European Journal of Organic Chemistry

Cover image for Vol. 2016 Issue 24

Editor: Haymo Ross, Deputy Editor: Anne Nijs

Impact Factor: 3.068

ISI Journal Citation Reports © Ranking: 2015: 17/59 (Chemistry Organic)

Online ISSN: 1099-0690

Associated Title(s): Advanced Synthesis & Catalysis, Asian Journal of Organic Chemistry

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Turbo-Packed RNA - Turbo Reagent Allows Precise Synthesis of tRNA Nucleosides

Latest News

Turbo-Packed RNA

Turbo Reagent Allows Precise Synthesis of tRNA Nucleosides.
Ribonucleic acid (RNA) is a biologically important molecule that is very similar to DNA, the blueprint of life. Naturally occurring RNAs, such as transfer RNA (tRNA), contain modified building blocks (“nucleosides”), which are involved in decoding genetic information. Deazaguanosine nucleosides, in particular, are of significant interest for their antibacterial, antifungal, antiviral, and anticancer activity. In the European Journal of Organic Chemistry, Thomas Carell and his team at Munich's Ludwig Maximilians University (Germany) have now introduced a method to prepare tRNA nucleosides through a novel Turbo-Grignard-based approach with an unprecedented level of control from a common intermediate.

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No.Press ReleaseOriginal Communication


Turbo-Packed RNA
Turbo Reagent Allows Precise Synthesis of tRNA Nucleosides

Efficient Synthesis of Deazaguanosine-Derived tRNA Nucleosides PreQ0, PreQ1, and Archaeosine Using the Turbo-Grignard Method

Thomas Carell, Ludwig-Maximilians-Universität München (Germany)


Eclectic Enzymes
Easily Modified Building Blocks for Drug Design

Oxygenated Stereotriads with Definite Absolute Configuration by Lipase-Mediated Kinetic Resolution: De Novo Synthesis of Imino Sugars and 6-Deoxy-C-glycosides

Elisabetta Brenna, Politecnico di Milano (Italy)


Written in Red
Red-Emitting Dyes for Optical Microscopy and Nanoscopy

A Versatile Route to Red-Emitting Carbopyronine Dyes for Optical Microscopy and Nanoscopy

Vladimir N. Belov, Max Planck Institute for Biophysical Chemistry, Göttingen (Germany)


Plain to See
New contrast agents for magnetic resonance imaging of tumors

Towards Selective Recognition of Sialic Acid Through Simultaneous Binding to Its cis-Diol and Carboxylate Functions

Carlos Platas-Iglesias, Universidade da Coruña (Spain)


The Key that Fits
New technique to trace disease-related agents

New Fluorous Photoaffinity Labels (F-PAL) and Their Application in V-ATPase Inhibition Studies

Stephanie Grond, Eberhard-Karls-Universität Tübingen (Germany)