Pyridylalkylamine ligands and their palladium complexes: structure and reactivity revisited by NMR
Alexandre Requet, Olivier Colin, Flavien Bourdreux, Salim M. Salim, Sylvain Marque, Christine Thomassigny, Christine Greck, Jonathan Farjon and Damien Prim
Article first published online: 20 MAR 2014 | DOI: 10.1002/mrc.4058
Pyridylmethylamines or pma are versatile platforms for Suzuki–Miyaura coupling. NMR permitted to understand the steric crowding and electronic effects at atomic resolution for five pma – Pd complexes couples. These results are in complete agreement with the solid state data. In this context, our study evidenced NMR as a pertinent and insightful tool to design ligands through chemical shifts of all active nuclei especially embedded in the metallacycle, giving a trend of reactivity in the pma–Pd complexes series.