Cover image for Vol. 65 Issue 9

Edited By: Bruce R. Ransom and Helmut Kettenmann

Impact Factor: 6.2

ISI Journal Citation Reports © Ranking: 2016: 23/258 (Neurosciences)

Online ISSN: 1098-1136

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  1. Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development

    Matthew L. O'Sullivan, Vanessa M. Puñal, Patrick C. Kerstein, Joseph A. Brzezinski IV, Tom Glaser, Kevin M. Wright and Jeremy N. Kay

    Version of Record online: 19 JUL 2017 | DOI: 10.1002/glia.23189

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    Main Points

    • Retinal astrocytes are required to pattern developing vasculature.
    • The astrocyte pattern, in turn, depends on directional cues from retinal ganglion cell (RGC) axons that guide astrocyte migration and control their fine-scale patterning.
  2. Cooperative interaction of hepatocyte growth factor and neuregulin regulates Schwann cell migration and proliferation through Grb2-associated binder-2 in peripheral nerve repair

    Yoon Kyoung Shin, So Young Jang, Seoug Hoon Yun, Yun Young Choi, Byeol-A Yoon, Young Rae Jo, So Young Park, Min Gyoung Pak, Joo In Park and Hwan Tae Park

    Version of Record online: 19 JUL 2017 | DOI: 10.1002/glia.23195

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    Main Points

    • Injury-induced plastic changes of Schwann cells are essential for peripheral nerve repair.
    • Grb2-associated binder-2 mediates neuregulin and hepatocyte growth factor signaling to promote Schwann cell migration and proliferation during nerve repair.
  3. Effects of cholesterol transport inhibitor U18666A on APP metabolism in rat primary astrocytes

    Hongyan Yang, Yanlin Wang and Satyabrata Kar

    Version of Record online: 19 JUL 2017 | DOI: 10.1002/glia.23191

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    Main Points

    • U18666A-induced cholesterol sequestration within the EL system and extracellular cholesterol can enhance APP levels/processing in astrocytes.
    • Altered cholesterol levels/distribution in astrocytes can influence AD by regulating APP metabolism.
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    Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease

    Yasmina Manso, Philip R. Holland, Akihiro Kitamura, Stefan Szymkowiak, Jessica Duncombe, Edel Hennessy, James L. Searcy, Martina Marangoni, Andrew D Randall, Jon T. Brown, Barry W. McColl and Karen Horsburgh

    Version of Record online: 19 JUL 2017 | DOI: 10.1002/glia.23190

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    Main Points

    • Cerebral hypoperfusion impairs the functional integrity of white matter, which is significantly associated with axon-glial integrity and microglia proliferation
    • Minocycline dampens microgliosis restoring white matter function
  5. Suppressed oligodendrocyte steroidogenesis in multiple sclerosis: Implications for regulation of neuroinflammation

    Roobina Boghozian, Brienne A. McKenzie, Leina B. Saito, Ninad Mehta, William G. Branton, JianQiang Lu, Glen B. Baker, Farshid Noorbakhsh and Christopher Power

    Version of Record online: 14 JUL 2017 | DOI: 10.1002/glia.23179

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    Main Points

    • This study represents the first report of CYP17A1 protein expression in adult human brain.
    • Suppression of CYP17A1 expression was associated with reduced DHEA production, induced by neuroinflammation in white matter from MS patients and animals with EAE compared to controls.
    • DHEA-S treatment improved disease outcomes in EAE.