Synapse

Cover image for Vol. 70 Issue 8

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Henrique von Gersdorff

Impact Factor: 2.026

ISI Journal Citation Reports © Ranking: 2015: 176/256 (Neurosciences)

Online ISSN: 1098-2396

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  1. 1 - 5
  1. Research Articles

    1. Differential regulation of spontaneous and evoked inhibitory synaptic transmission in somatosensory cortex by retinoic acid

      Ada Yee and Lu Chen

      Accepted manuscript online: 27 JUN 2016 12:21PM EST | DOI: 10.1002/syn.21921

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      Graphical Abstract

      In addition to its classic roles in brain development, retinoic acid (RA) has recently been shown to regulate excitatory and inhibitory transmission in the adult brain. Here, the authors show that in layer 2/3 (L2/3) of the somatosensory cortex (S1), acute RA induces increases in spontaneous but not action-potential evoked transmission, and that this requires retinoic acid receptor (RARα) both in presynaptic PV-positive interneurons and postsynaptic pyramidal (PN) neurons.

    2. Estimating the effect of endogenous dopamine on baseline [11C]-(+)-PHNO binding in the human brain

      Fernando Caravaggio, Lawrence S. Kegeles, Alan A. Wilson, Gary Remington, Carol Borlido, David C. Mamo and Ariel Graff-Guerrero

      Accepted manuscript online: 24 JUN 2016 10:20PM EST | DOI: 10.1002/syn.21920

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      We estimate the sensitivity of the agonist radioligand [11C]-(+)-PHNO for quantifying endogenous dopamine levels at D2/3 receptors in the living human brain. As proof of concept, we use [11C]-(+)-PHNO to estimate the in vivo dissociation constant (Kd) for dopamine at D2/3. These results are in accordance with in vitro findings.

    3. Calcium channel blockade attenuates abnormal synaptic transmission in the dentate gyrus elicited by entorhinal amyloidopathy

      Hamid Gholami Pourbadie, Nima Naderi, Mahyar Janahmadi, Nasrin Mehranfard and Fereshteh Motamedi

      Accepted manuscript online: 30 MAY 2016 10:00AM EST | DOI: 10.1002/syn.21915

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      Using whole cell patch clamp, the authors show that entorhinal amyloidopathy triggers a decreased excitatory transmission and paired pulse facilitation in the DG, leading to a prominent activity of inhibitory circuits and increased inhibition of granule cells which may contribute to the development of AD-related neurological deficits in AD. Treatment by calcium channel blockers (CCBs) could preserve normal synaptic transmission against Aβ toxicity. The entorhinal and DG granular cells both send excitatory collateral to inhibitory hilar cells which in turn inhibits DG granule cells by GABA transmission.

    4. Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants

      Steven G. Grinnell, Michael Ansonoff, Gina F. Marrone, Zhigang Lu, Ankita Narayan, Jin Xu, Grace Rossi, Susruta Majumdar, Ying-Xian Pan, Daniel L. Bassoni, John Pintar and Gavril Pasternak

      Accepted manuscript online: 25 MAY 2016 10:55AM EST | DOI: 10.1002/syn.21914

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      The mu opioid receptor gene Oprm1 undergoes alternatively splicing to generate several sets of splice variants. Traditional 7TM MOR-1 variants mediate morphine actions. The current study shows that buprenorphine produces analgesia through a combination of 7TM and 6TM splice variants.

    5. Resistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus

      F. Coune, B. Silvestre de Ferron, M. C. González-Marín, J. Antol, M. Naassila and O. Pierrefiche

      Accepted manuscript online: 22 FEB 2016 03:47AM EST | DOI: 10.1002/syn.21899

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      Only resistant mice to ethanol locomotor sensitization showed an abolition of hippocampus LTD, accompanied with an upregulation of GluN2A subunit of the NMDA receptor.

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