Journal of Cellular Biochemistry

Cover image for Vol. 117 Issue 4

Edited By: C. Fred Fox, Gary S. Stein, and Max M. Burger

Impact Factor: 3.263

ISI Journal Citation Reports © Ranking: 2014: 93/184 (Cell Biology); 107/290 (Biochemistry & Molecular Biology)

Online ISSN: 1097-4644

Virtual Issues


Non-coding RNAs

Published: July 2014

MicroRNAs and long non-coding RNAs contribute significantly to control of gene expression. Evidence is accruing that functionally implicates non-coding RNAs in transcriptional and post-transcriptional control. MicroRNAs are predominantly inhibitory, dampening or blocking protein synthesis by destabilizing messenger RNAs. Long non-coding RNAs are emerging as modulators of gene expression at the genomic level with reports of activities that include influencing the activities of transcriptional regulatory machinery and contributing to architectural organization of the genome.

We have selected a series of research articles and reviews that have recently been published in the Journal of Cellular Biochemistry to provide a well-documented overview of non-coding RNAs in biological control and pathology. Regulatory activities and experimental strategies are illustrated in these papers reflecting the challenges and opportunities to advance understanding of non-coding RNAs in regulatory processes. The current focus is to further develop the effectiveness of non-coding RNAs as reagents to interrogate controlled gene expression and to continue exploring the potential of non-coding RNAs as biomarkers and therapeutic agents with high specificity and minimal off-target consequences.

Radiation-induced microRNA: Discovery, functional analysis, and cancer radiotherapy.
M. Ahmad Chaudhry

HOX antisense lincRNA HOXA-AS2 is an apoptosis repressor in all Trans retinoic acid treated NB4 promyelocytic leukemia cells.
Hang Zhao, Xueqing Zhang, Josias Brito Frazão, Antonio Condino-Neto and Peter E. Newburger

Novel role of miR-181a in cartilage metabolism.
Kumi Sumiyoshi, Satoshi Kubota, Toshihiro Ohgawara, Kazumi Kawata, Tarek Abd El Kader, Takashi Nishida, Nao Ikeda, Tsuyoshi Shimo, Takashi Yamashiro and Masaharu Takigawa

Overexpression of microRNA-122 enhances in vitro hepatic differentiation of fetal liver-derived stem/progenitor cells.
Ravi Doddapaneni, Yogesh K. Chawla, Ashim Das, Jasvinder Kaur Kalra, Sujata Ghosh and Dr. Anuradha Chakraborti

Down-regulation of miR-21 biogenesis by estrogen action contributes to osteoclastic apoptosis.
Toshifumi Sugatani and Keith A. Hruska

MicroRNA 26b encoded by the intron of small CTD phosphatase (SCP) 1 has an antagonistic effect on its host gene.
Naoya Sowa, Takahiro Horie, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Minako Kinoshita, Rieko Takanabe-Mori, Hiromichi Wada, Akira Shimatsu, Koji Hasegawa, Takeshi Kimura and Koh Ono

Deep sequencing reveals predominant expression of miR-21 amongst the small non-coding RNAs in retinal microvascular endothelial cells.
Jasenka Guduric-Fuchs, Anna O'Connor, Angela Cullen, Laura Harwood, Reinhold J. Medina, Christina L. O'Neill, Alan W. Stitt, Tim M. Curtis and David A. Simpson


Epigenetic Control


Figure 1. miRNAs as oncogenes and tumor suppressors.

See Redis et al., “Non-coding RNAs as theranostics in human cancers”. J. Cell. Biochem. 113: 1451–1459, 2012.


Stem Cell Biology

Published: February 2014

Stem cell investigation is providing valuable insight into parameters of fundamental biological control that includes regulatory mechanisms operative in development, differentiation and tissue renewal. There are emerging applications for regenerative medicine and cell-based therapy that have the potential to significantly enhance our capabilities to treat diseases that have been refractory to conventional therapy. We have assembled a series of research and review articles on stem cell research that have recently been published in the Journal of Cellular Biochemistry. We selected articles that provide state-of-the-art information on the advances in stem cell investigation with balanced presentations of concepts and experimental approaches. With the expanded understanding of regulatory mechanisms that govern stem cell proliferation, pluripotency, and lineage commitment, we can anticipate advanced capabilities for mechanistically defining biological processes directly translatable to clinical applications.

Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells
Wang, Y., Chen, T., Yan, H., Qi, H., Deng, C., Ye, T., Zhou, S. and Li, F.-R.

TGF-β/BMP signaling pathway is involved in cerium-promoted osteogenic differentiation of mesenchymal stem cells
Liu, D.-D., Zhang, J.-C., Zhang, Q., Wang, S.-X. and Yang, M.-S.

Stem cells as promising therapeutic options for neurological disorders
Yoo, J., Kim, H.-S. and Hwang, D.-Y.

Stem cell-based therapy for Huntington's disease
Maucksch, C., Vazey, E. M., Gordon, R. J. and Connor, B.

Neural stem cells—trends and advances
English, D., Sharma, N. K., Sharma, K. and Anand, A.

Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance
Ahmed, N., Abubaker, K., Findlay, J. and Quinn, M.

The effects of zoledronic acid in the bone and vasculature support of hematopoietic stem cell niches
Soki, F. N., Li, X., Berry, J., Koh, A., Sinder, B. P., Qian, X., Kozloff, K. M., Taichman, R. S. and McCauley, L. K.


Editor's Choice

Published: May 2013

Journal of Cellular Biochemistry is pleased to announce their Virtual Issue on recent hot topics.

Our understanding of regulatory mechanisms that control gene expression is rapidly expanding. Novel dimensions of genetic and epigenetic mechanisms are emerging that contribute to fidelity of biological processes and properties that are linked to the onset and progression of tumorogenesis. We are featuring six recent Journal of Cellular Biochemistry papers that advance our capability to characterize genetic and epigenetic mechanisms which mediate proliferation and differentiation and are compromised in cancer. Emphasis is on properties of pleuriopent stem cells and tumor cells. The importance of non-coating RNA¹s in epigenetic regulation is emphasized as well as the influence of architecturally organized regulatory machinery on the control of gene expression.



Piwis and piwi-interacting RNAs in the epigenetics of cancer
Sara Siddiqi and Igor Matushansky


Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation
Siobhan K. O'Brien, Kendall L. Knight and Tariq M. Rana


Prospects for pluripotent stem cell therapies: Into the clinic and back to the bench
Laura Grabel


Non-coding RNAs as theranostics in human cancers
Roxana S. Redis, Ioana Berindan-Neagoe, Victor I. Pop and George A. Calin


Shaping the nucleus: Factors and forces
Alison D. Walters, Ananth Bommakanti and Orna Cohen-Fix


Epigenetic modulation by TFII-I during embryonic stem cell differentiation
Dashzeveg Bayarsaihan, Aleksandr V. Makeyev and Badam Enkhmandakh


MicroRNA-mediated somatic cell reprogramming
Chih-Hao Kuo and Shao-Yao Ying Art


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