Synapse

Cover image for Vol. 69 Issue 5

Edited By: Peter Jenner and Henrique von Gersdorff

Impact Factor: 2.428

ISI Journal Citation Reports © Ranking: 2013: 155/252 (Neurosciences)

Online ISSN: 1098-2396

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Editor's Choice

The articles below have been specially selected by our editors to highlight to the Synapse community. Read more

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Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans
Aniket D. Joshi, Sandra M. Sanabria-Bohórquez, Guy Bormans, Michel Koole, Jan De Hoon, Anne Van Hecken, Marleen Depre, Inge De Lepeleire, Koen Van Laere, Cyrille Sur and Terence G. Hamill

Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11C]ABP688 PET imaging
William B. Mathews, Hiroto Kuwabara, Kirstie Stansfield, Heather Valentine, Mohab Alexander, Anil Kumar, John Hilton, Robert F. Dannals, Dean F. Wong and Fabrizio Gasparini

Adolescent bisphenol-A exposure decreases dendritic spine density: Role of sex and age
Rachel E. Bowman, Victoria Luine, Hameda Khandaker, Joseph J. Villafane and Maya Frankfurt

Prefrontal cortex, hippocampus, and basolateral amygdala plasticity in a rat model of autism spectrum
Nuvia Sosa-Díaz, Maria Elena Bringas, Marco Atzori and Gonzalo Flores

News & Special Features

SYNAPSE SPECIAL ISSUES

The Super-resolution Revolution in Neuroscience

Conventional light microscopy is limited in spatial resolution by the wavelength of light and the point spread function of the microscope. This diffraction limit is about 200 nm to 250 nm. Over the past 15 years several research groups have realized that it is possible to improve the resolution of biological structures by tagging biological molecules with fluorescent molecules. These super-resolution microscopy techniques are revolutionizing our ability to visualize synaptic and neuronal structures. Extremely small biological structures like calcium channels, scaffolding proteins and synaptic vesicles are now being visualized by the techniques of PALM (PhotoActivated Localization Microscopy), STORM (Stochastic Optical Reconstruction Microscopy) and STED (Stimulated Emission Depletion Microscopy). In fact, the 2014 Nobel Prize for Chemistry was awarded to the inventors and developers of these super-resolution microscopy techniques.

In this special issue of Synapse, The Super-resolution Revolution in Neuroscience, we review these new techniques and discuss their potential to reveal synaptic structure and function with unprecedented resolution.

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The editors of Synapse also invite your submissions for publication in the following future special issues:

The Precise Preservation of Spike Timing in Auditory Pathways: A focused issue on the synaptic and cellular specializations that allow auditory circuits to compute time differences with submillisecond accuracy

Lipids and Synaptic Vesicle Recycling at Active Zones: A focused issue on the role of specialized membrane lipids in synaptic vesicle exocytosis and endocytosis at active zones.

We welcome Original Research Articles, Short Communications representing data on research projects which have progressed to a point where the preliminary observations should be disseminated, and Review Articles covering timely topics in the field.

New Editors of Synapse

Peter Jenner

Editor Peter Jenner

Peter Jenner is Emeritus Professor of Pharmacology at King’s College in London. He is a specialist in neurological and psychiatric diseases and in particular, the biochemistry and pharmacology of their underlying causes and treatments through the use of in vitro experimentation and in vivo modelling. Peter has a passion for translational research and possesses expertise in the major neurotransmitter networks in brain and the relationship to drug action, drug addiction and to imaging of receptor systems.

Henrique von Gersdorff

Editor Henrique von Gersdorff

Henrique von Gersdorff earned a Ph.D. in Physics from the University of Minnesota and a Ph.D. in Neurobiology from Stony Brook University in New York. He held postdoctoral fellowships at Stony Brook University and the Max-Planck Institute for Biophysical Chemistry (Department of Membrane Biophysics, Göttingen). He is a senior scientist at the Vollum Institute in Oregon Health and Sciences University (Portland, Oregon). He also holds a faculty appointment in the Cell and Developmental Biology department of OHSU. His major research interests are in synaptic physiology, short-term and long-term plasticity, sensory biophysics, ion channel modulation, and calcium dynamics in nerve terminals.

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