European Journal of Inorganic Chemistry

Cover image for Vol. 2017 Issue 3

Early View (Online Version of Record published before inclusion in an issue)

Editor: Karen Hindson, Deputy Editor: Preeti Vashi

Impact Factor: 2.686

ISI Journal Citation Reports © Ranking: 2015: 12/46 (Chemistry Inorganic & Nuclear)

Online ISSN: 1099-0682

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemCatChem, Zeitschrift für anorganische und allgemeine Chemie

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  1. Microreviews

    1. DNA Intercalator Pt Complexes

      Platinum Intercalators of DNA as Anticancer Agents

      Benjamin J. Pages, K. Benjamin Garbutcheon-Singh and Janice R. Aldrich-Wright

      Version of Record online: 20 JAN 2017 | DOI: 10.1002/ejic.201601204

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      Polyaromatic platinum complexes (PPCs) capable of intercalating between DNA nucleobases have great chemotherapeutic potential. We provide an overview of PPCs that are known to intercalate with DNA and also exhibit potent activity against cancerous cells and tumours. In particular we focus upon PPCs of phenanthroline and various diamines, which display activity up to 100 times that of cisplatin.

  2. Full Papers

    1. Prussian Blue Analogues

      Ordered Mesoporous Silica Monoliths as a Versatile Platform for the Study of Magnetic and Photomagnetic Prussian Blue Analogue Nanoparticles

      Robinson Moulin, Emilie Delahaye, Amélie Bordage, Emiliano Fonda, Jean-Pierre Baltaze, Patricia Beaunier, Eric Rivière, Giulia Fornasieri and Anne Bleuzen

      Version of Record online: 17 JAN 2017 | DOI: 10.1002/ejic.201601196

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      The use of mesoporous silica as a matrix for the formation of nanoparticles of magnetic and photomagnetic coordination compounds enables the study of the properties of the compounds at the nanoscale owing to the versatility of the synthetic pathway.

    2. Photodynamic Anticancer Agents

      Cyclometalated IrIII Complexes as Mitochondria-Targeted Photodynamic Anticancer Agents

      Miao Ouyang, Leli Zeng, Kangqiang Qiu, Yu Chen, Liangnian Ji and Hui Chao

      Version of Record online: 16 JAN 2017 | DOI: 10.1002/ejic.201601129

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      A series of cyclometalated IrIII complexes based on 2,2′-biimidazole with different alkyl substituents were evaluated towards four cell lines as photodynamic therapy (PDT) agents. They exhibit satisfying PDT effects with high phototoxicity index (PI) values and high selectivity between normal cells and cancer cells. The photoinduced cell death follows a mitochondria-mediated apoptotic pathway.

    3. Cytotoxic Ti Complexes

      Cytotoxic Titanium(IV) Complexes of Salalen-Based Ligands

      Avia Tzubery and Edit Y. Tshuva

      Version of Record online: 10 JAN 2017 | DOI: 10.1002/ejic.201601200

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      Phenolatotitanium(IV) complexes with salalen (half salan and half salen) ligands of varying lability and structural aspects were studied. These complexes represent a new family of highly effective titanium-based anticancer agents. The leading complex combines high cytotoxicity with high hydrolytic stability and biological accessibility.

    4. Silver Complexes and Clusters

      Acylchalcogenourea Complexes of Silver(I)

      Maik Dörner, J. Mikko Rautiainen, Jörg Rust, Christian W. Lehmann and Fabian Mohr

      Version of Record online: 29 DEC 2016 | DOI: 10.1002/ejic.201601074

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      Acylthio- and acylselenoureas react with silver(I) oxide to form tetranuclear silver(I) compounds. These tetrasilver(I) species react with 4 or 8 equiv. of a phosphine to afford either dinuclear silver(I) phosphine complexes or tetrahedral silver diphosphine complexes. A tricoordinate silver N-heterocyclic carbene (NHC) derivative is also prepared.

    5. Tetranuclear Copper Aggregates

      Trapping of a Methanoato Bridge in µ-1,1,3,3 Mode for [Cu4] Aggregate Formation: Synthesis, Steric Control on Nuclearity, Antimicrobial Activity, and DNA-Interaction Properties

      Tufan Singha Mahapatra, Anupam Roy, Susmitnarayan Chaudhury, Swagata Dasgupta, Shankar Lal Shrivastava, Valerio Bertolasi and Debashis Ray

      Version of Record online: 29 DEC 2016 | DOI: 10.1002/ejic.201601092

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      The presence of an HCO2 bridging ligand within a [Cu4] aggregate enables versatile coordination behavior, antibacterial and antifungal propensity to various strains, and DNA-interacting capacity in partial intercalative mode.

    6. Halobismuthates

      2,6-Diisopropylanilinium Bromobismuthates

      Souvik Pandey, Anju Nair, Alex P. Andrews and Ajay Venugopal

      Version of Record online: 23 DEC 2016 | DOI: 10.1002/ejic.201601087

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      A systematic approach to obtain bromobismuthates with specific bismuth/halide ratios stabilised by a 2,6-diisopropylanilinium cation is presented.

    7. Corroles

      Synthesis and Characterization of Ruffled Phosphorus meso-Ester Corroles

      Di Gao, Cloé Azarias, Anthony D'Aléo, Michel Giorgi, Olivier Siri, Teodor Silviu Balaban, Denis Jacquemin and Gabriel Canard

      Version of Record online: 23 DEC 2016 | DOI: 10.1002/ejic.201601172

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      The preparation and characterization of fluorescent hexacoordinate phosphorus(V) 5,15-meso-ester corroles illustrate the strong electron-withdrawing character of 5,15-meso-ester groups. The ruffling of the macrocycle is observed in four X-ray structures and increases with the electron-accepting strength of the remaining 10-meso substituent.

    8. Americium Complexation

      An Insight into the Complexation of Trivalent Americium Vis-à-Vis Lanthanides with Bis(1,2,4-triazinyl)bipyridine Derivatives

      Arunasis Bhattacharyya, Manoj Mohapatra, Prasanta K. Mohapatra, Trilochan Gadly, Sunil K. Ghosh, Debashree Manna, Tapan K. Ghanty, Neetika Rawat and Bhupendra S. Tomar

      Version of Record online: 23 DEC 2016 | DOI: 10.1002/ejic.201600829

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      The experimentally observed higher complexation ability of two bis(1,2,4-triazinyl)bipyridine (BTBP) derivatives for Am3+ over Ln3+ is explained on the basis of higher metal–ligand orbital overlap and higher bond order in the Am3+ complex.

    9. Tuning SMM/nonSMM Behavior

      Fine-Tuning Ligand Fields with Schiff-Base Ligands in Dy2 Compounds

      Min Li, Haipeng Wu, Sheng Zhang, Lin Sun, Hongshan Ke, Qing Wei, Gang Xie, Sanping Chen and Shengli Gao

      Version of Record online: 23 DEC 2016 | DOI: 10.1002/ejic.201601188

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      Magnetic studies of the dinuclear Dy2 compound [Dy2(Hhms)2(NO3)4]·MeCN revealed slow relaxation of the magnetization at zero field and a thermal energy barrier Ueff = 72.1 K at Hdc = 1200 Oe. Comparing this and two other analogous Dy2 compounds, the fine-tuning of the ligand field is dominated by µ-O bridges and the conjugation in the backbone of the ligand, which affects the SMM/non-SMM behavior.

    10. Metalloid Clusters

      Metalloid Ge9R3 Clusters with Various Silyl Substituents: From Shielded to Open Cluster Cores

      Oleksandr Kysliak, Tanja Kunz and Andreas Schnepf

      Version of Record online: 23 DEC 2016 | DOI: 10.1002/ejic.201601134

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      Different metalloid clusters of the composition [Ge9R3] (R = silyl ligand) were synthesized from the Zintl anion Ge94–, whereby in the case of R = SiHtBu2 the sterically least protected soluble Ge9R3 cluster was obtained, which opens the door to novel reaction routes.

  3. Microreviews

    1. EPR Spectroscopy

      Electron Paramagnetic Resonance as a Tool for Studying the Mechanisms of Paramagnetic Anticancer Metallodrugs

      Kathleen E. Prosser and Charles J. Walsby

      Version of Record online: 21 DEC 2016 | DOI: 10.1002/ejic.201601142

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      Electron paramagnetic resonance spectroscopy (EPR) is a valuable technique for characterizing the ligand fields and oxidation states of metal complexes. This review highlights the application of EPR methods to determine the structures and mechanisms of a variety of paramagnetic metallotherapeutics.

  4. Full Papers

    1. Platinum(IV) Prodrugs

      Halogenated PtIV Complexes from N-Halosuccinimide Oxidation of PtII Antitumor Drugs: Synthesis, Mechanistic Investigation, and Cytotoxicity

      Zoufeng Xu, Cai Li, Zixuan Tong, Lili Ma, Man-Kit Tse and Guangyu Zhu

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/ejic.201601130

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      Halogenated PtIV anticancer prodrugs are obtained by oxidation of PtII drugs with N-halosuccinimides. A detailed mechanism of the reaction of N-bromosuccinimide with cisplatin in ethanol is revealed.

    2. Ru–Arene Complexes

      Arene–Ruthenium(II) Complexes with Bioactive ortho-Hydroxydibenzoylmethane Ligands: Synthesis, Structure, and Cytotoxicity

      Riccardo Pettinari, Agnese Petrini, Fabio Marchetti, Claudio Pettinari, Tina Riedel, Bruno Therrien and Paul J. Dyson

      Version of Record online: 19 DEC 2016 | DOI: 10.1002/ejic.201601164

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      Arene–RuII complexes of ortho-hydroxydibenzoylmethane show an intramolecular H bond in both the solid state and solution. They display good cytotoxicity in vitro against human ovarian carcinoma A2780 and even superior activity against A2780cisR cells.

    3. Molecular Switches

      Molecular Switching of Copper Complexes with Quaterpyridine

      Ariel Adamski, Małgorzata Osińska, Maciej Kubicki, Zbigniew Hnatejko, Giuseppe Consiglio and Violetta Patroniak

      Version of Record online: 14 DEC 2016 | DOI: 10.1002/ejic.201601148

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      Chemically and electrochemically induced interconversion between mononuclear copper(II) complexes bearing the ligand quaterpyridine and the respective dinuclear helicates of copper(I) provides a clear color change.

    4. Chiral Magnets

      Trinuclear Complexes Derived from R/S Schiff Bases – Chiral Single-Molecule Magnets

      Albert Escuer, Julia Mayans, Merce Font-Bardia, Lorenzo Di Bari and Marcin Górecki

      Version of Record online: 9 DEC 2016 | DOI: 10.1002/ejic.201601138

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      The employment of enantiomerically pure Schiff bases allows the synthesis of the R and S pairs of trinuclear chiral clusters. Two discrete triangular MnIII3 enantiomers with one µ3-Cl bridge exhibit single-molecule magnet (SMM) responses.

    5. Zn Finger Proteins

      Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3H1 or C4 Motifs

      Siming Yuan, Xin Ding, Yang Cui, Kaiju Wei, Yuchuan Zheng and Yangzhong Liu

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/ejic.201601140

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      Cisplatin selectively binds to ZFPs containing C4 or C3H motifs. MDM2-zf (C4) and PARP-1-zf2 (C3H) show a higher reactivity to cisplatin than Sp1-zf2 (C2H2). The platination of ZFPs causes the zinc release and structural perturbation of the proteins. The different reactivity of the various ZFPs may be correlated with the targeting of cisplatin in cells.

    6. Ruthenium–Arene Complexes

      Cationic Ru(η6-p-cymene) Complexes of 3-Hydroxy-4-pyr(id)ones – Lipophilic Triphenylphosphine as Co-Ligand Is Key to Highly Stable and Cytotoxic Anticancer Agents

      Shahida Parveen, Muhammad Hanif, Sanam Movassaghi, Matthew P. Sullivan, Mario Kubanik, Muhammad Ashraf Shaheen, Tilo Söhnel, Stephen M. F. Jamieson and Christian G. Hartinger

      Version of Record online: 2 DEC 2016 | DOI: 10.1002/ejic.201601163

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      Replacing the labile chlorido ligand in Ru(η6-p-cymene)[3-hydroxy-4(1H)-pyr(id)one]Cl complexes with triphenylphosphine or 1,3,5-triaza-7-phoshatricyclo[3.3.1.1]decane resulted in compounds with higher anticancer activity. The improved activity can be rationalized by higher stability in aqueous solution and in the presence of biomolecules.

  5. Communications

    1. Targeting Integrin Receptors

      Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells

      Eva M. Hahn, Natalia Estrada-Ortiz, Jiaying Han, Vera F. C. Ferreira, Tobias G. Kapp, João D. G. Correia, Angela Casini and Fritz E. Kühn

      Version of Record online: 2 DEC 2016 | DOI: 10.1002/ejic.201601094

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      Two terpyridine-based ruthenium(II) complexes are designed to be coupled to a cyclic peptide targeting integrin receptor αvβ3 to achieve models for targeted anticancer agents.

  6. Full Papers

    1. Photocytotoxicity

      Platinum(II) Complexes of Curcumin Showing Photocytotoxicity in Visible Light

      Koushambi Mitra, Srishti Gautam, Paturu Kondaiah and Akhil R. Chakravarty

      Version of Record online: 29 NOV 2016 | DOI: 10.1002/ejic.201601078

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      Platinum(II)–curcumin complexes having diammine or chelating amines as ligands show photocytotoxicity: in visible light the curcumin ligand dissociates, thereby generating platinum(II)–DNA crosslinking agents and curcumin as a phototoxin.

    2. Metals in Medicine

      Enhancing the Cytotoxic Activity of Anticancer PtIV Complexes by Introduction of Lonidamine as an Axial Ligand

      Yulia N. Nosova, Lidia S. Foteeva, Ilia V. Zenin, Timur I. Fetisov, Kirill I. Kirsanov, Marianna G. Yakubovskaya, Taisya A. Antonenko, Viktor A. Tafeenko, Leonid A. Aslanov, Anna A. Lobas, Mikhail V. Gorshkov, Markus Galanski, Bernhard K. Keppler, Andrei R. Timerbaev, Elena R. Milaeva and Alexey A. Nazarov

      Version of Record online: 23 NOV 2016 | DOI: 10.1002/ejic.201600857

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      A series of PtIV complexes with lonidamine as a ligand coordinated in axial position is reported. Lonidamine affects strongly the in vitro cytotoxic activity, lowering the IC50 values down to the nanomolar range.

  7. Microreviews

    1. Metal-Containing Pharmacophores

      Metal-Containing Pharmacophores in Molecularly Targeted Anticancer Therapies and Diagnostics

      Mu Yang and Ulrich Bierbach

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/ejic.201601149

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      Metal-containing pharmaceuticals have a long history of applications in cytotoxic chemotherapies. Treatment of malignant disease in the postgenomic era has long moved beyond the use of indiscriminate cell poisons. Inorganic elements are now beginning to play exciting new roles in the design of smarter, molecularly targeted therapeutic agents and diagnostics.

  8. Full Papers

    1. Photolabile Ru Prodrugs

      Photolabile Ruthenium(II)–Purine Complexes: Phototoxicity, DNA Binding, and Light-Triggered Drug Release

      Hazel Chan, Joy B. Ghrayche, Jianhua Wei and Anna K. Renfrew

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/ejic.201601137

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      Photolabile ruthenium complexes can cage a biologically active ligand and release it when irradiated with visible light. We present a series of complexes for light-activated delivery of the anticancer agent 6-mercaptopurine. Several complexes are able to release 6-mercaptopurine on irradiation with visible light and exhibit photoselective DNA binding or toxicity towards MCF-7 breast cancer cells.

    2. Drug–Dendrimer Conjugates

      Low-Generation Polyamidoamine Dendrimers as Drug Carriers for Platinum(IV) Complexes

      Nadine S. Sommerfeld, Michaela Hejl, Matthias H. M. Klose, Ekaterina Schreiber-Brynzak, Andrea Bileck, Samuel M. Meier, Christopher Gerner, Michael A. Jakupec, Markus Galanski and Bernhard K. Keppler

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/ejic.201601205

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      An unsymmetrically carboxylated platinum(IV) analogue of oxaliplatin is coupled to generation two (G-2) and four (G-4) polyamidoamine (PAMAM) dendrimers. The platinum–dendrimer complexes showed load- and size-dependent potency with IC50 values down to the low-nanomolar range, in contrast to the rather moderate activity of the free platinum(IV) compound.

  9. Microreviews

    1. Ru Anticancer Complexes

      Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

      Enzo Alessio

      Version of Record online: 28 SEP 2016 | DOI: 10.1002/ejic.201600986

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      Almost 30 years after the discovery of NAMI-A, and after two clinical phase studies have been accomplished, the time seems to be appropriate for drawing up a balance sheet. The undemonstrated misconceptions (or myths) that, over the years, have thrived around NAMI-A and other ruthenium drug candidates are also critically addressed in detail.

  10. Full Papers

    1. Photodynamic Therapy

      Evaluation of Perylene Bisimide-Based RuII and IrIII Complexes as Photosensitizers for Photodynamic Therapy

      Cristina Mari, Huaiyi Huang, Riccardo Rubbiani, Marcus Schulze, Frank Würthner, Hui Chao and Gilles Gasser

      Version of Record online: 16 AUG 2016 | DOI: 10.1002/ejic.201600516

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      The biological activity of a RuII polypyridyl complex 1 and an IrIII organometallic complex 2 on four cell lines is presented. Although the cytotoxicity of 1 did not improve significantly upon light irradiation, 2 reached nanomolar IC50 values on all the cell lines tested when activated with 420 nm light in low doses.

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