One-Pot Synthesis of Benzopyran-4-ones with Cancer Preventive and Therapeutic Potential
Oualid Talhi, Lidia Brodziak-Jarosz, Jana Panning, Barbora Orlikova, Clemens Zwergel, Tzvetomira Tzanova, Stéphanie Philippot, Diana C. G. A. Pinto, Filipe A. Almeida Paz, Clarissa Gerhäuser, Tobias P. Dick, Claus Jacob, Marc Diederich, Denyse Bagrel, Gilbert Kirsch and Artur M. S. Silva
Article first published online: 15 JAN 2016 | DOI: 10.1002/ejoc.201501278
Chromanones 3p and 3r and 2-styrylchromones 3k potently activate the Nrf2 response in the AREc32 cell line at low micromolar concentrations (C5 <3 µM). Compounds 3k and 3r are also the most active in inhibiting cell proliferation by 50 % after 72 h incubation at concentrations of 4.5 and 7.7 µM, whereas normal peripheral blood mononuclear cells were not affected.