Journal of Applied Toxicology

Cover image for Vol. 36 Issue 12

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/89 (Toxicology)

Online ISSN: 1099-1263

Recently Published Issues

See all

Hot Topics, Unmissable Reviews and News

Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:

Post Doc Award: Justin Conley, USEPA, USA (left)

Student Award: Parker Duffney, Rochester University, USA (right)

SOT Mixtures Award winners 2016

 Nanotoxicology Virtual IssueZebrafish Virtual Issue 

Parabens Virtual Issue

Recently Published Articles

  1. The inadequacies of pre-market chemical risk assessment's toxicity studies—the implications

    Anthony C. Tweedale

    Version of Record online: 26 OCT 2016 | DOI: 10.1002/jat.3396

    Industry provides the data in pre-market chemical risk assessments. Comparison of two randomly chosen chemical's toxicity literature – academia's versus industry's – and a brief history of pre-market RA and of the OECD test guidelines, reveal inadequacies in industry's key chronic toxicity studies, which nevertheless are used to authorize chemicals for market.

  2. Toxicokinetics and toxicodynamics of chlorpyrifos is altered in embryos of Japanese medaka exposed to oil sands process-affected water: evidence for inhibition of P-glycoprotein

    Hattan A. Alharbi, Jane Alcorn, Ahmed Al-Mousa, John P. Giesy and Steve B. Wiseman

    Version of Record online: 24 OCT 2016 | DOI: 10.1002/jat.3397

    Effects of acidic, basic and neutral fractions of water soluble organic compounds from oil sands process water (OSPW) on the function of P-glycoprotein (P-gp) were investigated using Caco-2 cells and larvae of Japanese medaka. Basic and neutral fractions inhibited P-gp. Acute toxicity, accumulation, bioconcentration, and half-life of chlorpyrifos, a model compound used as a substrate of P-gp, were greater in larvae co-exposed with a mixture basic and neutral compounds. Results support chemosensitization as a potential mechanism of toxicity of OSPW.

  3. Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma

    Akiko Honda, Takahiro Sawahara, Tomohiro Hayashi, Kenshi Tsuji, Wataru Fukushima, Mizuki Oishi, Gaku Kitamura, Hitomi Kudo, Sho Ito, Seiichi Yoshida, Takamichi Ichinose, Kayo Ueda and Hirohisa Takano

    Version of Record online: 7 OCT 2016 | DOI: 10.1002/jat.3395

    Bjerkandera adusta ( and benzo[a]pyrene (BaP) each activated antigen-presenting cells (APCs) in the presence and the absence of heated Asian sand dust particles (H-ASDs). H-ASDs alone slightly activated APCs. The activation induced by was more apparent than that by BaP in the presence and absence of H-ASDs. rather than BaP contributes to the exacerbation of asthma regardless of the presence or absence of sand particles, particularly by activation of the immune system via APCs.

  4. Immunomodulatory effects of metal salts at sub-toxic concentrations

    Carmen Steinborn, Christoph Diegel, Manuel Garcia-Käufer, Carsten Gründemann and Roman Huber

    Version of Record online: 7 OCT 2016 | DOI: 10.1002/jat.3390

    Because different metals are used in complementary medicine for the treatment of diseases related to a dysfunction of the immune system, this study aimed at determining the immunomodulatory potential of Pb(NO3)2, AuCl3, Cu(NO3)2, HgCl2, AgNO3, SnCl2, AsCl3 and SbCl3 and possible toxic side effects of metal preparations. The results show that only copper preparations are promising to have immunomodulatory effects. Comparative analyses with upper limits of metals in the drinking water further showed that toxic side effects of low-concentrated metal preparations are improbable.

  5. Comparison of the local pulmonary distribution of nanoparticles administered intratracheally to rats via gavage needle or microsprayer delivery devices

    Guihua Zhang, Naohide Shinohara, Yutaka Oshima, Toshio Kobayashi, Nobuya Imatanaka, Kenji Kawaguchi and Masashi Gamo

    Version of Record online: 6 OCT 2016 | DOI: 10.1002/jat.3386

    Nanoparticle suspensions can be delivered in liquid state, via gavage needle or as liquid aerosol, using a microsprayer as the intratracheal delivery device. We quantitatively evaluated TiO2 pulmonary microdistribution (per mesh: 100 μm × 100 μm) in lung sections from rats administered an intratracheal dose of TiO2 nanoparticles (6 mg kg−1) via gavage needle or microsprayer, using microbeam X-ray fluorescence microscopy. The evidence suggests that the state of administered nanoparticle suspension does not markedly alter TiO2 pulmonary microdistribution.