European Journal of Organic Chemistry

Cover image for Vol. 2014 Issue 22

Editor: Haymo Ross, Deputy Editor: Susan Wilkinson

Impact Factor: 3.344

ISI Journal Citation Reports © Ranking: 2012: 14/57 (Chemistry Organic)

Online ISSN: 1099-0690

Associated Title(s): Advanced Synthesis & Catalysis, Asian Journal of Organic Chemistry

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Archive: 2012| 2011| 2010

Turbo-Packed RNA - Turbo Reagent Allows Precise Synthesis of tRNA Nucleosides

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Turbo-Packed RNA

Turbo Reagent Allows Precise Synthesis of tRNA Nucleosides.
Ribonucleic acid (RNA) is a biologically important molecule that is very similar to DNA, the blueprint of life. Naturally occurring RNAs, such as transfer RNA (tRNA), contain modified building blocks (“nucleosides”), which are involved in decoding genetic information. Deazaguanosine nucleosides, in particular, are of significant interest for their antibacterial, antifungal, antiviral, and anticancer activity. In the European Journal of Organic Chemistry, Thomas Carell and his team at Munich's Ludwig Maximilians University (Germany) have now introduced a method to prepare tRNA nucleosides through a novel Turbo-Grignard-based approach with an unprecedented level of control from a common intermediate.

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No.Press ReleaseOriginal Communication

05/2010

Turbo-Packed RNA
Turbo Reagent Allows Precise Synthesis of tRNA Nucleosides
(PDF)

Efficient Synthesis of Deazaguanosine-Derived tRNA Nucleosides PreQ0, PreQ1, and Archaeosine Using the Turbo-Grignard Method

Thomas Carell, Ludwig-Maximilians-Universität München (Germany)


04/2010

Eclectic Enzymes
Easily Modified Building Blocks for Drug Design
(PDF)

Oxygenated Stereotriads with Definite Absolute Configuration by Lipase-Mediated Kinetic Resolution: De Novo Synthesis of Imino Sugars and 6-Deoxy-C-glycosides

Elisabetta Brenna, Politecnico di Milano (Italy)


03/2010

Written in Red
Red-Emitting Dyes for Optical Microscopy and Nanoscopy
(PDF)

A Versatile Route to Red-Emitting Carbopyronine Dyes for Optical Microscopy and Nanoscopy

Vladimir N. Belov, Max Planck Institute for Biophysical Chemistry, Göttingen (Germany)


02/2010

Plain to See
New contrast agents for magnetic resonance imaging of tumors
(PDF)

Towards Selective Recognition of Sialic Acid Through Simultaneous Binding to Its cis-Diol and Carboxylate Functions

Carlos Platas-Iglesias, Universidade da Coruña (Spain)


01/2010

The Key that Fits
New technique to trace disease-related agents
(PDF)

New Fluorous Photoaffinity Labels (F-PAL) and Their Application in V-ATPase Inhibition Studies

Stephanie Grond, Eberhard-Karls-Universität Tübingen (Germany)


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