Eudesmane-Type Sesquiterpenes from Curcuma phaeocaulis and Their Inhibitory Activities on Nitric Oxide Production in RAW 264.7 Cells
Yue Liu, Jianghao Ma, Ying Wang, Paul Owusu Donkor, Qin Li, Suyu Gao, Yaguang Hou, Yang Xu, Jianing Cui, Liqin Ding, Feng Zhao, Ning Kang, Lixia Chen and Feng Qiu
Article first published online: 25 JUL 2014 | DOI: 10.1002/ejoc.201402465
Eight new sesquiterpenes (phaeusmanes A–H), together with eighteen known analogues, were isolated from the rhizomes of Curcuma phaeocaulis. Their complete structures were elucidated by NMR, MS, and CD spectroscopy. The NO inhibitory effects of the isolates are presented. A possible biogenetic pathway for N-containing eudesmane-type sesquiterpene 8 is postulated.