Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole-Derived Molecular Architectures
Yongqiang Zhang, Shanchao Wu, Shengzheng Wang, Kun Fang, Guoqiang Dong, Na Liu, Zhenyuan Miao, Jianzhong Yao, Jian Li, Wannian Zhang, Chunquan Sheng and Wei Wang
Article first published online: 5 FEB 2015 | DOI: 10.1002/ejoc.201403673
A powerful divergent cascade strategy has been developed for the rapid construction of five distinct diverse enantioenriched pyrazole-derived scaffolds using only six simple building blocks. Furthermore, screening of 10 compounds exemplifying the five synthesized scaffolds revealed potent anticancer lead compounds.