European Journal of Inorganic Chemistry
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Editor: Karen Hindson, Deputy Editor: Preeti Vashi
Impact Factor: 2.686
ISI Journal Citation Reports © Ranking: 2015: 12/46 (Chemistry Inorganic & Nuclear)
Online ISSN: 1099-0682
Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemCatChem, Zeitschrift für anorganische und allgemeine Chemie
Benjamin G. Harvey, Richard D. Ernst
Transition-Metal Complexes with (C-C)M Agostic Interactions
Unlike agostic C–H and H–H bond coordination with transition-metal centers, analogous coordination involving C–C bonds was discovered only recently. Already it has been found to play roles in olefin metathesis and polymerization. We summarize the early work in this area, focusing on the nature of these species and the recognition that such complexes were around but unrecognized for some time.
Eur. J. Inorg. Chem. 10.1002/ejic.201600989
This microreview describes the role of the β-diketone fragment in the field of medicinal chemistry. Non-steroidal anti-inflammatory drugs of the coxib family, the natural product curcumin, budotitane and other transition-metal complexes of β-diketonates serve to demonstrate the importance and versatility of this important subgroup of β-dicarbonyl compounds.
Eur. J. Inorg. Chem. 10.1002/ejic.201601314
Hui-Jing Xiang, Min Guo, Jin-Gang Liu
Transition-Metal Nitrosyls for Photocontrolled Nitric Oxide Delivery
This microreview describes recent major advances in the integration of metal nitrosyls with various nanoplatforms for photocontrolled nitric oxide delivery.
Eur. J. Inorg. Chem. 10.1002/ejic.201601135
Reece G. Kenny, Su Wen Chuah, Alanna Crawford, Celine J. Marmion
Platinum(IV) Prodrugs - A Step Closer to Ehrlich's Vision?
A summary of advances in the rational design and development of targeted PtIV prodrugs over the past decade is provided with an emphasis on derivatives that target not only DNA but also enzymes, proteins, peptides and hormones.
Eur. J. Inorg. Chem. 10.1002/ejic.201601278
Christian Gaiddon, Michel Pfeffer
The Fate of Cycloruthenated Compounds: From C-H Activation to Innovative Anticancer Therapy
Cycloruthenated compounds have been shown to be amazingly stable and exciting anticancer drug candidates featuring original modes of action. The role of the C–Ru bond that is intramolecularly stabilized by dative bonds is highlighted, because the cytotoxicity of these compounds is often up to two or three orders of magnitude higher than that of structurally related species lacking the C–Ru bond.
Eur. J. Inorg. Chem. 10.1002/ejic.201601216
Andrea Pettenuzzo, Rebecca Pigot, Luca Ronconi
Vitamin B12-Metal Conjugates for Targeted Chemotherapy and Diagnosis: Current Status and Future Prospects
The abnormal demand for vitamin B12 in tumor cells can be exploited by designing tailored cobalamin-metallodrug conjugates in order to achieve targeted delivery into the diseased tissues for therapeutic and diagnostic applications
Eur. J. Inorg. Chem. 10.1002/ejic.201601217
Benjamin J. Pages, K. Benjamin Garbutcheon-Singh, Janice R. Aldrich-Wright
Platinum Intercalators of DNA as Anticancer Agents
Polyaromatic platinum complexes (PPCs) capable of intercalating between DNA nucleobases have great chemotherapeutic potential. We provide an overview of PPCs that are known to intercalate with DNA and also exhibit potent activity against cancerous cells and tumours. In particular we focus upon PPCs of phenanthroline and various diamines, which display activity up to 100 times that of cisplatin.
Eur. J. Inorg. Chem. 10.1002/ejic.201601204
Kathleen E. Prosser, Charles J. Walsby
Electron Paramagnetic Resonance as a Tool for Studying the Mechanisms of Paramagnetic Anticancer Metallodrugs
Electron paramagnetic resonance spectroscopy (EPR) is a valuable technique for characterizing the ligand fields and oxidation states of metal complexes. This review highlights the application of EPR methods to determine the structures and mechanisms of a variety of paramagnetic metallotherapeutics.
Eur. J. Inorg. Chem. 10.1002/ejic.201601142
Mu Yang, Ulrich Bierbach
Metal-Containing Pharmacophores in Molecularly Targeted Anticancer Therapies and Diagnostics
Metal-containing pharmaceuticals have a long history of applications in cytotoxic chemotherapies. Treatment of malignant disease in the postgenomic era has long moved beyond the use of indiscriminate cell poisons. Inorganic elements are now beginning to play exciting new roles in the design of smarter, molecularly targeted therapeutic agents and diagnostics.
Eur. J. Inorg. Chem. 10.1002/ejic.201601149
Almost 30 years after the discovery of NAMI-A, and after two clinical phase studies have been accomplished, the time seems to be appropriate for drawing up a balance sheet. The undemonstrated misconceptions (or myths) that, over the years, have thrived around NAMI-A and other ruthenium drug candidates are also critically addressed in detail.
Eur. J. Inorg. Chem. 10.1002/ejic.201600986