European Journal of Organic Chemistry
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Editor: Haymo Ross, Deputy Editor: Susan Wilkinson
Online ISSN: 1099-0690
Associated Title(s): Advanced Synthesis & Catalysis, Asian Journal of Organic Chemistry
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A Fragrance That Breaks the Rules
Synthesis of a Spirocyclic Seco Structure of the Principal Vetiver Odorant Khusimone.
Approximately one third of all fragrances on the market contain vetiver oil as a key ingredient, for which no synthetic odorant is commercially available. Instead it has to be distilled from the dried roots of vetiver grass. To find out about the structural requirements of vetiver odorants, researchers in Switzerland devised a synthesis to a 7,8-seco-khusimone, which still contained all the structural features held responsible for the vetiver odour. As they report in the European Journal of Organic Chemistry, however, the final product displayed none of the expected olfactory characteristics, thus proving the vetiver rule wrong.

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