Journal of Cellular Physiology

Cover image for Vol. 231 Issue 9

Edited By: Gary S. Stein, Harvey M. Florman and Constance E. Brinckerhoff

Impact Factor: 3.839

ISI Journal Citation Reports © Ranking: 2014: 15/83 (Physiology); 71/184 (Cell Biology)

Online ISSN: 1097-4652

Author Guidelines

Introducing Accepted Articles publication for Journal of Cellular Physiology
Papers accepted for publication in JCP will now publish online as Accepted Articles within 5-7 days after acceptance and indexed by PubMed within 48 hours of release into the public domain. The paper will be published in its final format in print and this version will also replace the Accepted Article (unedited) version online. Please note that Accepted Article publication makes it incumbent upon the authors to submit their revisions with little or no alterations necessary. The author is responsible for all aspects of manuscript preparation and extensive changes to the manuscript cannot be undertaken by the Editor or during the production process.

Introducing Graphical Abstracts for Journal of Cellular Physiology
During the submission process authors will be asked for a graphical abstract to appear in the online Table of Contents listing for each published issue. This graphical abstract will consist of one of the article’s figures and an abbreviated abstract. These images are meant to attract reader interest and may encapsulate a key result or conclusion of the article. The abbreviated abstract text should be a brief non-technical summary of 2-3 sentences highlighting the key findings of the paper. It should complement, not repeat, the title of the article.

NIH Public Access Mandate
NOTE TO NIH GRANTEES: Pursuant to the April 2008 NIH mandate, Wiley-Blackwell has been posting the accepted version of contributions authored by NIH grant-holders to PubMed Central upon acceptance with a 12-month embargo.  Feedback over the last few years indicates a strong preference by authors to self-submit their contributions to PubMed Central directly. This allows NIH grant-holders complete control and oversight of the process.  In an effort to meet the needs of NIH-funded authors more effectively, Wiley-Blackwell is piloting author direct deposit for a small group of journals, including Journal of Cellular Physiology.

Effective July 10, 2012, Journal of Cellular Physiology authors who are NIH grant-holders have the following options:

Option A—Self Submit:  NIH-funded authors deposit the accepted version of their contributions directly to PubMed Central via the NIHMS system, setting the release delay to 12 months after publication. The “accepted version” includes the text, image, and supporting information files that were accepted by the editor. 

Option B – Pay for Immediate Open Access:  Wiley-Blackwell continues to offer OnlineOpen for Journal of Cellular Physiology. With OnlineOpen the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made available to non-subscribers immediately upon publication as well as deposited in the funding agency's preferred archive.  With OnlineOpen, Wiley-Blackwell would deposit your final published version to PubMed Central on your behalf and provide open access to the contribution on the journal’s website immediately upon publication. The fee for this option is $3,000.  Click here to order OnlineOpen.

If you have any questions or comments about these options, please contact Tiffany McKerahan at

All NIH authors should also be aware that after their accepted manuscript files have been posted to the NIH Manuscript Submission system, the corresponding author will receive an e-mail request from PubMed Central asking them to approve the upload for display on the PubMed Central system. Authors will need to provide approval to complete the process of deposition to PubMed Central.  This is a requirement of their grant/affiliation. 

Author Guidelines

Online Submission and Peer Review
Supplementary Online Material

Journal of Cellular Physiology

The Journal of Cellular Physiology publishes reports of high biological significance in areas of eukaryotic cell biology and physiology, focusing on those articles that adopt a molecular mechanistic approach to investigate cell structure and function. There is appreciation for the application of cellular, biochemical, molecular and in vivo genetic approaches, as well as the power of genomics and proteomics. In particular, the Journal actively encourages submission of high-interest papers investigating the genetic and epigenetic regulation of growth and differentiation by growth factors, cytokines and their cognate receptors as well as signal transduction pathways and conditions that influence the expression, integration and activities of these physiological mediators. Similarly, the Journal actively encourages submission of manuscripts exploring the regulation of growth and differentiation by cell adhesion molecules as well as the interplay between these processes and those induced by growth factors and cytokines. Studies on the genes and processes that regulate cell cycle progression and phase transition in eukaryotic cells, and the mechanisms that determine whether cells enter quiescence, proliferate or undergo apoptosis are also welcomed. Submission of papers that address contributions of the extracellular matrix to cellular phenotypes and physiological control as well as regulatory mechanisms governing fertilization, embryogenesis, gametogenesis, differentiation, development, stem cell biology and dynamic parameters of cell motility are encouraged. Finally, the investigation of basic changes that differentiate cancer cells from normal cells including studies on the properties and functions of oncogenes and tumor suppressor genes will remain as one of the major interests of the Journal.



The journal to which you are submitting your manuscript employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works.


The Journal of Cellular Physiology abides by Wiley's ethics guidelines and by the guidelines produced by the Committee on Publication Ethics. Please contact the editorial office with any questions on ethics or authorship.

The Journal of Cellular Physiology welcomes submitted manuscripts online at: . Online submission offers receipt of manuscript on the day of submission, expedited transfer to reviewers; status review by authors of online submissions; and e-mail notification of manuscript disposition received by the corresponding author on the day of the decision. Failure to reformat the manuscript in accordance with the author guidelines after multiple attempts will result in rejection of the submission.

Please note our new on-line submission format requirements. Incorrectly formatted manuscripts will be returned for resubmission.

GUIDELINES FOR COVER SUBMISSIONS: If you would like to send suggestions for artwork related to your manuscript to be considered to appear on the cover of the journal, please follow these general guidelines.

TEXT: Submit in .doc, .docx, or .rtf format only.

Do not embed figures or tables in the document. These must be uploaded as separate files.

TABLES: Submit in .doc, .docx, or .rtf format only. Each table should be uploaded as a separate file.

FIGURES: Submit in .tif or .eps format only. Each figure should be uploaded as a separate file. Do not submit figures in .jpg, .gif, .bmp, .ppt, .doc, .docx, or .xls format.

VIDEOS: Files should not be uploaded to the submission site, they should be sent by DropBox or File Transfer to production in the event that the article is eventually accepted.


· Please submit your manuscript online at .

· Click on "Check for Existing Account" . If you do not already have an account, click on"Create an Account" Be sure to enter Keywords .

· Follow instructions carefully. Please review that your submission has uploaded correctly before clicking on the "Submit" button.

· On completion of a successful submission, a confirmation screen with manuscript will appear and you will receive an e-mail confirming that the manuscript has been received by the journal. If you do not receive an email acknowledgment that your paper has been received, it means that your submission is incomplete. Contact for the editorial office or for ScholarOne Support if you require assistance.

Routine decisions will be provided in 4-6 weeks.

The authors must provide a primary email address that is associated with their given institution, or an active account that is monitored on a daily basis.

It is suggested that original unprocessed images should be submitted as supplementary files alongside images that have been processed.

Write in clear, concise English. The author is responsible for all aspects of manuscript preparation. Extensive changes to the manuscript will not be undertaken by the Editor or during the production process.

Non-English Speaking Authors. Authors in non-English speaking countries are requested to find persons who are fully conversant and competent in English writing and also familiar with medical terminology to edit manuscripts before they are submitted to the editor.

Wiley English Language Editing Services are available. The English Language Editing Service can help to ensure your paper is clearly written in standard, scientific English language appropriate to your discipline.

Visit the following site to learn about the options:

Using the Wiley English Language Editing Service does not guarantee that your paper will be accepted for publication.

How to handle authorship disputes: a guide for new researchers

By Tim Albert and Liz Wager

This document aims to help new researchers prevent and resolve authorship problems.
In particular it provides:

  • suggestions for good authorship practice that should reduce the incidence of such dilemmas,
  • advice on what to do when authorship problems do arise, and
  • a glossary of key concepts in authorship, with some reading lists and websites for those who wish to take this further.

Download PDF (64 kb)


When submitting a Rapid Communications Paper or a Review Article, please be sure to provide a cover letter that highlights this submission category. Please also designate in bold letters on the TITLE PAGE of the manuscript that it is a "Review" or a "Rapid Communications" submission.

Publication of Reviews and Mini-Reviews is accelerated. We welcome the opportunity to assist you to facilitate the preparation of your manuscript.

(1) What is the word limit for a Review? 10,000-12,000

(2) What is the word limit for a Mini-Review? 5,000-7,000

(3) Does the word limit include references? No

(4) Is there a limit on figures and tables? No

(5) Is there a reference limit? 100

(6) What is the word limit for the abstract? 250

The Perspectives section of the Journal of Cellular Physiology provides a forum for editorial commentary on timely issues that are within the scope of the Journal. Perspectives are restricted to 600 words with a maximum of 15 references and there are no figures or tables. The Abstract is confined to 100 words.

When submitting a Perspectives article online at our website: please include a Cover Letter that indicates same. It will be reviewed and processed accordingly.

From the Bench section of Journal of Cellular Physiology presents novel techniques and strategies. Each article concisely evaluates opportunities, strengths and limitations of experimental approaches that can expand insight into biology and pathology. Specific protocols are encouraged for inclusion as supplementary material. “From the Bench” articles will be available on PubMed.

The objective is to provide access to novel experimental strategies. “From the Bench” articles should be developed to enhance awareness of capabilities to resolve complexities of cell structure and function. Submission of articles that focus on development of technologies and instrumentation to enable exploration of regulatory mechanisms previously unapproachable are encouraged. Coverage of topics can include (but not limited) to:

-Cell-based and animal models for in vitro and in vivo validation of molecular components to regulatory networks that mediate cell cycle control, proliferation, phenotype, cell fate and responsiveness to physiological cues.

-Breakthroughs in imaging and experimental approaches to discriminate subtleties in common or total control contributing to resolve and complexities in biological processes that include development, lineage commitment, tissue remodeling, apoptosis, pluripotency transformation and tumorigenesis.

-Capabilities to acquire, configure and integrate data from rapidly evolving, high throughput genomic and proteomic screens.

-Bioinformatic strategies that support dimensions for biological control that link to the prevention, early detection and treatment of human disease.

Abstract: In 150 words describe capability of the method to provide novel insights into biological/biomedical control. Indicate applications for resolving fundamental regulatory mechanisms and/or clinically relevant questions. Present validations for the approach and summarize strengths as well as potential limitations.

Presentation: Begin each “From the Bench” with an introduction that provides the background for the method. Focus on the unique capabilities of the approach to address compelling biological/biomedical questions. Highlight opportunities to increase resolution and/or scope of structural as well as regulatory parameters that can be evaluated.

The method should then be presented with schematic illustrations and described with emphasis on instrumentation, resolution, experimental applications and complexities with alternative strategies. Validation should be presented and examples of data that can be anticipated are encouraged. Considerations of options to accommodate specialized requirements is informative.

“From the Bench” should not exceed 2500–3500 words. To maximize the utility of “From the Bench” it is important for descriptions of technology to be accessible to a broad audience.

Experimental protocols and specifications for instrumentation and reagents are valuable; but, in general, will be presented as supplemental material that is available online. “From the Bench” articles will be invited by the Journal of Cellular Physiology editors to cover emerging methods and strategies. However, authors are encouraged to submit unsolicited manuscripts or letters of inquiry to the editorial office.

Manuscripts for consideration by Journal of Cellular Physiology must be submitted solely to this journal and may not have been published in another publication of any type, professional or lay. The journal will not be responsible for loss of manuscripts at any time. Upon acceptance of a manuscript for publication, the corresponding author will be required to sign an agreement transferring copyright to the publisher. All such manuscripts become the property of the publisher and no material published in Journal of Cellular Physiology may be reproduced or published elsewhere without written permission from the publisher, who reserves copyright. Any possible conflict of interest, financial or otherwise, related to the submitted work must be clearly indicated in the manuscript, or in a cover letter accompanying the submission.

TITLE PAGE must contain:

· Complete article title 16 words or less

· Names and affiliations of all authors. Author's name(s) must carry superscript number(s). The corresponding author should be indicated by an asterisk.

· Institution(s) at which the work was performed with city and state. Affiliations must be listed at the departmental level. Each distinct affiliation should be listed as a separate entity, with a superscript number that links it to the individual author(s).

· Complete name, address, telephone number, fax number, and e-mail address of corresponding author.

· A running head of not more than 45 characters, including spaces.

· Bullet point Keywords (in bold).

· Total number of text figures and tables.

· All grant information should be provided in the following format: Contract grant sponsor:_____; Contract grant number:_____.

ABSTRACT: This should summarize the major findings and conclusions in the paper in not more than 250 words compressed into a single paragraph. The abstract will serve in lieu of a concluding summary and should be intelligible without reference to the rest of the paper.

TEXT: The text should follow the format: Abstract, Introduction, Materials and Methods, Results, Discussion, and Acknowledgments. Use subheadings and paragraph titles whenever possible. Define unusual abbreviations at first mention. Units of measure must be written in metric units.

For all studies involving the use of animals, the following conditions should be met:
a. All research animals must have been obtained and used in compliance with federal, state, and local laws and institutional regulations.
b. The Journal recommends that animals be maintained in accordance with the guidelines of the NIH (Guide for the Care and Use of Laboratory Animals, 1996), the European Communities Council, or equivalent regulatory guidelines in other countries. Any veterinary accreditation should be noted in the manuscript.
c. The author must have received permission from their institutional Animal Care and Use Committee, and the manuscript must indicate that such approval was received."


Wiley’s Journal Styles Are In EndNote

EndNote is a software product that we recommend to our journal authors to help simplify and streamline the research process. Using EndNote’s bibliographic management tools, you can search bibliographic databases, build and organize your reference collection, and then instantly output your bibliography in any Wiley journal style.

Download Reference Style for this Journal: If you already use EndNote, you can download the reference style for this journal online.

The citation style is Author-Year. If you are not familiar with EndNote and would like to download in another file format, then you may select the Harvard reference system. More information can be found online at Wiley Author Services.

Reference should be made only to articles that are published or in press. Unpublished results and personal communications should be cited parenthetically in the text. Authors are responsible for the accuracy of the references. References in the text to the literature should be made by author's name followed by year of publication:
. . . studies by Briggs (1993) reveal . . .
. . . studies by Briggs and Porter (1994) reveal . . .
. . . an earlier report (Briggs, 1994) . . .
. . . earlier reports (Briggs, 1993; Briggs and Porter, 1993, 1994) . . .

If there are more than two authors, use the first author and et al. The final list must be alphabetized and include only references cited in the text. Each entry must include the names of all authors, complete title of the work cited, and inclusive page numbers. Abbreviations of journal titles should follow those used in Index Medicus.


Journal Article:
Wright CD, Mülsh A, Busse R, Newman P. 1998. Generation of nitric oxide by human neutrophils. Biochem Biophys Res Commun 29:813-820.

Book Cited:
Whistler P, Wilks S. 1989. Methods in carbohydrate chemistry. New York: Academic Press. 244 p.

Book Chapter Cited:
Smith A. 1990. Transport of antigens: mechanisms and biological and regulatory consequences. In: Ariano MA, editor. Biosynthesis of heme and chlorophylls. New York:Wiley-Liss. p 230-278.

LEGENDS: Each illustration must have a legend and be numbered consecutively with arabic numerals. Abbreviations pertaining to the labeling of figures should be listed once, alphabetically, and placed before the first figure containing these abbreviations.

TABLES: Each table must be typed on a separate page, be numbered in order of appearance with arabic numerals, have a title, and be keyed into the text.

ILLUSTRATIONS: Use illustrations sparingly; they should not duplicate information already made clear in the text. A charge will be made for color. All color figures will be reproduced in full color in the online edition of the journal at no cost to authors. Authors are requested to pay the cost of reproducing color figures in print ($500 per figure). Authors are encouraged to submit color illustrations that highlight the text and convey essential scientific information. For best reproduction, bright, clear colors should be used. Dark colors against a dark background do not reproduce well; please place your color images on a white background wherever possible. Please contact JCP Production at for further information. All graphics and lettering must be legible after reduction in size. Illustrations must be numbered in order of appearance with arabic numerals and keyed into the text.

Research Integrity


Research misconduct is defined in the US Federal Policy on Research Misconduct:

"Research misconduct is defined as fabrication, falsification, or plagiarism in proposing, performing, or reviewing research, or in reporting research results".

· Cases of suspected misconduct are handled following established processes, for example, those presented in the COPE Flowcharts.

· Cases are handled at a speed that allows appropriate care to be taken.

· Investigations may lead to retractions, expressions of concern, or other sanctions.

Whistle blowing

Allegations of suspected misconduct that have specific, detailed evidence to support the claim are investigated, whether they are raised anonymously or by named "whistle-blowers."

Fabrication, falsification, and image manipulation

Changes to images can create misleading results when research data are collected as images. Thus inappropriate image manipulation is one form of fabrication or falsification that journals can identify.

It may, however, be legitimate and even necessary to edit images. For example, the selective enlargement of part of an artwork may be needed to reveal features that would not otherwise be visible, and editing of video data may be needed to protect the privacy of participants.

The six CLIP (Clinical and Laboratory Images in Publications) principles present guidance for documenting and publishing clinical and laboratory images. The Office of Research Integrity provides forensic tools for quick examination of scientific images and samples.

· Specific features within an image should not be enhanced, obscured, removed, moved, or introduced.

· Original unprocessed images must be provided by authors should any indication of enhancement be identified. We suggest that original unprocessed images should be submitted alongside any images that have been processed.

· Adjustments to brightness or contrast are only acceptable if they apply equally across the entire image and are applied equally to controls, and as long as they do not obscure, eliminate, or misrepresent any information present in the information originally captured.

· Excessive manipulations, such as processing to emphasize one region in the image at the expense of others, are inappropriate, as is emphasizing experimental data relative to the control.

· Nonlinear adjustments or deleting portions of a recording must be disclosed in a figure legend.

· Constructing figures from different gels, fields, exposures, and experimental series is discouraged. When this is necessary the component parts of composite images should be indicated by dividing lines clearly demarcated in the figure, and described in the legend.

These recommendations are based on guidance developed at the Journal of Cell Biology and Rossner and Yamada's discussion. Cromey discusses image manipulation in "Avoiding twisted pixels: ethical guidelines for the appropriate use and manipulation of scientific digital images."

Other Misconduct

· Plagiarism

· Duplicate and redundant publication

· Text recycling

· Duplicate submission

· Duplicate information published in translations


Wiley has published advice about sanctions in which we refer to the COPE guidelines. Journals may, for example, publish a retraction, may inform the author's institution, and may refuse for a time to consider future work from the authors.

If your paper is accepted, the author identified as the formal corresponding author for the paper will receive an email prompting them to login into Author Services; where via the Wiley Author Licensing Service (WALS) they will be able to complete the license agreement on behalf of all authors on the paper.
For authors signing the copyright transfer agreement:
If the OnlineOpen option is not selected the corresponding author will be presented with the copyright transfer agreement (CTA) to sign. The terms and conditions of the CTA can be previewed in the samples associated with the Copyright FAQs below:
CTA Terms and Conditions
For authors choosing OnlineOpen:
If the OnlineOpen option is selected the corresponding author will have a choice of the following Creative Commons License Open Access Agreements (OAA):
Creative Commons Attribution License OAA
Creative Commons Attribution Non-Commercial License OAA
Creative Commons Attribution Non-Commercial -NoDerivs License OAA
To preview the terms and conditions of these open access agreements please visit the Copyright FAQs hosted on Wiley Author Services and visit
If you select the OnlineOpen option and your research is funded by The Wellcome Trust and members of the Research Councils UK (RCUK) you will be given the opportunity to publish your article under a CC-BY license supporting you in complying with Wellcome Trust and Research Councils UK requirements. For more information on this policy and the Journal’s compliant self-archiving policy please visit:

Conflict of Interest Disclosure
Wiley-Blackwell requires that all authors disclose any potential sources of conflict of interest. Any interest or relationship, financial or otherwise, that might be perceived as influencing an author’s objectivity is considered a potential source of conflict of interest. These must be disclosed when directly relevant or indirectly related to the work that the authors describe in their manuscript. Potential sources of conflict of interest include but are not limited to patent or stock ownership, membership of a company board of directors, membership of an advisory board or committee for a company, and consultancy for or receipt of speaker’s fees from a company. The existence of a conflict of interest does not preclude publication in this journal.

If the authors have no conflict of interest to declare, they must also state this at submission.It is the responsibility of the corresponding author to review this policy with all authors and to collectively list in the cover letter to the Editor-in-Chief, in the manuscript (under the Acknowledgments section), and in the online submission system ALL pertinent commercial and other relationships.

Supplementary Online Material: Supplementary material for posting in the electronic version of the journal must be submitted at the time of online peer review. This material will not appear in the print edition. There are no file type restrictions, but the more universal the file type, the more accessible it will be to the community: PDFs, tiff or eps files, and Excel spreadsheets are examples of common file types. For questions regarding file suitability, please contact JCP Production (

Reprints: Reprints may be purchased at

All manuscripts submitted to the Journal of Cellular Physiology must be submitted solely to this journal, may not have been published in any part or form in another publication of any type, professional or lay, and become the property of the publisher. Any material reproduced or adapted from any other published or unpublished source must be duly acknowledged. It is the author�s responsibility to obtain permission to reproduce copyrighted material. Upon acceptance of a manuscript for publication, the author will be requested to sign an agreement transferring copyright to the publisher, who reserves copyright. No published material may be reproduced or published elsewhere without the written permission of the publisher and the author. The journal will not be responsible for the loss of manuscripts at any time. All statements in, or omissions from, published manuscripts are the responsibility of the author, who will assist the editor and publisher by reviewing proofs before publication. Reprint order forms will be sent with the proofs. It is important to order, initially, a sufficient quantity of reprints since the cost is substantially higher if ordered after publication.

Self-Archiving Policy: Authors of articles published in Wiley journals are permitted to self-archive the submitted (preprint) version of the article at any time, and may self-archive the accepted (peer-reviewed) version after an embargo period. Please visit our Self-Archiving Policy page for details or refer to your Copyright Transfer Agreement.

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