Biotechnology and Bioengineering

Cover image for Vol. 112 Issue 3

Edited By: Douglas S. Clark

Impact Factor: 4.164

ISI Journal Citation Reports © Ranking: 2013: 26/165 (Biotechnology & Applied Microbiology)

Online ISSN: 1097-0290

Most Accessed 2012


Top 25 Most Downloaded Articles

From September-December 2012

Determination of the volumetric mass transfer coefficient (kLa) using the dynamic "gas out-gas in" method: Analysis of errors caused by dissolved oxygen probes
L. A. Tribe, C. L. Briens, A. Margaritis
Volume 46, Issue 4, 1995

Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi, Giulia Padovani, Natascia Biondi, Gimena Bonini, Mario R. Tredici
Volume 102, Issue 1, 2009

A review of the mammalian unfolded protein response
Anirikh Chakrabarti, Aaron W. Chen, Jeffrey D. Varner
Volume 108, Issue 12, 2011

Comparison of α-amylase activities from different assay methods
Young J. Yoo, Juan Hong, Randolph T. Hatch
Volume 30, Issue 1, 1987

Vaccine process technology
Jessica O. Josefsberg, Barry Buckland
Volume 109, Issue 6, 2012

Hydrogels as extracellular matrix mimics for 3D cell culture
Mark W. Tibbitt, Kristi S. Anseth
Volume 103, Issue 4, 2009

Yield coefficients for cell mass and product formation
J. Hong
Volume 33, Issue 4, 1989

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process
Jun Luo, Natarajan Vijayasankaran, Jennifer Autsen, Rodell Santuray, Terry Hudson, Ashraf Amanullah, Feng Li
Volume 109, Issue 1, 2012

Synthesis and application of virus-based hybrid nanomaterials
Sang-Yup Lee, Jung-Sun Lim, Michael T. Harris
Volume 109, Issue 1, 2012

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture
Suresh Selvarasu, Ying Swan Ho, William P. K. Chong, Niki S. C. Wong, Faraaz N. K. Yusufi, Yih Yean Lee, Miranda G. S. Yap, Dong-Yup Lee
Volume 109, Issue 6, 2012

Aggregates in monoclonal antibody manufacturing processes
María Vázquez-Rey, Dietmar A. Lang
Volume 108, Issue 7, 2011

Bio-based production of C2–C6 platform chemicals
Yu-Sin Jang, Byoungjin Kim, Jae Ho Shin, Yong Jun Choi, Sol Choi, Chan Woo Song, Joungmin Lee, Hye Gwon Park, Sang Yup Lee
Volume 109, Issue 10, 2012

Quantitative analysis of the fermentative metabolism of glycerol in Escherichia coli
Angela Cintolesi, James M. Clomburg, Venetia Rigou, Kyriacos Zygourakis, Ramon Gonzalez
Volume 109, Issue 1, 2012

Metabolite Profiling of CHO cells with different growth characteristics
Stefanie Dietmair, Mark P. Hodson, Lake-Ee Quek, Nicholas E. Timmins, Panagiotis Chrysanthopoulos, Shana S. Jacob, Peter Gray, Lars K. Nielsen
Volume 109, Issue 6, 2012

By-product inhibition effects on ethanolic fermentation by Saccharomyces cerevisiae
Brian Maiorella, Harvey W. Blanch, Charles R. Wilke
Volume 25, Issue 1, 1983

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

Culture temperature modulates aggregation of recombinant antibody in cho cells
Natalia Gomez, Jayashree Subramanian, Jun Ouyang, Mary D.H. Nguyen, Matthew Hutchinson, Vikas K. Sharma, Andy A. Lin, Inn H. Yuk
Volume 109, Issue 1, 2012

Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells
Lianchun Fan, Ibrahim Kadura, Lara E. Krebs, Christopher C. Hatfield, Margaret M. Shaw, Christopher C. Frye
Volume 109, Issue 4, 2012

Limitations of the DNS assay for reducing sugars from saccharified lignocellulosics
Douglas B. Rivers, Stephen J. Gracheck, Lindley C. Woodford, George H. Emert
Volume 26 Issue 7, 1984

Fermentative butanol production by clostridia
Sang Yup Lee, Jin Hwan Park, Seh Hee Jang, Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung
Volume 101, Issue 2, 2008

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
Jincai Li, Chun Loong Wong, Natarajan Vijayasankaran, Terry Hudson, Ashraf Amanullah
Volume 109, Issue 5, 2012

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines
James F. Zawada, Gang Yin, Alexander R. Steiner, Junhao Yang, Alpana Naresh, Sushmita M. Roy, Daniel S. Gold, Henry G. Heinsohn, Christopher J. Murray
Volume 108, Issue 7, 2011

Host cell proteins in biologics development: Identification, quantitation and risk assessment
Xing Wang, Alan K. Hunter, Ned M. Mozier
Volume 103, Issue 3, 2009

Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle
Kierston Shill, Sasisanker Padmanabhan, Qin Xin, John M. Prausnitz, Douglas S. Clark, Harvey W. Blanch
Volume 108, Issue 3, 2011

Different expression systems for production of recombinant proteins in Saccharomyces cerevisiae
Zihe Liu, Keith E.J. Tyo, José L. Martínez, Dina Petranovic, Jens Nielsen
Volume 109, Issue 5, 2012

Top 25 Most Downloaded Articles

From May-August 2012

Determination of the volumetric mass transfer coefficient (kLa) using the dynamic "gas out-gas in" method: Analysis of errors caused by dissolved oxygen probes
L. A. Tribe, C. L. Briens, A. Margaritis
Volume 46, Issue 4, 1995

Comparison of α-amylase activities from different assay methods
Young J. Yoo, Juan Hong, Randolph T. Hatch
Volume 30, Issue 1, 1987

A review of the mammalian unfolded protein response
Anirikh Chakrabarti, Aaron W. Chen, Jeffrey D. Varner
Volume 108, Issue 12, 2011

Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi, Giulia Padovani, Natascia Biondi, Gimena Bonini, Mario R. Tredici
Volume 102, Issue 1, 2009

Vaccine process technology
Jessica O. Josefsberg, Barry Buckland
Volume 109, Issue 6, 2012

Synthesis and application of virus-based hybrid nanomaterials
Sang-Yup Lee, Jung-Sun Lim, Michael T. Harris
Volume 109, Issue 1, 2012

Hydrogels as extracellular matrix mimics for 3D cell culture
Mark W. Tibbitt, Kristi S. Anseth
Volume 103, Issue 4, 2009

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture
Suresh Selvarasu, Ying Swan Ho, William P. K. Chong, Niki S. C. Wong, Faraaz N. K. Yusufi, Yih Yean Lee, Miranda G. S. Yap, Dong-Yup Lee
Volume 109, Issue 6, 2012

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process
Jun Luo, Natarajan Vijayasankaran, Jennifer Autsen, Rodell Santuray, Terry Hudson, Ashraf Amanullah, Feng Li
Volume 109, Issue 1, 2012

Quantitative analysis of the fermentative metabolism of glycerol in Escherichia coli
Angela Cintolesi, James M. Clomburg, Venetia Rigou, Kyriacos Zygourakis, Ramon Gonzalez
Volume 109, Issue 1, 2012

Aggregates in monoclonal antibody manufacturing processes
María Vázquez-Rey, Dietmar A. Lang
Volume 108, Issue 7, 2011

Metabolite Profiling of CHO cells with different growth characteristics
Stefanie Dietmair, Mark P. Hodson, Lake-Ee Quek, Nicholas E. Timmins, Panagiotis Chrysanthopoulos, Shana S. Jacob, Peter Gray, Lars K. Nielsen
Volume 109, Issue 6, 2012

Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells
Lianchun Fan, Ibrahim Kadura, Lara E. Krebs, Christopher C. Hatfield, Margaret M. Shaw, Christopher C. Frye
Volume 109, Issue 4, 2012

Culture temperature modulates aggregation of recombinant antibody in cho cells
Natalia Gomez, Jayashree Subramanian, Jun Ouyang, Mary D.H. Nguyen, Matthew Hutchinson, Vikas K. Sharma, Andy A. Lin, Inn H. Yuk
Volume 109, Issue 1, 2012

By-product inhibition effects on ethanolic fermentation by Saccharomyces cerevisiae
Brian Maiorella, Harvey W. Blanch, Charles R. Wilke
Volume 25, Issue 1, 1983

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
Jincai Li, Chun Loong Wong, Natarajan Vijayasankaran, Terry Hudson, Ashraf Amanullah
Volume 109, Issue 5, 2012

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines
James F. Zawada, Gang Yin, Alexander R. Steiner, Junhao Yang, Alpana Naresh, Sushmita M. Roy, Daniel S. Gold, Henry G. Heinsohn, Christopher J. Murray
Volume 108, Issue 7, 2011

Fermentative butanol production by clostridia
Sang Yup Lee, Jin Hwan Park, Seh Hee Jang, Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung
Volume 101, Issue 2, 2008

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line
A.S. Tait, C.E.M. Hogwood, C.M. Smales, D.G. Bracewell
Volume 109, Issue 4, 2012

Cation exchange chromatography provides effective retrovirus clearance for antibody purification processes
Lisa Connell-Crowley, Thao Nguyen, Julia Bach, Shivanthi Chinniah, Houman Bashiri, Ron Gillespie, John Moscariello, Peter Hinckley, Houman Dehghani, Suresh Vunnum, Ganesh Vedantham
Volume 109, Issue 1, 2012

Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics
Mark D. Ungrin, Geoff Clarke, Ting Yin, Sylvia Niebrugge, M. Cristina Nostro, Farida Sarangi, Geoffrey Wood, Gordon Keller, Peter W. Zandstra
Volume 109, Issue 4, 2012

Host cell proteins in biologics development: Identification, quantitation and risk assessment
Xing Wang, Alan K. Hunter, Ned M. Mozie
Volume 103, Issue 3, 2009

Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by Ralstonia eutropha in high cell density palm oil fermentations
Sebastian L. Riedel, Johannes Bader, Christopher J. Brigham, Charles F. Budde, Zainal Abidin Mohd Yusof, ChoKyun Rha, Anthony J. Sinskey
Volume 109, Issue 1, 2012

Esophageal tissue engineering: An in-depth review on scaffold design
J.Y. Tan, C.K. Chua, K.F. Leong, K.S. Chian, W.S. Leong, L.P. Tan
Volume 109, Issue 1, 2012

Top 25 Most Downloaded Articles

From January-April 2012

Determination of the volumetric mass transfer coefficient (kLa) using the dynamic "gas out-gas in" method: Analysis of errors caused by dissolved oxygen probes
L. A. Tribe, C. L. Briens, A. Margaritis
Volume 46, Issue 4, 1995

Comparison of α-amylase activities from different assay methods
Young J. Yoo, Juan Hong, Randolph T. Hatch
Volume 30, Issue 1, 1987

A review of the mammalian unfolded protein response
Anirikh Chakrabarti, Aaron W. Chen, Jeffrey D. Varner
Volume 108, Issue 12, 2011

Microalgae for oil: Strain selection, induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor
Liliana Rodolfi, Graziella Chini Zittelli, Niccolò Bassi, Giulia Padovani, Natascia Biondi, Gimena Bonini, Mario R. Tredici
Volume 102, Issue 1, 2009

Synthesis and application of virus-based hybrid nanomaterials
Sang-Yup Lee, Jung-Sun Lim, Michael T. Harris
Volume 109, Issue 1, 2012

Aggregates in monoclonal antibody manufacturing processes
María Vázquez-Rey, Dietmar A. Lang
Volume 108, Issue 7, 2011

Comparative metabolite analysis to understand lactate metabolism shift in Chinese hamster ovary cell culture process
Jun Luo, Natarajan Vijayasankaran, Jennifer Autsen, Rodell Santuray, Terry Hudson, Ashraf Amanullah, Feng Li
Volume 109, Issue 1, 2012

Quantitative analysis of the fermentative metabolism of glycerol in Escherichia coli
Angela Cintolesi, James M. Clomburg, Venetia Rigou, Kyriacos Zygourakis, Ramon Gonzalez
Volume 109, Issue 1, 2012

Culture temperature modulates aggregation of recombinant antibody in cho cells
Natalia Gomez, Jayashree Subramanian, Jun Ouyang, Mary D.H. Nguyen, Matthew Hutchinson, Vikas K. Sharma, Andy A. Lin, Inn H. Yuk
Volume 109, Issue 1, 2012

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture
Suresh Selvarasu, Ying Swan Ho, William P. K. Chong, Niki S. C. Wong, Faraaz N. K. Yusufi, Yih Yean Lee, Miranda G. S. Yap, Dong-Yup Lee
Volume 109, Issue 6, 2012

Improving the efficiency of CHO cell line generation using glutamine synthetase gene knockout cells
Lianchun Fan, Ibrahim Kadura, Lara E. Krebs, Christopher C. Hatfield, Margaret M. Shaw, Christopher C. Frye
Volume 109, Issue 4, 2012

Hydrogels as extracellular matrix mimics for 3D cell culture
Mark W. Tibbitt, Kristi S. Anseth
Volume 103, Issue 4, 2009

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
Jincai Li, Chun Loong Wong, Natarajan Vijayasankaran, Terry Hudson, Ashraf Amanullah
Volume 109, Issue 5, 2012

By-product inhibition effects on ethanolic fermentation by Saccharomyces cerevisiae
Brian Maiorella, Harvey W. Blanch, Charles R. Wilke
Volume 25, Issue 1, 1983

Vaccine process technology
Jessica O. Josefsberg, Barry Buckland
Volume 109, Issue 6, 2012

Host cell protein dynamics in the supernatant of a mAb producing CHO cell line
A.S. Tait, C.E.M. Hogwood, C.M. Smales, D.G. Bracewell
Volume 109, Issue 4, 2012

Microscale to manufacturing scale-up of cell-free cytokine production-a new approach for shortening protein production development timelines
James F. Zawada, Gang Yin, Alexander R. Steiner, Junhao Yang, Alpana Naresh, Sushmita M. Roy, Daniel S. Gold, Henry G. Heinsohn, Christopher J. Murray
Volume 108, Issue 7, 2011

Rational bioprocess design for human pluripotent stem cell expansion and endoderm differentiation based on cellular dynamics
Mark D. Ungrin, Geoff Clarke, Ting Yin, Sylvia Niebrugge, M. Cristina Nostro, Farida Sarangi, Geoffrey Wood, Gordon Keller, Peter W. Zandstra
Volume 109, Issue 4, 2012

Fermentative butanol production by clostridia
Sang Yup Lee, Jin Hwan Park, Seh Hee Jang, Lars K. Nielsen, Jaehyun Kim, Kwang S. Jung
Volume 101, Issue 2, 2008

Esophageal tissue engineering: An in-depth review on scaffold design
J.Y. Tan, C.K. Chua, K.F. Leong, K.S. Chian, W.S. Leong, L.P. Tan
Volume 109, Issue 1, 2012

Host cell proteins in biologics development: Identification, quantitation and risk assessment
Xing Wang, Alan K. Hunter, Ned M. Mozie
Volume 103, Issue 3, 2009

Salting-out of enzymes with ammonium sulphate
P. R. Foster, P. Dunnill, M. D. Lilly
Volume 13, Issue 5, 1971

Ionic liquid pretreatment of cellulosic biomass: Enzymatic hydrolysis and ionic liquid recycle
Kierston Shill, Sasisanker Padmanabhan, Qin Xin,John M. Prausnitz, Douglas S. Clark, Harvey W. Blanch
Volume 108, Issue 3, 2011

Cation exchange chromatography provides effective retrovirus clearance for antibody purification processes
Lisa Connell-Crowley, Thao Nguyen, Julia Bach, Shivanthi Chinniah, Houman Bashiri, Ron Gillespie, John Moscariello, Peter Hinckley, Houman Dehghani, Suresh Vunnum, Ganesh Vedantham
Volume 109, Issue 1, 2012

Toward an aggregated understanding of enzymatic hydrolysis of cellulose: Noncomplexed cellulase systems
Yi-Heng Percival Zhang, Lee R. Lynd
Volume 88, Issue 7, 2004

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