Applied Organometallic Chemistry

The synthesis and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes (1–8) with 4′-substituted terpyridine are reported. Complexes 3, 5, 7 and 8 exerted 9-, 5-, 12- and 7-folds higher cytotoxicity than cisplatin against Bel-7402 cell line; 3, 5, 6, 7 and 8 exhibited higher cytotoxicity than cisplatin against BGC-823 cell line; 7 exhibited higher cytotoxicity than cisplatin against HL-60 cell line.

The protecting group free palladium-catalyzed hydroxylation, C-O and C-N cross coupling protocol offers a straightforward and general method for the synthesis of chiral 6-substituted and 6,6′-disubstituted binols with good yields, avoiding the tedious procedures of introduction and removal of protecting groups.

β-diketiminato ytterbium aryloxides were proven to be efficient precatalysts for addition of amines to carbodiimides giving guanidines with a wide range of substituents.

N-(ferrocenylmethyl amino acid) fluorinated benzene-carboxamide derivatives have been synthesised and biologically evaluated on the estrogen positive MCF-7 breast cancer cell line. N-(ferrocenylmethyl-L-alanine)-3,4,5-trifluorobenzene-carboxamide 5h was the most active compound with an IC₅₀ value of 2.84 μM.

Bis(phenoxy-imine) zirconium complexes bearing bulky o-bis(aryl)methyl- substituted aryl groups on the aniline moiety have been synthesized, characterized and tested as catalyst precursors for ethylene polymerization. The introduction of a excessively bulky o-bis(aryl)methyl substituents adjacent to the the imine-N produces low molecular weights aluminium terminated polyethylenes (Al-PEs) (M_v 1.6–10.1 × 10³) due to the enhanced rate of chain transfer to alkylaluminum groups during the polymerization.