Synapse

Cover image for Vol. 71 Issue 6

Accepted Articles (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Edited By: Henrique von Gersdorff

Impact Factor: 2.026

ISI Journal Citation Reports © Ranking: 2015: 176/256 (Neurosciences)

Online ISSN: 1098-2396

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  1. Research Articles

    1. Role of allopregnanolone biosynthesis in acute stress-induced anxiety-like behaviors in mice

      Kazumi Yoshizawa, Ayano Okumura, Kozue Nakashima, Tomoyo Sato and Tatsuya Higashi

      Accepted manuscript online: 13 APR 2017 11:44AM EST | DOI: 10.1002/syn.21978

      Thumbnail image of graphical abstract

      Finasteride, which is a 5α-reductase inhibitor, pretreated immobilization-stressed mice decreased the % of time spent in open arms of EPM test. In contrast, alfaxalone, the ALLO mimetic drug, increased the % of time spent in open arms of EPM test in finasteride (10mg/kg)-pretreated immobilization-stressed mice. Therefore, ALLO biosynthesis may contribute to stress resistance.

    2. U18666A, an Activator of Sterol Regulatory Element Binding Protein (SREBP) Pathway Modulates Presynaptic Dopaminergic Phenotype of SH-SY5Y Neuroblastoma Cells

      Mathieu Schmitt, Benjamin Dehay, Erwan Bezard and F. Javier Garcia-Ladona

      Accepted manuscript online: 13 APR 2017 11:44AM EST | DOI: 10.1002/syn.21980

      Thumbnail image of graphical abstract

      Using an activator of SREBP (sterol regulatory element-binding protein), the authors show that the SREBP transcriptional activation reinforces the dopaminergic phenotype of the SH-SY5Y neuroblastoma cells. This dopaminergic differentiation may lead to the restoration of the presynaptic dopamine markers and may contribute to neuroprotection of dopaminergic neurons afforded by statins.

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