Synthesis and biological evaluation of 99mTc tricarbonyl complex of O,O′-diethylethylenediamine-N,N′-di-3-propanoate as potential tumour diagnostic agent
Mladen Lakić, Ljubica Sabo, Slavica Ristić, Aleksandar Savić, Saša Petričević, Nadežda Nikolić, Aleksandar Vukadinović, Drina Janković, Tibor J. Sabo and Sanja Vranješ-Đurić
Article first published online: 16 NOV 2015 | DOI: 10.1002/aoc.3401
A new O,O′-diethylethylenediamine-N,N′-di-3-propanoate ligand was successfully radiolabelled by coordination towards the octahedral fac-[99mTc(CO)3(H2O)3]+ intermediate. The 99mTc-labelled complex (Tc1) presented high in vitro stability in saline and human plasma. Due to significant tumour uptake in female C57BL/6 mice bearing B16/F1 melanoma metastases, the radiolabelled ligand could be promising as a tumour-diagnostic agent.