Applied Organometallic Chemistry

The synthesis and cytotoxicity of Pt(II), Pd(II), Cu(II) and Zn(II) complexes (1–8) with 4′-substituted terpyridine are reported. Complexes 3, 5, 7 and 8 exerted 9-, 5-, 12- and 7-folds higher cytotoxicity than cisplatin against Bel-7402 cell line; 3, 5, 6, 7 and 8 exhibited higher cytotoxicity than cisplatin against BGC-823 cell line; 7 exhibited higher cytotoxicity than cisplatin against HL-60 cell line.

The protecting group free palladium-catalyzed hydroxylation, C-O and C-N cross coupling protocol offers a straightforward and general method for the synthesis of chiral 6-substituted and 6,6′-disubstituted binols with good yields, avoiding the tedious procedures of introduction and removal of protecting groups.

β-diketiminato ytterbium aryloxides were proven to be efficient precatalysts for addition of amines to carbodiimides giving guanidines with a wide range of substituents.

N-(ferrocenylmethyl amino acid) fluorinated benzene-carboxamide derivatives have been synthesised and biologically evaluated on the estrogen positive MCF-7 breast cancer cell line. N-(ferrocenylmethyl-L-alanine)-3,4,5-trifluorobenzene-carboxamide 5h was the most active compound with an IC₅₀ value of 2.84 μM.

Bis(phenoxy-imine) zirconium complexes bearing bulky o-bis(aryl)methyl- substituted aryl groups on the aniline moiety have been synthesized, characterized and tested as catalyst precursors for ethylene polymerization. The introduction of a excessively bulky o-bis(aryl)methyl substituents adjacent to the the imine-N produces low molecular weights aluminium terminated polyethylenes (Al-PEs) (M_v 1.6–10.1 × 10³) due to the enhanced rate of chain transfer to alkylaluminum groups during the polymerization.

An optimized terpolymer organosilicate resist prepared with p-chloromethylphenyl trimethoxysilane, norbornene ethyltrimethoxysilane, and tetraethoxysilane exhibits an excellent stability and allows the fabrication of 20-nm patterns with excellent line-edge roughness, with one quarter of the required dose for conventional HSQ resist.

A systematic study showed, the encapsulated Pd(OAc)₂/ethylenediamine complex into the SBA-15 as an organic–inorganic hybrid nanoreactor (Pd(OAc)₂@SBA-15/PrEn) exhibit higher activity and selectivity toward Suzuki cross-coupling reaction in aerobic condition and mixture of water solvent.

Several deposited palladium catalysts were obtained by grafting palladium(II) acetate onto all-siliceous SBA-15 type mesoporous molecular sieve and conventional silica gel both modified with 3-[2-(diethylamino)ethyl]propyl groups as potentially chelating N,N-donor moieties. These catalysts were evaluated in Stille cross-coupling reaction of various stannanes and aryl halides with attention being paid predominantly to the influence of the reaction conditions on the reaction course.

A series of new α-Diimine Nickel(II) Catalysts bearing bulky chiral sec-phenethyl groups, have been synthesized and characterized. The chiral complexes, activated by diethylaluminum chloride (DEAC), showed highly catalytic activity for the polymerization of ethylene, and produced branched polyethylene with methyl, ethyl, propyl and butyl or longer branches.