European Journal of Organic Chemistry

Cover image for Vol. 2016 Issue 4

Editor: Haymo Ross, Deputy Editor: Susan Wilkinson

Impact Factor: 3.065

ISI Journal Citation Reports © Ranking: 2014: 14/58 (Chemistry Organic)

Online ISSN: 1099-0690

Associated Title(s): Advanced Synthesis & Catalysis, Asian Journal of Organic Chemistry

2016_04/2016Room-Temperature Alkynylation of Phosphine Oxides with Copper Acetylides: Practical Synthesis of Alkynylphosphine Oxides (Eur. J. Org. Chem. 4/2016)

The cover picture shows the alkynylation of phosphine oxides with copper acetylides. These polymeric, rock-stable and unreactive reagents can be readily activated by coordination with simple ligands and oxidation with molecular oxygen. This activation enables the in situ generation of highly reactive, oxidized copper acetylides that can be trapped by a series of phosphine oxides to give, after a formal reductive elimination step, the corresponding alkynylation product, i.e., alkynylphosphine oxides, which can be readily and easily obtained at room temperature by this mix-and-stir process. Details are discussed in the Communication by C. Alayrac, A.-C. Gaumont, G. Evano et al. on p. 633 ff.

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