Journal of Cellular Physiology

Cover image for Journal of Cellular Physiology

Edited By: Gary S. Stein, Harvey M. Florman and Constance E. Brinckerhoff

Impact Factor: 3.839

ISI Journal Citation Reports © Ranking: 2014: 15/83 (Physiology); 71/184 (Cell Biology)

Online ISSN: 1097-4652

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Top Cited Articles 2014

Franchina, T., Amodeo, V., Bronte, G., Savio, G., Ricciardi, G. R.R., Picciotto, M., Russo, A., Giordano, A. and Adamo, V.
Circulating miR-22, miR-24 and miR-34a as Novel Predictive Biomarkers to Pemetrexed-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer
Journal of Cellular Physiology 2014, vol. 229, p. 97

Basile, D. P. and Yoder, M. C.
Circulating and Tissue Resident Endothelial Progenitor Cells
Journal of Cellular Physiology 2014, vol. 229, p. 10

Anderson, M., Roshanravan, H., Khine, J. and Dryer, S. E.
Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species
Journal of Cellular Physiology 2014, vol. 229, p. 434

Zhang, Y.-Y., Yue, J., Che, H., Sun, H.-Y., Tse, H.-F. and Li, G.-R
BKCa and hEag1 Channels Regulate Cell Proliferation and Differentiation in Human Bone Marrow-Derived Mesenchymal Stem Cells
Journal of Cellular Physiology 2014, vol. 229, p. 202

Basile, D. P. and Yoder, M. C.
Circulating and Tissue Resident Endothelial Progenitor Cells
Journal of Cellular Physiology 2014, vol. 229, p. 10

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JCP Spotlight Article

CD44 Influences Fibroblast Behaviors Via Modulation of Cell-Cell and Cell-Matrix Interactions, Affecting Survivin and Hippo Pathways

Masayuki Tsuneki and Joseph A. Madri

CD44 has been studied in a wide variety of cell types, in a diverse array of cell behaviors and in a diverse range of signaling pathways. We now document a role for CD44 in mediating fibroblast behaviors via regulation of N-cadherin, extracellular matrix expression, Survivin and the Hippo pathway. Here we report our findings on the roles of CD44 in modulating proliferation, apoptosis, migration and invasion of murine wild-type (WT-FB) and CD44 knockout dermal fibroblasts (CD44KO-FB). As we have documented in microvascular endothelial cells lacking CD44, we found persistent increased proliferation, reduced activation of cleaved caspase 3, increased initial attachment, but decreased strength of cell attachment in high cell density, post confluent CD44KO-FB cultures. Additionally, we found that siRNA knock-down of CD44 mimicked the behaviors of CD44KO-FB, restoring the decreases in N-cadherin, collagen type I, fibronectin, Survivin, nuclear fractions of YAP and phospho-YAP and decreased levels of cleaved caspase 3 to the levels observed in CD44KO-FB. Interestingly, plating CD44KO-FB on collagen type I or fibronectin resulted in significant decreases in secondary proliferation rates compared to plating cells on non-coated dishes, consistent with increased cell adhesion compared to their effects on WT-FB. Lastly, siRNA knockdown of CD44 in WT-FB resulted in increased fibroblast migration compared to WT-FB, albeit at reduced rates compared to CD44KO-FB. These results are consistent with CD44's pivotal role in modulating several diverse behaviors important for adhesion, proliferation, apoptosis, migration and invasion during development, growth, repair, maintenance and regression of a wide variety of mesenchymal tissues.

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