CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously
Tsuyoshi Hattori, Minoru Kaji, Hiroshi Ishii, Roboon Jureepon, Mika Takarada-Iemata, Hieu Minh Ta, Thuong Manh Le, Ayumu Konno, Hirokazu Hirai, Yoshitake Shiraishi, Noriyuki Ozaki, Yasuhiko Yamamoto, Hiroshi Okamoto, Shigeru Yokoyama, Haruhiro Higashida, Yasuko Kitao and Osamu Hori
Version of Record online: 13 MAR 2017 | DOI: 10.1002/glia.23139
- CD38-deficient mice exhibit impaired development of astrocytes and oligodendrocytes.
- CD38 increases astrocytic Cx43 expression by reducing NAD+ level.
- Cx43 promotes astrocytic maturation and OL differentiation.