Journal of Applied Toxicology

Cover image for Vol. 36 Issue 7

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.982

ISI Journal Citation Reports © Ranking: 2014: 27/88 (Toxicology)

Online ISSN: 1099-1263

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The hottest articles in Nanotoxicology, Zebrafish and Parabens from the Journal of Applied Toxicology are presented here in three Virtual Issues. Click on the images to access these key research areas.

 Nanotoxicology Virtual Issue Zebrafish Virtual Issue

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Recently Published Articles

  1. Lithium limits trimethyltin-induced cytotoxicity and proinflammatory response in microglia without affecting the concurrent autophagy impairment

    Cinzia Fabrizi, Elena Pompili, Francesca Somma, Stefania De Vito, Viviana Ciraci, Marco Artico, Paola Lenzi, Francesco Fornai and Lorenzo Fumagalli

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/jat.3344

    Trimethyltin (TMT) is a highly toxic molecule present as an environmental contaminant causing neurodegeneration particularly of the limbic systemboth in humans and in rodents. We recently described the occurrence of impairment in the late stages of autophagy in TMT-intoxicated astrocytes. Here we show that similarly to astrocytes also in microglia, TMT induces the precocious block of autophagy indicated by the accumulation of the autophagosome marker, microtubule associated protein light chain 3.

  2. Toxic effects of chemical dispersant Corexit 9500 on water flea Daphnia magna

    Kenji Toyota, Nicole A. McNabb, Demetri D. Spyropoulos, Taisen Iguchi and Satomi Kohno

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/jat.3343

    To understand the toxic effects of chemical dispersant, Corexit 9500, on freshwater zooplankton, we conducted the acute and chronic toxicity tests using Daphnia magna. Our results indicate that it has toxic effects on daphnids, particularly during the neonatal developmental stage, which is consistent with marine zooplankton results. Therefore, our findings of its adverse effects on daphnids suggest that application of this type of chemical dispersant may have catastrophic impacts on freshwater ecosystems by disrupting the key food chain network.

  3. Cytotoxic and inflammatory responses of TiO2 nanoparticles on human peripheral blood mononuclear cells

    Supunsa Kongseng, Krongtong Yoovathaworn, Kanokpan Wongprasert, Rodjana Chunhabundit, Patinya Sukwong and Dakrong Pissuwan

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/jat.3342

    The effect of commercial titanium dioxide nanoparticles (TiO2-NPs) on induction of cytotoxic effect in human peripheral blood mononuclear cells (PBMCs) was investigated in serum-free medium. We assessed how TiO2-NPs affect cell viability, cell apoptosis, reactive oxygen species production and proinflammatory cytokine secretion of PBMCs. Our results suggest that the used concentration of TiO2-NPs has a significant impact on toxic induction of PBMCs.

  4. Integrated approach to testing and assessment for predicting rodent genotoxic carcinogenicity

    Petko I. Petkov, Terry W. Schultz, E. Maria Donner, Masamitsu Honma, Takeshi Morita, Shuichi Hamada, Akihiro Wakata, Masayuki Mishima, Jiro Maniwa, Milen Todorov, Elena Kaloyanova, Stefan Kotov and Ovanes G. Mekenyan

    Version of Record online: 25 MAY 2016 | DOI: 10.1002/jat.3338

    The performance of an integrated approach to testing and assessment (IATA) is investigated, covering different genotoxic mechanisms causing cancer and to replicate measured carcinogenicity data included in a new consolidated database. The IATA is docked to the OECD Toolbox and uses measured data for different genotoxicity endpoints when available. Alternatively, the system automatically provides predictions from structure–activity relationship genotoxicity models. When assigned only within the models' domains, performance of the IATA was high, with sensitivity of 74% and specificity of 83%.

  5. Investigation on the mechanism of non-photocatalytically TiO2-induced reactive oxygen species and its significance on cell cycle and morphology

    Nirmal Kumar Gali, Zhi Ning, Walid Daoud and Peter Brimblecombe

    Version of Record online: 18 MAY 2016 | DOI: 10.1002/jat.3341

    Titanium dioxide nanoparticles are widely used in daily activities of human life. However its toxic effects are not fully understood. In this study, a new mechanism of TiO2 catalytic action was discussed to understand its long-term cytotoxic effects, where cytoskeletal rearrangement was hypothesized to be induced by particle mediated-cellular ROS. The study was further extended in identifying dissolved oxygen as the driving agent in TiO2 catalytic activity in dark environment.

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