Biopharmaceutics & Drug Disposition

Cover image for Vol. 38 Issue 4

Edited By: K. Sandy Pang

Impact Factor: 2.091

ISI Journal Citation Reports © Ranking: 2016: 157/256 (Pharmacology & Pharmacy)

Online ISSN: 1099-081X

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Special Issue: Role of Gut Wall in the Fate of Orally Administered Drugs
Part 1Part 2

These special issues contain a series of articles that bring together original research as well as critical reviews on gut wall drug metabolism and absorption, with emphasis on topics of gut wall attributes and their importance in considering the fate of orally administered drugs.

Free Review articles
Projecting human pharmacokinetics of monoclonal antibodies from nonclinical data: comparative evaluation of prediction approaches in early drug development
Jing Wang, Suhasini Iyer, et al.

Challenges and advances in the assessment of the disposition of antibody-drug conjugates
Amrita V. Kamath and Suhasini Iyer

Plasma vs heart tissue concentration in humans – literature data analysis of drugs distribution
Zofia Tylutki and Sebastian Polak

Dealing with the complex drug–drug interactions: Towards mechanistic models
Manthena V. Varma, K. Sandy Pang,et al.

Recently Published Articles

  1. SGK1/Nedd4-2 signaling pathway regulates the activity of Human Organic Anion Transporters 3

    Haoxun Wang and Guofeng You

    Accepted manuscript online: 13 JUN 2017 03:40AM EST | DOI: 10.1002/bdd.2085

  2. Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

    Masahiro Utoh, Tomonori Miura, Takashi Kusama, Shotaro Uehara, Makiko Shimizu, Yasuhiro Uno and Hiroshi Yamazaki

    Accepted manuscript online: 13 JUN 2017 03:40AM EST | DOI: 10.1002/bdd.2084

  3. Development of a physiologically based pharmacokinetic model to predict the effects of flavin-containing monooxygenase 3 (FMO3) polymorphisms on itopride exposure

    Wangda Zhou, Helen Humphries, Sibylle Neuhoff, Iain Gardner, Eric Masson, Nidal Al-Huniti and Diansong Zhou

    Version of Record online: 28 MAY 2017 | DOI: 10.1002/bdd.2074

  4. Influence of the pharmacokinetic profile on the plasma glucose lowering effect of the PPARγ agonist pioglitazone in Wistar fatty rats

    Akihiko Goto, Yoshihiko Tagawa, Yoshiaki Kimura, Akifumi Kogame, Yuu Moriya and Nobuyuki Amano

    Version of Record online: 28 MAY 2017 | DOI: 10.1002/bdd.2076

  5. Impact of acute fat mobilisation on the pharmacokinetics of the highly fat distributed compound TAK-357, investigated by physiologically based pharmacokinetic (PBPK) modeling and simulation

    Akihiko Goto, Yoshihiko Tagawa, Yuu Moriya, Sho Sato, Yoshiyuki Furukawa, Takeshi Wakabayashi, Tetsuya Tsukamoto, Joost DeJongh, Tamara J. van Steeg, Toshiya Moriwaki and Satoru Asahi

    Version of Record online: 23 MAY 2017 | DOI: 10.1002/bdd.2075