Synapse

Cover image for Vol. 69 Issue 8

Edited By: Peter Jenner and Henrique von Gersdorff

Impact Factor: 2.127

ISI Journal Citation Reports © Ranking: 2014: 170/252 (Neurosciences)

Online ISSN: 1098-2396

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Editor's Choice

The articles below have been specially selected by our editors to highlight to the Synapse community. Read more

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Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans
Aniket D. Joshi, Sandra M. Sanabria-Bohórquez, Guy Bormans, Michel Koole, Jan De Hoon, Anne Van Hecken, Marleen Depre, Inge De Lepeleire, Koen Van Laere, Cyrille Sur and Terence G. Hamill

Dose-dependent, saturable occupancy of the metabotropic glutamate subtype 5 receptor by fenobam as measured with [11C]ABP688 PET imaging
William B. Mathews, Hiroto Kuwabara, Kirstie Stansfield, Heather Valentine, Mohab Alexander, Anil Kumar, John Hilton, Robert F. Dannals, Dean F. Wong and Fabrizio Gasparini

Adolescent bisphenol-A exposure decreases dendritic spine density: Role of sex and age
Rachel E. Bowman, Victoria Luine, Hameda Khandaker, Joseph J. Villafane and Maya Frankfurt

Prefrontal cortex, hippocampus, and basolateral amygdala plasticity in a rat model of autism spectrum
Nuvia Sosa-Díaz, Maria Elena Bringas, Marco Atzori and Gonzalo Flores

News & Special Features

SYNAPSE SPECIAL ISSUES

The Super-resolution Revolution in Neuroscience

Conventional light microscopy is limited in spatial resolution by the wavelength of light and the point spread function of the microscope. This diffraction limit is about 200 nm to 250 nm. Over the past 15 years several research groups have realized that it is possible to improve the resolution of biological structures by tagging biological molecules with fluorescent molecules. These super-resolution microscopy techniques are revolutionizing our ability to visualize synaptic and neuronal structures. Extremely small biological structures like calcium channels, scaffolding proteins and synaptic vesicles are now being visualized by the techniques of PALM (PhotoActivated Localization Microscopy), STORM (Stochastic Optical Reconstruction Microscopy) and STED (Stimulated Emission Depletion Microscopy). In fact, the 2014 Nobel Prize for Chemistry was awarded to the inventors and developers of these super-resolution microscopy techniques.

In this special issue of Synapse, The Super-resolution Revolution in Neuroscience, we review these new techniques and discuss their potential to reveal synaptic structure and function with unprecedented resolution.

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The editors of Synapse also invite your submissions for publication in the following future special issues:

The Precise Preservation of Spike Timing in Auditory Pathways: A focused issue on the synaptic and cellular specializations that allow auditory circuits to compute time differences with submillisecond accuracy

Lipids and Synaptic Vesicle Recycling at Active Zones: A focused issue on the role of specialized membrane lipids in synaptic vesicle exocytosis and endocytosis at active zones.

We welcome Original Research Articles, Short Communications representing data on research projects which have progressed to a point where the preliminary observations should be disseminated, and Review Articles covering timely topics in the field.

New Associate Editor for Synapse

Synapse is pleased to welcome Erwan Bezard as a new Associate Editor

Editor Erwan Bezard

Erwan Bezard is the Director of the Institute of Neurodegenerative Diseases at University of Bordeaux, which features preclinical and clinical researchers working towards development of therapeutic solutions. He has authored or co-authored over 198 professional publications, most of which are on Parkinson's disease and related disorders. Listed in the Top 1% of the most cited neuroscientists, he is known for his work (i) on the compensatory mechanisms that mask the progression of Parkinson's disease, (ii) on the pathophysiology of levodopa-induced dyskinesia and (iii) on the mechanisms of neurodegeneration in synucleopathies. His current research interests include the study of the levodopa-induced dyskinesia, the intimate mechanisms of cell death in Parkinson’s disease, the modelling of disease progression and the development of new strategies to alleviate symptoms and/or to slow disease progression.

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