Journal of Applied Toxicology
© John Wiley & Sons Ltd
Editor-in-Chief: Philip W. Harvey
Impact Factor: 2.722
ISI Journal Citation Reports © Ranking: 2015: 33/89 (Toxicology)
Online ISSN: 1099-1263
Hot Topics, Unmissable Reviews and News
Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:
Post Doc Award: Justin Conley, USEPA, USA (left)
Student Award: Parker Duffney, Rochester University, USA (right)
Recently Published Articles
- Toxicity of single-wall carbon nanotubes functionalized with polyethylene glycol in zebrafish (Danio rerio) embryos
Felipe A. Girardi, Gisele E. Bruch, Carolina S. Peixoto, Lidiane Dal Bosco, Sangram K. Sahoo, Carla O. F. Gonçalves, Adelina P. Santos, Clascídia A. Furtado, Cristiano Fantini and Daniela M. Barros
Version of Record online: 20 JUN 2016 | DOI: 10.1002/jat.3346
Individual zebrafish embryos were exposed to the single-wall carbon nanotubes functionalized with 2 kDa polyethylene glycol. The sample was characterized by transmission electron microscopy, thermogravimetric analysis and Raman spectroscopy. The results demonstrate that single-wall carbon nanotube–polyethylene glycol have low toxicity in zebrafish embryos and were unable to reach the internal tissues of the animals. The presence of residual metals is possibly among the primary mechanisms responsible for the toxic effects observed.
- Framework for human health risk assessment of non-cancer effects resulting from short-duration and intermittent exposures to chemicals
Lynne T. Haber, Reena Sandhu, Angela Li-Muller, Asish Mohapatra, Sanya Petrovic and M. E. (Bette) Meek
Version of Record online: 14 JUN 2016 | DOI: 10.1002/jat.3345
To aid in assessing potential noncancer health effects from short-duration and intermittent exposures, a working framework was developed utilizing a tiered approach, drawing as much as possible on existing TRVs or minor adaptations of same. Toxicokinetic and toxicodynamic considerations are included. The framework incorporates the use of TRVs based on exposure periods as similar as possible to the ‘actual’ exposure periods and application of dose averaging under limited, specified conditions.
- Cytotoxic effects of psychotropic benzofuran derivatives, N-methyl-5-(2-aminopropyl)benzofuran and its N-demethylated derivative, on isolated rat hepatocytes
Yoshio Nakagawa, Toshinari Suzuki, Yukie Tada and Akiko Inomata
Version of Record online: 13 JUN 2016 | DOI: 10.1002/jat.3351
The novel psychoactive compounds derived from amphetamine have been illegally abused as recreational drugs, some of which are known to be hepatotoxic in humans and experimental animals. The cytotoxic effects and mechanisms of 5-(2-aminopropyl)benzofuran (5-APB) and N-methyl-5-(2-aminopropyl)benzofuran (5-MAPB), both of which are benzofuran analogues of amphetamine, and 3,4-methylenedioxy-N-methamphetamine (MDMA) were studied in freshly isolated rat hepatocytes. 5-MAPB caused not only concentration-dependent (0–4.0mM) and time-dependent (0–3 h) cell death accompanied by the depletion of cellular ATP and reduced glutathione and protein thiol levels, but also accumulation of oxidized glutathione. Of the other analogues examined at a concentration of 4mM, 5-MAPB/5-APB-induced cytotoxicity with the production of reactive oxygen species and loss of mitochondrial membrane potential was greater than that induced by MDMA.
- Detection of exposure effects of mixtures of heavy polycyclic aromatic hydrocarbons in zebrafish embryos
Alejandro Barranco, Laura Escudero, Jon Sanz Landaluze and Sandra Rainieri
Version of Record online: 10 JUN 2016 | DOI: 10.1002/jat.3353
Our objective was to detect in a realistic and accurate manner the effects of mixtures of heavy polycyclic aromatic hydrocarbons (PAHs) in zebrafish embryos. Assays were performed in the darkness, supplementing the exposure solution with dimethyl sulfoxide and Tween 20. PAHs did not bioaccumulate in zebrafish embryos; however, genes were induced already after 6 h of exposure indicating that the exposure effects are due to PAH metabolites formed shortly after uptake. Benzo[k]fluoranthene was responsible for the induction of cyp1a1 in the mixture at low concentration, but not at the high concentration tested.
- What determines skin sensitization potency: Myths, maybes and realities. The 500 molecular weight cut-off: An updated analysis
Jeremy M. Fitzpatrick, David W. Roberts and Grace Patlewicz
Version of Record online: 10 JUN 2016 | DOI: 10.1002/jat.3348
This updated analysis systematically interrogated a large repository of sensitization information collected under the EU REACH regulation. A data set of 2904 substances that had been tested for skin sensitization, using guinea pigs and/or mice were collected. The data set contained 197 substances with a MW > 500; 33 of these were skin sensitizers. Metal containing complexes, reaction products and mixtures were excluded from further consideration. The final set of 14 sensitizers substantiated the original findings.