Drug Development Research

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Anti-Oligomannose Antibodies as Potential Serum Biomarkers of Aggressive Prostate Cancer

Denong Wang, Laila Dafik1, Rosalie Nolley, Wei Huang, Russell D. Wolfinger, Lai-Xi Wang, Donna M. Peehl

Prostate cancer (PCa) is the most common noncutaneous malignancy in men. Based on autopsy studies, a significant number of American men in their 30s already have cancer in their prostates; this frequency rises to about 80% for men in their 70s. Despite such a high incidence of PCa, only 8% of men in the United States in their lifetime present with clinically significant disease that affects their quality of life [Stamey et al., 1993], and only 3% of all men in the United States die of PCa [Ries, 1994]. No other human cancer possesses such an enormous disparity between the very high incidence of malignancy microscopically and the relatively low death rate. Read on

Read Special Issue: Biomarkers in Drug Development and Companion Diagnostics

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