Journal of Cellular Biochemistry

Cover image for Vol. 116 Issue 5

Edited By: C. Fred Fox, Gary S. Stein, and Max M. Burger

Impact Factor: 3.368

ISI Journal Citation Reports © Ranking: 2013: 90/185 (Cell Biology); 107/291 (Biochemistry & Molecular Biology)

Online ISSN: 1097-4644

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Gillies, L. A. and Kuwana, T.
Apoptosis Regulation at the Mitochondrial Outer Membrane
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Song, L., Li, Y., Li, W., Wu, S. and Li, Z.
miR-495 Enhances the Sensitivity of Non-Small Cell Lung Cancer Cells to Platinum by Modulation of Copper-Transporting P-type Adenosine Triphosphatase A (ATP7A)
Journal of Cellular Biochemistry 2014, vol. 115, p. 1234

Shang, J., Yang, F., Wang, Y., Wang, Y., Xue, G., Mei, Q., Wang, F. and Sun, S..
MicroRNA-23a Antisense Enhances 5-Fluorouracil Chemosensitivity Through APAF-1/Caspase-9 Apoptotic Pathway in Colorectal Cancer Cells
Journal of Cellular Biochemistry 2014, vol. 115, p. 772

Tsimbouri, P., Gadegaard, N., Burgess, K., White, K., Reynolds, P., Herzyk, P., Oreffo, R. and Dalby, M. J
Nanotopographical Effects on Mesenchymal Stem Cell Morphology and Phenotype
Journal of Cellular Biochemistry 2014, vol. 115, p. 380

Cai, Y., Cai, T. and Chen, Y.
Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic
Journal of Cellular Biochemistry 2014, vol. 115, p. 625

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JCB Spotlight Article

Mammary branching morphogenesis requires reciprocal signaling by heparanase and mmp-14
Angélica Maciel Gomes, Ramray Bhat, Ana Luisa Correia, Joni D Mott, Neta Ilan, Israel Vlodavsky, Mauro S. G. Pavão, and Mina Bissell

The development of the mammary gland involves formation of a branched arboreal structure resulting from the penetration and proliferation of epithelial cells into the fat pad. The mammary cells invade by remodeling their surrounding extracellular matrix (ECM), which are rich in proteins, and glycans such as heparan sulfate proteoglycans (HSPG). There is increasing literature on how the interaction between signaling by ECM and matrix metalloproteinases (MMPs) is relevant to morphogenetic and physiological contexts. Here we sought to understand how heparanase, the sole mammalian heparan sulfate-degrading endoglycosidase may regulate mammary gland development. We found a robust localization of heparanase within growing end buds during branching in vivo. Using three dimensional (3D) organotypic cultures, we showed that heparanase expression and activity are required for mammary epithelial invasion/branching within dense collagen I gels. Morphometric analysis of glands from both heparanase-overexpressing and knockout mice showed a direct correlation between degree of branching and the heparanase levels, confirming our 3D organotypic culture observations. Finally, we uncovered a reciprocal association between levels of heparanase and MMP14, a membrane-bound MMP, shedding further light on how branching occurs within developing mammary glands.

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