European Journal of Organic Chemistry
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Total Synthesis of (+)-Antimycin A3b on Solid Supports (Eur. J. Org. Chem. 22/2014)
The cover picture shows a straightforward total synthesis of (+)-antimycin A3b. Four fragments were assembled on a solid support, and the fully functionalized seco acid was cyclized in the solution phase. This convergent synthetic route is useful, because it minimizes the number of manipulations in the solution phase and is hence suitable for a combinatorial library synthesis. Details are discussed in the article by T. Takahashi et al. on p. 4725 ff.