European Journal of Organic Chemistry
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Organic Chemistry Meets Life Sciences
The European Journal of Organic Chemistry covers all aspects of organic chemistry, including the exciting interface to the life sciences. Read the latest articles:
Hsin-Pei Wu, Tai-Ni Lu, Nai-Yun Hsu, Che-Chien Chang
Absolute Stereochemical Assignment of SCH 71450, a Selective Dopamine D4 Receptor Antagonist, Through Enantioselective Epimer Synthesis [Full Paper]
Eur. J. Org. Chem.2013, 2898–2905.
Rustam T. Iminov, Alexander V. Mashkov, Bohdan A. Chalyk, Pavel K. Mykhailiuk, Anton V. Tverdokhlebov, Andrey A. Tolmachev, Yulian M. Volovenko, Oleg V. Shishkin, Svetlana V. Shishkina
A Convenient Route to 1-Alkyl-5-trifluoromethyl-1,2,3-triazole-4-carboxylic Acids Employing a Diazo Transfer Reaction [Full Paper]
Eur. J. Org. Chem.2013, 2891–2897.
J. S. Yadav, K. V. Raghavendra Rao, Aala Kavita, Debendra K. Mohapatra
Stereoselective Synthesis of the C31–C41 Spirolactam Fragment of Sanglifehrin A [Full Paper]
Eur. J. Org. Chem.2013, 2849–2858.
Recently Published Articles
- Potassium (1-Organo-1H-1,2,3-triazol-4-yl)trifluoroborates from Ethynyltrifluoroborate through a Regioselective One-Pot Cu-Catalyzed Azide–Alkyne Cycloaddition Reaction
Taejung Kim, Jung Ho Song, Kyu Hyuk Jeong, Seokjoon Lee and Jungyeob Ham
Article first published online: 17 MAY 2013 | DOI: 10.1002/ejoc.201300365
The preparation of potassium (1-organo-1H-1,2,3-triazol-4-yl)trifluoroborates from potassium ethynyltrifluoroborate and alkyl or aryl halides by employing a regioselective one-pot Cu-catalyzed azide–alkyne cycloaddition (CuAAC) is elaborated. This strategy allows unrestricted access to an infinite variety of 1,4-disubstituted 1,2,3-triazoles.
- A Facile Synthesis of 4,6,7,8,8a,9-Hexahydropyrrolo[1,2-a][1,2,3]triazolo[1,5-d]pyrazines by a Three-Component Coupling Reaction Followed by Intramolecular 1,3-Dipolar Cycloaddition
Attrimuni P. Dhondge, Shakil N. Afraj, Cut Nuzlia, Chinpiao Chen and Gene-Hsian Lee
Article first published online: 17 MAY 2013 | DOI: 10.1002/ejoc.201300226
A two-step protocol for the synthesis of 4,6,7,8,8a,9-hexahydropyrrolo[1,2-a][1,2,3]triazolo[1,5-d]pyrazines was developed. The first step is an AuBr3-catalyzed three-component coupling of aldehydes, alkynes, and an amine to give propargylamines under solvent-free conditions at 80 °C. The second step is the ring-closure to give the final products under mild reaction conditions.
- One-Pot Three-Component Heteroannulation of β-Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5-Substituted 3-Aminoisoxazoles
Subhasis Samai, Tanmoy Chanda, Hiriyakkanavar Ila and Maya Shankar Singh
Article first published online: 16 MAY 2013 | DOI: 10.1002/ejoc.201300038
A highly regioselective synthesis of 5-substituted 3-aminoisoxazoles has been achieved by a one-pot three-component coupling of β-oxo dithioesters, amines and hydroxylamine in ethanol at reflux via an in situ generated β-oxo thioamide intermediate. The mechanism of the reaction has been established experimentally and shown to be in agreement with the HSAB theory.
- Syntheses of Hydrazino Peptides and Conjugates
Siva S. Panda, Claudia El-Nachef, Kiran Bajaj and Alan R. Katritzky
Article first published online: 16 MAY 2013 | DOI: 10.1002/ejoc.201201731
Benzyloxycarbonyl-protected hybrid hydrazino dipeptides and benzyloxycarbonyl-protected hydrazino aminoacyl conjugates with N-, S-, O-, and C-nucleophiles were prepared by using benzotriazole methodology.
- Catalytic Enantioconvergent Decarboxylative Allylic Alkylation of Allyl Indolenin-3-carboxylates
Thomas M. Kaiser and Jiong Yang
Article first published online: 16 MAY 2013 | DOI: 10.1002/ejoc.201300515
The enantioconvergent conversion of racemic allyl indolenin-3-carboxylates into enantiomerically enriched C3-quaternary indolenines is reported. A Pd-catalyzed decarboxylative allylic alkylation reaction is employed for both stereoablation and enantioselective formation of the quaternary carbon center.