European Journal of Inorganic Chemistry

Cover image for Vol. 2014 Issue 36

Editor: Karen Hindson, Deputy Editor: Preeti Vashi

Impact Factor: 2.965

ISI Journal Citation Reports © Ranking: 2013: 10/45 (Chemistry Inorganic & Nuclear)

Online ISSN: 1099-0682

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemCatChem, Zeitschrift für anorganische und allgemeine Chemie

2008_21/2008Lanthanide Complexes and Quantum Dots: A Bright Wedding for Resonance Energy Transfer (Eur. J. Inorg. Chem. 21/2008)

The cover picture shows the schematic realization of a homogeneous fluoroimmunoassay using Förster resonance energy transfer (FRET) from luminescent lanthanide complexes (LLCs – an example of a Tb complex is shown in the top right corner) to a biocompatible CdSe/ZnS quantum dot (QD). Excitation of the immunocomplex formed by the association of QD-labeled antibodies, antigen and LLC-labeled antibodies by UV light (e.g. 315 nm) leads to a long-lived Tb and QD luminescence (luminescence spectra shown in the bottom right corner) due to FRET sensitization by the LLCs. This new immunoassay approach opens doors to extremely sensitive background-free fluoroimmunoassays suitable for multiplexing by using several different QDs as FRET acceptors with a single LLC donor. Details are discussed in the Microreview by L. J. Charbonnière and N. Hildebrandt on p. 3241 ff.

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