy Sandoval and Martin Vanderlaan


Critical review of activated sludge modeling: State of process knowledge, modeling concepts, and limitations
H. Hauduc, L. Rieger, A. Oehmen, M.C.M. van Loosdrecht, Y. Comeau, A. Héduit, P.A. Vanrolleghem and S. Gillot

Review of reactive kinetic models describing reductive dechlorination of chlorinated ethenes in soil and groundwater
Julie C. Chambon, Poul L. Bjerg, Charlotte Scheutz, Jacob Bælum, Rasmus Jakobsen and Philip J. Binning

Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation
Jenna L. Wilson and Todd C. McDevitt

Oxygen transfer characteristics of miniaturized bioreactor systems
Timothy V. Kirk and Nicolas Szita

An 'omics approach towards CHO cell engineering
Payel Datta, Robert J. Linhardt and Susan T. Sharfstein

Visualizing cellulase activity
Patricia Bubner, Harald Plank and Bernd Nidetzky

Glycans-by-design: Engineering bacteria for the biosynthesis of complex glycans and glycoconjugates
Judith H. Merritt, Anne A. Ollis, Adam C. Fisher and Matthew P. DeLisa

Transcription activator-like effector nucleases (TALENs): A highly efficient and versatile tool for genome editing
Ning Sun and Huimin Zhao

Microfluidic culture models to study the hydrodynamics of tumor progression and therapeutic response
Cara Buchanan and Marissa Nichole Rylander


Synthesis and application of virus-based hybrid nanomaterials
Lee, Sang-Yup; Lim, Jung-Sun; Harris, Michael T.

Esophageal tissue engineering: An in-depth review on scaffold design
Tan, J. Y.; Chua, C. K.; Leong, K. F.; Chian, K. S.; Leong, W. S.; Tan, L. P.

Residual DNA analysis in biologics development: Review of measurement and quantitation technologies and future directions
Wang, Xing; Morgan, Donna M.; Wang, Gan; Mozier, Ned M.

The use of high-solids loadings in biomass pretreatment-a review
Modenbach, Alicia A.; Nokes, Sue E.

Vaccine process technology
Josefsberg, Jessica O.; Buckland, Barry

Engineering biomaterials to integrate and heal: The biocompatibility paradigm shifts
Bryers, James D.; Giachelli, Cecilia M.; Ratner, Buddy D.

Biologically produced nanosilver: Current state and future perspectives
Sintubin, Liesje; Verstraete, Willy; Boon, Nico

Bio-based production of C2-C6 platform chemicals
Jang, Yu-Sin; Kim, Byoungjin; Shin, Jae Ho; Choi, Yong Jun; Choi, Sol; Song, Chan Woo; Lee, Joungmin; Park, Hye Gwon; Lee, Sang Yup

Separation technologies for stem cell bioprocessing
Diogo, Maria Margarida; da Silva, Claudia Lobato; Cabral, Joaquim M. S.


Room Temperature Ionic Liquids as Emerging Solvents for the Pretreatment of Lignocellulosic Biomass
Mora-Pale, Mauricio; Meli, Luciana; Doherty, Thomas V.; Linhardt, Robert J.; Dordick, Jonathan S.

Intracellular signal transduction as a factor in the development of “Smart” biomaterials for bone tissue engineering
Willian F. Zambuzzi, Paulo G. Coelho, Gutemberg G. Alves and José M. Granjeiro

Process Considerations for the Asymmetric Synthesis of Chiral Amines Using Transaminases
Tufvesson, Par; Lima-Ramos, Joana; Jensen, Jacob S.; Al-Haque, Naweed; Neto, Watson; Woodley, John M.

Aggregates in Monoclonal Antibody Manufacturing Processes
Vazquez-Rey, Maria; Lang, Dietmar A.

A Review of the Mammalian Unfolded Protein Response
Chakrabarti, Anirikh; Chen, Aaron W.; Varner, Jeffrey D.