Biotechnology and Bioengineering

Cover image for Vol. 114 Issue 4

Edited By: Douglas S. Clark

Impact Factor: 4.243

ISI Journal Citation Reports © Ranking: 2015: 24/161 (Biotechnology & Applied Microbiology)

Online ISSN: 1097-0290

Most Accessed 2011


Top 25 Most Downloaded Articles

From September-December 2011

Enhanced butyric acid tolerance and bioproduction by Clostridium tyrobutyricum in a fibrous bed bioreactor

Ling Jiang, Jufang Wang, Shizhong Liang, Jin Cai, Zhinan Xu, Peilin Cen, Shangtian Yang, Shuang Li

Volume 108, Issue 1, 2011


Determination of the volumetric mass transfer coefficient (kLa) using the dynamic “gas out–gas in” method: Analysis of errors caused by dissolved oxygen probes

L. A. Tribe, C. L. Briens, A. Margaritis

Volume 46, Issue 4, 1995


Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics

Mark D. Ungrin, Geoff Clarke, Ting Yin, Sylvia Niebrugge, M. Cristina Nostro, Farida Sarangi,Geoffrey Wood, Gordon Keller, PeterW. Zandstra

In Early View


Aggregates in monoclonal antibody manufacturing processes

María Vázquez-Rey, Dietmar A. Lang

Volume 108, Issue 7, 2011


A review of the mammalian unfolded protein response

Anirikh Chakrabarti, Aaron W. Chen, Jeffrey D. Varner

Volume 108, Issue 12, 2011


Comparison of α-amylase activities from different assay methods

Young J. Yoo, Juan Hong, Randolph T. Hatch

Volume 30, Issue 1, 1987


Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor

Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi, Giulia Padovani, Natascia Biondi, Gimena Bonini, Mario R. Tredici

Volume 102, Issue 1, 2009


Culture temperature modulates aggregation of recombinant antibody in cho cells

Natalia Gomez, Jayashree Subramanian, Jun Ouyang, Mary D.H. Nguyen, Matthew Hutchinson, Vikas K. Sharma, Andy A. Lin, Inn H. Yuk

Volume 109, Issue 1, 2012


Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers

Yu Kyung Jung, Tae Yong Kim, Si Jae Park, Sang Yup Lee

Volume 105, Issue 1, 2010


Expression of anti-apostosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture

Haimanti Dorai, Yun Seung Kyung, Dawn Ellis, CherylAnn Kinney, Chengbin Lin, David Jan, Gordon Moore, Michael J. Betenbaugh

Volume 103, Issue 3, 2009


Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells

Lianchun Fan, Ibrahim Kadura, Lara E. Krebs, Christopher C. Hatfield, Margaret M. Shaw, Christopher C. Frye

In Early View


Metabolic flux analysis of CHO cell metabolism in the late non-growth phase

Neelanjan Sengupta, Steven T. Rose, John A. Morgan

Volume 108, Issue 1, 2011


Increasing cellulose accessibility is more important than removing lignin: A comparison of cellulose solvent-based lignocellulose fractionation and soaking in aqueous ammonia

Joseph A. Rollin, Zhiguang Zhu, Noppadon Sathitsuksanoh, Y.-H. Percival Zhang

Volume 108, Issue 1, 2011


Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines

James F. Zawada, Gang Yin, Alexander R. Steiner, Junhao Yang, Alpana Naresh, Sushmita M. Roy, Daniel S. Gold, Henry G. Heinsohn, Christopher J. Murray

Volume 108, Issue 7, 2011


Synthesis and application of virus-based hybrid nanomaterials

Sang-Yup Lee, Jung-Sun Lim, Michael T. Harris

Volume 109, Issue 1, 2012


Hydrogels as extracellular matrix mimic for 3D cell culture

Mark W. Tibbitt, Kristi S. Anseth

Volume 103, Issue 4, 2009


Fermentative butanol production by clostridia

Sang Yup Lee, Jin Hwan Park, Seh Hee Jang, Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung

Volume 101, Issue 2, 2008


Quantitative analysis of the fermentative metabolism of glycerol in Escherichia coli

Angela Cintolesi, James M. Clomburg, Venetia Rigou, Kyriacos Zygourakis, Ramon Gonzalez

Volume 109, Issue 1, 2012


Bioproduction of butanol in bioreactors: New insights from simultaneous in situ butanol recovery to eliminate product toxicity

Adriano Pinto Mariano, Nasib Qureshi, Rubens Maciel Filho, Thaddeus Chukwuemeka Ezeji

Volume 108, Issue 8, 2011


Mobile phase modifier effects in multimodal cation exchange chromatography

Melissa A. Holstein, Siddharth Parimal, Scott A. McCallum, Steven M. Cramer

Volume 109, Issue 1, 2012


Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production

Christopher A. Sellick, Alexandra S. Croxford, Arfa R. Maqsood, Gill Stephens, Hans V. Westerhoff, Royston Goodacre, Alan J. Dickson

Volume 108, Issue 12, 2011


Effects of cell culture conditions on antibody N-linked glycosylation--what affects high mannose 5 glycoform

Efren Pacis, Marcella Yu, Jennifer Autse, Robert Bayer, Feng Li

Volume 108, Issue 10, 2011


Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies

Laetitia Malphettes, Yevgeniy Freyvert, Jennifer Chang, Pei-Qi Liu, Edmond Chan, Jeffrey C. Miller, Zhe Zhou, Thu Nguyen, Christina Tsai, Andrew W. Snowden, Trevor N. Collingswood, Philip D. Gregory, Gregory J. Cost

Volume 106, Issue 5, 2010


Culture of microalgae Chlorella minutissima for biodiesel feedstock production

Haiying Tang, Meng Chen, M.E.D. Garcia, Nadia Abunasser, K.Y. Simon Ng, Steven O. Salley

Volume 108, Issue 10, 2011


Improved galactose fermentation of Saccharomyoces cerevisiae through inverse metabolic engineering

Ki-Sung Lee, Min-Eui Hong, Suk-Chae Jung, Suk-Jin Ha, Byung Jo Yu,Hyun Min Koo, Sung Min Park, Jin-Ho Seo, Dae-Hyuk Kweon, Jae Chan Park, Yong-Su Jin

Volume 108, Issue 3, 2011


Top 25 Most Downloaded Articles

From May-August 2011

A review of the mammalian unfolded protein response

Anirikh Chakrabarti, Aaron W. Chen, Jeffrey D. Varner

In Early View

 

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines

James F. Zawada, Gang Yin, Alexander R. Steiner, Junhao Yang, Alpana Naresh, Sushmita M. Roy, Daniel S. Gold, Henry G. Heinsohn, Christopher J. Murray

Volume 108, Issue 7, 2011

 

Aggregates in monoclonal antibody manufacturing processes

María Vázquez-Rey, Dietmar A. Lang

Volume 108, Issue 7, 2011

 

Room temperature ionic liquids as emerging solvents for the pretreatment of lignocellulosic biomass

Mauricio Mora-Pale, Luciana Meli, Thomas V. Doherty, Robert J. Linhardt, Jonathan S. Dordick

Volume 108, Issue 6, 2011

 

Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor

Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi, Giulia Padovani, Natascia Biondi, Gimena Bonini, Mario R. Tredici

Volume 102, Issue 1, 2009

 

Fermentative butanol production by clostridia

Sang Yup Lee, Jin Hwan Park, Seh Hee Jang, Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung

Volume 102, Issue 1, 2009

 

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies

Minsoo Kim, Peter M. O'Callaghan, Kurt A. Droms, David C. James

Volume 108, Issue 10, 2011

 

Improved galactose fermentation of Saccharomyces cerevisiae through inverse metabolic engineering

Ki-Sung Lee, Min-Eui Hong, Suk-Chae Jung, Suk-Jin Ha, Byung Jo Yu, Hyun Min Koo, Sung Min Park, Jin-Ho Seo, Dae-Hyuk Kweon, Jae Chan Park, Yong-Su Jin

Volume 108, Issue 3, 2011

 

Effects of cell culture conditions on antibody N‐linked glycosylation—what affects high mannose 5 glycoform

Efren Pacis, Marcella Yu, Jennifer Autsen, Robert Bayer, Feng Li

Volume 108, Issue 10, 2011

 

Determination of the volumetric mass transfer coefficient (kLa) using the dynamic “gas out–gas in” method: Analysis of errors caused by dissolved oxygen probes

L. A. Tribe, C. L. Briens, A. Margaritis

Volume 46, Issue 4, 1995

 

Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle

Kierston Shill, Sasisanker Padmanabhan, Qin Xin, John M. Prausnitz, Douglas S. Clark, Harvey W. Blanch

Volume 108, Issue 3, 2011

 

Synchronous fluorescence spectroscopy as a novel tool to enable PAT applications in bioprocesses

Ana P. Teixeira, Tiago M. Duarte, M.J.T. Carrondo, Paula M. Alves

Volume 108, Issue 8, 2011

 

Increasing cellulose accessibility is more important than removing lignin: A comparison of cellulose solvent-based lignocellulose fractionation and soaking in aqueous ammonia

Joseph A. Rollin, Zhiguang Zhu, Noppadon Sathitsuksanoh, Y.-H. Percival Zhang

Volume 108, Issue 1, 2011

 

Modeling the competition between aggregation and self-assembly during virus-like particle processing

Yong Ding, Yap Pang Chuan, Lizhong He, Anton P.J. Middelberg

Volume 107, Issue 3, 2010

 

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

Matthew Gagnon, Gregory Hiller, Yen-Tung Luan, Amy Kittredge, Jordy DeFelice, Denis Drapeau

Volume 108, Issue 6, 2011

 

Engineering butanol-tolerance in escherichia coli with artificial transcription factor libraries

Ju Young Lee, Kyung Seok Yang, Su A Jang, Bong Hyun Sung, Sun Chang Kim

Volume 108, Issue 4, 2011

 

Metabolic flux analysis of CHO cell metabolism in the late non-growth phase

Neelanjan Sengupta, Steven T. Rose, John A. Morgan

Volume 108, Issue 1, 2011

 

Three-dimensional cell culture microarray for high-throughput studies of stem cell fate

Tiago G. Fernandes, Seok-Joon Kwon, Shyam Sundhar Bale, Moo-Yeal Lee, Maria Margarida Diogo, Douglas S. Clark, Joaquim M.S. Cabral, Jonathan S. Dordick

Volume 106, Issue 1, 2010

 

Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers

Yu Kyung Jung, Tae Yong Kim, Si Jae Park, Sang Yup Lee

Volume 105, Issue 1, 2010

 

Primary rat hepatocyte culture on 3D nanofibrous polymer scaffolds for toxicology and pharmaceutical research

Jeanette Bierwolf, Marc Lutgehetmann, Kai Feng, Johannes Erbes, Steffen Deichmann, Eva Toronyi, Christina Stieglitz, Bjoern Nashan, Peter X. Ma, Joerg M. Pollok

Volume 108, Issue 1, 2011

 

Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production

Christopher A. Sellick, Alexandra S. Croxford, Arfa R. Maqsood, Gill Stephens, Hans V. Westerhoff, Royston Goodacre, Alan J. Dickson

In Early View

 

Characterization of combinatorial patterns generated by multiple two-component sensors in E. coli that respond to many stimuli

Elizabeth J. Clarke, Christopher A. Voigt

Volume 108, Issue 3, 2011

 

Inhibition of starch synthesis results in overproduction of lipids in Chlamydomonas reinhardtii

Yantao Li, Danxiang Han, Guangrong Hu, Milton Sommerfeld, Qiang Hu

Volume 108, Issue 2, 2011

 

Metabolite profiling of recombinant CHO cells: Designing tailored feeding regimes that enhance recombinant antibody production

Christopher A. Sellick, Alexandra S. Croxford, Arfa R. Maqsood, Gill Stephens, Hans V. Westerhoff, Royston Goodacre, Alan J. Dickson

In Early View

 

Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle

Kierston Shill, Sasisanker Padmanabhan, Qin Xin, John M. Prausnitz, Douglas S. Clark, Harvey W. Blanch

Volume 108, Issue 3, 2011

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Top 25 Most Downloaded Articles

From January-April 2011


Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi , Giulia Padovani , Natascia Biondi , Gimena Bonini , Mario R. Tredici
Volume 102, Issue 1, 2009

Industrial systems biology
José Manuel Otero, Jens Nielsen
Volume 105, Issue 3, 2010

Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers
Yu Kyung Jung, Tae Yong Kim, Si Jae Park, Sang Yup Lee
Volume 105, Issue 1, 2010

Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases
Pei-Qi Liu, Edmond M. Chan, Gregory J. Cost, Lin Zhang, Jianbin Wang, Jeffrey C. Miller, Dmitry Y. Guschin, Andreas Reik, Michael C. Holmes, John E. Mott, Trevor N. Collingwood, Philip D. Gregory
Volume 106, Issue 1, 2010

A review of the current state of biodiesel production using enzymatic transesterification
Lene Fjerbaek, Knud V. Christensen, Birgir Norddahl
Volume 102, Issue 5, 2009

A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes
Rebecca M. Lennen, Drew J. Braden, Ryan M. West, James A. Dumesic, Brian F. Pfleger
Volume 106, Issue 2, 2010

Hydrogels as extracellular matrix mimics for 3D cell culture
Mark W. Tibbitt, Kristi S. Anseth
Volume 103, Issue 4, 2009

Large-scale biodiesel production from microalga Chlorella protothecoides through heterotrophic cultivation in bioreactors
Xiufeng Li, Han Xu, Qingyu Wu
Volume 98, Issue 4, 2007

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

Fermentative butanol production by clostridia
Sang Yup Lee, Jin Hwan Park, Seh Hee Jang , Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung
Volume 101, Issue 2, 2008

A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?
Janet Chusainow, Yuan Sheng Yang, Jessna H.M. Yeo, Poh Choo Toh, Parisa Asvadi, Niki S.C. Wong, Miranda G.S. Yap
Volume 102, Issue 4, 2009

Opportunities for renewable bioenergy using microorganisms
Bruce E. Rittmann
Volume 100, Issue 2, 2008

Biosynthesis of polylactic acid and its copolymers using evolved propionate CoA transferase and PHA synthase
Taek Ho Yang, Tae Wan Kim, Hye Ok Kang, Sang-Hyun Lee, Eun Jeong Lee, Sung-Chul Lim, Sun Ok Oh, Ae-Jin Song, Si Jae Park , Sang Yup Lee
Volume 105, Issue 1, 2010

Metabolite stress and tolerance in the production of biofuels and chemicals: Gene-expression-based systems analysis of butanol, butyrate, and acetate stresses in the anaerobe Clostridium acetobutylicum
Keith V. Alsaker, Carlos Paredes, Eleftherios T. Papoutsakis
Volume 105, Issue 6, 2010

Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures
Ashraf Amanullah, Jose Manuel Otero, Mark Mikola, Amy Hsu, Jinyou Zhang, John Aunins, H. Brett Schreyer, James A. Hope, A. Peter Russo
Volume 106, Issue 1, 2010

Ionic liquid-mediated selective extraction of lignin from wood leading to enhanced enzymatic cellulose hydrolysis
Sang Hyun Lee, Thomas V. Doherty, Robert J. Linhardt, Jonathan S. Dordick
Volume 102, Issue 5, 2009

Host cell proteins in biologics development: Identification, quantitation and risk assessment
Xing Wang, Alan K. Hunter, Ned M. Mozier
Volume 103, issue 3, 2009

A mechanistic model of the enzymatic hydrolysis of cellulose
Seth E. Levine, Jerome M. Fox, Harvey W. Blanch, Douglas S. Clark
Volume 107, Issue 1, 2010

Inhibition of starch synthesis results in overproduction of lipids in Chlamydomonas reinhardtii
Yantao Li, Danxiang Han, Guangrong Hu, Milton Sommerfeld, Qiang Hu
Volume 107, Issue 2, 2010

High-level recombinant protein production in CHO cells using lentiviral vectors and the cumate gene-switch
Bruno Gaillet, Rénald Gilbert, Sophie Broussau, Amélie Pilotte, Félix Malenfant, Alaka Mullick, Alain Garnier and Bernard Massie
Volume 106, Issue 2, 2010

Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
Paul J. Hung, Philip J. Lee, Poorya Sabounchi, Robert Lin, Luke P. Lee
Volume 89, Issue 1, 2005

Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing
Melody Trexler-Schmidt, Sandy Sargis, Jason Chiu, Stefanie Sze-Khoo, Melissa Mun, Yung-Hsiang Kao, Michael W. Laird
Volume 106, Issue 3, 2010

Scale-up analysis for a CHO cell culture process in large-scale bioreactors
Zizhuo Xing, Brian M. Kenty, Zheng Jian Li, Steven S. Lee

TCR-β repertoire analysis of antigen-specific single T cells using a high-density microcavity array
Atsushi Arakaki, Kaori Ooya, Yasuto Akiyama, Masahito Hosokawa, Masaru Komiyama, Akira Iizuka, Ken Yamaguchi, Tadashi Matsunaga
Volume 106, Issue 2, 2010

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