Reversibly light-responsive biodegradable poly(carbonate)s micelles constructed via CuAAC reaction
Ding Hu, Hua Peng, Yile Niu, Yefei Li, Yingchun Xia, Ling Li, Jingwen He, Xiangyu Liu, Xinnian Xia, Yanbing Lu and Weijian Xu
Article first published online: 26 DEC 2014 | DOI: 10.1002/pola.27499
A facile method for the construction of light-responsive poly(carbonate)s PEG113-b-PMPCn-SP was developed via introducing spiropyran chromophore into the side chain of the hydrophobic poly(carbonate)s block via copper catalyzed azide-alkyne cycloaddition reaction. Under alternative UV and visible light irradiation, the amphiphile carried on a reversible micelle transition in water due to the photoisomerization between spiropyran (SP) and merocyanine form. The light-controlled release and re-encapsulation behaviors of coumarin 102-loaded micelles were further investigated by fluorescence spectroscopy. All results showed that PEG113-b-PMPC25-SP obtained in this study has potential application in drug delivery systems.