Cover image for Vol. 66 Issue 3

Edited By: Bruce R. Ransom and Helmut Kettenmann

Impact Factor: 6.2

ISI Journal Citation Reports © Ranking: 2016: 25/259 (Neurosciences)

Online ISSN: 1098-1136

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2016 Impact Factor:
GLIA is pleased to announce its new Impact Factor is 6.2!

2017 Release of Journal Citation Reports®. Source: Thomson Reuters 2016 Citation Data

Recently Published Articles

  1. The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain

    Sigrid Ottestad-Hansen, Qiu Xiang Hu, Virgine Veronique Follin-Arbelet, Eduard Bentea, Hideyo Sato, Ann Massie, Yun Zhou and Niels Christian Danbolt

    Version of Record online: 19 JAN 2018 | DOI: 10.1002/glia.23294

    Thumbnail image of graphical abstract

    Main Points

    • Immunohistochemistry (validated using knockout mice) reveals a selective, but variable xCT expression in astrocytes and strong labeling in the leptomeninges, along blood vessels and in some tanycytes.
    • The hippocampal xCT/EAAT3 ratio is close to one.
  2. Ephrin-A1-EphA4 signaling negatively regulates myelination in the central nervous system

    Mette Harboe, Julie Torvund-Jensen, Kasper Kjaer-Sorensen and Lisbeth S. Laursen

    Version of Record online: 19 JAN 2018 | DOI: 10.1002/glia.23293

    Thumbnail image of graphical abstract

    Main Points

    • Axonal Ephrin-A1 inhibits myelination
    • EphA4 activation inhibits myelination
    • Inhibition of signaling through EphA4, RhoA or Rock enhances myelination by increasing the number of myelin sheahts generated pr cell.
  3. Astrocytic glutamine synthetase is expressed in the neuronal somatic layers and down-regulated proportionally to neuronal loss in the human epileptic hippocampus

    Ismini E. Papageorgiou, Nektarios A. Valous, Bernd Lahrmann, Hana Janova, Zin-Juan Klaft, Arend Koch, Ulf C. Schneider, Peter Vajkoczy, Frank L. Heppner, Niels Grabe, Niels Halama, Uwe Heinemann and Oliver Kann

    Version of Record online: 19 JAN 2018 | DOI: 10.1002/glia.23292

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    Main Points

    • Glutamine synthetase in human cortex and hippocampus is expressed by astrocytes in the neuronal somatic layer
    • Downregulation of glutamine synthetase in hippocampal sclerosis is proportional to the neuronal loss
  4. Cocaine and HIV-1 Tat disrupt cholesterol homeostasis in astrocytes: Implications for HIV-associated neurocognitive disorders in cocaine user patients

    Bianca Cotto, Kalimuthusamy Natarajaseenivasan, Kimberly Ferrero, Leroy Wesley, Matthew Sayre and Dianne Langford

    Version of Record online: 13 JAN 2018 | DOI: 10.1002/glia.23291

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    Main Points

    • Liver X receptors (LXRs) are the master regulators of cholesterol homeostasis in the central nervous system.
    • HIV-1 infection and cocaine abuse disrupt cholesterol homeostasis.
    • Cocaine and HIV-1 Tat disrupt astrocyte LXR signaling leading to decreased bioavailability of cholesterol.
  5. Cell therapy for spinal cord injury with olfactory ensheathing glia cells (OECs)

    Rosa M. Gómez, Magdy Y. Sánchez, Maria Portela-Lomba, Kemel Ghotme, George E. Barreto, Javier Sierra and M. Teresa Moreno-Flores

    Version of Record online: 13 JAN 2018 | DOI: 10.1002/glia.23282