Journal of Cellular Physiology

Cover image for Vol. 230 Issue 6

Edited By: Gary S. Stein, Harvey M. Florman and Constance E. Brinckerhoff

Impact Factor: 3.874

ISI Journal Citation Reports © Ranking: 2013: 14/81 (Physiology); 77/185 (Cell Biology)

Online ISSN: 1097-4652

Recently Published Issues

See all

Top Cited Articles 2014

Franchina, T., Amodeo, V., Bronte, G., Savio, G., Ricciardi, G. R.R., Picciotto, M., Russo, A., Giordano, A. and Adamo, V.
Circulating miR-22, miR-24 and miR-34a as Novel Predictive Biomarkers to Pemetrexed-Based Chemotherapy in Advanced Non-Small Cell Lung Cancer
Journal of Cellular Physiology 2014, vol. 229, p. 97

Basile, D. P. and Yoder, M. C.
Circulating and Tissue Resident Endothelial Progenitor Cells
Journal of Cellular Physiology 2014, vol. 229, p. 10

Anderson, M., Roshanravan, H., Khine, J. and Dryer, S. E.
Angiotensin II Activation of TRPC6 Channels in Rat Podocytes Requires Generation of Reactive Oxygen Species
Journal of Cellular Physiology 2014, vol. 229, p. 434

Zhang, Y.-Y., Yue, J., Che, H., Sun, H.-Y., Tse, H.-F. and Li, G.-R
BKCa and hEag1 Channels Regulate Cell Proliferation and Differentiation in Human Bone Marrow-Derived Mesenchymal Stem Cells
Journal of Cellular Physiology 2014, vol. 229, p. 202

Basile, D. P. and Yoder, M. C.
Circulating and Tissue Resident Endothelial Progenitor Cells
Journal of Cellular Physiology 2014, vol. 229, p. 10

See More Here

SEO Tips for Authors

SEO Author

JCP Spotlight Article

GRP78 is a universal therapeutic target for human disease.
Laurence Booth, Jane L. Roberts, Devin R. Cash, Seyedmehrad Tavallai, Sophonie Jean, Abigail Fidanza, Tanya Cruz-Luna, Paul Siembiba, Kelly A. Cycon, Cynthia N. Cornelissen and Paul Dent
Volume 230, Issue 7

A drug combination of OSU-03012 (AR-12) and Phosphodiesterase 5 Inhibitors (Viagra, Cialis) decreased virus infectivity via reduced viral receptor expression on the surface of target cells and prevented virus replication in infected cells via down-regulation of the protein chaperone GRP78. Data were obtained using Chikungunya, Influenza, Mumps, Measles, Rubella, RSV, CMV, Coxsackie virus and serotype 5 Adenovirus. AR-12/Viagra was also able to reduce expression of viral receptors for Ebola, Marburg, Hepatitis A / B / C and Lassa Fever viruses. The chaperone GRP78 / Dna K is conserved throughout evolution down to prokaryotes. AR-12 reduced expression of the proteins Dna K and Rec A in bacteria and induced cell death in pan-antibiotic resistant forms of E. coli and N. gonorrhoeae. AR-12 restored antibiotic sensitivity in resistant E. coli and N. gonorrhoeae. In brain cancer stem cells, AR12/Viagra killing was reduced by GRP78 over-expression but not by HSP90 over-expression. Collectively these findings indicate that Dna K and bacterial phosphodiesterases may represent novel antibiotic targets and that targeting of GRP78 / Dna K is of significant therapeutic value for both cancer therapy and for the treatment of multiple bacterial and viral infections. A provisional patent has been filed by Virginia Commonwealth University on this technology, and Dr. Dent will donate any monies he receives from this discovery to Great Ormond Street Hospital for Sick Children, London, England.

Freely Available for A Limited Time

Read

PHYSIOLOGY EcThis content will be freely available to all through September 17th. Don't miss out.

New Content

Subscribe to RSS headline updates from: Journal of Cellular Physiology
Powered by FeedBurner

SEARCH

SEARCH BY CITATION