Biopharmaceutics & Drug Disposition

Cover image for Vol. 36 Issue 4

Edited By: K. Sandy Pang

Impact Factor: 2.34

ISI Journal Citation Reports © Ranking: 2014: 131/254 (Pharmacology & Pharmacy)

Online ISSN: 1099-081X

Author Guidelines

Thank you for your interest in Biopharmaceutics and Drug Disposition. Please read the complete Author Guidelines carefully prior to submission, including the section on copyright. To ensure fast peer review and publication, manuscripts that do not adhere to the following instructions will be returned to the corresponding author for technical revision before undergoing peer review. Note that submission implies that the content has not been published or submitted for publication elsewhere except as a brief abstract in the proceedings of a scientific meeting or symposium.

Once you have prepared your submission in accordance with the Guidelines, manuscripts should be submitted online at

We are looking forward to your submission.


Unless indicated, authors are given 1 to 3 months to resubmit revisions. An extension to deadline must be communicated by the corresponding author for approval to the Editor who is handling the manuscript. If the Author has created the revision or resubmission and the work is in progress but expires prior to the Author submitting the revised paper, s/he must seek extension in writing. There is no mechanism to accept delayed submissions. A lapsed manuscript may be re-submitted to the journal as a new submission. However, the new submission will be subject to a new process of review and cause delay in the review process.


Conflict of Interest
All authors must declare financial/commercial conflicts of interest. Even if there is none, this should be stated in a separate paragraph following on from the acknowledgements section. This is a mandatory requirement for all articles.

Plagiarism and COPE Membership
Biopharmaceutics and Drug Disposition endorses the COPE (Committee on Publication Ethics) guidelines and will pursue cases of suspected research and publication misconduct (e.g. falsification, fabrication, plagiarism, inappropriate image manipulation, redundant publication). In such cases, the journal will follow the processes set out in by COPE. For more information about COPE please visit the COPE website.

Reproduction of Copyright Material
If excerpts from copyrighted works owned by third parties are included, credit must be shown in the contribution. It is the author’s responsibility to also obtain written permission for reproduction from the copyright owners. For more information visit Wiley’s Copyright Terms & Conditions FAQ at


Pre-acceptance English-language editing
Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English. Visit our site to learn about the options. All services are paid for and arranged by the author. Please note using the Wiley English Language Editing Service does not guarantee that your paper will be accepted by this journal.

Optimising Your Article for Search Engines
Many students and researchers looking for information online will use search engines such as Google, Yahoo or similar. By optimising your article for search engines, you will increase the chance of someone finding it. This in turn will make it more likely to be viewed and/or cited in another work. We have compiled these guidelines to enable you to maximise the web-friendliness of the most public part of your article.


The journal accepts short communications, original research papers, and review articles from the editors or guest editors. The language of the journal is American English. All submissions must have a margin of 2.2cm all round, and be double-spaced. Illustrations must be on separate sheets, and not be incorporated into the text. All of the article types should follow the instructions described hereafter. Submissions that do not follow the proposed format will not be reviewed. Each manuscript should contain the following text sections: Title page, Running title page, Abstract, Introduction, Material and Methods, Results, Discussion and Conclusion in the order listed. Each section should be titled and begin on a new page. All pages, excluding figure pages, should be numbered consecutively.

Title page. The title should be pertinent and descriptive, and the page must list the full title and names and affiliations of all authors. At the bottom of the tile page, include the name(s) of any sponsor(s) of the research contained in the paper, along with grant number(s).

Running page title. Provide a short title no more than 60 characters. Give the full address, including e-mail, telephone and fax, of the corresponding author.

Abstract page. Supply an abstract of no more than 250 words for all article types. An abstract is a concise summary of the whole paper not just the conclusions, and is understandable without reference to the rest of the paper. It should contain no citation to other published work. Include 3-5 keywords that describe Authors' paper for indexing purposes.

Text.The text includes Introduction, Material and Methods, Results, Discussion, and Conclusion.

Appendix. Appendices, if present, should come immediately after the main text and before the references.

Acknowledgments. The Acknowledgments section is placed at the end of the text. Grant support and personal assistance are noted here.

References. References should not exceed 50, and cited by numbers in square brackets and listed at the end of the paper in the order in which they appear in the text. All references must be complete and accurate. Where possible the DOI for the reference should be included at the end of the reference. Online citations should include date of access. Use Index Medicus abbreviations for journal names. If necessary, cite unpublished or personal work in the text but do not include it in the reference list. References should be listed in the following style:

1. Aungst BJ, Blake JA, Hussain MA. An in vitro evaluation of metabolism and poor membrane permeation impeding intestinal absorption of leucine enkephalin, and methods to increase adsorption. Biopharm Drug Dispos 2003; 24 : 1-16. DOI:10.1002/bdd.258

2. Altman DG. Practical Statistics for Medical Research. Chapman & Hall: London, 1991; 36- 38.

3. Smith QR. Quantitation of blood-brain barrier permeability. In Implication of the Blood-Brain Barrier and Its Manipulation, Neuwelt EA (ed). Plenum Medical Book Company: New York, 1989; 85-117.

4. The Oncology Website. [24 April 1999].

Figure legends.The legend page follows immediately after reference pages in the main document.

Tables.Tables should be part of the main document and should be placed after the figure legend pages. Do not use excel files for tables for submission.

Group all of the above sections into one, main document for submission.

Figures. Do not include figures in the main document. Upload each figure as a separate file in either .tiff or .eps format, with the lead author's name, the figure number at the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be of reasonable size that would still be clearly legible upon reduction and consistent within each figure and set of figures. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All instructions must be supplied at the correct resolution:

● Black and white and colour photos - 300 dpi minimum
● Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum
● Combinations of photos and drawings (black and white and colour) - 500 dpi minimum

Others. Structural formulae of parent compounds and metabolites should be given; where possible, these should be general formulae with variable groups identified in a legend.

Short Communications
Short communications are intended for the dissemination of the results of studies that are slightly more limited in scope than those warranting a full paper, and should not exceed 1500 words (excluding references) plus a maximum of one figure and/or one table. Short Communications are subject to the same review process as full papers. Short Communications should contain the same sections as full papers. The Results and Discussion sections may be combined.

Contemporary reviews on topics of interest covering more recent aspects of a topic will be published. These may be critical reviews that present the authors' view of the current state of the subject or prospective articles intended to stimulate discussion and research. Manuscripts submitted under this category may be unsolicited or may be invited by the editor.

File Types for Submission

File types
Preferred formats for the text and tables of Authors’ manuscript are .doc, .docx, .rtf, .ppt, .xls. LaTeX files may be submitted provided that an .eps or .pdf file is provided in addition to the source files. Figures may be provided in .tiff or .eps format.

Initial Submission
Non-LaTeX Users: Upload Authors’ manuscript files and any supplementary material files. At this stage, further source files do not need to be uploaded.

LaTeX Users: For reviewing purposes Author should upload a single .pdf (including any supplementary material) that Author have generated from Authors’ source files. Authors must use the File Designation "Main Document" from the dropdown box.

Revision Submission
Non-LaTeX Users: Editable source files must be uploaded at this stage. Tables must appear after the reference list, and be incorporated into the main text. Figures should be uploaded as separate figure files.

LaTeX Users: When submitting the revision, Authors must still upload a single .pdf that Authors have generated from the now revised source files. Authors must use the File Designation "Main Document" from the dropdown box. In addition Authors must upload the TeX source files. For all Authors’ source files Authors must use the File Designation "Supplemental Material not for review". Previous versions of uploaded documents must be deleted. For the accepted manuscript, Wiley will use the files which Authors have uploaded to typeset the article within a totally digital workflow.

Authors are advised to highlight the changes made according to the suggestions of the reviewers in the revised manuscript – show with different color fonts. Authors can load this version after the “unmarked or clean” revised version. The rebuttal should be uploaded as a supplemental file. The ID# and the revision version should be centered in the header (e.g. BDD-00189-R2).

No Color Charges
Biopharmaceutical & Drug Disposition offers authors the opportunity to reproduce color figures at no charge in both online and printed versions of the article.


Accepted papers will be passed to Wiley’s production team for publication. The author identified as the formal corresponding author for the paper will receive an email prompting them to login into Wiley’s Author Services, where via the Wiley Author Licensing Service (WALS) they will be asked to complete an electronic license agreement on behalf of all authors on the paper. More details on the Author Services and Copyright and Licensing options for the journal appear below.

Wiley’s Author Services: Tracking your paper's progress
Author Services also enables authors to track their article through the production process to publication online and in print. Authors can check the status of their articles online and choose to receive automated e-mails at key stages of production. The corresponding author will receive a unique link that enables them to register and have their article automatically added to the system. Please ensure that a complete e-mail address is provided when submitting the manuscript. Visit Wiley Author Services for more details on online production tracking and for a wealth of resources including FAQs and tips on article preparation, submission and more.

Accepted Articles
The journal offers Wiley’s Accepted Articles service for all manuscripts. This service ensures that accepted ‘in press’ manuscripts are published online very soon after acceptance, prior to copy-editing or typesetting. Accepted Articles are published online a few days after final acceptance, appear in PDF format only, are given a Digital Object Identifier (DOI), which allows them to be cited and tracked, and are indexed by PubMed.

Proof Corrections
Once the paper has been typeset the corresponding author will receive an e-mail alert containing instructions on how to provide proof corrections to the article. It is therefore essential that a working e-mail address is provided for the corresponding author.

Early View
The journal offers rapid speed to publication via Wiley’s Early View service. Early View articles are complete full-text articles published online in advance of their publication in a printed issue. Early View articles are complete and final. They have been fully reviewed, revised and edited for publication, and the authors' final corrections have been incorporated. Because they are in final form, no changes can be made after online publication. Early View articles are given a Digital Object Identifier (DOI), which allows the article to be cited and tracked before allocation to an issue. After print publication, the DOI remains valid and can continue to be used to cite and access the article.

A PDF reprint of the article will be supplied free of charge to the corresponding author. Additional printed offprints may be ordered online for a fee. Please click on the following link and fill in the necessary details and ensure that you type information in all of the required fields: http://offprin you have queries about offprints please email: offprint@cosprinte


Accepted papers will be passed to Wiley’s production team for publication. The author identified as the formal corresponding author for the paper will receive an email prompting them to login into Wiley’s Author Services, where via the Wiley Author Licensing Service (WALS) they will be asked to complete an electronic license agreement on behalf of all authors on the paper.

Authors may choose to publish under the terms of the journal’s standard copyright transfer agreement (CTA), or under open access terms made available via Wiley OnlineOpen.

Standard Copyright Transfer Agreement: FAQs about the terms and conditions of the standard CTA in place for the journal, including standard terms regarding archiving of the accepted version of the paper, are available at Copyright Terms and Conditions FAQs. Note that in signing the journal’s license agreement authors agree that consent to reproduce figures from another source has been obtained.

OnlineOpen – Wiley’s Open Access Option: OnlineOpen is available to authors of articles who wish to make their article freely available to all on Wiley Online Library under a Creative Commons license. With OnlineOpen, the author, the author's funding agency, or the author's institution pays a fee to ensure that the article is made open access. Authors of OnlineOpen articles are permitted to post the final, published PDF of their article on their personal website, and in an institutional repository or other free public server immediately after publication. All OnlineOpen articles are treated in the same way as any other article. They go through the journal's standard peer-review process and will be accepted or rejected based on their own merit.

OnlineOpen licenses. Authors choosing OnlineOpen retain copyright in their article and have a choice of publishing under the following Creative Commons License terms: Creative Commons Attribution License (CC BY); Creative Commons Attribution Non-Commercial License (CC BY NC); Creative Commons Attribution Non-Commercial- NoDerivs License (CC BY NC ND). To preview the terms and conditions of these open access agreements please visit the Copyright Terms and Conditions FAQs.

Funder Open Access and Self-Archiving Compliance: Please click here for more information on Wiley’s compliance with specific Funder Open Access and Self Archiving Policies, and click here for more detailed information specifically about Self-Archiving definitions and policies.

NIH Public Access Mandate: For those interested in the Wiley policy on the NIH Public Access Mandate, please visit our policy statement.

Guidelines Updated May 2015