Journal of Applied Toxicology

Cover image for Vol. 37 Issue 10

Editor-in-Chief: Philip W. Harvey

Impact Factor: 3.159

ISI Journal Citation Reports © Ranking: 2016: 26/92 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2017, our congratulations go to:

Post Doc Award: Justin Conley, NHREEL, USA (left)

Student Award: Ms. Changqing Zhou, University of Illinois, USA (right)

Justin Conley SOT PhD 2017SOT 2017 Student winner Zhou

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Recently Published Articles

  1. NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells

    Xia Sun, Yi Yang, Junpeng Shi, Chengcheng Wang, Zhenfeng Yu and Hongwu Zhang

    Version of Record online: 16 AUG 2017 | DOI: 10.1002/jat.3511

    Silver nanoparticles (AgNPs) induced excess reactive oxygen species production that affected the signaling pathways by a mechanism that depended on activation of nicotinamide adenine dinucleotide phosphate oxidase activity through upregulation of NOX4 protein expression. Moreover, AgNPs could disrupt the nuclear factor erythroid 2-related factor 2-mediated antioxidant response, which is considered another important element for oxidative stress caused by AgNPs in human umbilical vein endothelial cells. The redox imbalance between NOX4 and nuclear factor erythroid 2-related factor 2 was an important cause for the reactive oxygen species overproduction that led to cell injury in human umbilical vein endothelial cells.

  2. A novel endpoint for the assessment of chemotherapy-induced peripheral neuropathy in rodents: biomechanical properties of peripheral nerve

    Chang-Ning Liu, Edwin Berryman, David Zakur, Ahmed M. Shoieb, Ingrid D. Pardo, Magalie Boucher, Chris J. Somps, Chedo M. Bagi and Jon C. Cook

    Version of Record online: 16 AUG 2017 | DOI: 10.1002/jat.3513

    Rats and mice administered vincristine were employed as the chemotherapy-induced peripheral neuropathy models. Behavior and ex vivo sural (rats) or sciatic nerve (mice) were assessed. It was found that the load and the load/extension ratio were decreased in the nerves collected from the animals dosed with vincristine. We concluded that mechanical properties of the nerves are a sensitive endpoint for chemotherapy-induced peripheral neuropathy prediction.

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    In vitro genotoxicity of airborne Ni-NP in air–liquid interface

    Siiri Latvala, Daniel Vare, Hanna L. Karlsson and Karine Elihn

    Version of Record online: 16 AUG 2017 | DOI: 10.1002/jat.3510

    The aim of this study was to investigate the genotoxicity of airborne Ni nanoparticles using a recently developed air-liquid interface exposure system that mimics real-life exposure. Cytotoxicity, DNA damage and mutagenicity were in the V79 cell line. Ni nanoparticle exposure of the cells in the air-liquid interface resulted in increased DNA strand breaks and reduced cellular viability at concentrations of 0.15 and 0.32 μg cm −2. These DNA lesions were repaired with BER in an error-free manner without resulting in mutations

  4. Comparison of four different fuller's earth formulations in skin decontamination

    Annick Roul, Cong-Anh-Khanh Le, Marie-Paule Gustin, Emmanuel Clavaud, Bernard Verrier, Fabrice Pirot and Françoise Falson

    Version of Record online: 26 JUL 2017 | DOI: 10.1002/jat.3506

    Industrial accidents, wars and terrorist threats are potential sources of skin contamination by highly toxic chemical warfare agents and manufacturing chemicals. We compare the time-dependent adsorption capacity of four formulations of FE and the decontamination efficiency for the water-soluble molecular tracer, 4-cyanophenol, in vitro and ex vivo using water decontamination as standard. Successful decontamination of fuller's earth suspension, enabling a dramatic reduction of skin contamination after a brief exposure scenario, appears to be rapid, reliable and could be developed for self-decontamination.