Irma Rojas-Oviedo, Carlos Camacho-Camacho, Luis Sánchez-Sánchez, Jorge Cárdenas, Hugo López-Muñoz, Hugo Eugenio-Robledo, Israel Velázquez and Rubén Alfredo Toscano
Uterine (cervix and corpus) cancer is one of the major causes of mortality in women in Mexico. Organotin carboxylated derivatives have been shown to have high cytotoxic activity against various cell lines of human origin. We describe the synthesis of three new tributyltin derivatives, the structures of which were confirmed using spectral data (1H NMR, 13C NMR, 119Sn NMR and infrared), elemental analyses, mass spectrometry and X-ray diffraction. All the compounds showed potency against HeLa, CaSki and ViBo.