Journal of Cellular Physiology

Cover image for Vol. 231 Issue 11

Edited By: Gary S. Stein, Harvey M. Florman and Constance E. Brinckerhoff

Impact Factor: 4.155

ISI Journal Citation Reports © Ranking: 2015: 12/83 (Physiology); 63/187 (Cell Biology)

Online ISSN: 1097-4652

Virtual Issues

Epigenetic Control

Published: July 2014

There have been spectacular advances in mechanistically defining parameters of epigenetic control. From a regulatory perspective, post-replication modifications of DNA, post-transcriptional modifications of histone proteins, the regulatory contributions of non-coding RNAs and mitotic gene bookmarking are becoming increasingly recognized as pivotal for biological control.

Beyond biological relevance, the central role of epigenetic regulation in human disease is minimally understood. It is difficult to overstate the growing awareness of epigenetic regulation in a broad spectrum of biological processes that are obligatory for development, differentiation, proliferation, tissue remodeling and physiological control of homeostasis. There is growing recognition for the epigenetic contribution to the initiation and progression of human diseases that include cancer, neurological diseases, metabolic syndromes and skeletal disorders.

In addition to the value of epigenetic parameters of control as biomarkers, there is increasing evidence for epigenetic-based druggable targets that are selective and with minimal off-target consequences.

We have assembled a series of research articles and reviews that were recently published in the Journal of Cellular Physiology on epigenetic control. These articles illustrate the challenges and opportunities of epigenetic control for establishing novel dimensions to biological regulation and for transformational advances in the diagnosis and treatment of human disease.

Altered Histone Mark Deposition and DNA Methylation at Homeobox Genes in Human Oral Squamous Cell Carcinoma.
Katarzyna M. Marcinkiewicz and Lorraine J. Gudas

Pathway Modulations and Epigenetic Alterations in Ovarian Tumorbiogenesis.
Sabita N. Saldanha and Trygve O. Tollefsbol

SWI/SNF chromatin remodeling enzymes are associated with cardiac hypertrophy in a genetic rat model of hypertension.
Aanchal Mehrotra, Bina Joe and Ivana L. de la Serna

Targeting deregulated epigenetic control in cancer.
Sayyed K. Zaidi, Andre J. Van Wijnen, Jane B. Lian, Janet L. Stein and Gary S. Stein

Regulation of human Cripto-1 expression by nuclear receptors and DNA promoter methylation in human embryonal and breast cancer cells.
Caterina Bianco, Nadia P. Castro, Christina Baraty, Kelly Rollman, Natalie Held, Maria Cristina Rangel, Hideaki Karasawa, Monica Gonzales, Luigi Strizzi and David S. Salomon

Chromatin dynamics in living cells: Identification of oscillatory motion.
Artem Pliss, Kishore S. Malyavantham, Sambit Bhattacharya and Ronald Berezney

Rules of engagement for base excision repair in chromatin.
Ian D. Odell, Susan S. Wallace and David S. Pederson

Epigenetic Control

Figure 1. Combinatorial epigenetic signatures for a comprehensive personalized therapy. Four major epigenetic mechanisms are depicted that regulate gene expression in a rapid and reversible manner. Extensive studies have shown interplay and tight integration between these mechanisms (shown as solid, dark green lines). For example, DNA methylation and histone modifications often function in concert to regulate gene expression both synergistically and in an opposing fashion. It is becoming evident that these two epigenetic mechanisms also function together with non-coding RNA-mediated silencing of gene expression; X-chromosome inactivation is a well-understood example of integrative regulation of gene expression by epigenetic means. Mitotic bookmarking of genes is a recently described epigenetic mechanisms and its integration with three well-established mechanisms is only being explored (shown as dotted, light green lines). A comprehensive understanding of these epigenetic mechanisms and their interplay will yield an epigenetic landscape of normal cells and how it is altered in cancer, leading to the development of viable personalized therapy.

See Zaidi et al., “Targeting deregulated epigenetic control in cancer”. J. Cell. Physiol. 228: 2103–2108, 2013.

Stem Cell Biology

Published: February 2014

Advances in stem cell biology are providing a platform for mechanistic insight into biological control in areas that have been historically confined to insightful, but descriptive observations. Equally important, lessons learned from understanding the rules that govern pluripotency and lineage commitment are paving the way for breakthroughs in regenerative medicine and cell-based therapies. We have assembled a series of research articles and reviews on stem cell biology that were recently published in the Journal of Cellular Physiology. These articles encapsulate fundamental dimensions of control in stem cells that are beginning to be understood from the perspectives of genetic and epigenetic control as well as within the context of regulatable plasticity.

Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells
Guo, C.-W., Kawakatsu, M., Idemitsu, M., Urata, Y., Goto, S., Ono, Y., Hamano, K. and Li, T.-S.

Carcinoma-associated fibroblasts: Non-neoplastic tumour-promoting mesenchymal cells
Polanska, U. M. and Orimo, A.

Genetic and molecular characterization of the human Osteosarcoma 3AB-OS cancer stem cell line: A possible model for studying osteosarcoma origin and stemness
Di Fiore, R., Fanale, D., Drago-Ferrante, R., Chiaradonna, F., Giuliano, M., De Blasio, A., Amodeo, V., Corsini, L. R., Bazan, V., Tesoriere, G., Vento, R. and Russo, A.

Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: Perspectives from stem cell biology and molecular medicine
Wu, L., Cai, X., Zhang, S., Karperien, M. and Lin, Y.

An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells
Kim, J.-M., Choi, J. S., Kim, Y.-H., Jin, S. H., Lim, S., Jang, H.-J., Kim, K.-T., Ryu, S. H. and Suh, P.-G.

Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells
Choi, S.-C., Choi, J.-H., Park, C.-Y., Ahn, C.-M., Hong, S.-J. and Lim, D.-S.

The abbreviated pluripotent cell cycle
Kapinas, K., Grandy, R., Ghule, P., Medina, R., Becker, K., Pardee, A., Zaidi, S. K., Lian, J., Stein, J., van Wijnen, A. and Stein, G.

Editor's Choice

Published: May 2013

Journal of Cellular Physiology is pleased to announce their Virtual Issue on recent hot topics.

Evidence for pivotal roles of genetic and epigenetic control of gene expression is rapidly accruing. The importance of genetic and epigenetic mechanisms is expanding understanding of biological processes. Applications for therapeutically targeting cancer cells are emerging. These strategies are featured in six recent papers that were recently published in Journal of Cellular Physiology. Aberrant regulation in transformed and tumor cells is presented and the power of experimental strategies including systems of biology and genomic approaches are presented to illustrate the necessity for defining regulatory networks that integrate parameters of control which are operative in biology and compromised in pathology.

Systems biology provides new insights into the molecular mechanisms that control the fate of embryonic stem cells hematopoietic stem cell fate
Sunil K. Mallanna and Angie Rizzino

Phosphorylation of histone H1 by P-TEFb is a necessary step in skeletal muscle differentiation
Siobhan K. O'Brien, Kendall L. Knight and Tariq M. Rana

Integrating post-transcriptional regulation into the embryonic stem cell gene regulatory network
Paul A. Cassar and William L. Stanford

Metaboloepigenetics: Interrelationships between energy metabolism and epigenetic control of gene expression
Dallas R. Donohoe and Scott J.Bultman

The abbreviated pluripotent cell cycle
Kristina Kapinas, Rodrigo Grandy, Prachi Ghule, Ricardo Medina, Klaus Becker, Arthur Pardee, Sayyed K. Zaidi, Jane Lian, Janet Stein, Andre van Wijnen and Gary Stein

FOXP3 expression in tumor cells and implications for cancer progression
Tiziana Triulzi, Elda Tagliabue, Andrea Balsari and Patrizia Casalini