Journal of Applied Toxicology

Cover image for Vol. 37 Issue 3

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/90 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:

Post Doc Award: Justin Conley, USEPA, USA (left)

Student Award: Parker Duffney, Rochester University, USA (right)

SOT Mixtures Award winners 2016

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Recently Published Articles

  1. Automated image analysis of intra-tumoral and peripheral endocrine organ vascular bed regression using ‘Fibrelength’ as a novel structural biomarker

    Adam Hargreaves, Alison Bigley, Shirley Price, Jane Kendrew and Simon T. Barry

    Version of Record online: 10 FEB 2017 | DOI: 10.1002/jat.3438

    The study of vascular modulation has received a great deal of attention in recent years. Here we present the generation of a novel structural biomarker, which can be incorporated into a number of contemporary image analysis platforms and used to compare tumour versus systemic host tissue vascularity. By contrasting the measurements obtained, the preclinical efficacy of vascular modulating chemotherapies can be evaluated in light of concomitant systemic vascular toxicity.

  2. Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark dose analysis

    Kazuhiro Nogawa, Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa and Yasushi Suwazono

    Version of Record online: 10 FEB 2017 | DOI: 10.1002/jat.3444

    The aim of this study was to estimate the lower limit of the benchmark dose (BMDL) as the threshold limit level of the Cd concentration in rice for itai-itai disease and/or suspected disease based upon a logistic regression model. The estimated BMDLs of the Cd concentration in rice for itai-itai disease and/or suspected disease were 0.62–0.76 and 0.27–0.56 mg kg−1 in men and women, respectively. This result provides important information about the worldwide standard for the Cd concentration in rice.

  3. Effects of neonatal 17α-ethinyloestradiol exposure on female-paced mating behaviour in the rat

    Chiaki Komine, Shingo Nakajima, Yasuhiko Kondo, Yasuyuki Horii, Midori Yoshida and Maiko Kawaguchi

    Version of Record online: 8 FEB 2017 | DOI: 10.1002/jat.3449

    Perinatal exposure to xeno-oestrogens can disrupt female sexual development, leading to changes in reproductive behaviour in adulthood, but the effects remain to be fully determined. We examined the effects of a single perinatal exposure to low (0.02 mg kg−1) and high (2.0 mg kg−1) doses of 17α-ethinyloestradiol (EE) on female rats in a paced mating test. The high EE dose, but not the low dose, disrupted females' sexual behaviours in adulthood. Such exposure could pose a risk to reproductive health.

  4. Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells

    Qingping Liu, Xiaoli Ji, Zehe Ge, Haipeng Diao, Xiuli Chang, Lihua Wang and Qing Wu

    Version of Record online: 8 FEB 2017 | DOI: 10.1002/jat.3441

    The roles of the protein connexin 43 (Cx43) in the effects of Cd on the prostate have not been reported previously. In this study, the human prostate epithelial cell line RWPE-1 was exposed to Cd. A low dose of Cd stimulated cell proliferation, along with a lower degree of gap junction intercellular communication and an elevated level of Cx43. Knockdown of Cx43 blocked Cd-induced proliferation. Thus, Cx43 might be a target for prostatic abnormality associated with Cd exposure.

  5. Pancreatic impairment and Igf2 hypermethylation induced by developmental exposure to bisphenol A can be counteracted by maternal folate supplementation

    Zhenxing Mao, Wei Xia, Wenqian Huo, Tongzhang Zheng, Bryan A. Bassig, Huailong Chang, Tian Chen, Feie Li, Yunxin Pan, Yang Peng, Yuanyuan Li and Shunqing Xu

    Version of Record online: 6 FEB 2017 | DOI: 10.1002/jat.3430

    Perinatal BPA exposure can induced epigenetic modification in offspring islet. Maternal folate supplementation can ameliorate perinatal BPA-induced glucose intolerance and β-cell dysfunction in the offspring. Perinatal BPA exposure induced DNA hypermethylation of Igf2 in offspring islets which can be counteracted by maternal folate supplementation. The changes of epigenetics in islet may contribute to the protection.