Journal of Cellular Biochemistry

Cover image for Vol. 117 Issue 6

Edited By: C. Fred Fox, Gary S. Stein, and Max M. Burger

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2014: 93/184 (Cell Biology); 107/290 (Biochemistry & Molecular Biology)

Online ISSN: 1097-4644

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JCB Spotlight Article

γ-Secretase Dependent Nuclear Targeting of Dystroglycan

Daniel Leocadio, Andrew Mitchell, and Steve J. Winder

We have used LNCaP prostate cancer cells as a model system to investigate proteases and tyrosine phosphorylation affecting β-dystroglycan proteolysis and nuclear targeting. Our data support a cell density-dependent γ-secretase and furin mediated proteolysis of β-dystroglycan, which could be notch stimulated, leading to nuclear targeting and subsequent degradation.

Transition to Online-Only


Wiley is delighted to announce that the Journal of Cellular Biochemistry will be available online-only as of January 2016.

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