European Journal of Inorganic Chemistry

Cover image for European Journal of Inorganic Chemistry

Early View (Online Version of Record published before inclusion in an issue)

Editor: Karen Hindson, Deputy Editor: Preeti Vashi

Impact Factor: 2.686

ISI Journal Citation Reports © Ranking: 2015: 12/46 (Chemistry Inorganic & Nuclear)

Online ISSN: 1099-0682

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemCatChem, Zeitschrift für anorganische und allgemeine Chemie


  1. 1 - 40
  1. Full Papers

    1. Anticancer Complexes

      Synthesis, Crystal Structure, Cytotoxicity, and Mechanism of Action of ZnII, MnII, and FeIII Complexes with 6-Hydroxyloxoisoaporphine

      Qi-Pin Qin, Ting Meng, Zu-Zhuang Wei, Chuan-Hui Zhang, Yan-Cheng Liu, Hong Liang and Zhen-Feng Chen

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/ejic.201601030

      Thumbnail image of graphical abstract

      Complexes [Zn(L)2(H2O)] (1), [Mn(L)2(CH3OH)2] (2), and [Fe(L)2(CH3OH)Cl] (3) (H–L = 6-hydroxyloxoisoaporphine) were more selective for T-24 cells than for HL-7702 cells, induced T-24 cell arrest in the G1 and G2/M phases, and triggered cell apoptosis by a mitochondrial-dysfunction pathway.

  2. Cover Profile

    1. You have free access to this content
      Transition-Metal Complexes with (C–C)[RIGHTWARDS ARROW]M Agostic Interactions

      Benjamin G. Harvey and Richard D. Ernst

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/ejic.201700152

      Thumbnail image of graphical abstract

      C–C agostic interactions play a vital role in Ziegler–Natta and olefin metathesis catalysis, as well as C–C bond activation…

      Read more about the story behind the cover in the Cover Profile and about the research itself on page -- ff (DOI:10.1002/ejic.201600989).

  3. Cover Picture

    1. You have free access to this content
      Front Cover: Transition-Metal Complexes with (C–C)[RIGHTWARDS ARROW]M Agostic Interactions (Eur. J. Inorg. Chem. /2017)

      Benjamin G. Harvey and Richard D. Ernst

      Version of Record online: 21 FEB 2017 | DOI: 10.1002/ejic.201700151

      Thumbnail image of graphical abstract

      The cover picture shows at the top the first two recognized examples of C–C agostic interactions with a metal center. A stylized arrow demonstrates the progression from the recognition that C–C bonds could donate electron density to a metal center to the understanding that these interactions are present in intermediates of both the Ziegler–Natta and olefin metathesis catalytic cycles. The impact of these interactions is then highlighted by depicting some of the ubiquitous consumer products that are manufactured by use of these catalytic cycles. Details are presented in the Microreview by B. G. Harvey and R. D. Ernst on page -- ff (DOI: 10.1002/ejic.201600989). For more on the story behind the cover research, see the Cover Profile (DOI: 10.1002/ejic.201700152).

  4. Full Papers

    1. Zinc Alkanesulfonates

      Synthesis and Structural Studies of Three-Dimensional Supramolecular Motifs Derived from Neutral and Cationic Zinc Alkanesulfonates

      Ravi Shankar, Rohit Singh, Swati Mendiratta, Amanpreet Kaur Jassal, Gabriele Kociok-Köhn and Kieran C. Molloy

      Version of Record online: 20 FEB 2017 | DOI: 10.1002/ejic.201601320

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      Zincate salts with weakly coordinating alkanesulfonate anions are prepared in situ for the design of hydrogen-bonded supramolecular assemblies with neutral and cationic coordination frameworks.

    2. Heterometallic Ln Complexes

      Triheterometallic Lanthanide Complexes Prepared from Kinetically Inert Lanthanide Building Blocks

      Thomas Just Sørensen, Manuel Tropiano, Alan M. Kenwright and Stephen Faulkner

      Version of Record online: 20 FEB 2017 | DOI: 10.1002/ejic.201700027

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      We have prepared large distinct heteronuclear lanthanide architectures from kinetically inert building blocks. By combining optical and magnetic resonance spectroscopy, we are able to conclude that conformational freedom allowing for intramolecular collision is more important than apparent proximity for efficient energy transfer.

    3. Pt–Peptide Conjugates

      Nonconventional trans-Platinum Complexes Functionalized with RDG Peptides: Chemical and Cytototoxicity Studies

      Maria Angeles Medrano, Maurício Morais, Vera F. C. Ferreira, João D. G. Correia, António Paulo, Isabel Santos, Carmen Navarro-Ranninger, Amparo Alvarez Valdes, Angela Casini, Filipa Mendes and Adoración G. Quiroga

      Version of Record online: 20 FEB 2017 | DOI: 10.1002/ejic.201700072

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      We present the conjugation of the cyclic peptide cRGDfK (cRGD) to trans-PtII or trans-PtIV complexes through its 4-picolinic acid spectator ligand.

  5. Communications

    1. Platinum Hydrides

      Linear Triplatinum Tetrahydride Complex Supported by Triphosphine Ligands, [Pt3(µ-H)2(H)2(µ-dpmp)2](BF4)2 {dpmp = bis(diphenylphosphinomethyl)phenylphosphine}

      Tomoaki Tanase, Kana Yamamoto, Rika Hatano, Kanako Nakamae, Bunsho Kure, Yasuyuki Ura and Takayuki Nakajima

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201601505

      Thumbnail image of graphical abstract

      The triplatinum tetrahydride complex [Pt3(µ-H)2(H)2(µ-dpmp)2](BF4)2 [5, dpmp = bis(diphenylphosphinomethyl)phenylphosphine] is synthesized and characterized by spectroscopic, crystallographic, and theoretical methods to demonstrate the linear {Pt3(µ-dpmp)2}6+ scaffold accommodating fluxional tetrahydride ligands.

  6. Full Papers

    1. Drug Delivery

      (Pentamethylcyclopentadienato)rhodium Complexes for Delivery of the Curcumin Anticancer Drug

      Jack Markham, Jun Liang, Aviva Levina, Rachel Mak, Bernt Johannessen, Peter Kappen, Chris J. Glover, Barry Lai, Stefan Vogt and Peter A. Lay

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201601331

      Thumbnail image of graphical abstract

      [RhIII(*Cp)(curcuminato)Cl] (*Cp = pentamethylcyclopentadienato) is readily taken up by the A549 lung-cancer cell line and enables the slow intracellular release of curcumin that causes cytotoxicity by apoptosis. This makes the complex an effective drug-delivery system for the poorly bioavailable curcumin drug.

  7. Microreviews

    1. Agostic Interactions

      Transition-Metal Complexes with (C–C)[RIGHTWARDS ARROW]M Agostic Interactions

      Benjamin G. Harvey and Richard D. Ernst

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201600989

      Thumbnail image of graphical abstract

      Unlike agostic C–H and H–H bond coordination with transition-metal centers, analogous coordination involving C–C bonds was discovered only recently. Already it has been found to play roles in olefin metathesis and polymerization. We summarize the early work in this area, focusing on the nature of these species and the recognition that such complexes were around but unrecognized for some time.

    2. β-Diketonate Metallodrug Scaffolds

      β-Diketones as Scaffolds for Anticancer Drug Design – From Organic Building Blocks to Natural Products and Metallodrug Components

      Jakob Kljun and Iztok Turel

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201601314

      Thumbnail image of graphical abstract

      This microreview describes the role of the β-diketone fragment in the field of medicinal chemistry. Non-steroidal anti-inflammatory drugs of the coxib family, the natural product curcumin, budotitane and other transition-metal complexes of β-diketonates serve to demonstrate the importance and versatility of this important subgroup of β-dicarbonyl compounds.

  8. Full Papers

    1. Structure–Reactivity Relationships

      Dioxygenation of Flavonol Catalyzed by Copper(II) Complexes Supported by Carboxylate-Containing Ligands: Structural and Functional Models of Quercetin 2,4-Dioxygenase

      Ying-Ji Sun, Pei Li, Qian-Qian Huang, Jian-Jun Zhang and Shinobu Itoh

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201601371

      Thumbnail image of graphical abstract

      The CuII complexes [CuIIL(AcO)] and [CuIIL(fla)] (fla = flavonolate) supported by a series of carboxylate-containing ligands (L1L4) are reported as structural and functional models of quercetin 2,4-dioxygenase (2,4-QD) to obtain insights into the role of the carboxylate group of Glu73 in the active site of 2,4-QD.

    2. Ru–Arene Complexes

      Ruthenium(II)–Arene Metallacycles: Crystal Structures, Interaction with DNA, and Cytotoxicity

      Hong-Yan Wang, Yong Qian, Fang-Xin Wang, Abraha Habtemariam, Zong-Wan Mao, Peter J. Sadler and Hong-Ke Liu

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201601226

      Thumbnail image of graphical abstract

      A series of 26-membered RuII2 metallamacrocycles containing 1-{3-[(1H-imidazol-1-yl)methyl]benzyl}-1H-imidazole (m-bib) and 1-{4-[(1H-imidazol-1-yl)methyl]benzyl}-1H-imidazole (p-bib) ligands have been synthesized and characterized. One complex, [Ru26-p-cymene)2(p-bib)2Cl2](NO3)2 (10), had activity comparable (IC50 = 16.7 µm) with the anticancer drug cisplatin (IC50 = 15.8 µm).

  9. Communications

    1. Fe Pincer Anticancer Complexes

      Iron(III) Pincer Complexes as a Strategy for Anticancer Studies

      Aldo S. Estrada-Montaño, Alexander D. Ryabov, Alexandre Gries, Christian Gaiddon and Ronan Le Lagadec

      Version of Record online: 16 FEB 2017 | DOI: 10.1002/ejic.201601350

      Thumbnail image of graphical abstract

      [Fe(NCN)2]PF6 [NCHN = 1,3-di(pyridin-2-yl)benzene] as a bis(pincer)iron(III) compound shows much higher cytotoxic activity than cisplatin against the HTC15, SKLU, AGS, and KATOIII cancer cell lines with IC50 < 1 µm.

  10. Full Papers

    1. Photochemical Anticancer Complexes | Very Important Paper

      Photochemical Properties and Structure–Activity Relationships of RuII Complexes with Pyridylbenzazole Ligands as Promising Anticancer Agents

      Dmytro Havrylyuk, David K. Heidary, Leona Nease, Sean Parkin and Edith C. Glazer

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/ejic.201601450

      Thumbnail image of graphical abstract

      A structure–activity relationship study, focused on benzazole-core bioisosterism in RuII complexes, revealed compounds with a potential for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT).

    2. Radiolabeled Tracers

      Biological Evaluation of l-Tyrosine Labelled with fac-[99mTc(CO)3]+ at a para-OH-Coupled 2,3-Diaminopropionic Acid Based Chelator

      Michael Felber, Matthias Bauwens, Sebastian Imstepf, Thomas Fox, Felix M. Mottaghy and Roger Alberto

      Version of Record online: 15 FEB 2017 | DOI: 10.1002/ejic.201601316

      Thumbnail image of graphical abstract

      Radiolabeled amino acids are important imaging agents for rapidly proliferating cells. Tyrosine has been coupled to a tripod ligand and labeled with 99mTc in a two-step or one-pot reaction. Accumulation in tumor xenografts was small, but fast uptake into the gallbladder and retention over an extended period suggest that this compound is suitable for gallbladder imaging and related dysfunctions.

  11. Communications

    1. Cyclometalation

      C(sp3)–H Bond Activation Induced by Monohydroborane Coordination at an Iridium(III)–Phosphoramidate Complex

      Marcus W. Drover, Cheyenne J. Christopherson, Laurel L. Schafer and Jennifer A. Love

      Version of Record online: 13 FEB 2017 | DOI: 10.1002/ejic.201601518

      Thumbnail image of graphical abstract

      Two is better than one to generate cyclometalated Cp*IrIII phosphoramidate complexes by sequential intramolecular B–H and C(sp3)–H bond-activation events. Such complexes represent a first step in an overall Ir-catalyzed process for organophosphate functionalization. Cp* = pentamethylcyclopentadienyl; Mes = mesityl.

  12. Microreviews

    1. NO-Releasing Molecules

      Transition-Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery

      Hui-Jing Xiang, Min Guo and Jin-Gang Liu

      Version of Record online: 8 FEB 2017 | DOI: 10.1002/ejic.201601135

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      This microreview describes recent major advances in the integration of metal nitrosyls with various nanoplatforms for photocontrolled nitric oxide delivery.

    2. Platinum Prodrugs

      Platinum(IV) Prodrugs – A Step Closer to Ehrlich's Vision?

      Reece G. Kenny, Su Wen Chuah, Alanna Crawford and Celine J. Marmion

      Version of Record online: 7 FEB 2017 | DOI: 10.1002/ejic.201601278

      Thumbnail image of graphical abstract

      A summary of advances in the rational design and development of targeted PtIV prodrugs over the past decade is provided with an emphasis on derivatives that target not only DNA but also enzymes, proteins, peptides and hormones.

  13. Full Papers

    1. Cu Anticancer Complexes

      Isomeric Effect on the Pharmacokinetic Behavior of Anticancer CuII Mixed Chelate Complexes: Experimental and Theoretical Approach

      Juan Carlos García-Ramos, Guadalupe Vértiz-Serrano, Lucia Macías-Rosales, Rodrigo Galindo-Murillo, Yanis Toledano-Magaña, Juan Pablo Bernal, Fernando Cortés-Guzmán and Lena Ruiz-Azuara

      Version of Record online: 27 JAN 2017 | DOI: 10.1002/ejic.201601199

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      The isomeric effect on the interaction of CuII antineoplastic coordination compounds with cellular membranes as well as on their biological activity has been studied. The isomer CasIII-La presents a lower-energy cost for crossing the cell membrane, which is reflected in a lower half-life and a greater cytotoxicity towards human peripheral blood lymphocytes compared with its isomer CasIII-Ea.

    2. Gold(III) Antitumor Complexes

      Cell and Cell-Free Mechanistic Studies on Two Gold(III) Complexes with Proven Antitumor Properties

      Chiara Nardon, Giulia Boscutti, Chiara Gabbiani, Lara Massai, Nicolò Pettenuzzo, Ambrogio Fassina, Luigi Messori and Dolores Fregona

      Version of Record online: 23 JAN 2017 | DOI: 10.1002/ejic.201601215

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      Two Au–dithiocarbamato complexes are promising anticancer agents. Spectrometric studies revealed different patterns of interaction with HSA and ctDNA as model biomolecules, likely due to differences in redox chemistry. One complex was tested against A549 lung carcinoma cells using an xCELLigence Real-Time Cell Analysis system; measures of impedance by non-invasive Au microelectrodes showed that the complex inhibits cell proliferation after only 4 h.

  14. Microreviews

    1. Cycloruthenated Compounds

      The Fate of Cycloruthenated Compounds: From C–H Activation to Innovative Anticancer Therapy

      Christian Gaiddon and Michel Pfeffer

      Version of Record online: 23 JAN 2017 | DOI: 10.1002/ejic.201601216

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      Cycloruthenated compounds have been shown to be amazingly stable and exciting anticancer drug candidates featuring original modes of action. The role of the C–Ru bond that is intramolecularly stabilized by dative bonds is highlighted, because the cytotoxicity of these compounds is often up to two or three orders of magnitude higher than that of structurally related species lacking the C–Ru bond.

    2. Cyanocobalamin–Metal Conjugates

      Vitamin B12–Metal Conjugates for Targeted Chemotherapy and Diagnosis: Current Status and Future Prospects

      Andrea Pettenuzzo, Rebecca Pigot and Luca Ronconi

      Version of Record online: 23 JAN 2017 | DOI: 10.1002/ejic.201601217

      Thumbnail image of graphical abstract

      The abnormal demand for vitamin B12 in tumor cells can be exploited by designing tailored cobalamin-metallodrug conjugates in order to achieve targeted delivery into the diseased tissues for therapeutic and diagnostic applications

  15. Full Papers

    1. Cytotoxic Vanadium Complexes

      Cytotoxic Vanadium Complexes of Branched [ONNO]-Type Diamine Bis(phenolato) Ligands

      Gilad Nahari, Lilia Reytman, Laure Vendier, Edit Y. Tshuva and Christian Lorber

      Version of Record online: 23 JAN 2017 | DOI: 10.1002/ejic.201601276

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      Two vanadium(V) complexes, based on a common branched diaminobis(phenolato) ligand but differing in their labile ligands, are highly cytotoxic toward human colon and ovarian cells, including cells that are resistant to cisplatin. Their rapid loss of the labile group in water implies that, unlike the chelating ligand, the labile ligand type is insignificant.

  16. Microreviews

    1. DNA Intercalator Pt Complexes

      Platinum Intercalators of DNA as Anticancer Agents

      Benjamin J. Pages, K. Benjamin Garbutcheon-Singh and Janice R. Aldrich-Wright

      Version of Record online: 20 JAN 2017 | DOI: 10.1002/ejic.201601204

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      Polyaromatic platinum complexes (PPCs) capable of intercalating between DNA nucleobases have great chemotherapeutic potential. We provide an overview of PPCs that are known to intercalate with DNA and also exhibit potent activity against cancerous cells and tumours. In particular we focus upon PPCs of phenanthroline and various diamines, which display activity up to 100 times that of cisplatin.

  17. Full Papers

    1. Prussian Blue Analogues

      Ordered Mesoporous Silica Monoliths as a Versatile Platform for the Study of Magnetic and Photomagnetic Prussian Blue Analogue Nanoparticles

      Robinson Moulin, Emilie Delahaye, Amélie Bordage, Emiliano Fonda, Jean-Pierre Baltaze, Patricia Beaunier, Eric Rivière, Giulia Fornasieri and Anne Bleuzen

      Version of Record online: 17 JAN 2017 | DOI: 10.1002/ejic.201601196

      Thumbnail image of graphical abstract

      The use of mesoporous silica as a matrix for the formation of nanoparticles of magnetic and photomagnetic coordination compounds enables the study of the properties of the compounds at the nanoscale owing to the versatility of the synthetic pathway.

    2. Photodynamic Anticancer Agents

      Cyclometalated IrIII Complexes as Mitochondria-Targeted Photodynamic Anticancer Agents

      Miao Ouyang, Leli Zeng, Kangqiang Qiu, Yu Chen, Liangnian Ji and Hui Chao

      Version of Record online: 16 JAN 2017 | DOI: 10.1002/ejic.201601129

      Thumbnail image of graphical abstract

      A series of cyclometalated IrIII complexes based on 2,2′-biimidazole with different alkyl substituents were evaluated towards four cell lines as photodynamic therapy (PDT) agents. They exhibit satisfying PDT effects with high phototoxicity index (PI) values and high selectivity between normal cells and cancer cells. The photoinduced cell death follows a mitochondria-mediated apoptotic pathway.

    3. Cytotoxic Ti Complexes

      Cytotoxic Titanium(IV) Complexes of Salalen-Based Ligands

      Avia Tzubery and Edit Y. Tshuva

      Version of Record online: 10 JAN 2017 | DOI: 10.1002/ejic.201601200

      Thumbnail image of graphical abstract

      Phenolatotitanium(IV) complexes with salalen (half salan and half salen) ligands of varying lability and structural aspects were studied. These complexes represent a new family of highly effective titanium-based anticancer agents. The leading complex combines high cytotoxicity with high hydrolytic stability and biological accessibility.

  18. Microreviews

    1. EPR Spectroscopy

      Electron Paramagnetic Resonance as a Tool for Studying the Mechanisms of Paramagnetic Anticancer Metallodrugs

      Kathleen E. Prosser and Charles J. Walsby

      Version of Record online: 21 DEC 2016 | DOI: 10.1002/ejic.201601142

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      Electron paramagnetic resonance spectroscopy (EPR) is a valuable technique for characterizing the ligand fields and oxidation states of metal complexes. This review highlights the application of EPR methods to determine the structures and mechanisms of a variety of paramagnetic metallotherapeutics.

  19. Full Papers

    1. Platinum(IV) Prodrugs

      Halogenated PtIV Complexes from N-Halosuccinimide Oxidation of PtII Antitumor Drugs: Synthesis, Mechanistic Investigation, and Cytotoxicity

      Zoufeng Xu, Cai Li, Zixuan Tong, Lili Ma, Man-Kit Tse and Guangyu Zhu

      Version of Record online: 20 DEC 2016 | DOI: 10.1002/ejic.201601130

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      Halogenated PtIV anticancer prodrugs are obtained by oxidation of PtII drugs with N-halosuccinimides. A detailed mechanism of the reaction of N-bromosuccinimide with cisplatin in ethanol is revealed.

    2. Ru–Arene Complexes

      Arene–Ruthenium(II) Complexes with Bioactive ortho-Hydroxydibenzoylmethane Ligands: Synthesis, Structure, and Cytotoxicity

      Riccardo Pettinari, Agnese Petrini, Fabio Marchetti, Claudio Pettinari, Tina Riedel, Bruno Therrien and Paul J. Dyson

      Version of Record online: 19 DEC 2016 | DOI: 10.1002/ejic.201601164

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      Arene–RuII complexes of ortho-hydroxydibenzoylmethane show an intramolecular H bond in both the solid state and solution. They display good cytotoxicity in vitro against human ovarian carcinoma A2780 and even superior activity against A2780cisR cells.

    3. Zn Finger Proteins

      Cisplatin Preferentially Binds to Zinc Finger Proteins Containing C3H1 or C4 Motifs

      Siming Yuan, Xin Ding, Yang Cui, Kaiju Wei, Yuchuan Zheng and Yangzhong Liu

      Version of Record online: 5 DEC 2016 | DOI: 10.1002/ejic.201601140

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      Cisplatin selectively binds to ZFPs containing C4 or C3H motifs. MDM2-zf (C4) and PARP-1-zf2 (C3H) show a higher reactivity to cisplatin than Sp1-zf2 (C2H2). The platination of ZFPs causes the zinc release and structural perturbation of the proteins. The different reactivity of the various ZFPs may be correlated with the targeting of cisplatin in cells.

    4. Ruthenium–Arene Complexes

      Cationic Ru(η6-p-cymene) Complexes of 3-Hydroxy-4-pyr(id)ones – Lipophilic Triphenylphosphine as Co-Ligand Is Key to Highly Stable and Cytotoxic Anticancer Agents

      Shahida Parveen, Muhammad Hanif, Sanam Movassaghi, Matthew P. Sullivan, Mario Kubanik, Muhammad Ashraf Shaheen, Tilo Söhnel, Stephen M. F. Jamieson and Christian G. Hartinger

      Version of Record online: 2 DEC 2016 | DOI: 10.1002/ejic.201601163

      Thumbnail image of graphical abstract

      Replacing the labile chlorido ligand in Ru(η6-p-cymene)[3-hydroxy-4(1H)-pyr(id)one]Cl complexes with triphenylphosphine or 1,3,5-triaza-7-phoshatricyclo[]decane resulted in compounds with higher anticancer activity. The improved activity can be rationalized by higher stability in aqueous solution and in the presence of biomolecules.

  20. Communications

    1. Targeting Integrin Receptors

      Functionalization of Ruthenium(II) Terpyridine Complexes with Cyclic RGD Peptides To Target Integrin Receptors in Cancer Cells

      Eva M. Hahn, Natalia Estrada-Ortiz, Jiaying Han, Vera F. C. Ferreira, Tobias G. Kapp, João D. G. Correia, Angela Casini and Fritz E. Kühn

      Version of Record online: 2 DEC 2016 | DOI: 10.1002/ejic.201601094

      Thumbnail image of graphical abstract

      Two terpyridine-based ruthenium(II) complexes are designed to be coupled to a cyclic peptide targeting integrin receptor αvβ3 to achieve models for targeted anticancer agents.

  21. Full Papers

    1. Photocytotoxicity

      Platinum(II) Complexes of Curcumin Showing Photocytotoxicity in Visible Light

      Koushambi Mitra, Srishti Gautam, Paturu Kondaiah and Akhil R. Chakravarty

      Version of Record online: 29 NOV 2016 | DOI: 10.1002/ejic.201601078

      Thumbnail image of graphical abstract

      Platinum(II)–curcumin complexes having diammine or chelating amines as ligands show photocytotoxicity: in visible light the curcumin ligand dissociates, thereby generating platinum(II)–DNA crosslinking agents and curcumin as a phototoxin.

    2. Metals in Medicine

      Enhancing the Cytotoxic Activity of Anticancer PtIV Complexes by Introduction of Lonidamine as an Axial Ligand

      Yulia N. Nosova, Lidia S. Foteeva, Ilia V. Zenin, Timur I. Fetisov, Kirill I. Kirsanov, Marianna G. Yakubovskaya, Taisya A. Antonenko, Viktor A. Tafeenko, Leonid A. Aslanov, Anna A. Lobas, Mikhail V. Gorshkov, Markus Galanski, Bernhard K. Keppler, Andrei R. Timerbaev, Elena R. Milaeva and Alexey A. Nazarov

      Version of Record online: 23 NOV 2016 | DOI: 10.1002/ejic.201600857

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      A series of PtIV complexes with lonidamine as a ligand coordinated in axial position is reported. Lonidamine affects strongly the in vitro cytotoxic activity, lowering the IC50 values down to the nanomolar range.

  22. Microreviews

    1. Metal-Containing Pharmacophores

      Metal-Containing Pharmacophores in Molecularly Targeted Anticancer Therapies and Diagnostics

      Mu Yang and Ulrich Bierbach

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/ejic.201601149

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      Metal-containing pharmaceuticals have a long history of applications in cytotoxic chemotherapies. Treatment of malignant disease in the postgenomic era has long moved beyond the use of indiscriminate cell poisons. Inorganic elements are now beginning to play exciting new roles in the design of smarter, molecularly targeted therapeutic agents and diagnostics.

  23. Full Papers

    1. Photolabile Ru Prodrugs

      Photolabile Ruthenium(II)–Purine Complexes: Phototoxicity, DNA Binding, and Light-Triggered Drug Release

      Hazel Chan, Joy B. Ghrayche, Jianhua Wei and Anna K. Renfrew

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/ejic.201601137

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      Photolabile ruthenium complexes can cage a biologically active ligand and release it when irradiated with visible light. We present a series of complexes for light-activated delivery of the anticancer agent 6-mercaptopurine. Several complexes are able to release 6-mercaptopurine on irradiation with visible light and exhibit photoselective DNA binding or toxicity towards MCF-7 breast cancer cells.

    2. Drug–Dendrimer Conjugates

      Low-Generation Polyamidoamine Dendrimers as Drug Carriers for Platinum(IV) Complexes

      Nadine S. Sommerfeld, Michaela Hejl, Matthias H. M. Klose, Ekaterina Schreiber-Brynzak, Andrea Bileck, Samuel M. Meier, Christopher Gerner, Michael A. Jakupec, Markus Galanski and Bernhard K. Keppler

      Version of Record online: 15 NOV 2016 | DOI: 10.1002/ejic.201601205

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      An unsymmetrically carboxylated platinum(IV) analogue of oxaliplatin is coupled to generation two (G-2) and four (G-4) polyamidoamine (PAMAM) dendrimers. The platinum–dendrimer complexes showed load- and size-dependent potency with IC50 values down to the low-nanomolar range, in contrast to the rather moderate activity of the free platinum(IV) compound.

  24. Microreviews

    1. Ru Anticancer Complexes

      Thirty Years of the Drug Candidate NAMI-A and the Myths in the Field of Ruthenium Anticancer Compounds: A Personal Perspective

      Enzo Alessio

      Version of Record online: 28 SEP 2016 | DOI: 10.1002/ejic.201600986

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      Almost 30 years after the discovery of NAMI-A, and after two clinical phase studies have been accomplished, the time seems to be appropriate for drawing up a balance sheet. The undemonstrated misconceptions (or myths) that, over the years, have thrived around NAMI-A and other ruthenium drug candidates are also critically addressed in detail.

  25. Full Papers

    1. Photodynamic Therapy

      Evaluation of Perylene Bisimide-Based RuII and IrIII Complexes as Photosensitizers for Photodynamic Therapy

      Cristina Mari, Huaiyi Huang, Riccardo Rubbiani, Marcus Schulze, Frank Würthner, Hui Chao and Gilles Gasser

      Version of Record online: 16 AUG 2016 | DOI: 10.1002/ejic.201600516

      Thumbnail image of graphical abstract

      The biological activity of a RuII polypyridyl complex 1 and an IrIII organometallic complex 2 on four cell lines is presented. Although the cytotoxicity of 1 did not improve significantly upon light irradiation, 2 reached nanomolar IC50 values on all the cell lines tested when activated with 420 nm light in low doses.


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