Journal of Cellular Biochemistry

Cover image for Vol. 116 Issue 4

Edited By: C. Fred Fox, Gary S. Stein, and Max M. Burger

Impact Factor: 3.368

ISI Journal Citation Reports © Ranking: 2013: 90/185 (Cell Biology); 107/291 (Biochemistry & Molecular Biology)

Online ISSN: 1097-4644

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Top Cited Articles 2014

Gillies, L. A. and Kuwana, T.
Apoptosis Regulation at the Mitochondrial Outer Membrane
Journal of Cellular Biochemistry 2014, vol. 115, p. 632

Song, L., Li, Y., Li, W., Wu, S. and Li, Z.
miR-495 Enhances the Sensitivity of Non-Small Cell Lung Cancer Cells to Platinum by Modulation of Copper-Transporting P-type Adenosine Triphosphatase A (ATP7A)
Journal of Cellular Biochemistry 2014, vol. 115, p. 1234

Shang, J., Yang, F., Wang, Y., Wang, Y., Xue, G., Mei, Q., Wang, F. and Sun, S..
MicroRNA-23a Antisense Enhances 5-Fluorouracil Chemosensitivity Through APAF-1/Caspase-9 Apoptotic Pathway in Colorectal Cancer Cells
Journal of Cellular Biochemistry 2014, vol. 115, p. 772

Tsimbouri, P., Gadegaard, N., Burgess, K., White, K., Reynolds, P., Herzyk, P., Oreffo, R. and Dalby, M. J
Nanotopographical Effects on Mesenchymal Stem Cell Morphology and Phenotype
Journal of Cellular Biochemistry 2014, vol. 115, p. 380

Cai, Y., Cai, T. and Chen, Y.
Wnt Pathway in Osteosarcoma, from Oncogenic to Therapeutic
Journal of Cellular Biochemistry 2014, vol. 115, p. 625

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JCB Spotlight Article

Quantitative Superresolution Microscopy Reveals Differences in Nuclear DNA Organization of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance
Chirawadee Sathitruangsak, Christiaan H. Righolt, Ludger Klewes, Pille Tammur, Tiiu Ilus, Anu Tamm, Mari Punab, Adebayo Olujohungbe and Sabine Mai
Volume 116, Issue 5

The mammalian nucleus has a distinct substructure that cannot be visualized directly by conventional microscopy. In this study, the organization of the DNA within the nucleus of multiple myeloma (MM) cells, their precursor cells (monoclonal gammopathy of undetermined significance; MGUS) and control lymphocytes of the representative patients is visualized and quantified by superresolution microscopy. Three-dimensional structured illumination microscopy (3D-SIM) increases the spatial resolution beyond the limitation of conventional widefield fluorescence microscopy. 3D-SIM reveals new insights into the nuclear architecture of cancer as we show for the first time that it resolves organizational differences in intranuclear DNA organization of myeloma cells in MGUS and in MM patients. In addition, we report a significant increase in nuclear submicron DNA structure and structure of the DNA-free space in myeloma nuclei compared to normal lymphocyte nuclei. Our study provides previously unknown details of the nanoscopic DNA architecture of interphase nuclei of the normal lymphocytes, MGUS and MM cells. This study opens new avenues to understanding the disease progression from MGUS to MM.

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