Biotechnology and Bioengineering

Cover image for Vol. 115 Issue 1

Edited By: Douglas S. Clark

Impact Factor: 4.481

ISI Journal Citation Reports © Ranking: 2016: 23/160 (Biotechnology & Applied Microbiology)

Online ISSN: 1097-0290

Most Accessed 2008


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From September-December 2008


Opportunities for renewable bioenergy using microorganisms
Bruce E. Rittmann
Volume 100, Issue 2, 2008

Fermentative butanol production by clostridia
Sang Yup Lee, Jin Hwan Park, Seh Hee Jang , Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung
Volume 101, Issue 2, 2008

Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi , Giulia Padovani , Natascia Biondi , Gimena Bonini , Mario R. Tredici
Volume 102, Issue 1, 2008

Large-scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors
Xiufeng Li, Han Xu, Qingyu Wu
Volume 98, Issue 4, 2007

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

Rapid cloning and purification of proteins: Gateway vectors for protein purification by self-cleaving tags
Alison R. Gillies, Judy F. Hsii, Seachol Oak, David W. Wood
Volume 101, Issue 2, 2008

Engineered enzymes for chemical production
Stephan Luetz, Lori Giver, James Lalonde
Volume 101, Issue 4, 2008

Extracellular recombinant protein production from an Escherichia coli lpp deletion mutant
Hyun-Dong Shin, Rachel R. Chen
Volume 101, Issue 6, 2008

Generation of baculovirus vectors for the high-throughput production of proteins in insect cells
Robert D. Possee, Richard B. Hitchman, Kevin S. Richards, Susan G. Mann, Evangelia Siaterli, Clare P. Nixon, Helen Irving, Rene Assenberg, David Alderton, Raymond J. Owens, Linda A. King
Volume 101, Issue 6, 2008

Enzymatic hydrolysis of cellulose coupled with electricity generation in a microbial fuel cell
Farzaneh Rezaei, Tom L. Richard, Bruce E. Logan
Volume 101, Issue 6, 2008

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
Ruben J. Boado, Yufeng Zhang, Yun Zhang, William M. Pardridge
Volume 96, Issue 2, 2006

Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL
Brian S. Majors, Michael J. Betenbaugh, Nels E. Pederson, Gisela G. Chiang
Volume 101 Issue 3, 2008

Effects of oxygen on mouse embryonic stem cell growth, phenotype retention, and cellular energetics
Daryl E. Powers, Jeffrey R. Millman, Ryan B. Huang, Clark K. Colton
Volume 101, Issue 2, 2008

Stem cell-based composite tissue constructs for regenerative medicine
Mohamed N. Rahaman , Jeremy J. Mao
Volume 91, Issue 3, 2005

Determination of protein aggregation with differential mobility analysis: Application to IgG antibody
Leonard F. Pease III, John T. Elliott, De-Hao Tsai, Michael R. Zachariah, Michael J. Tarlov
Volume 101, Issue 6, 2008

Medical biofilms
James D. Bryers
Volume 100, Issue 1, 2008

Control of protein adsorption on functionalized electrospun fibers
Dirk Grafahrend, Julia Lleixa Calvet, Kristina Klinkhammer, Jochen Salber, Paul D. Dalton, Martin Möller, Doris Klee
Volume 101, Issue 3, 2008

Ethanol and hydrogen production by two thermophilic, anaerobic bacteria isolated from Icelandic geothermal areas
Perttu E.P. Koskinen, Steinar R. Beck, Jóhann Örlygsson, Jaakko A. Puhakka
Volume 101, Issue 4, 2008

Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor
Sylvia Niebruegge, Céline L. Bauwens, Raheem Peerani, Nimalan Thavandiran, Stephane Masse, Elias Sevaptisidis, Kumar Nanthakumar, Kim Woodhouse , Mansoor Husain, Eugenia Kumacheva, Peter W. Zandstra
Volume 102, Issue 2, 2009

A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?
Janet Chusainow, Yuan Sheng Yang, Jessna H.M. Yeo, Poh Choo Toh, Parisa Asvadi, Niki S.C. Wong, Miranda G.S. Yap
Volume 102, Issue 4, 2009

Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
Ryan S. Senger, Eleftherios T. Papoutsakis
Volume 101, Issue 5, 2008

Comparison of SHF and SSF processes from steam-exploded wheat straw for ethanol production by xylose-fermenting and robust glucose-fermenting Saccharomyces cerevisiae strains
Elia Tomás-Pejó, Jose M. Oliva, Mercedes Ballesteros, Lisbeth Olsson
Volume 100, Issue 6, 2008

Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells
Woo Suk Ahn, Jae-Jin Jeon, Yeong-Ran Jeong, Seung Joo Lee, Sung Kwan Yoon
Volume 101, Issue 6, 2008

Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: Influence of collagen type II extracellular matrix on MSC chondrogenesis
Darko Bosnakovski, Morimichi Mizuno, Gonhyung Kim, Satoshi Takagi, Masahiro Okumura, Toru Fujinaga
Volume 93, Issue 6, 2006

Calcium phosphate transfection generates mammalian recombinant cell lines with higher specific productivity than polyfection
Sebastien Chenuet, Danielle Martinet, Nathalie Besuchet-Schmutz, Marianne Wicht, Nicolas Jaccard, Anne-Charlotte Bon, Madiha Derouazi
Volume 101, Issue 5, 2008



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From May-August 2008


Opportunities for renewable bioenergy using microorganisms
Bruce E. Rittmann
Volume 100, Issue 2, 2008

A novel method for monitoring monoclonal antibody production during cell culture
Henryk Szmacinski, Derek S. Smith, Michael A. Hanson, Yordan Kostov, Joseph R. Lakowicz, Govind Rao
Volume 100, Issue 3, 2008

Identification of novel small molecule enhancers of protein production by cultured mammalian cells
Martin J. Allen, James P. Boyce, Michael T. Trentalange, David L. Treiber, Brian Rasmussen, Benjamin Tillotson, Raymond Davis, Pranhitha Reddy
Volume 100, Issue 6, 2008

Medical biofilms
James D. Bryers
Volume 100, Issue 1, 2008

Micro biochemical engineering to accelerate the design of industrial-scale downstream processes for biopharmaceutical proteins
N.J. Titchener-Hooker, P. Dunnill, M. Hoare
Volume 100, Issue 3, 2008

High-throughput screening of chromatographic separations: I. Method development and column modeling
Jonathan L. Coffman, Jack F. Kramarczyk, Brian D. Kelley
Volume 100, Issue 4, 2008

Charge-directed targeting of antimicrobial protein-nanoparticle conjugates
Rohan Satishkumar, Alexey Vertegel
Volume 100, Issue 3, 2008

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

Large-scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors
Xiufeng Li, Han Xu, Qingyu Wu
Volume 98, Issue 4, 2007

High-throughput microplate technique for enzymatic hydrolysis of lignocellulosic biomass
Shishir P.S. Chundawat, Venkatesh Balan, Bruce E. Dale
Volume 99, Issue 6, 2008

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier
Ruben J. Boado, Yufeng Zhang, Yun Zhang, William M. Pardridge
Volume 96, Issue 2, 2007

Valproic acid: A viable alternative to sodium butyrate for enhancing protein expression in mammalian cell cultures
Gaurav Backliwal, Markus Hildinger, Ivan Kuettel, Fanny Delegrange, David L. Hacker, Florian M. Wurm
Volume 101 Issue 1, 2008

Variability of the response of Saccharomyces cerevisiae strains to lignocellulose hydrolysate
Tobias Modig, João R.M. Almeida, Marie F. Gorwa-Grauslund, Gunnar Lidén
Volume 100, Issue 3, 2008

Comparison of SHF and SSF processes from steam-exploded wheat straw for ethanol production by xylose-fermenting and robust glucose-fermenting Saccharomyces cerevisiae strains
Elia Tomás-Pejó, Jose M. Oliva, Mercedes Ballesteros, Lisbeth Olsson
Volume 100, Issue 6, 2008

Effect of humic acids on electricity generation integrated with xylose degradation in microbial fuel cells
Liping Huang, Irini Angelidaki
Volume 100, Issue 3, 2008

Metabolic capacity estimation of Escherichia coli as a platform for redox biocatalysis: constraint-based modeling and experimental verification
Lars M. Blank, Birgitta E. Ebert, Bruno Bühler, Andreas Schmid
Volume 100, Issue 6, 2008

Glycerol fermentation by (open) mixed cultures: A chemostat study
Margarida F. Temudo, Rolf Poldermans, Robbert Kleerebezem, Mark C.M. van Loosdrecht
Volume 100, issue 6, 2008

The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells
Jong Hyun Nam, Fuming Zhang, Myriam Ermonval, Robert J. Linhardt, Susan T. Sharfstein
Volume 100, Issue 6, 2008

Viral clearance using disposable systems in monoclonal antibody commercial downstream processing
Joe X. Zhou, Felix Solamo, Tony Hong, Michael Shearer, Tim Tressel
Volume 100, Issue 3, 2008

Quantification of power consumption and oxygen transfer characteristics of a stirred miniature bioreactor for predictive fermentation scale-up
N.K. Gill, M. Appleton, F. Baganz, G.J. Lye
Volume 100, Issue 6, 2008

Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady-state and highly dynamic conditions
André B. Canelas, Walter M. van Gulik, Joseph J. Heijnen
Volume 100, Issue 4, 2008

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
Derek W. Bartlett, Mark E. Davis
Volume 99, Issue 4, 2008

Multiplex bacterial growth monitoring in 24-well microplates using a dual optical sensor for dissolved oxygen and pH
Anna S. Kocincová, Stefan Nagl, Sarina Arain, Christian Krause, Sergey M. Borisov, Matthias Arnold, Otto S. Wolfbeis
Volume 100, Issue 3, 2008

Identification of optimal measurement sets for complete flux elucidation in metabolic flux analysis experiments
YoungJung Chang, Patrick F. Suthers, Costas D. Maranas
Volume 100, Issue 6, 2008

High-throughput screening of chromatographic separations: II. Hydrophobic interaction
Jack F. Kramarczyk, Brian D. Kelley, Jonathan L. Coffman
Volume 100, Issue 4, 2008



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Top 25 Most Downloaded Articles

From January-April 2008


Application of statistically-based experimental designs for the optimization of eicosapentaenoic acid production by the diatom Nitzschia laevis
Zhi-You Wen, Feng Chen
Volume 75, Issue 2, 2001

Anchorage of cyclodextrin glucanotransferase on the outer membrane of Escherichia coli
Hsiao-Ming Wan, Ban-Yang Chang, Sung-Chyr Lin
Volume 79, Issue 4, 2002

Production of plant sesquiterpenes in Saccharomyces cerevisiae: Effect of ERG9 repression on sesquiterpene biosynthesis
Mohammad A. Asadollahi, Jérôme Maury, Kasper Møller, Kristian Fog Nielsen, Michel Schalk, Anthony Clark, Jens Nielsen
Volume 99, Issue 3, 2008

Biorefining of softwoods using ethanol organosolv pulping: Preliminary evaluation of process streams for manufacture of fuel-grade ethanol and co-products
Xuejun Pan, Claudio Arato, Neil Gilkes, David Gregg, Warren Mabee, Kendall Pye, Zhizhuang Xiao, Xiao Zhang, John Saddler
Volume 90, Issue 4, 2005

Chemometric analysis of in-line multi-wavelength fluorescence measurements obtained during cultivations with a lipase producing Aspergillus oryzae strain
Martin B. Haack, Anna Eliasson Lantz, Peter P. Mortensen, Lisbeth Olsson
Volume 96, Issue 5, 2007

Simultaneous saccharification and fermentation of steam-pretreated bagasse using Saccharomyces cerevisiae TMB3400 and Pichia stipitis CBS6054
Andreas Rudolf, Henrique Baudel, Guido Zacchi, Bärbel Hahn-Hägerdal, Gunnar Lidén
Volume 99, Issue 4, 2008

Natural cellulose fibers from switchgrass with tensile properties similar to cotton and linen
Narendra Reddy, Yiqi Yang
Volume 97, Issue 5, 2007

Effect of compounds released during pretreatment of wheat straw on microbial growth and enzymatic hydrolysis rates
Gianni Panagiotou, Lisbeth Olsson
Volume 96, Issue 2 , 2007

Metabolic engineering of the nonmevalonate isopentenyl diphosphate synthesis pathway in Escherichia coli enhances lycopene production
Seon-Won Kim, J. D. Keasling
Volume 72, Issue 4, 2000

Kinetic model of laccase-catalyzed oxidation of aqueous phenol
Selvia Kurniawati, James A. Nicell
Volume 91, Issue 1, 2005

BSA treatment to enhance enzymatic hydrolysis of cellulose in lignin containing substrates
Bin Yang, Charles E. Wyman
Volume 94, Issue 4, 2006

Engineering Escherichia coli for xylitol production from glucose-xylose mixtures
Patrick C. Cirino, Jonathan W. Chin, Lonnie O. Ingram
Volume 95, Issue 6, 2006

Investigation of protein retention and selectivity in HIC systems using quantitative structure retention relationship models
Asif Ladiwala, Fang Xia, Qiong Luo, Curt M. Breneman, Steven M. Cramer
Volume 93, Issue 5, 2006

Large-scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors
Xiufeng Li, Han Xu, Qingyu Wu
Volume 98, Issue 4, 2007

Intracellular fluxes in a recombinant xylose-utilizing Saccharomyces cerevisiae cultivated anaerobically at different dilution rates and feed concentrations
C. Fredrik Wahlbom, Anna Eliasson, Bärbel Hahn-Hägerdal
Volume 72, Issue 3, 2000

Affinity-enhanced protein partitioning in decyl &bgr;-D-glucopyranoside two-phase aqueous micellar systems
Henry Lam, Mojgan Kavoosi, Charles A. Haynes, Daniel I.C. Wang, Daniel Blankschtein
Volume 89, Issue 4 , 2005

Modeling and simulation of oxygen-limited partial nitritation in a membrane-assisted bioreactor (MBR)
Stijn Wyffels, Stijn W. H. Van Hulle, Pascal Boeckx, Eveline I. P. Volcke, Oswald Van Cleemput, Peter A. Vanrolleghem, Willy Verstraete
Volume 86, Issue 5 , 2004

Optimizing the salt-induced activation of enzymes in organic solvents: Effects of lyophilization time and water content
Michael T. Ru, Jonathan S. Dordick, Jeffrey A. Reimer, Douglas S. Clark
Volume 63, Issue 2, 2000

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

Fermentation performance of engineered and evolved xylose-fermenting Saccharomyces cerevisiae strains
Marco Sonderegger, Marie Jeppsson, Christer Larsson, Marie-Françoise Gorwa-Grauslund, Eckhard Boles, Lisbeth Olsson, Isabel Spencer-Martins, Bärbel Hahn-Hägerdal, Uwe Sauer
Volume 87, Issue 1 , 2004

Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
Derek W. Bartlett, Mark E. Davis
Volume 99, Issue 4, 2008

Engineering of baker's yeasts, E. coli and Bacillus hosts for the production of Bacillus subtilis Lipase A
Marta Sánchez, Núria Prim, Francisca Rández-Gil, F. I. Javier Pastor, Pilar Diaz
Volume 78, Issue 3 , 2002

Identification of genes affecting lycopene accumulation in Escherichia coli using a shot-gun method
Min Jung Kang, Young Mi Lee, Sang Hwal Yoon, Jung Heon Kim, So Won Ock, Kyung Hwa Jung, Yong Chul Shin, Jay D. Keasling, Seon Won Kim
Volume 91, Issue 5, 2005

High-density transfection with HEK-293 cells allows doubling of transient titers and removes need for a priori DNA complex formation with PEI
Gaurav Backliwal, Markus Hildinger, Vivek Hasija, Florian M. Wurm
Volume 99, Issue 3, 2008

Fractionating recalcitrant lignocellulose at modest reaction conditions
Yi-Heng Percival Zhang, Shi-You Ding, Jonathan R. Mielenz, Jing-Biao Cui, Richard T. Elander, Mark Laser, Michael E. Himmel, James R. McMillan, Lee R. Lynd
Volume 97, Issue 2, 2007



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