Journal of Cellular Biochemistry

Cover image for Vol. 116 Issue 8

Edited By: C. Fred Fox, Gary S. Stein, and Max M. Burger

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2014: 93/184 (Cell Biology); 107/289 (Biochemistry & Molecular Biology)

Online ISSN: 1097-4644

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Top Cited Articles 2014

Gillies, L. A. and Kuwana, T.
Apoptosis Regulation at the Mitochondrial Outer Membrane
Journal of Cellular Biochemistry 2014, vol. 115, p. 632

Song, L., Li, Y., Li, W., Wu, S. and Li, Z.
miR-495 Enhances the Sensitivity of Non-Small Cell Lung Cancer Cells to Platinum by Modulation of Copper-Transporting P-type Adenosine Triphosphatase A (ATP7A)
Journal of Cellular Biochemistry 2014, vol. 115, p. 1234

Shang, J., Yang, F., Wang, Y., Wang, Y., Xue, G., Mei, Q., Wang, F. and Sun, S..
MicroRNA-23a Antisense Enhances 5-Fluorouracil Chemosensitivity Through APAF-1/Caspase-9 Apoptotic Pathway in Colorectal Cancer Cells
Journal of Cellular Biochemistry 2014, vol. 115, p. 772

Tsimbouri, P., Gadegaard, N., Burgess, K., White, K., Reynolds, P., Herzyk, P., Oreffo, R. and Dalby, M. J
Nanotopographical Effects on Mesenchymal Stem Cell Morphology and Phenotype
Journal of Cellular Biochemistry 2014, vol. 115, p. 380

Cai, Y., Cai, T. and Chen, Y.
Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic
Journal of Cellular Biochemistry 2014, vol. 115, p. 625

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JCB Spotlight Article

Risks and Benefits of Bisphosphonate Therapies

Carlen Reyes, Mette Hitz, Daniel Prieto-Alhambra and Bo Abrahamsen

Bisphosphonates are known to be the mainstay of osteoporosis treatment but also play a fundamental role in treating other bone diseases such as Osteogenesis Imperfecta, Pagets' disease and in the prevention of adverse skeletal effects in certain cancers such as prostate cancer or multiple myeloma. In the last decades, the refinement of bisphosphonates and an increase in the number of new bisphosphonates commercialized has altered the clinical management of these diseases. Despite differences between randomized controlled trials and observational studies, overall all bisphosphonates have proven to reduce the risk of fracture through the inhibition of bone resorption. Other beneficial effects include pain reduction in bone metastasis and potentially a decrease in mortality. However, the chronic nature of most of these disorders implies long-term treatments, which can be associated with long-term adverse effects. Some of the adverse effects identified include an increased risk of atypical femur fractures, osteonecrosis of the jaw, gastrointestinal side effects or atrial fibrillation. The harm/benefit thinking and the constant update regarding these medications are vital in the day-to-day decision-making in clinical practices. The aims of this review is to compile the basic characteristics of these drugs and outline the most important benefits and side effects and provide a clinical context as well as a research agenda to fill the gaps in knowledge.

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