European Journal of Organic Chemistry
Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Palladium-Catalyzed α-Arylation Reactions in Total Synthesis (Eur. J. Org. Chem. 1/2015)
The cover picture shows the scope of the α-arylation reaction of carbonyl compounds, such as ketones, aldehydes, esters and amides in the total syntheses of natural products and active pharmaceutical ingredients (API). This is exciting, because α-arylation reactions have emerged recently as one of the new trends in cross-coupling reactions, in which the CH at the α position of the carbonyl group undergoes functionalization by enolization in the presence of a base, followed by a C–C coupling under the influence of a metal catalyst, typically Pd. The potential of this powerful methodology will be enormous for key steps in organic synthesis for small and large molecules. Details are presented in the Microreview by T. J. Colacot et al. on 38 ff.