European Journal of Organic Chemistry
© WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Thiourea-Bridged Nanodiamond Glycoconjugates as Inhibitors of Bacterial Adhesion (Eur. J. Org. Chem. 25/2015)
The cover picture shows glyconanodiamond where the sugars are immobilized onto the diamond by thiourea bridging. This novel ligation technique for the functionalization of nanodiamond enables the grafting of different types of saccharide motifs. These glycoconjugates can be used to probe the carbohydrate-specific interaction of bacteria and furthermore to inhibit biofilm formation. The article also reports on the quantification of bacterial adhesion to different glyconanodiamond conjugates by employing a tailor-made sandwich assay. Details are discussed in the article by T. K. Lindhorst, A. Krueger et al. on 5519 ff.