European Journal of Organic Chemistry
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Organic Chemistry Meets Life Sciences
The European Journal of Organic Chemistry covers all aspects of organic chemistry, including the exciting interface to the life sciences. Read the latest articles:
Viktor O. Iaroshenko, Sergii Dudkin, Vyacheslav Ya. Sosnovskikh, Alexander Villinger, Peter Langer
(β-D-Ribofuranosyl)formamidine in the Design and Synthesis of 2-(β-D-Ribofuranosyl)pyrimidines, Including RF-Containing Derivatives [Full Paper]
Eur. J. Org. Chem.2013, 3166–3173.
Eva Schütznerová, Allen G. Oliver, Jaroslav Zajíček, Viktor Krchnák
Polymer-Supported Stereoselective Synthesis of (1S,5S)-6-Oxa-3,8-diazabicyclo[3.2.1]octanes [Full Paper]
Eur. J. Org. Chem.2013, 3158–3165.
Vladimir S. Yarmolchuk, Oleg V. Shishkin, Viktoriia S. Starova, Olga A. Zaporozhets, Olga Kravchuk, Sergey Zozulya, Igor V. Komarov, Pavel K. Mykhailiuk
Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines [Full Paper]
Eur. J. Org. Chem.2013, 3086–3093.
Recently Published Articles
- Potassium (1-Organo-1H-1,2,3-triazol-4-yl)trifluoroborates from Ethynyltrifluoroborate through a Regioselective One-Pot Cu-Catalyzed Azide–Alkyne Cycloaddition Reaction
Taejung Kim, Jung Ho Song, Kyu Hyuk Jeong, Seokjoon Lee and Jungyeob Ham
Article first published online: 17 MAY 2013 | DOI: 10.1002/ejoc.201300365
The preparation of potassium (1-organo-1H-1,2,3-triazol-4-yl)trifluoroborates from potassium ethynyltrifluoroborate and alkyl or aryl halides by employing a regioselective one-pot Cu-catalyzed azide–alkyne cycloaddition (CuAAC) is elaborated. This strategy allows unrestricted access to an infinite variety of 1,4-disubstituted 1,2,3-triazoles.
- A Facile Synthesis of 4,6,7,8,8a,9-Hexahydropyrrolo[1,2-a][1,2,3]triazolo[1,5-d]pyrazines by a Three-Component Coupling Reaction Followed by Intramolecular 1,3-Dipolar Cycloaddition
Attrimuni P. Dhondge, Shakil N. Afraj, Cut Nuzlia, Chinpiao Chen and Gene-Hsian Lee
Article first published online: 17 MAY 2013 | DOI: 10.1002/ejoc.201300226
A two-step protocol for the synthesis of 4,6,7,8,8a,9-hexahydropyrrolo[1,2-a][1,2,3]triazolo[1,5-d]pyrazines was developed. The first step is an AuBr3-catalyzed three-component coupling of aldehydes, alkynes, and an amine to give propargylamines under solvent-free conditions at 80 °C. The second step is the ring-closure to give the final products under mild reaction conditions.
- One-Pot Three-Component Heteroannulation of β-Oxo Dithioesters, Amines and Hydroxylamine: Regioselective, Facile and Straightforward Entry to 5-Substituted 3-Aminoisoxazoles
Subhasis Samai, Tanmoy Chanda, Hiriyakkanavar Ila and Maya Shankar Singh
Article first published online: 16 MAY 2013 | DOI: 10.1002/ejoc.201300038
A highly regioselective synthesis of 5-substituted 3-aminoisoxazoles has been achieved by a one-pot three-component coupling of β-oxo dithioesters, amines and hydroxylamine in ethanol at reflux via an in situ generated β-oxo thioamide intermediate. The mechanism of the reaction has been established experimentally and shown to be in agreement with the HSAB theory.
- Syntheses of Hydrazino Peptides and Conjugates
Siva S. Panda, Claudia El-Nachef, Kiran Bajaj and Alan R. Katritzky
Article first published online: 16 MAY 2013 | DOI: 10.1002/ejoc.201201731
Benzyloxycarbonyl-protected hybrid hydrazino dipeptides and benzyloxycarbonyl-protected hydrazino aminoacyl conjugates with N-, S-, O-, and C-nucleophiles were prepared by using benzotriazole methodology.
- Catalytic Enantioconvergent Decarboxylative Allylic Alkylation of Allyl Indolenin-3-carboxylates
Thomas M. Kaiser and Jiong Yang
Article first published online: 16 MAY 2013 | DOI: 10.1002/ejoc.201300515
The enantioconvergent conversion of racemic allyl indolenin-3-carboxylates into enantiomerically enriched C3-quaternary indolenines is reported. A Pd-catalyzed decarboxylative allylic alkylation reaction is employed for both stereoablation and enantioselective formation of the quaternary carbon center.