European Journal of Inorganic Chemistry

Cover image for Vol. 2016 Issue 27

Editor: Karen Hindson, Deputy Editor: Preeti Vashi

Impact Factor: 2.686

ISI Journal Citation Reports © Ranking: 2015: 12/46 (Chemistry Inorganic & Nuclear)

Online ISSN: 1099-0682

Associated Title(s): Angewandte Chemie International Edition, Chemistry - A European Journal, Chemistry – An Asian Journal, ChemistryOpen, ChemCatChem, Zeitschrift für anorganische und allgemeine Chemie

2009_15/2009Cytotoxic Titanium(IV) Complexes: Renaissance (Eur. J. Inorg. Chem. 15/2009)

The cover picture The cover picture shows the cytotoxic activity of diamine bis(phenolato) bis(isopropoxo) TiIV complexes, which is strongly dependent on ligand features and on incubation time and period of water exposure, as represented metaphorically by the hourglass. Particularly slow hydrolysis of the isopropoxo groups enables cell insertion of an active species, while upon water addition in the absence of cells, a highly stable phenolato-bound trinuclear cluster is formed, which is inactive. The results obtained thus far with this new family of cytotoxic TiIV compounds in the context of the current knowledge of the activity and operation mode of established TiIV cytotoxic complexes is described in the Microreview by E. Y. Tshuva and J. A. Ashenhurst on p. 2203 ff.

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