Journal of Cellular Biochemistry

Cover image for Vol. 117 Issue 4

Early View (Online Version of Record published before inclusion in an issue)

Edited By: C. Fred Fox, Gary S. Stein, and Max M. Burger

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2014: 93/184 (Cell Biology); 107/290 (Biochemistry & Molecular Biology)

Online ISSN: 1097-4644

VIEW

  1. 1 - 81
  1. Articles

    1. CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection

      Sotirios Botsios and Laura Manuelidis

      Article first published online: 11 FEB 2016 | DOI: 10.1002/jcb.25495

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      To ask if TSE agents, as other viruses, require protected nucleic acids, we exposed high titer FU-CJD and 22L scrapie particles to potent nucleases that do not degrade prion protein. Both agent strains showed infectivity was reduced by >99% when nucleic acids were selectively destroyed. These findings demonstrate that TSE agents are viruses that require protected genetic material to infect their hosts.

    2. Human Umbilical Cord Wharton's Jelly Stem Cell Conditioned Medium Induces Tumoricidal Effects on Lymphoma Cells Through Hydrogen Peroxide Mediation

      Hao Daniel Lin, Chui-Yee Fong, Arijit Biswas, Mahesh Choolani and Ariff Bongso

      Article first published online: 11 FEB 2016 | DOI: 10.1002/jcb.25501

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      Several groups have reported that human umbilical cord Wharton's jelly stem cells (hWJSCs) possess unique tumoricidal properties against many ancers. We report that the 3 kDa-MWCO concentrate of hWJSC-conditioned medium inhibits the rowth of lymphoma cells and the tumoricidal effect was mediated via hydrogen peroxide signaling. The hWJSC-CM-3 kDa MWCO concentrate may thus be a promising anti-lymphoma agent.

  2. Prospects

    1. TGF-β Signaling in Cancer

      Viqar Syed

      Article first published online: 11 FEB 2016 | DOI: 10.1002/jcb.25496

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      TGF-β is implicated in carcinogenesis. Members of the TGF-β family control numerous cellular functions including proliferation, apoptosis, differentiation, epithelial-mesenchymal transition (EMT), and migration. Given the pivotal role of TGF-β in tumor progression, this pathway is an attractive target for cancer therapy.

  3. Articles

    1. A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene

      Babajan Banaganapalli, Kaleemuddin Mohammed, Imran Ali Khan, Jumana Y. Al-Aama, Ramu Elango and Noor Ahmad Shaik

      Article first published online: 10 FEB 2016 | DOI: 10.1002/jcb.25499

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      Computational methods as a primary filter to verify the plausible impact of pathogenic mutations based on the perspective of evolution, expression, and phenotype of proteins.

    2. PPARγ Represses Apolipoprotein A-I Gene but Impedes TNFα-Mediated ApoA-I Downregulation in HepG2 Cells

      Vladimir S. Shavva, Denis A. Mogilenko, Alexandra M. Bogomolova, Artemy A. Nikitin, Ella B. Dizhe, Alexander M. Efremov, Galina N. Oleinikova, Andrej P. Perevozchikov and Sergey V. Orlov

      Article first published online: 8 FEB 2016 | DOI: 10.1002/jcb.25498

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      PPARgamma agonist GW1929 negatively regulates apoA-I mRNA transcription and ApoA-I protein secretion in PPARgamma-dependent manner, and these effects are mediated by both direct interaction of PPARgamma with the hepatic enhancer of apoA-I gene and PPARgamma-dependent change in the levels of LXRbeta and PPARalpha binding with the hepatic enhancer of apoA-I gene. Activation of PPARgamma by GW1929 interferes with TNFalpha-mediated suppression of apoA-I transcription but does not alter TNFalpha-mediated inhibition of ApoA-I secretion by HepG2 cells.

    3. TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways

      Dae-Hee Lee, Ki Sa Sung, Zong Sheng Guo, William Taehyung Kwon, David L. Bartlett, Sang Cheul Oh, Yong Tae Kwon and Yong J. Lee

      Article first published online: 5 FEB 2016 | DOI: 10.1002/jcb.25289

    4. Placenta Mesenchymal Stem Cell Derived Exosomes Confer Plasticity on Fibroblasts

      Masayuki Tooi, Motohiro Komaki, Chikako Morioka, Izumi Honda, Kengo Iwasaki, Naoki Yokoyama, Hirohito Ayame, Yuichi Izumi and Ikuo Morita

      Article first published online: 5 FEB 2016 | DOI: 10.1002/jcb.25459

    5. Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells

      Mayumi Ukita, Taihiko Yamaguchi, Noboru Ohata and Masato Tamura

      Article first published online: 5 FEB 2016 | DOI: 10.1002/jcb.25432

    6. Modulation of the Isoprenoid/Cholesterol Biosynthetic Pathway During Neuronal Differentiation In Vitro

      Veronica Cartocci, Marco Segatto, Ilenia Di Tunno, Stefano Leone, Frank W. Pfrieger and Valentina Pallottini

      Article first published online: 5 FEB 2016 | DOI: 10.1002/jcb.25500

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      During neuronal differentiation the activity of the MVA pathway decreases.Pharmacologic inhibition of HMGR by simvastatin accelerated neuronal differentiation by modulating geranylated proteins.MVA pathway appears as an attractive pharmacological target to modulate neurological and metabolic symptoms of developmental neuropathologies.

    7. Possible Involvement of the Inhibition of NF-κB Factor in Anti-Inflammatory Actions That Melatonin Exerts on Mast Cells

      M.D. Maldonado, H. García-Moreno, C. González-Yanes and J.R. Calvo

      Article first published online: 3 FEB 2016 | DOI: 10.1002/jcb.25491

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      This study reveals that PMACI induces the activation of NF-κB and causes an inflammatory toxicity on mast cells, which could be mitigated by MELx. This mitigation is shown by the improvement of cell viability and the decrease of TNF-α, IL-6 and MELn levels.

    8. Expression of cFLIPL Determines the Basal Interaction of Bcl-2 With Beclin-1 and Regulates p53 Dependent Ubiquitination of Beclin-1 During Autophagic Stress

      Kishu Ranjan and Chandramani Pathak

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25474

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      cFLIPL regulates the basal interaction of Bcl-2 with Beclin-1 and regulates p53 dependent ubiquitination of Beclin-1 during autophagic stress to determine the fate of cell death and survival.

    9. Smad8/9 Is Regulated Through the BMP Pathway

      Yuko Katakawa, Masayuki Funaba and Masaru Murakami

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25478

    10. The CREB Transcription Factor Controls Transcriptional Activity of the Human RIC8B Gene

      Alejandro Maureira, Rodolfo Sánchez, Nicole Valenzuela, Marcela Torrejón, María V. Hinrichs, Juan Olate and José L. Gutiérrez

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25479

    11. Dexamethasone-Induced Skeletal Muscle Atrophy Increases O-GlcNAcylation in C2C12 Cells

      Luca Massaccesi, Giancarlo Goi, Cristina Tringali, Alessandra Barassi, Bruno Venerando and Nadia Papini

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25483

    12. Molecular Characterization of a Copper Metallothionein Gene From a Ciliate Tetrahymena farahensis

      Muhammad Tariq Zahid, Farah Rauf Shakoori, Soumble Zulifqar, Ishtiaq Ahmed, Khalid Al-Ghanim, Shahid Mehboob and Abdul Rauf Shakoori

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25484

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      A new copper metallothionein (TfCuMT) gene isolated from a locally isolated ciliate Tetrahymena farahensis encodes a peptide chain of 108 amino acids. Optimum expression was obtained after 6–8 h of 0.1 mM IPTG induction in pET28a. The modeled structure of the TfCuMT showed a cleft for Cu binding with correct orientation of Cys residues in the motif CKC.

    13. The Effects of Severe Hypoxia on Glycolytic Flux and Enzyme Activity in a Model of Solid Tumors

      Hannah Smith, Mary Board, Andrea Pellagatti, Helen Turley, Jacqueline Boultwood and Richard Callaghan

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25488

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      Solid tumours contend with a hostile micro-environment that includes limited availability of nutrient fuels and oxygen. Analysis of tumor oxygenation has revealed large gradients of oxygen tension and significant regions under severe hypoxia. The investigation reveals that severe hypoxia leads to a significantly abridged Hif1 response, yet one still able to elevate glycolytic flux and prevent loss of intermediates to anabolism.

    14. TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes

      Aurélie Pépin, Marie-Alix Espinasse, Perle Latré de Laté, Natacha Szely, Marc Pallardy and Armelle Biola-Vidamment

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25485

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      Expression of TSC-22 promotes T-lymphocytes apoptosis by inhibiting gilz expression at the transcriptional level in the murine lymphoid CTLL-2 cell line. Pro-apoptotic BIM expression and caspases-9 and -3 activities were markedly increased in TSC-22 expressing clones compared to control clones. TSC-22 may represent a potent repressor of GILZ expression in IL-2-dependent cells, independently of the cell type or the stimulus, leading to an increase of IL-2-deprived T-cells apoptosis.

    15. HIV-1 Infection Dysregulates Cell Cycle Regulatory Protein p21 in CD4+ T Cells Through miR-20a and miR-106b Regulation

      Debjani Guha, Allison Mancini, Jessica Sparks and Velpandi Ayyavoo

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25489

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      p21, a cell cycle protein, has been differentially regulated in CD4+ T cells and macrophages by HIV-1. Importantly, expression of p21 was regulated at the post-transcriptional level by miR-106b and miR-20a.

    16. The Dietary Flavonoid Fisetin Causes Cell Cycle Arrest, Caspase-Dependent Apoptosis, and Enhanced Cytotoxicity of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

      Matthew L. Smith, Kaylee Murphy, Carolyn D. Doucette, Anna L. Greenshields and David W. Hoskin

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25490

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      Fisetin (3,3′,4′,7-tetrahydroxyflavone) inhibited the proliferation of triple-negative breast cancer (TNBC) cells and caused cell death by caspase-dependent apoptosis. Fisetin also inhibited Aurora B kinase in TNBC cells and sensitized TNBC cells to chemotherapeutic drugs. Fisetin therefore shows promise as a possible treatment for TNBC.

    17. FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice

      Erxia Du, Liping Xiao and Marja M. Hurley

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25493

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      This study examined the effect of short-term blocking of FGFRs using NVP-BGJ398 on phosphate homeostasis in kidneys of FGF2 high molecular weight isoform transgenic mice. FGFR inhibitor ameliorates hypophosphatemia and impaired Engrailed-1/Wnt signaling in HMWTg mice.

    18. Transcription Factors and Medium Suitable for Initiating the Differentiation of Human-Induced Pluripotent Stem Cells to the Hepatocyte Lineage

      Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto and Naoki Ishige

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25494

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      Liver-specific transcription factors initiated differentiation of human-induced pluripotent stem cells to hepatocyte lineage in William's E medium.

    19. ECM-Dependence of Endothelial Progenitor Cell Features

      Vahid Siavashi, Seyed Mahdi Nassiri, Reza Rahbarghazi, Rana Vafaei and Reyhaneh Sariri

      Article first published online: 2 FEB 2016 | DOI: 10.1002/jcb.25492

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      Fibronectin matrix protects the stemness characteristics of EPCs. EPCs pre-expanded on fibronectin repopulate the bone marrow after irradiation and possess a great capacity for engraftment to various tissues.

    20. Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells

      Rosana Kral, Angelina Doriguzzi, Christoph-Erik Mayer, Dagmar Krenbek, Ulrike Setinek and Hedwig Sutterlüty-Fall

      Article first published online: 21 JAN 2016 | DOI: 10.1002/jcb.25482

    21. GRP78 Interacting Partner Bag5 Responds to ER Stress and Protects Cardiomyocytes From ER Stress-Induced Apoptosis

      Manish K. Gupta, Farzaneh G. Tahrir, Tijana Knezevic, Martyn K. White, Jennifer Gordon, Joseph Y. Cheung, Kamel Khalili and Arthur M. Feldman

      Article first published online: 21 JAN 2016 | DOI: 10.1002/jcb.25481

    22. Presence of the Paternal Pronucleus Assists Embryo in Overcoming Cycloheximide Induced Abnormalities in Zygotic Mitosis

      Michael A. Ortega, Myungjun Ko, Joel Marh, Ariel Finberg, Marissa Oshiro and W. Steven Ward

      Article first published online: 21 JAN 2016 | DOI: 10.1002/jcb.25480

    23. Transcriptomic Changes in Osteoblasts Following Endothelial Cell-Cocultivation Suggest a Role of Extracellular Matrix in Cellular Interaction

      Florian M. Lampert, Filip Simunovic, Günter Finkenzeller, Dietmar Pfeifer, G. Björn Stark, Oscar Winninger and Dominik Steiner

      Article first published online: 21 JAN 2016 | DOI: 10.1002/jcb.25486

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      We performed a microarray analysis of human osteoblasts (hOBs) cultivated in direct contact with HUVECs to scritinize their intercellular communication in more detail with specific focus on the extracellular matrix (ECM). The differentially expressed genes could be assigned to the functional clusters ECM as well as proliferation, apoptosis and osteogenic differentiation; the results were confirmed by PCR and functional assays. In summary, our data demonstrate that HUVECs provoke complex changes in gene expression patterns in cocultivated hOBs and that ECM plays and important role in this interaction.

    24. Macrophage Recruitment Contributes to Regeneration of Mechanosensory Hair Cells in the Zebrafish Lateral Line

      Simón A. Carrillo, Consuelo Anguita-Salinas, Oscar A. Peña, Rodrigo A. Morales, Salomé Muñoz-Sánchez, Carlos Muñoz-Montecinos, Susana Paredes-Zúñiga, Karina Tapia and Miguel L. Allende

      Article first published online: 21 JAN 2016 | DOI: 10.1002/jcb.25487

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      The role of inflammatory cells on regeneration of mechanosensory hair cells was examined in zebrafish. While neutrophils are dispensable, macrophages were found to be required for proper timing of hair cell regeneration. The use of clodronate liposomes for specifically and locally ablating zebrafish macrophages in vivo is introduced.

    25. Foxc1 Expression in Early Osteogenic Differentiation Is Regulated by BMP4-SMAD Activity

      Alexander Hopkins, Freda Mirzayans and Fred Berry

      Article first published online: 15 JAN 2016 | DOI: 10.1002/jcb.25464

    26. Mitochondrial Inhibitory Factor Protein 1 Functions as an Endogenous Inhibitor for Coupling Factor 6

      Misato Kawai, Tomohiro Osanai, Makoto Tanaka, Koji Magota, Hirofumi Tomita and Ken Okumura

      Article first published online: 15 JAN 2016 | DOI: 10.1002/jcb.25461

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      We tested the hypothesis that IF1 may antagonize the biological action of CF6 in human embryonic kidney 293 cells. IF1 antagonizes the pro-apoptotic action of CF6 by relief of intracellular acidification and resultant phosphorylation of PKB. Given the widespread biological actions of CF6, the physiological and pathological functions of IF1 may be expected to be complex.

    27. Effect of Adipocyte Secretome in Melanoma Progression and Vasculogenic Mimicry

      Pedro Coelho, Joana Almeida, Cristina Prudêncio, Rúben Fernandes and Raquel Soares

      Article first published online: 15 JAN 2016 | DOI: 10.1002/jcb.25463

    28. Dehydroepiandrosterone Stimulation of Osteoblastogenesis in Human MSCs Requires IGF-I Signaling

      Xiaonan Liang, Julie Glowacki, Jochen Hahne, Li Xie, Meryl S. LeBoff and Shuanhu Zhou

      Article first published online: 15 JAN 2016 | DOI: 10.1002/jcb.25475

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      The stimulation by DHEA on both IGF-I gene expression and osteoblastogenesis in hMSCs requires IGF-I receptor, PI3K, p38 MAPK, or p42/44 MAPK signaling pathways. This study adds information to indicate that DHEA may be useful for treating bone diseases through its stimulation of anabolic IGF-I-mediated mechanisms.

    29. Titanium With Nanotopography Induces Osteoblast Differentiation by Regulating Endogenous Bone Morphogenetic Protein Expression and Signaling Pathway

      Larissa M.S. Castro-Raucci, Marcelo S. Francischini, Lucas N. Teixeira, Emanuela P. Ferraz, Helena B. Lopes, Paulo T. de Oliveira, Mohammad Q. Hassan, Adalberto L. Losa and Marcio M. Beloti

      Article first published online: 15 JAN 2016 | DOI: 10.1002/jcb.25469

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      Nanotopography of titanium (Ti) surface generated by a simple and low-cost treatment with H2SO4/H2O2 induces in vitro osteogenesis. This study aimed at evaluating the effect of Ti with nanotopography on the endogenous expression of BMPs and the relevance of this process to the nanotopography-induced osteoblast differentiation. We have demonstrated for the first time that this nanotopography induces osteoblast differentiation, at least in part, by upregulating the endogenous production of BMP-2 and modulating BMP signaling pathway.

    30. microRNA-16 Is Downregulated During Insulin Resistance and Controls Skeletal Muscle Protein Accretion

      David E. Lee, Jacob L. Brown, Megan E. Rosa, Lemuel A. Brown, Richard A. Perry Jr., Michael P. Wiggs, Mats I. Nilsson, Stephen F. Crouse, James D. Fluckey, Tyrone A. Washington and Nicholas P. Greene

      Article first published online: 15 JAN 2016 | DOI: 10.1002/jcb.25476

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      microRNAs control various cellular processes in many different tissues types and hold great potential as a target for therapeutics. Insulin resistance downregulates the amount of miR-16 in skeletal muscle and by controlling levels of miR-16 in muscle cells, the synthesis and autophagic degradation of protein can be altered.

    31. Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent

      Duo Zhang, Hui-Peng Chen, Hai-Feng Duan, Li-Hua Gao, Yong Shao, Ke-Yan Chen, You-Liang Wang, Feng-Hua Lan and Xian-Wen Hu

      Article first published online: 30 DEC 2015 | DOI: 10.1002/jcb.25458

    32. Antiviral Action of Diphenyl Diselenide on Herpes Simplex Virus 2 Infection in Female BALB/c Mice

      Gláubia Sartori, Natália Silva Jardim, Marcel Henrique Marcondes Sari, Fernando Dobrachinski, Ana Paula Pesarico, Luiz Carlos Rodrigues Jr., Juliana Cargnelutti, Eduardo F. Flores, Marina Prigol and Cristina W. Nogueira

      Article first published online: 30 DEC 2015 | DOI: 10.1002/jcb.25457

    33. IL-1α Counteract TGF-β Regulated Genes and Pathways in Human Fibroblasts

      Anita Koskela von Sydow, Chris Janbaz, Caroline Kardeby, Dirk Repsilber and Mikael Ivarsson

      Article first published online: 28 DEC 2015 | DOI: 10.1002/jcb.25455

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      The aim of this study was to explore the effects of IL-1α on genes and pathways elicited by TGF-β in fibroblasts. Transcriptional microarray and gene set enrichment indicate prominent antagonistic effects of IL-1α on TGF-β regulated interferon signaling, as well as on a wide variety of other genes and pathways in fibroblasts.

    34. Mitochondrial Damage and Apoptosis Induced by Adenosine Deaminase Inhibition and Deoxyadenosine in Human Neuroblastoma Cell Lines

      Mercedes Garcia-Gil, Maria Grazia Tozzi, Francesco Balestri, Laura Colombaioni and Marcella Camici

      Article first published online: 28 DEC 2015 | DOI: 10.1002/jcb.25460

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      The treatment with deoxycoformycin, a strong adenosine deaminase inhibitor, in combination with deoxyadenosine, causes apoptotic cell death of two human neuroblastoma cell lines, SH-SY5Y and LAN-5. In previous papers we have shown that a human astrocytoma cell line, subjected to the same treatment, undergoes apoptotic death as well. This work indicates that the neuroblastoma cell lines, like the line of astrocytic origin, are very sensitive to purine metabolism perturbation thus suggesting new therapeutic approaches to nervous system tumors.

    35. Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 Transcription, and Proliferation of MCF-7 Breast Cancer Cells

      Gregory W. Peek and Trygve O. Tollefsbol

      Article first published online: 28 DEC 2015 | DOI: 10.1002/jcb.25462

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      MCF-7 estrogen receptor-positive (ER+) breast cancer cells were treated with raloxifene to upregulate the TGF-beta pathway and PX-866 to down-regulate the PI3K/Akt pathway. All combinations of raloxifene and PX-866 produced significant or highly significant results for reduced MCF-7 cell proliferation, reduced Cyclin E2 transcription, and reduced Rb phosphorylation. These studies demonstrated that uncontrolled proliferation of ER+ breast cancer cells can be significantly reduced by combinational targeting of two relevant pathways.

    36. Increased Rat Placental Fatty Acid, but Decreased Amino Acid and Glucose Transporters Potentially Modify Intrauterine Programming

      Eva Nüsken, Alexandra Gellhaus, Elisabeth Kühnel, Isabelle Swoboda, Maria Wohlfarth, Christina Vohlen, Holm Schneider, Jörg Dötsch and Kai-Dietrich Nüsken

      Article first published online: 14 DEC 2015 | DOI: 10.1002/jcb.25450

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      We show that placental nutrient transporters are differentially affected both by utero-placental insufficiency [induced by bilateral ligation (LIG) of the uterine vessels] and prenatal surgical stress [induced by sham operation (SOP)] in rats, which probably contributes to intrauterine growth restriction (IUGR) and fetal programming. The mean protein expressions of placental nutrient transporters for fatty acids (h-FABP, CD36) were increased by LIG and SOP, amino acid transporter (SNAT1, SNAT2) protein and gene expressions as well as glucose transporter (GLUT-1, Connexin 26) protein expressions were reduced. Increased fatty acid transport capacity may affect energy metabolism and could be a compensatory reaction with positive effects on brain development.

    37. Pyk2 and Megakaryocytes Regulate Osteoblast Differentiation and Migration Via Distinct and Overlapping Mechanisms

      Pierre P. Eleniste, Vruti Patel, Sumana Posritong, Odette Zero, Heather Largura, Ying-Hua Cheng, Evan R. Himes, Matthew Hamilton, Jenna Baughman, Melissa A. Kacena and Angela Bruzzaniti

      Article first published online: 10 DEC 2015 | DOI: 10.1002/jcb.25430

    38. Distinction Between Cell Proliferation and Apoptosis Signals Regulated by Brain-Derived Neurotrophic Factor in Human Periodontal Ligament Cells and Gingival Epithelial Cells

      Kei Kashiwai, Mikihito Kajiya, Shinji Matsuda, Kazuhisa Ouhara, Katsuhiro Takeda, Takashi Takata, Masae Kitagawa, Tsuyoshi Fujita, Hideki Shiba and Hidemi Kurihara

      Article first published online: 8 DEC 2015 | DOI: 10.1002/jcb.25446

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      BDNF activates periodontal ligament cells proliferation via TrkB-Erk Pathway. On the other hand, gingival epithelial cells growth is attenuated by BDNF via p75-JNK signaling.

    39. Dietary Saturated Fat Promotes Development of Hepatic Inflammation Through Toll-Like Receptor 4 in Mice

      Alton G. Sutter, Arun P. Palanisamy, Julie H. Lench, Scott Esckilsen, Tuoyu Geng, David N.B. Lewin, Lauren A. Cowart and Kenneth D. Chavin

      Article first published online: 8 DEC 2015 | DOI: 10.1002/jcb.25453

    40. Molecular Mechanisms Associated With Particulate and Soluble Heteroglycan Mediated Immune Response

      K. Sanjana P. Devi, Dhanesh Krishna, Joyjyoti Das, Tarun Agarwal, Kalpana Kumari, Somnath Maji, Sudip K. Ghosh and Tapas K. Maiti

      Article first published online: 7 DEC 2015 | DOI: 10.1002/jcb.25449

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      Size and molecular weight are key governing factors of heteroglycan induced immune response. NF-κβ and MAPK cascade gets activated on heteroglycan binding to Dectin-1 and TLR2 receptors in macrophages, following which a gamut of immune effector molecules get synthesized.

    41. Physiological Expression and Accumulation of the Products of Two Upstream Open Reading Frames mrtl and MycHex1 Along With p64 and p67 Myc From the Human c-myc Locus

      Mi Hong Ji, Seung-Ki Kim, Chae-Yong Kim, Ji Hoon Phi, Hyun Jin Jun, Scott W. Blume and Hyoung Soo Choi

      Article first published online: 2 DEC 2015 | DOI: 10.1002/jcb.25431

    42. NME1L Negatively Regulates IGF1-Dependent Proliferation of Breast Cancer Cells

      Dong-Joo You, Sunam Mander, Cho Rong Park, Okjae Koo, Cheolju Lee, Seong-Hyun Oh, Curie Ahn, Jae Young Seong and Jong-Ik Hwang

      Article first published online: 30 NOV 2015 | DOI: 10.1002/jcb.25441

    43. Dysregulation of Norepinephrine Release in the Absence of Functional Synaptotagmin 7

      Alvin M. Shih, Lincy Varghese, Alice Bittar, Sung-Hoon Park, Jin Mo Chung and Ok-Ho Shin

      Article first published online: 30 NOV 2015 | DOI: 10.1002/jcb.25436

    44. Molecular Dynamics Studies on D835N Mutation in FLT3—Its Impact on FLT3 Protein Structure

      Rayapadi G. Swetha, Sudha Ramaiah and Anand Anbarasu

      Article first published online: 30 NOV 2015 | DOI: 10.1002/jcb.25434

    45. Regulation of the Expression of Heparan Sulfate 3-O-Sulfotransferase 3B (HS3ST3B) by Inflammatory Stimuli in Human Monocytes

      Anne-Sophie Sikora, Maxime Delos, Pierre Martinez, Mathieu Carpentier, Fabrice Allain and Agnès Denys

      Article first published online: 30 NOV 2015 | DOI: 10.1002/jcb.25444

    46. Inhibition of Histone Deacetylases Enhances the Osteogenic Differentiation of Human Periodontal Ligament Cells

      Nam Cong-Nhat Huynh, Vincent Everts, Prasit Pavasant and Ruchanee Salingcarnboriboon Ampornaramveth

      Article first published online: 26 NOV 2015 | DOI: 10.1002/jcb.25429

  4. Prospects

    1. Long Non-Coding RNA Central of Glucose Homeostasis

      Xiangbo Ruan

      Article first published online: 26 NOV 2015 | DOI: 10.1002/jcb.25427

  5. Articles

  6. Prospects

    1. AKT as Locus of Cancer Unknown Primary Site

      Ziv Radisavljevic

      Article first published online: 26 NOV 2015 | DOI: 10.1002/jcb.25435

  7. Articles

    1. Bafilomycin A1 Attenuates Osteoclast Acidification and Formation, Accompanied by Increased Levels of SQSTM1/p62 Protein

      Sipin Zhu, Sarah L. Rea, Taksum Cheng, Hao Tian Feng, John P. Walsh, Thomas Ratajczak, Jennifer Tickner, Nathan Pavlos, Hua-Zi Xu and Jiake Xu

      Article first published online: 26 NOV 2015 | DOI: 10.1002/jcb.25442

    2. MiR-221 and miR-26b Regulate Chemotactic Migration of MSCs Toward HGF Through Activation of Akt and FAK

      Aisi Zhu, Naixin Kang, Lihong He, Xianyang Li, Xiaojing Xu and Huanxiang Zhang

      Article first published online: 24 NOV 2015 | DOI: 10.1002/jcb.25428

    3. Generation of Oxtr cDNAHA-Ires-Cre Mice for Gene Expression in an Oxytocin Receptor Specific Manner

      Shizu Hidema, Tomokazu Fukuda, Yuichi Hiraoka, Hiroaki Mizukami, Ryotaro Hayashi, Ayano Otsuka, Shingo Suzuki, Shinji Miyazaki and Katsuhiko Nishimori

      Article first published online: 24 NOV 2015 | DOI: 10.1002/jcb.25393

    4. ERK Plays a Role in Chromosome Alignment and Participates in M-Phase Progression

      Erika Iwamoto, Natsumi Ueta, Yuki Matsui, Keiju Kamijo, Takahisa Kuga, Youhei Saito, Naoto Yamaguchi and Yuji Nakayama

      Article first published online: 20 NOV 2015 | DOI: 10.1002/jcb.25424

    5. Suppression of RAD21 Induces Senescence of MDA-MB-231 Human Breast Cancer Cells Through RB1 Pathway Activation Via c-Myc Downregulation

      Shan Zhu, Li Zhao, Yueyang Li, Pingfu Hou, Ruosi Yao, Jiang Tan, Dongxu Liu, Liping Han, Baiqu Huang, Jun Lu and Yu Zhang

      Article first published online: 20 NOV 2015 | DOI: 10.1002/jcb.25426

    6. Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells

      Mohamed Hassan, Abdelouahid El Khattouti, Ahmed Ejaeidi, Tangeng Ma, William A. Day, Ingrid Espinoza, Srinivasan Vijayakumar and Christian R. Gomez

      Article first published online: 17 NOV 2015 | DOI: 10.1002/jcb.25419

    7. Recombinant Mitochondrial Manganese Containing Superoxide Dismutase Protects Against Ochratoxin A-Induced Nephrotoxicity

      Roberto Ciarcia, Sara Damiano, Caterina Squillacioti, Nicola Mirabella, Ugo Pagnini, Alessia Florio, Lorella Severino, Giovambattista Capasso, Antonella Borrelli, Aldo Mancini, Silvia Boffo, Gaetano Romano, Antonio Giordano and Salvatore Florio

      Article first published online: 16 NOV 2015 | DOI: 10.1002/jcb.25425

    8. Low-Dose Actinomycin-D Induces Redistribution of Wild-Type and Mutated Nucleophosmin Followed by Cell Death in Leukemic Cells

      Barbora Brodská, Aleš Holoubek, Petra Otevřelová and Kateřina Kuželová

      Article first published online: 9 NOV 2015 | DOI: 10.1002/jcb.25420

    9. Crataegus azarolus Leaves Induce Antiproliferative Activity, Cell Cycle Arrest, and Apoptosis in Human HT-29 and HCT-116 Colorectal Cancer Cells

      Nadia Mustapha, Aline Pinon, Youness Limami, Alain Simon, Kamel Ghedira, Thierry Hennebelle and Leila Chekir-Ghedira

      Article first published online: 5 NOV 2015 | DOI: 10.1002/jcb.25416

    10. Autophagy-Mediated Degradation of IAPs and c-FLIPL Potentiates Apoptosis Induced by Combination of TRAIL and Chal-24

      Jennings Xu, Xiuling Xu, Shaoqing Shi, Qiong Wang, Bryanna Saxton, Weiyang He, Xin Gou, Jun-Ho Jang, Toru Nyunoya, Xia Wang, Chengguo Xing, Lin Zhang and Yong Lin

      Article first published online: 2 NOV 2015 | DOI: 10.1002/jcb.25397

    11. Lewis Lung Cancer Cells Promote SIGNR1(CD209b)-Mediated Macrophages Polarization Induced by IL-4 to Facilitate Immune Evasion

      Xiaolong Yan, Wenhai Li, Lei Pan, Enqing Fu, Yonghong Xie, Min Chen and Deguang Mu

      Article first published online: 2 NOV 2015 | DOI: 10.1002/jcb.25399

    12. Incretinomimetic and Insulinomimetic Effect of (2E)-N′-(1′-Naphthyl)-3,4,5-Trimethoxybenzohydrazide for Glycemic Homeostasis

      Marisa Jádna Silva Frederico, Alessandra Mascarello, Allisson Jhonatan Gomes Castro, Gabrielle Da Luz, Delsi Altenhofen, Camila Pires Mendes, Paulo Cesar Leal, Rosendo Augusto Yunes, Ricardo José Nunes and Fátima Regina Mena Barreto Silva

      Article first published online: 20 OCT 2015 | DOI: 10.1002/jcb.25403

    13. Comparative Analysis of Human Mesenchymal Stem Cells Derived from Bone Marrow, Placenta, and Adipose Tissue as Sources of Cell Therapy

      Young-Joo Jeon, Jumi Kim, Jin Hyoung Cho, Hyung-Min Chung and Jung-Il Chae

      Article first published online: 20 OCT 2015 | DOI: 10.1002/jcb.25395

    14. Bombesin Receptor-Activated Protein (BRAP) Modulates NF-κB Activation in Bronchial Epithelial Cells by Enhancing HDAC Activity

      Ying Liu, Xiao-Qun Qin, Horst Christian Weber, Yang Xiang, Chi Liu, Hui-Jun Liu, Huan Yang, Jianxin Jiang and Xiangping Qu

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25406

  8. Article

    1. Regulation of cAMP Intracellular Levels in Human Platelets Stimulated by 2-Arachidonoylglycerol

      Maria Grazia Signorello and Giuliana Leoncini

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25408

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    1. Statins Modulate Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 in Human Hepatic Myofibroblasts

      Charbel A. Mouawad, May F. Mrad, Ghewa A. El-Achkar, Ali Abdul-Sater, Georges M. Nemer, Christophe Creminon, Sophie Lotersztajn and Aïda Habib

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25401

    2. PTEN Regulates Renal Extracellular Matrix Deposit via Increased CTGF in Diabetes Mellitus

      Lin Zhu, Song Zhao, Shuxia Liu, Qingjuan Liu, Fan Li and Jun Hao

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25402

    3. Esculetin Induces Apoptosis Through EGFR/PI3K/Akt Signaling Pathway and Nucleophosmin Relocalization

      Young-Joo Jeon, Jin Hyoung Cho, Seung-Yeop Lee, Yung Hyun Choi, Hongju Park, Seunggon Jung, Jung-Hyun Shim and Jung-Il Chae

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25404

    4. Efficient Fludarabine-Activating PNP From Archaea as a Guidance for Redesign the Active Site of E. Coli PNP

      Giovanna Cacciapuoti, Maria Libera Bagarolo, Elisa Martino, Bernardina Scafuri, Anna Marabotti and Marina Porcelli

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25396

    5. In Vitro and In Vivo Anti-Melanoma Effects of Pituranthos tortuosus Essential Oil Via Inhibition of FAK and Src Activities

      Mounira Krifa, Salah Edin El Meshri, Nawel Bentouati, Antonio Pizzi, Emilie Sick, Leila Chekir-Ghedira and Philippe Rondé

      Article first published online: 18 OCT 2015 | DOI: 10.1002/jcb.25400

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