Journal of Applied Toxicology

Cover image for Vol. 37 Issue 4

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/90 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:

Post Doc Award: Justin Conley, USEPA, USA (left)

Student Award: Parker Duffney, Rochester University, USA (right)

SOT Mixtures Award winners 2016

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Recently Published Articles

  1. Evidence for persistent organochlorine pollutants in the human adrenal cortex

    Enza Fommei, Roberta Turci, Andrea Ripoli, Silvana Balzan, Fabrizio Bianchi, Luca Morelli and Alessio Coi

    Version of Record online: 23 MAR 2017 | DOI: 10.1002/jat.3460

    Surgical fragments of aldosterone-producing adenomas (APA) from 11 patients and normal adrenals (NA) from 8 kidney donors were analyzed for 16 polychlorinated biphenyls (PCBs) and 10 organochlorine pesticides (OCPs) by Matrix Solid-Phase Dispersion together with Triple Quad GC-MS. OCPs and PCBs were found in specimens from both types with higher concentrations in APA for α-, β-, γ-HCH, HCB, and for PCBs 28, 52, and 101. Chlorinated pollutants may accumulate in the human adrenal cortex. Studies are needed to clarify their possible role as human adrenal endocrine disruptors.

  2. Reproductive disorders in female rats after prenatal exposure to betamethasone

    Cibele S. Borges, Tainá L. Pacheco, Marina T. Guerra, Aline L. Barros, Patricia V. Silva, Gabriela Missassi, Katiussia Pinho da Silva, Janete A. Anselmo-Franci, André S. Pupo and Wilma De G. Kempinas

    Version of Record online: 21 MAR 2017 | DOI: 10.1002/jat.3457

    Betamethasone promoted the reduction in litter weight and morphological masculinization in females, delay in puberty onset, reduction in estrus number with increase in estrus cycle length and luteinizing hormone serum levels. The uterus showed an increase in myometrial area with higher contractility activity and decrease in endometrial area. These animals also performed less lordosis and showed impaired reproductive performance. In conclusion, prenatal betamethasone exposure promoted female reproductive disorders.

  3. The percutaneous toxicokinetics of Sulphur mustard in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant

    Charlotte A. Hall, Helen L. Lydon, Christopher H. Dalton, J. Kevin Chipman, John S. Graham and Robert P. Chilcott

    Version of Record online: 17 MAR 2017 | DOI: 10.1002/jat.3453

    Application of 14C–radiolabelled sulphur mustard (14C–SM) to damaged pig skin without decontamination resulted in advanced signs of toxicity with rapid onset (n = 6). Application of WoundStat™ post exposure prevented or delayed signs of toxicity in all decontaminated animals (n = 6) and improved perfusion at the exposure site, while significantly smaller quantities of 14C–SM were detected in the blood and recovered from the skin. This study demonstrates that WoundStat™ is suitable for reducing the ingress and toxicity of a vesicant agent.

  4. Toxicity of inhaled particulate matter on the central nervous system: neuroinflammation, neuropsychological effects and neurodegenerative disease

    Yan Wang, Lilin Xiong and Meng Tang

    Version of Record online: 16 MAR 2017 | DOI: 10.1002/jat.3451

    Particulate matter (PM) combined with meteorological factors cause the haze, which deeply endanger people's health. Due to its special physicochemical property, the brain could be a potential target beyond the pulmonary system. It has been reported that PM, in particular the smallest particles (nano-sized particles), was involved in neural developmental disorder and neurodegenerative disease. Chronic vicious circulation called reactive microgliosis and astrogliosis may be the potential mechanism. This review highlighted research advances on the health effect of PM with emphasis on neurotoxicity.

  5. Altered expression of the Olr59, Ethe1, and Slc10a2 genes in the liver of F344 rats by neonatal thyroid hormone disruption

    Kana Matsubara, Naoki Nakamura, Seigo Sanoh, Shigeru Ohta, Shigeyuki Kitamura, Naoto Uramaru, Shinichi Miyagawa, Taisen Iguchi and Nariaki Fujimoto

    Version of Record online: 16 MAR 2017 | DOI: 10.1002/jat.3452

    To understand the long-term alteration in gene expressions by neonatal administration of thyroid hormone-like chemicals, we identified hepatic genes whose expression was altered by neonatal exposure to T3 in rats. The cDNA microarray analysis showed that mRNA expression of Olr59, Ethe1, and Slc10a2 increased specifically in rats neonatally exposed to T3. Our data suggest that neonatal thyroid hormone disruption could affect long-term expression of the genes which would be useful markers for the neonatal endocrine disruption.