Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants
Steven G. Grinnell, Michael Ansonoff, Gina F. Marrone, Zhigang Lu, Ankita Narayan, Jin Xu, Grace Rossi, Susruta Majumdar, Ying-Xian Pan, Daniel L. Bassoni, John Pintar and Gavril Pasternak
Accepted manuscript online: 25 MAY 2016 10:55AM EST | DOI: 10.1002/syn.21914
The mu opioid receptor gene Oprm1 undergoes alternatively splicing to generate several sets of splice variants. Traditional 7TM MOR-1 variants mediate morphine actions. The current study shows that buprenorphine produces analgesia through a combination of 7TM and 6TM splice variants.