Journal of Cellular Physiology

Cover image for Vol. 232 Issue 8

Edited By: Gary S. Stein, Harvey M. Florman and Constance E. Brinckerhoff

Impact Factor: 4.155

ISI Journal Citation Reports © Ranking: 2015: 12/83 (Physiology); 63/187 (Cell Biology)

Online ISSN: 1097-4652

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Methylated of genes behaving as potential biomarkers in evaluating malignant degree of glioblastoma

Wan-Shun Wen, Sheng-Li Hu, Zhibing Ai, Lin Mou, Jing-Min Lu and Sen Li

Abnormal methylation genes usually act as oncogenes or anti-oncogenes in the occurrence and development of tumors, indicating their potential role as biomarkers in the evaluation of malignant tumors. A total of 668, 412, 470 and 620 genes relevant with the methylation or demethylation were found to be associated with the malignant degree, Grade1,Grade2,Grade3,Grade4 of glioblastoma. Of note, CCL11 and LCN11 were found to be significantly related to the progression of GBM.

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