Journal of Neuroscience Research

Cover image for Vol. 95 Issue 6

Early View (Online Version of Record published before inclusion in an issue)

Edited By: Eric M Prager

Impact Factor: 2.689

ISI Journal Citation Reports © Ranking: 2015: 131/256 (Neurosciences)

Online ISSN: 1097-4547

VIEW

  1. 1 - 82
  1. Research Articles

    1. Systemic and local anti-nociceptive effects of simvastatin in the rat formalin assay: Role of peroxisome proliferator-activated receptor γ and nitric oxide

      Mohammad Taghi Mansouri, Bahareh Naghizadeh, Behnam Ghorbanzadeh and Soheila Alboghobeish

      Version of Record online: 17 APR 2017 | DOI: 10.1002/jnr.24008

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      This study provides evidences of systemic (A, B, C) and local (D) anti-nociceptive effects of simvastatin that are modulated by the agents influencing the NO signaling pathway and PPARγ receptors.

    2. Increase of aquaporin 9 expression in astrocytes participates in astrogliosis

      Lorenz Hirt, Melanie Price, Nabil Mastour, Jean-François Brunet, Grégory Barrière, Frédéric Friscourt and Jerome Badaut

      Version of Record online: 17 APR 2017 | DOI: 10.1002/jnr.24061

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      Increased AQP9 contributes to morphological changes in astrocytes. Higher astrocytic AQP9 expression after TPC is associated with better recovery, suggesting a beneficial role of an early increase of AQP9 and morphological changes of the astrocytes.

    3. The novel anticonvulsant neuropeptide and galanin analogue, NAX-5055, does not alter energy and amino acid metabolism in cultured brain cells

      Blanca I. Aldana, Helle S. Waagepetersen, Arne Schousboe, H. Steve White, Grzegorz Bulaj and Anne B. Walls

      Version of Record online: 11 APR 2017 | DOI: 10.1002/jnr.24057

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      The neuropeptide NAX-5055 exerts a potent anticonvulsant action by decreasing excitatory glutamatergic neurotransmission while increasing inhibitory GABA activity. Using 13C-labeled energy substrates and mass-spectrometry in primary cultures of brain cells, we show that these changes in excitatory and inhibitory neurotransmission do not involve alterations in cerebral energy metabolism.

    4. K channel impairment determines sex and age differences in epinephrine-mediated outcomes after brain injury

      William M. Armstead, John Riley and Monica S. Vavilala

      Version of Record online: 11 APR 2017 | DOI: 10.1002/jnr.24063

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      Axonal domain disorganization in Caspr1 and Caspr2 mutant myelinated axons affects neuromuscular junction integrity, leading to muscle atrophy

      Julia Saifetiarova, Xi Liu, Anna M. Taylor, Jie Li and Manzoor A. Bhat

      Version of Record online: 3 APR 2017 | DOI: 10.1002/jnr.24052

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      To effectively communicate with muscles to allow muscle contraction and to maintain muscle health, neurons send electrical signals along myelinated axons, which are organized into distinct molecular domains. Using Caspr1 and Caspr2 mouse mutants, which have disrupted paranodal and juxtaparanodal domains, we demonstrate that disruption of these domains differentially affects electrical properties of myelinated fibers and, consequently, the health of the muscles they innervate.

  2. Reviews

    1. Astrocytic Vesicle-based Exocytosis in Cultures and Acutely Isolated Hippocampal Rodent Slices

      Jernej Jorgačevski, Maja Potokar, Marko Kreft, Alenka Guček, Jean-Pierre Mothet and Robert Zorec

      Version of Record online: 31 MAR 2017 | DOI: 10.1002/jnr.24051

  3. Minireviews

  4. Research Articles

    1. Morphological study of a connexin 43-GFP reporter mouse highlights glial heterogeneity, amacrine cells, and olfactory ensheathing cells

      Panos Theofilas, Christian Steinhäuser, Martin Theis and Amin Derouiche

      Version of Record online: 30 MAR 2017 | DOI: 10.1002/jnr.24055

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      Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network

      Ying Li, Hailing Hao, Mavis R. Swerdel, Hyeon-Yeol Cho, Ki-Bum Lee, Ronald P. Hart, Yi Lisa Lyu and Li Cai

      Version of Record online: 30 MAR 2017 | DOI: 10.1002/jnr.24037

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      Three major stages are well defined in photoreceptor cell development: 1) cell proliferation and cell fate determination, during which the multipotent retinal progenitors proliferate and their competence being restricted as photoreceptor cell precursors; 2) early differentiation stage, during which genes for morphogenesis and phototransduction are expressed; and 3) late differentiation stage, which includes the axonal growth, synapse formation and outer segment (OS) biogenesis (Swaroop et al. 2010). Top2b functions in both cell-autonomous and non-cell-autonomous manners in regulating late stage photoreceptor development by controlling key genes in the photoreceptor transcriptional network.

    3. Otoprotective effects of mouse nerve growth factor in DBA/2J mice with early-onset progressive hearing loss

      Qingzhu Wang, Hongchun Zhao, Tihua Zheng, Wenjun Wang, Xiaolin Zhang, Andi Wang, Bo Li, Yanfei Wang and Qingyin Zheng

      Version of Record online: 27 MAR 2017 | DOI: 10.1002/jnr.24056

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      mNGF can inhibit apoptosis of the spiral ganglion cells, prevent degeneration of stria vascularis and protect the hair cells. Ultimately, mNGF protect the age related hearing loss in the DBA/2J mice.

    4. The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

      Michaela C. Hohnholt, Eva-Maria Blumrich*, Helle S. Waagepetersen and Ralf Dringen

      Version of Record online: 19 MAR 2017 | DOI: 10.1002/jnr.24050

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      The antidiabetic drug metformin decreases tricarboxylic acid cycle activity as experimentally shown by metabolic mapping using uniformly labeled glucose. In addition, complex I substrate-dependent oxygen consumption is strongly lowered in mitochondria isolated from metformin-treated astrocytes

    5. Energy metabolism in the rat cortex under thiopental anaesthesia measured In Vivo by 13C MRS

      Sarah Sonnay, João M. N. Duarte, Nathalie Just and Rolf Gruetter

      Version of Record online: 19 MAR 2017 | DOI: 10.1002/jnr.24032

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      By quantifying neuronal and glial oxidative metabolism in the living brain under thiopental anaesthesia, we verified a general metabolic depression and further identified that there is an alteration of the relative fraction of glucose oxidation in each cell type. This is relative to experiments under other anaesthesia protocols and that substrates, other than glucose, are substantially used as source of pyruvate for oxidative metabolism.

  5. Mini Review

    1. The involvement of thrombin in the pathogenesis of glioblastoma

      Harald Krenzlin, Viola Lorenz and Beat Alessandri

      Version of Record online: 19 MAR 2017 | DOI: 10.1002/jnr.24049

  6. Reviews

    1. Metabolomic-guided discovery of Alzheimer's disease biomarkers from body fluid

      Che Nor Adlia Enche Ady, Siong Meng Lim, Lay Kek Teh, Mohd Zaki Salleh, Ai-Vyrn Chin, Maw Pin Tan, Philip Jun Hua Poi, Shahrul Bahyah Kamaruzzaman, Abu Bakar Abdul Majeed and Kalavathy Ramasamy

      Version of Record online: 16 MAR 2017 | DOI: 10.1002/jnr.24048

    2. Mitochondrial biogenesis in neurodegeneration

      P. Andy Li, Xiaolin Hou and Shaocai Hao

      Version of Record online: 16 MAR 2017 | DOI: 10.1002/jnr.24042

  7. Research Articles

    1. Time-dependent change of in vivo optical imaging of oxidative stress in a mouse stroke model

      Yumiko Nakano, Toru Yamashita, Qian Li, Kota Sato, Yasuyuki Ohta, Ryuta Morihara, Nozomi Hishikawa and Koji Abe

      Version of Record online: 9 MAR 2017 | DOI: 10.1002/jnr.24047

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      This study investigated the time-dependent change of in vivo optical imaging of oxidative stress after stroke with Keap1-dependent oxidative stress detector, No.48 (OKD48) transgenic mice. Our results revealed that the in vivo optical signals showed a peak at 1 day (d) after tMCAO. Those signals indicative of nuclear factor erythroid 2-related factor 2 (Nrf2) expression decreased until 3 d, and finally disappeared at 7 d after tMCAO.

    2. Contribution of dopamine neurotransmission in proconvulsant effect of Toxoplasma gondii infection in male mice

      Jalal Babaie, Mohammad Sayyah, Pezhman Fard-Esfahani, Majid Golkar and Kourosh Gharagozli

      Version of Record online: 7 MAR 2017 | DOI: 10.1002/jnr.24036

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      Acute and chronic Toxoplasma infection decrease seizure threshold in mice. D1 and D2 dopamine receptors play role in proconvulsant effect of toxoplasmosis.

    3. Claudin domain containing 1 contributing to endothelial cell adhesion decreases in presence of cerebellar hemorrhage

      Masatoshi Ohnishi, Hiroyuki Ochiai, Kohei Matsuoka, Marina Akagi, Yuta Nakayama, Akiho Shima, Arisa Uda, Hiroshi Matsuoka, Jun Kamishikiryo, Akihiro Michihara and Atsuko Inoue

      Version of Record online: 28 FEB 2017 | DOI: 10.1002/jnr.24040

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      When cerebellar hemorrhage insults occur, the claudin domain containing (CLDND) 1 expression level on endothelial cells decreases, resulting in the hyperpermeability of small molecules.

    4. Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

      Jens Velde Andersen, Laura Frendrup McNair, Arne Schousboe and Helle Sønderby Waagepetersen

      Version of Record online: 28 FEB 2017 | DOI: 10.1002/jnr.24038

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      Glutamate and acetate has been applied to study metabolism in astrocytes. The aim of the current study was to evaluate the astrocyte specificity of acetate and glutamate in acute brain slices. Using [1,2-13C]acetate and [U-13C]glutamate we show considerable neuronal uptake and metabolism of acetate and glutamate.

    5. Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain

      Bryan L. Clossen and Doodipala Samba Reddy

      Version of Record online: 25 FEB 2017 | DOI: 10.1002/jnr.24028

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      Critical role of extrasynaptic δGABA-A receptors in catamenial epilepsy.

    6. Idiopathic Parkinson's disease patient-derived induced pluripotent stem cells function as midbrain dopaminergic neurons in rodent brains

      Tetsuhiro Kikuchi, Asuka Morizane, Daisuke Doi, Keisuke Okita, Masato Nakagawa, Hodaka Yamakado, Haruhisa Inoue, Ryosuke Takahashi and Jun Takahashi

      Version of Record online: 24 FEB 2017 | DOI: 10.1002/jnr.24014

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      Dopaminergic neurons generated from induced pluripotent stem cells of Parkinson's disease patient caused behavioral improvement of 6-OHDA-lesioned rats as well as those derived from healthy individual. Even in the brains of α-Synuclein transgenic mice, there was no sign of the transfer of pathological α-Synuclein, suggesting their applicability for autologous transplantation.

  8. Letters to the Editor

    1. Journal of neuroscience research policy on addressing sex as a biological variable: Comments, clarifications, and elaborations

      Gina Rippon, Rebecca Jordan-Young, Anelis Kaiser, Daphna Joel and Cordelia Fine

      Version of Record online: 22 FEB 2017 | DOI: 10.1002/jnr.24045

  9. Research Articles

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      α4βδ-GABAA receptors in dorsal hippocampal CA1 of adolescent female rats traffic to the plasma membrane of dendritic spines following voluntary exercise and contribute to protection of animals from activity-based anorexia through localization at excitatory synapses

      Chiye Aoki, Yi-Wen Chen, Tara Gunkali Chowdhury and Walter Piper

      Version of Record online: 20 FEB 2017 | DOI: 10.1002/jnr.24035

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      EM immunocytochemistry reveals that trafficking of α4βδ-GABAA receptors to synaptic clefts of excitatory synapses in the hippocampus is influenced by food restriction (FR), voluntary exercise (EX), and social isolation (SI). These α4βδ-GABAA receptors contribute to adolescent female rats' resilience to activity-based anorexia (ABA), an excessive EX behavior induced by FR.

    2. Exploration of the Brn4-regulated genes enhancing adult hippocampal neurogenesis by RNA sequencing

      Jingjing Guo, Xiang Cheng, Lei Zhang, Linmei Wang, Yongxin Mao, Guixiang Tian, Wenhao Xu, Yuhao Wu, Zhi Ma, Jianbing Qin, Meiling Tian, Guohua Jin, Wei Shi and Xinhua Zhang

      Version of Record online: 18 FEB 2017 | DOI: 10.1002/jnr.24043

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      Our previous studies indicated that Brn4 was upregulated and promoted neuronal differentiation of neural stem cells (NSCs) in the surgically denervated hippocampus in rats. In this study, we used high-throughput RNA sequencing to explore the molecular mechanisms underlying the enhancement of adult hippocampal neurogenesis induced by lentivirus-mediated Brn4 overexpression in vivo. RNA sequencing revealed that 658 genes were differentially expressed in the Brn4-overexpressed hippocampi compared with GFP-overexpressed controls and that the expression levels of genes related to neuronal development and maturation were significantly increased and the expression levels of genes related to NSC maintenance were significantly decreased, indicating enhanced neurogenesis in the hippocampus after Brn4 overexpression. Real-time PCR validated the expression changes of Ctbp2, Notch2, and Gli1. Importantly, the expression levels of Ctbp2 and Notch2 were also significantly changed in the hippocampus of Brn4 KO mice, which indicates that the expression levels of Ctbp2 and Notch2 may be directly regulated by Brn4. Our current study provides a solid foundation for further investigations and identifies Ctbp2 and Notch2 as possible downstream targets of Brn4.

  10. Letter to the Editors

    1. Health and disease, an orchestra of three players: Serotonin, orexins, and nitric oxide

      Simona Tafuri, Valeria De Pasquale, Anna Costagliola, Rossella Della Morte, Luigi Avallone and Luigi Michele Pavone

      Version of Record online: 18 FEB 2017 | DOI: 10.1002/jnr.24030

  11. Research Articles

    1. Cortical spreading depolarizations in the postresuscitation period in a cardiac arrest male rat model

      Frederik Boe Hansen, Niels Secher, Morten Skovgaard Jensen, Leif Østergaard, Else Tønnesen and Asger Granfeldt

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/jnr.24033

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      It is unknown whether cortical-spreading depolarizations are present in the postresuscitation period after cardiac arrest. In a rat model of asphyxial cardiac arrest, we detected four spontaneous depolarizations and found cortical-spreading depolarizations to be severely altered in the postresuscitation period.

  12. Reviews

    1. Rab7 may be a novel therapeutic target for neurologic diseases as a key regulator in autophagy

      Haixia Wen, Lixuan Zhan, Siyuan Chen, Long Long and En Xu

      Version of Record online: 10 FEB 2017 | DOI: 10.1002/jnr.24034

  13. Research Articles

    1. Transplantation with hypoxia-preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest–induced global cerebral ischemia in rats

      Ji-wen Wang, Yu-ru Qiu, Yue Fu, Jun Liu, Zhi-Jie He and Zi-tong Huang

      Version of Record online: 10 FEB 2017 | DOI: 10.1002/jnr.24025

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      Hypoxia at 1% O2 increases the expansion and migration of MSCs by activating the PI3K/ AKT and hypoxia-inducible factor-1a/CXC chemokine receptor-4 pathways. Transplantation of hypoxia-preconditioned MSCs promotes the migration and integration of MSCs and decreased neuronal death and inflammation in the ischemic cortex.

  14. Reviews

    1. Lack of appropriate stoichiometry: Strong evidence against an energetically important astrocyte–neuron lactate shuttle in brain

      Gerald A. Dienel

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24015

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      Lactate shuttling in activated brain is not substantial because total CMRglc > oxidative CMRglc, CMRO2/CMRglc falls, small CMRO2 increases cannot support necessary lactate oxidation, labeled metabolites of glucose are not quantitatively retained, lactate is rapidly dispersed and released, and regulation of aerobic glycolysis involves β2-adrenergic receptors, not glutamate uptake.

  15. Research Articles

    1. Activity-dependent modulation of intracellular ATP in cultured cortical astrocytes

      Ulrike Winkler, Pauline Seim, Yvonne Enzbrenner, Susanne Köhler, Marit Sicker and Johannes Hirrlinger

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24020

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      During uptake of the neurotransmitter glutamate into astrocytes, intracellular ATP is decreased irrespective of the exogenous energy substrate. In contrast, ATP remains unaffected in astrocytes during exposure to dopamine.

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      Monoamine oxidase-A and B activities in the cerebellum and frontal cortex of children and young adults with autism

      Feng Gu, Ved Chauhan and Abha Chauhan

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24027

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      Monoamine oxidase-A (MAO-A) activity was lower in brain samples from children with autism than in control subjects. There was no significant difference in monoamine oxidase-B activity between subjects with autism and the control group. Reduced MAO-A activity can cause increased levels of neurotransmitters such as serotonin, which have been reported in a subset of subjects with autism.

    3. Probing nano-organization of astroglia with multi-color super-resolution microscopy

      Janosch P Heller, Piotr Michaluk, Kohtaroh Sugao and Dmitri A Rusakov

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24026

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      We employed direct stochastic optical reconstruction microscopy (dSTORM), to visualize astroglial organization on the nanoscale, in culture, and in thin brain slices, as an initial step to understand the structural basis of astrocytic nano-physiology.

    4. Axonal sprouting in commissurally projecting parvalbumin-expressing interneurons

      Zoé Christenson Wick, Caara H. Leintz, Casey Xamonthiene, Bin H. Huang and Esther Krook-Magnuson

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24011

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      Parvalbumin-expressing interneurons sparsely innervate the contralateral hippocampus in saline-injected control mice. Six months after intrahippocampal kainate injection (to model temporal lobe epilepsy), axonal sprouting of commissurally projecting parvalbumin-expressing interneurons occurs, primarily targeting the dentate gyrus. This illustrates long-range reorganization of the inhibitory hippocampal network in temporal lobe epilepsy.

  16. Reviews

    1. Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission

      Ciaran Murphy-Royal, Julien Dupuis, Laurent Groc and Stéphane H R Oliet

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24029

    2. Cellular and Molecular Neuroscience

      Differential effects of energy deprivation on intracellular sodium homeostasis in neurons and astrocytes

      Niklas J. Gerkau, Cordula Rakers, Gabor C. Petzold and Christine R. Rose

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.23995

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      Neurons and astrocytes experience substantial influx of sodium through different mechanisms and its re-export by the Na+/K+-ATPase consumes a major share of cellular ATP. Energy deprivation and metabolic failure therefore cause a rapid breakdown of the sodium gradient, exerting various secondary events and promoting excitotoxicity.

    3. Near-critical GLUT1 and Neurodegeneration

      L. Felipe Barros, Alejandro San Martín, Ivan Ruminot, Pamela Y. Sandoval, Ignacio Fernández-Moncada, Felipe Baeza-Lehnert, Robinson Arce-Molina, Yasna Contreras-Baeza, Francisca Cortés-Molina, Alex Galaz and Karin Alegría

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.23998

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      Glucose flows from blood into endothelial cells, astrocytes, and neurons, its passage through membranes being mediated by GLUT1 and GLUT3. The degree of flux control exerted by these transporters depends on their relative resistance to flux, which also determines the tolerance of neurons to transport deficits. One of nine possible configurations of brain glucose dynamics is depicted here in which neurons are highly exposed to deficits in astrocytic GLUT1, but not in endothelial GLUT1 or in neuronal GLUT3.

    4. Roles of palmitoylation in axon growth, degeneration and regeneration

      Sabrina M. Holland and Gareth M. Thomas

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24003

    5. Cellular and Molecular Neuroscience

  17. Research Articles

    1. Chronic inhibition of brain glycolysis initiates epileptogenesis

      Evgeniya Samokhina, Irina Popova, Anton Malkov, Anton I. Ivanov, Daniela Papadia, Alexander Osypov, Maxim Molchanov, Svetlana Paskevich, André Fisahn, Misha Zilberter and Yuri Zilberter

      Version of Record online: 2 FEB 2017 | DOI: 10.1002/jnr.24019

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      Major risk factors for acquired epilepsy share brain hypometabolism as a common outcome, while epilepsy patients exhibit reduced glucose consumption. We found that inducing a chronic inhibition in glucose consumption in the brains of healthy rats results in epileptogenesis, suggesting that brain hypometabolism is a primary initiating factor in acquired epilepsy.

    2. Α-synuclein induces microglial cell migration through stimulating HIF-1α accumulation

      Hongfei Qiao, Xijing He, Qiaojun Zhang, Ni Zhang, Libo Li, Yanping Hui, Wenjuan Li, Dong Wang and Zhonghen Wu

      Version of Record online: 30 JAN 2017 | DOI: 10.1002/jnr.24012

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      α-synuclein treatment led to HIF-1α accumulation by stimulating TLR7/8. Accumulated HIF-1α, cooperating with c-Src, enhanced caveolin-1 expression and phosphorylation, thus leding to microglial cell migration.

    3. Combined ipsilateral limb use score as an index of motor deficits and neurorestoration in parkinsonian rats

      Juuso V. Leikas, Tiina M. Kääriäinen, Aaro J. Jalkanen, Marko Lehtonen, Tomi Rantamäki and Markus M. Forsberg

      Version of Record online: 30 JAN 2017 | DOI: 10.1002/jnr.24022

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      The Combined Ipsilateral Score calculated from three sensorimotor tests (cylinder, adjusting steps and vibrissae tests) is a sensitive marker for the functionality of the nigrostriatal system and can be used as an index of motor deficits and neurorestoration in partially 6-OHDA lesioned animals.

    4. Microstructural and functional correlates of glutamate concentration in the posterior cingulate cortex

      Jorge Arrubla, Ezequiel Farrher, Johanna Strippelmann, Desmond H. Y. Tse, Farida Grinberg, N. Jon Shah and Irene Neuner

      Version of Record online: 24 JAN 2017 | DOI: 10.1002/jnr.24010

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      Glutamate concentration was measured in the posterior cingulate cortex in a sample of healthy male volunteers. The measured concentrations were tested for correlation with metrics provided by electroencephalography, functional MRI and diffusion tensor imaging, which were measured in the same session and under the same conditions.

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      Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein

      Theodore A. Sarafian, Kaitlyn Littlejohn, Sarah Yuan, Charlene Fernandez, Marianne Cilluffo, Bon-Kyung Koo, Julian P. Whitelegge and Joseph B. Watson

      Version of Record online: 24 JAN 2017 | DOI: 10.1002/jnr.24024

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      The proteoform structures of α-synuclein that modulate presynaptic neurotransmitter release in Parkinson's disease (PD) pathology are not clearly defined. In this study, an in vitro enzyme-based assay was used to measure glutamate release from mouse forebrain synaptoneurosomes (SNs) utilizing various mouse genotypes and reconstituted human α-synuclein proteoforms (monomers, oligomers, fibrils). Notably, exogenous applications (SN Treated) of fibrillated forms of α-synuclein preferentially enhanced glutamate release, lending support to synaptic excitotoxicity as a neuropathological pathway during the progression of PD and other synucleinopathies.

  18. Review

    1. ADAMTS-4 in central nervous system pathologies

      Sighild Lemarchant, Sara Wojciechowski, Denis Vivien and Jari Koistinaho

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/jnr.24021

  19. Research Articles

    1. Netrin-1 overexpression improves neurobehavioral outcomes and reduces infarct size via inhibition of the notch1 pathway following experimental stroke

      Xiaosheng Yang, Shiting Li, Bin Li, Xiaoqiang Wang, Chongran Sun, Haiqiang Qin and Hui Sun

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/jnr.24018

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      Netrin-1 overexpression increased neurobehavioral test scores and reduced cerebral infarct volume following middle cerebral artery occlusion. Under these conditions, Notch1 and Jagged1 were colocalized at the cell surface but not within the cell, the complex was not internalized and the downstream effects of Notch1 signaling were abrogated.

  20. Review

    1. You have full text access to this OnlineOpen article
      Diversity of immune cell types in multiple sclerosis and its animal model: Pathological and therapeutic implications

      Yun Cheng, Li Sun, Zhongxiang Xie, Xueli Fan, Qingqing Cao, Jinming Han, Jie Zhu and Tao Jin

      Version of Record online: 13 JAN 2017 | DOI: 10.1002/jnr.24023

  21. Research Articles

    1. Cortical hemorrhage-associated neurological deficits and tissue damage in mice are ameliorated by therapeutic treatment with nicotine

      Junpei Anan, Masanori Hijioka, Yuki Kurauchi, Akinori Hisatsune, Takahiro Seki and Hiroshi Katsuki

      Version of Record online: 9 JAN 2017 | DOI: 10.1002/jnr.24016

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      We established an experimental model of intracerebral hemorrhage in the cerebral cortex of mice that was accompanied by motor dysfunction, neurodegeneration, and local inflammation. Daily treatment with nicotine diminished these pathological features, providing a clue for therapeutic interventions on cortical hemorrhage.

    2. Best time window for the use of calcium-modulating agents to improve functional recovery in injured peripheral nerves—An experiment in rats

      Yuhui Yan, Feng-Yi Shen, Michael Agresti, Lin-Ling Zhang, Hani S. Matloub, John A. LoGiudice, Robert Havlik, Jifeng Li, Yu-dong Gu and Ji-Geng Yan

      Version of Record online: 4 JAN 2017 | DOI: 10.1002/jnr.24009

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      Crushed sciatic nerve after 4 weeks. A: A calcium fluorescent-stained nerve bundle from the nifedipine treatment group; the myelinated nerve fibers are clearly shown by white arrows. B: The saline group has a lot of calcium accumulation showing bright mass indicated by black arrow heads. Bar = 100 μm. C: Nifedipine group: white arrows show healthy axons. D: Saline group: black arrows are showing degenerated axons with higher calcium spots. The numbers of these calcium accumulation spots in panel D apparently were more than in panel C. Panels C and D were from semithin sections with toluidine blue stain. Bar = 50 μm.

    3. Reduction of intracerebral hemorrhage by rivaroxaban after tPA thrombolysis is associated with downregulation of PAR-1 and PAR-2

      Ryuta Morihara, Toru Yamashita, Syoichiro Kono, Jingwei Shang, Yumiko Nakano, Kota Sato, Nozomi Hishikawa, Yasuyuki Ohta, Stefan Heitmeier, Elisabeth Perzborn and Koji Abe

      Version of Record online: 30 DEC 2016 | DOI: 10.1002/jnr.24013

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      In an animal stroke model followed by tissue-type plasminogen activator (tPA), we observed that warfarin pretreatment (W+tPA) enhanced the expression of protease-activated receptor-1 (PAR-1) in the brain compared with the vehicle group (V+tPA), whereas rivaroxaban pretreatment (R+tPA) did not.

    4. Morphological brain measures of cortico-limbic inhibition related to resilience

      Arpana Gupta, Aubrey Love, Lisa A. Kilpatrick, Jennifer S. Labus, Ravi Bhatt, Lin Chang, Kirsten Tillisch, Bruce Naliboff and Emeran A. Mayer

      Version of Record online: 28 DEC 2016 | DOI: 10.1002/jnr.24007

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      The relationship between resilience measures and morphology of regions involved in cognitive and affective processes are demonstrated, consistent with previous suggestions that individuals with low resilience may have compromised cortico-limbic inhibition, increasing their vulnerability to stress related morbidity. Higher resilient individuals have a better ability to bounce back from adverse events, have greater emotional and cognitive control, and are more persistent.

    5. Dynamic mislocalizations of nuclear pore complex proteins after focal cerebral ischemia in rat

      Qian Li, Yasuyuki Ohta, Toru Yamashita, Jingwei Shang, Kentaro Deguchi, Tian Feng, Kota Sato, Nozomi Hishikawa, Yumiko Nakano and Koji Abe

      Version of Record online: 28 DEC 2016 | DOI: 10.1002/jnr.24005

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      RanGap1 was clearly observed along the nuclear periphery in sham control brains. After tMCAO, RanGap1 immunoreactivity continuously increased in the peri-ischemic area from 2 days until 28 days, which also displayed progressive precipitations within the nucleus in the peri-ischemic area, while in the ischemic core, RanGap1 immunoreactivity was only weak.

  22. Review

    1. The function of NOD-like receptors in central nervous system diseases

      Xiangxi Kong, Zengqiang Yuan and Jinbo Cheng

      Version of Record online: 28 DEC 2016 | DOI: 10.1002/jnr.24004

  23. Research Articles

    1. MTEP impedes the neuronal polarization and the activity of the Akt–NF-κB pathway in rat hippocampal neurons

      Xiaohua Zhang, Ming Hu, Lin Zhang, Jing An, Wenhui Yan, Zhichao Zhang, Jianxin Liu, Haixia Lu, Xinlin Chen and Yong Liu

      Version of Record online: 26 DEC 2016 | DOI: 10.1002/jnr.24002

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      MTEP Impedes the Neuronal Polarization and the Activity of the Akt-NF-κB Pathway in Rat Hippocampal Neurons

      In cultured hippocampal neurons, MTEP inhibits the activation of mGluR5 (light green), which results in the decrease of the activity of Akt (yellow), as well as downregulating the phosphorylation level and the nuclear translocation of p65 (green) subunit of NF-κB. Furthermore, both the mGluR5 antagonist and Akt-NF-κB Pathway inhibition can impede the neuronal polarization and axon outgrowth. It is possible that Akt-NF-κB pathway might play a role in mGluR5-regulated axon development.

    2. Cellular and Molecular Neuroscience

      Co-expression changes of lncRNAs and mRNAs in the cervical sympathetic ganglia in diabetic cardiac autonomic neuropathic rats

      Guilin Li, Xuan Sheng, Yurong Xu, Huaide Jiang, Chaoran Zheng, Jingjing Guo, Shanshan Sun, Zhihua Yi, Shulan Qin, Shuangmei Liu, Yun Gao, Chunping Zhang, Hong Xu, Bing Wu, Lifang Zou, Shangdong Liang and Gaochun Zhu

      Version of Record online: 19 DEC 2016 | DOI: 10.1002/jnr.24000

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      Diabetic autonomic neuropathy was confirmed by HRV. GO processes and KEGG pathway results from lncRNA microarray revealed that most of the target genes of the lncRNAs were located in cell adhesion molecules, chemokine signaling pathway, et al. The coding-non-coding gene co-expression network showed that lncRNAs and mRNAs were closely related.

    3. Ultrastructural abnormalities and loss of myelinated fibers in the corpus callosum of demyelinated mice induced by cuprizone

      Yun Xiu, Guo-hua Cheng, Chao Peng, Yun Wang, Yong-de Li, Feng-lei Chao and Yong Tang

      Version of Record online: 9 DEC 2016 | DOI: 10.1002/jnr.23997

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      Combining transmission electron microscope technique and the stereological methods, we found ultrastructural abnormalities of myelinated fibers and a significant loss of myelinated fibers in the corpus callosum of cuprizone-exposed mice. These results might help us to further understand the underlying mechanism of white matter abnormalities in demyelinating diseases or a wide range of psychiatric disorders.

    4. GPNMB ameliorates mutant TDP-43-induced motor neuron cell death

      Yuki Nagahara, Masamitsu Shimazawa, Kazuki Ohuchi, Junko Ito, Hitoshi Takahashi, Kazuhiro Tsuruma, Akiyoshi Kakita and Hideaki Hara

      Version of Record online: 9 DEC 2016 | DOI: 10.1002/jnr.23999

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      GPNMB ameliorated motor neuronal cell death induced by mutant TDP-43 and serum deprivation.

    5. Behavior, Cognition and Synaptic Plasticity

      High-intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response

      Li-na Sun, Xiao-long Li, Fei Wang, Jun Zhang, Dan-dan Wang, Li Yuan, Mei-na Wu, Zhao-jun Wang and Jin-shun Qi

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/jnr.23996

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      The present study investigated the effects of compulsory high-intensity exercise (HIE) on hippocampal-dependent cognitive behavior and neural plasticity. We found that HIE not only impaired the learning and memory of rats in a Y-maze (A–D) but also significantly suppressed the induction and maintenance of hippocampal long-term potentiation (LTP) (E–F). In addition, HIE also triggered inflammatory responses in the hippocampus (H, J) and upregulated the levels of phosphorylated JNK/p38/ERK. These results provide a new fundamental evidence for the side effects of HIE to brain functions.

    6. Neuroinflammation

      Temporal kinetics of CD8+CD28+ and CD8+CD28 T lymphocytes in the injured rat spinal cord

      Yan Wu, Yu-Hong Lin, Ling-Ling Shi, Zong-Feng Yao, Xiu-Mei Xie, Zheng-Song Jiang, Jie Tang, Jian-Guo Hu and He-Zuo Lü

      Version of Record online: 29 NOV 2016 | DOI: 10.1002/jnr.23993

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      Using rat SCI model, we demonstrated that CD8+ T-cells can rapidly infiltrate into the injured spinal cords, where they can sustain less than 3 weeks, and regulatory CD8+CD28 T-cells are rare. Based on CD8+ regulatory T-cells, two weeks after injury should be “time window” for treating SCI.

  24. Reviews

    1. Cellular and Molecular Neuroscience

      The role of the miR-17–92 cluster in neurogenesis and angiogenesis in the central nervous system of adults

      Ping Yang, Linghu Cai, Guan Zhang, Zhiqun Bian and Gaofeng Han

      Version of Record online: 21 NOV 2016 | DOI: 10.1002/jnr.23991

  25. Review

    1. Translational Neuroscience

      Genetically modified rodent models of SCA17

      Yiting Cui, Su Yang, Xiao-Jiang Li and Shihua Li

      Version of Record online: 18 NOV 2016 | DOI: 10.1002/jnr.23984

  26. Research Articles

    1. Behavior, Cognition and Synaptic Plasticity

      Short-term exposure to enriched environment rescues chronic stress-induced impaired hippocampal synaptic plasticity, anxiety, and memory deficits

      VenkannaRao Bhagya, Bettadapura N. Srikumar, Jayagopalan Veena and Byrathnahalli S. Shankaranarayana Rao

      Version of Record online: 16 NOV 2016 | DOI: 10.1002/jnr.23992

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      Exposure to chronic restraint stress for 21 days impairs hippocampal long-term potentiation and spatial working memory and enhances anxiety. Interestingly, short-term exposure to an enriched environment restores hippocampal synaptic plasticity, ameliorates cognitive deficits, and reduces anxiety in stressed rats. Thus, a positive environment could have a significant impact in restoring cognitive deficits in stress and stress-associated disorders including depression.

    2. Neuroinflammation

      You have full text access to this OnlineOpen article
      The antiviral cytokine interferon-gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation

      Apurva Kulkarni, Taylor J. Scully and Lauren A. O'Donnell

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/jnr.23987

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      The anti-viral cytokine interferon-gamma (IFNγ) inhibits neural stem/progenitor (NSPC) progression through the cell cycle by reducing phosphorylation of the retinoblastoma protein (pRb) in a STAT1-dependent manner. NSPCs are restricted in the late G1 phase with reduced cyclin E/cdk2 expression and a loss of phosphorylation at serine 795 on pRb.

  27. Reviews

    1. Systems, Circuits and Microcircuits

      Long distance projections of cortical pyramidal neurons

      Charles R. Gerfen, Michael N. Economo and Jayaram Chandrashekar

      Version of Record online: 12 NOV 2016 | DOI: 10.1002/jnr.23978

  28. Research Articles

    1. The effects of intra-hippocampal L-thyroxine infusion on long-term potentiation and long-term depression: A possible role for the αvβ3 integrin receptor

      Soner Bitiktaş, Burak Tan, Şehrazat Kavraal, Marwa Yousef, Yeliz Bayar, Nurcan Dursun and Cem Süer

      Version of Record online: 10 NOV 2016 | DOI: 10.1002/jnr.23985

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      T4-infused rats display impaired LTP, but a marked LTD of population spike (PS) amplitude and excitatory postsynaptic potential (EPSP) slope as compared to saline-infused rats. These effects are antagonized by co-application of tetraiodothyroacetic acid (tetrac).

  29. Reviews

    1. Cellular and Molecular Neuroscience

      Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

      Manuela Pennisi, Rosalia Crupi, Rosanna Di Paola, Maria Laura Ontario, Rita Bella, Edward J. Calabrese, Roberto Crea, Salvatore Cuzzocrea and Vittorio Calabrese

      Version of Record online: 8 NOV 2016 | DOI: 10.1002/jnr.23986

  30. Research Articles

    1. Behavior, Cognition and Synaptic Plasticity

      You have free access to this content
      Investigation of brain electrophysiological properties among heroin addicts: Quantitative EEG and event-related potentials

      Farid Motlagh, Fatimah Ibrahim, Rusdi Rashid, Tahereh Seghatoleslam and Hussain Habil

      Version of Record online: 8 NOV 2016 | DOI: 10.1002/jnr.23988

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      This study introduces a paradigm to evaluate EEG spectral power as well as amplitudes and latencies of MMN, P300, and P600 components among addicts. Results show abnormal brain electrical activities as well as neurobiological vulnerability measured by ERPs among addicts compared to healthy controls. This paradigm benefits comprehensive spatio-temporal investigation of EEG frequencies and cognitive responses (ERP) among addicts, which can promote a better understanding of drug effects on the brain as well as define new neuro-electrophysiological characteristics of addiction properties. The union of EEG power spectrum and ERP features, especially those associated with brain discrimination abilities, orientation of attention, response resolution, and working memory is likely to be most valuable, in light of specific hypotheses and predictions for current studies in this field.

    2. Cellular and Molecular Neuroscience

      Orexin-A increases the firing activity of hippocampal CA1 neurons through orexin-1 receptors

      Xin-Yi Chen, Lei Chen and Yi-Feng Du

      Version of Record online: 31 OCT 2016 | DOI: 10.1002/jnr.23975

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      1) Both exogenous application of orexin-A and endogenously released orexins from the lateral hypothalamus (LH) increase the spontaneous firing rate of hippocampal CA1 neurons. 2) Orexin-A increases the firing activity of hippocampal CA1 neurons through OX1 receptors. 3) The PLC pathway may be involved in activation of OX1 receptor–induced excitation of hippocampal CA1 neurons.

  31. Cellular and Molecular Neuroscience

    1. You have full text access to this OnlineOpen article
      Fluorodopa is a Promising Fluorine-19 MRI Probe for Evaluating Striatal Dopaminergic Function in a Rat Model of Parkinson's Disease

      Daijiro Yanagisawa, Keisuke Oda, Masatoshi Inden, Shigehiro Morikawa, Toshiro Inubushi, Takashi Taniguchi, Masanori Hijioka, Yoshihisa Kitamura and Ikuo Tooyama

      Version of Record online: 28 OCT 2016 | DOI: 10.1002/jnr.23983

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      Fluorodopa displayed an intense peak with a high signal-to-noise ratio value in brain homogenates. 19F MRI using a 7T ultra high-field MR scanner successfully detected 19F MR signal of fluorodopa in the isolated rat brain. Our findings suggest that fluorodopa is a promising imaging probe for evaluating dopaminergic function.

  32. Research Articles

    1. Neuroinflammation

      Long-term effects of autoimmune CNS inflammation on adult hippocampal neurogenesis

      Aggeliki Giannakopoulou, George A. Lyras and Nikolaos Grigoriadis

      Version of Record online: 26 OCT 2016 | DOI: 10.1002/jnr.23982

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      The long-term effects of a MOG-induced EAE model of MS on adult hippocampal neurogenesis are an elevated number of immature neurons in parallel with a trending decrease in the percentage of newborn mature neurons, enhanced migration of newborn cells into the GCL, prominent gliogenesis, and differentiation of newborn cells to astrocytes.

    2. Translational Neuroscience

      Genetic risk mechanisms of posttraumatic stress disorder in the human brain

      Rahul A. Bharadwaj, Andrew E. Jaffe, Qiang Chen, Amy Deep-Soboslay, Aaron L. Goldman, Michelle I. Mighdoll, John A. Cotoia, Anna C. Brandtjen, JooHeon Shin, Thomas M. Hyde, Venkata S. Mattay, Daniel R. Weinberger and Joel E. Kleinman

      Version of Record online: 24 OCT 2016 | DOI: 10.1002/jnr.23957

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      PTSD genetic risk mechanisms in the human brain. Legend: The graphical overview of our research findings is a proven example of how genetic risk mechanisms potentially operate through multiple modalities including gene expression (RNA sequencing), epigenetics (DNA methylation), and neurophysiology (fMRI) in the human brain. Using “risk” DNA biomarkers such as SNPs improves the tractability insofar as studies addressing plain case–control differences are confounded by substance abuse, treatment, and epiphenomena that are unknown in the absence of a tractable genetic sequence biomarker. To illustrate, we show associations for allelic variation at candidate PTSD “risk” SNP rs363276 (CC/CT/TT) where the risk allele “T” carriers show significant changes across multiple modalities. We present an approach of how we can map mechanisms associated with clinical risk that progress towards either “resilience to” or “risk of” developing PTSD in “normal” controls. Now that we have dissected these mechanisms in “normal” brains, the next step would include evaluating these findings in the brains of subjects diagnosed with PTSD where any differences in these associations can be attributable to PTSD disease phenomena, especially when a control psychiatric group such as “major depression” or “bipolar disorder” is included.

    3. Cellular and Molecular Neuroscience

      Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction

      Andrei Tsentsevitsky, Leniz Nurullin, Evgeny Nikolsky and Artem Malomouzh

      Version of Record online: 22 OCT 2016 | DOI: 10.1002/jnr.23977

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      At the frog neuromuscular junction, the activation of (i) Group I mGlu receptors reduces the intensity of spontaneous and evoked acetylcholine release, and (ii) NMDA receptors synchronize evoked acetylcholine release. The presence of these receptor types was confirmed by immunocytochemistry.

    4. Systems, Circuits and Microcircuits

      Participation of the dentate-rubral pathway in the kindling model of epilepsy

      Miguel Hernández-Cerón, Juan Carlos Martínez-Lazcano, Carmen Rubio, Verónica Custodio, Edith González-Guevara, Carlos Castillo-Pérez and Carlos Paz

      Version of Record online: 18 OCT 2016 | DOI: 10.1002/jnr.23974

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      Kindled stage, characterized by generalized seizures caused by electrical activity at both the basolateral amygdala (BL) and the contralateral sensorimotor cortex (SMC), provoked a reduction in both glutamate and GABA at the red nucleus (RN), whereas kainic lesions in the dentate nucleus (DN) reduced the seizure duration (gray bars) and reestablished GABA at the RN.

    5. Brain Diffusivity and Structural Changes in the R6/2 Mouse Model of Huntington Disease

      Ivan Vorisek, Michael Syka and Lydia Vargova

      Version of Record online: 11 OCT 2016 | DOI: 10.1002/jnr.23965

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      Degenerative tissue changes in the globus pallidus (GP) of R6/2 mouse model of Huntington disease include extracellular matrix reduction, loss of neurons, and astrocytic rebuilding. These alterations result in a decrease of apparent diffusion coefficient of water associated with the enlargement of the extracellular space with the maintenance of an anisotropic diffusion.

    6. Cellular and Molecular Neuroscience

      You have full text access to this OnlineOpen article
      Limitations of the hCMEC/D3 cell line as a model for Aβ clearance by the human blood-brain barrier

      Elisanne ALM Biemans, Lieke Jäkel, Robert MW de Waal, H Bea Kuiperij and Marcel M Verbeek

      Version of Record online: 11 OCT 2016 | DOI: 10.1002/jnr.23964

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      In this study we evaluated the commonly used hCMEC/D3 in vitro cell model of the human blood-brain barrier to elucidate clearance mechanisms of Aβ (4 kDa) from the brain, which is relevant to Alzheimer's disease pathology. This model has limitations for this purpose indicating the need to develop new models.

    7. Translational Neuroscience

      Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells

      Hirofumi Masutomi, Saki Kawashima, Yoshitaka Kondo, Yoshiaki Uchida, Byungki Jang, Eun-Kyoung Choi, Yong-Sun Kim, Kentaro Shimokado and Akihito Ishigami

      Version of Record online: 5 OCT 2016 | DOI: 10.1002/jnr.23959

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      Dibutyryl cAMP (dbcAMP) induced a greatly heightened expression of PAD2 and PAD3 mRNAs and proteins in human astrocytoma U-251MG cells. Moreover, dbcAMP-induced PAD2 and PAD3 mRNA expression was mediated via the cAMP-PKA signaling pathway in U-251MG cells.

    8. Behavior, Cognition and Synaptic Plasticity

      Dopamine D3 receptor knockout mice exhibit abnormal nociception in a sex-different manner

      Peng Liu, Bo Xing, Zheng Chu, Fei Liu, Gang Lei, Li Zhu, Ya Gao, Teng Chen and Yong-hui Dang

      Version of Record online: 26 SEP 2016 | DOI: 10.1002/jnr.23952

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      The absence of the dopamine D3 receptor leads to hypoalgesia in nociception. The dopamine D3 receptor plays a vital role in the modulation of nociception, and the effect of the receptor differs between sexes.

    9. Methylation of glucocorticoid receptor gene promoter modulates morphine dependence and accompanied hypothalamus–pituitary–adrenal axis dysfunction

      Jie Zhu, Feng Zhu, Na Zhao, Xin Mu, Pingping Li, Wei Wang, Jian Liu and Xiancang Ma

      Version of Record online: 12 SEP 2016 | DOI: 10.1002/jnr.23913

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      Chronic morphine induced hypermethylation of GR 17 promoter via increasing hippocampal DNMT1 expression and its binding at GR 17 promoter, which then downregulated the expression of hippocampal GR, and was thus involved in morphine-induced hyperreactivity of the HPA axis and morphine dependence. MBD2 may also contribute to downregulation of GR 17 mRNA.

    10. Systems, Circuits and Microcircuits

      Hindbrain A2 noradrenergic neuron adenosine 5′-monophosphate-activated protein kinase activation, upstream kinase/phosphorylase protein expression, and receptivity to hormone and fuel reporters of short-term food deprivation are regulated by estradiol

      Karen P. Briski, Fahaad S.H. Alenazi, Manita Shakya and Paul W. Sylvester

      Version of Record online: 12 SEP 2016 | DOI: 10.1002/jnr.23892

      Thumbnail image of graphical abstract

      Brackets indicating effects of short-term food deprivation on A2 nerve cell total and phosphorylated AMPK protein content show that this metabolic challenge elevated total AMPK without altering in activity in ovariectomized (OVX) animals implanted with oil (right-hand side), but augmented AMPK activation alongside decreased upstream phosphatase expression in OVX rats replaced with estradiol (left-hand side).

    11. Preferential conduction block of myelinated axons by nitric oxide

      Peter Shrager and Margaret Youngman

      Version of Record online: 10 SEP 2016 | DOI: 10.1002/jnr.23918

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      NO, produced in inflammatory lesions of the CNS, blocks axonal conduction. Compound action potentials from postnatal day 16 mouse optic nerves contain components from both myelinated and unmyelinated axons. NO reversibly blocks specifically the myelinated component, and this may be responsible for some deficits in multiple sclerosis.

  33. Reviews

    1. You have full text access to this OnlineOpen article
      Optogenetic study of networks in epilepsy

      ManKin Choy, Ben A. Duffy and Jin Hyung Lee

      Version of Record online: 14 JUL 2016 | DOI: 10.1002/jnr.23767

  34. Research Articles

    1. Amyloid-β induces sleep fragmentation that is rescued by fatty acid binding proteins in Drosophila

      Jason R. Gerstner, Olivia Lenz, William M. Vanderheyden, May T. Chan, Cory Pfeiffenberger and Allan I. Pack

      Version of Record online: 19 JUN 2016 | DOI: 10.1002/jnr.23778

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      Human Aβ42 expression in neurons generates sleep deficits that are rescued by Fabp overexpression in a fly model of AD.

    2. Spatial and temporal distribution of laminins in permanent focal ischemic brain damage of the adult rat

      Antti Väänänen, Juha Risteli and Päivi Liesi

      Version of Record online: 23 MAY 2008 | DOI: 10.1002/jnr.21723

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