Synapse

Cover image for Vol. 68 Issue 11

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Peter Jenner and Henrique von Gersdorff

Impact Factor: 2.428

ISI Journal Citation Reports © Ranking: 2013: 155/251 (Neurosciences)

Online ISSN: 1098-2396

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  1. 1 - 6
  1. Short Communication

    1. Detection of monoamine oxidase A in brain of living rats with [18F]fluoroethyl-harmol PET

      Paul Cumming, Dirk Skaper, Torsten Kuwert, Simone Maschauer and Olaf Prante

      Accepted manuscript online: 17 SEP 2014 03:05AM EST | DOI: 10.1002/syn.21785

      Thumbnail image of graphical abstract

      The efficient radiosynthesis for the MAO-A ligand [18F]fluoroethyl-harmol is reported. Initial PET examinations reveal the ligand to be retained throughout rat brain during 90 minutes, whereas pretreatment with pargyline results in substantially increased washout, from which binding potentials in the range of 1.4 to 2.1 can be calculated.

  2. Short Communications

    1. Differential effects of NMDA receptor antagonism on spine density

      Rebecca M. Ruddy, Yuxiao Chen, Marija Milenkovic and Amy J. Ramsey

      Accepted manuscript online: 12 SEP 2014 11:54AM EST | DOI: 10.1002/syn.21784

      Thumbnail image of graphical abstract

      Differential effects of NMDA receptor antagonism on spine density

      The authors demonstrate that different NMDAR antagonists (ketamine and MK-801) have varying effects on spine density depending on dose, drug regimen and brain region. While acute ketamine treatment increases cortical spine density in mice, subchronic exposure to either drug reduces spine density in both the cortex and striatum.

  3. Research Articles

    1. Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans

      Aniket D. Joshi, Sandra M Sanabria-Bohórquez, Guy Bormans, Michel Koole, Jan de Hoon, Anne Van Hecken, Marleen Depre, Inge De Lepeleire, Koen Van Laere, Cyrille Sur and Terence G. Hamill

      Accepted manuscript online: 5 SEP 2014 11:31AM EST | DOI: 10.1002/syn.21782

    2. Assessment of glutamine synthetase activity by [13N]ammonia uptake in living rat brain

      Sotaro Momosaki, Miwa Ito, Misato Tonomura and Kohji Abe

      Accepted manuscript online: 5 SEP 2014 04:39AM EST | DOI: 10.1002/syn.21781

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      Changes of [13N]ammonia uptake induced by intra-striatal microinjection of 30 nmol MSO to rat detected by a small animal PET system. [13N]Ammonia uptake dose-dependently decreased with MSO injection, indicating that [13N]ammonia PET might enable measurement of glutamine synthetase activity in the living brain.

    3. Effects of hypoxic preconditioning on synaptic ultrastructure in mice

      Yi Liu, Zhishan Sun, Shufeng Sun, Yunxia Duan, Jingfei Shi, Zhifeng Qi, Ran Meng, Yongxin Sun, Xianwei Zeng, Dehua Chui and Xunming Ji

      Accepted manuscript online: 25 AUG 2014 09:01AM EST | DOI: 10.1002/syn.21777

    4. Reduced gene expression levels of Munc13-1 and additional components of the presynaptic exocytosis machinery upon conditional targeting of Vglut2 in the adolescent mouse

      Aparna Rajagopalan, Nadine Schweizer, Karin Nordenankar, Sultana Nilufar Jahan, Lina Emilsson and Åsa Wallén-Mackenzie

      Accepted manuscript online: 19 AUG 2014 03:37AM EST | DOI: 10.1002/syn.21776

      Thumbnail image of graphical abstract

      Using global microarray analysis and RT-PCR we found down-regulation of several genes encoding components of the presynaptic exocytosis machinery as an effect of targeted deletion of Vglut2 in selected forebrain areas.

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