Journal of Applied Toxicology

Cover image for Vol. 36 Issue 11

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/89 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:

Post Doc Award: Justin Conley, USEPA, USA (left)

Student Award: Parker Duffney, Rochester University, USA (right)

SOT Mixtures Award winners 2016

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Recently Published Articles

  1. Toxicological role of an acyl glucuronide metabolite in diclofenac-induced acute liver injury in mice

    Shingo Oda, Yuji Shirai, Sho Akai, Akira Nakajima, Koichi Tsuneyama and Tsuyoshi Yokoi

    Version of Record online: 27 SEP 2016 | DOI: 10.1002/jat.3388

    The acyl glucuronide (AG) metabolites of carboxylic acid-containing drugs are suggested to be implicated in toxicity, including hepatotoxicity. However, whether AG formation is related to toxicity in vivo remains unknown. We found that pretreatment of mice with the UDP-glucuronosyltransferase inhibitor (−)-borneol alleviated diclofenac (DIC)-induced acute liver injury by suppressing neutrophil infiltration into the liver. Thus, DIC-AG is partly involved in the pathogenesis of DIC-induced acute liver injury in mice by activating innate immunity.

  2. Natural remedies for non-steroidal anti-inflammatory drug-induced toxicity

    Jerine Peter Simon and Sabina Evan Prince

    Version of Record online: 22 SEP 2016 | DOI: 10.1002/jat.3391

    The liver play a vital role in drug metabolism. Non-steroidal anti-inflammatory drug (NSAID) are known to cause hepato-renal toxicity and gastric ulcers. This review suggest natural products as a better remedies against NSAID-induced complications.

  3. Toxic effects of 4-methylthio-3-butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity

    Isamu Suzuki, Young-Man Cho, Tadashi Hirata, Takeshi Toyoda, Jun-ichi Akagi, Yasushi Nakamura, Azusa Sasaki, Takako Nakamura, Shigehisa Okamoto, Koji Shirota, Noboru Suetome, Akiyoshi Nishikawa and Kumiko Ogawa

    Version of Record online: 15 SEP 2016 | DOI: 10.1002/jat.3384

    We investigated whether 4-methylthio-3-butenyl isothiocyanate (MTBITC), which has known to have chemopreventive effects on rat carcinogenesis at a dose of 80 ppm in the diet, exhibited toxic effects or in vivo genotoxicity in the urinary bladder of rats. We found that treatment with 1000 ppm MTBITC caused non-genotoxic effects in the urinary bladder, whereas 100 or 300 ppm MTBITC had no toxic effects.

  4. Oxidative stress and cytotoxic effects of silver ion in mouse lung macrophages J774.1 cells

    Ilseob Shim, Kyunghee Choi and Seishiro Hirano

    Version of Record online: 14 SEP 2016 | DOI: 10.1002/jat.3382

    Cytotoxic effects of silver ion (Ag+) were investigated. Ag+ caused oxidative stress, activated mitogen-activated protein kinase, and rapidly and remarkably decreased glutathione level with a reciprocal induction of metallothionein in J774.1 cells. The reporter gene assay indicated that Ag+ activated both antioxidant responsive element and nuclear factor-κB pathways. Ag+ also increased the activity of caspase-3/7. However, caspase inhibitors did not ameliorate the cell viability, suggesting that the mode of cell death was necrotic rather than apoptotic.

  5. Biologic activity of cyclic and caged phosphates: a review

    Dietrich E. Lorke, Anka Stegmeier-Petroianu and Georg A. Petroianu

    Version of Record online: 9 SEP 2016 | DOI: 10.1002/jat.3369

    This review summarizes the diverse biologic effects associated with various cyclic and caged phosphates and phosphonates such as inhibition of acetylcholine esterase, neurotoxic esterase, lipase and β-lactamase, GABA antagonism, signal transduction, ryanodine channel modulation and pharmacokinetic modulation of numerous drugs. Possible clinical applications of these compounds are considered.