Sulfur–Carbon Bond Formation through Ring-Opening of Triazolothiadiazole with Organometallics
Raja Ben Othman, Stéphane Massip, Mathieu Marchivie, Christian Jarry, Johnny Vercouillie, Sylvie Chalon, Gérald Guillaumet, Franck Suzenet and Sylvain Routier
Article first published online: 8 APR 2014 | DOI: 10.1002/ejoc.201400151
An efficient and convenient method was developed for the formation of S-substituted thiotriazoles through an unprecedented organometallic addition and subsequent ring-opening sequence. A wide range of substrates containing different functional groups were used, and the corresponding N-unsubstituted 3-alkyl, aryl, alkynyl and alkenyl sulfanyl-1,2,4-triazole products were produced.