Journal of Applied Toxicology

Cover image for Vol. 37 Issue 1

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/90 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:

Post Doc Award: Justin Conley, USEPA, USA (left)

Student Award: Parker Duffney, Rochester University, USA (right)

SOT Mixtures Award winners 2016

 Nanotoxicology Virtual IssueZebrafish Virtual Issue 

Parabens Virtual Issue

Recently Published Articles

  1. Zebrafish larva as a reliable model for in vivo assessment of membrane remodeling involvement in the hepatotoxicity of chemical agents

    Normand Podechard, Martine Chevanne, Morgane Fernier, Arnaud Tête, Aurore Collin, Doris Cassio, Olivier Kah, Dominique Lagadic-Gossmann and Odile Sergent

    Version of Record online: 28 NOV 2016 | DOI: 10.1002/jat.3421

    The easy-to-use in vivo model, zebrafish larva, is increasingly used to screen chemical-induced hepatotoxicity. However, nothing is known about its applicability in exploring the mechanism called membrane remodeling, depicted as changes in membrane fluidity or lipid raft properties. Its suitability and sensitivity were demonstrated by the ability to maintain membrane remodeling after 1 week of ethanol exposure, and by alleviating or enhancing ethanol-induced hepatotoxicity after membrane manipulation with membrane stabilizer, lipid raft disrupter or stimulator of lipid raft clustering.

  2. Lack of in vivo mutagenicity of 1,2-dichloropropane and dichloromethane in the livers of gpt delta rats administered singly or in combination

    Tadashi Hirata, Young-Man Cho, Takeshi Toyoda, Jun-ichi Akagi, Isamu Suzuki, Akiyoshi Nishikawa and Kumiko Ogawa

    Version of Record online: 28 NOV 2016 | DOI: 10.1002/jat.3416

    In the present study,we evaluated the in vivo mutagenicity of 1,2-DCP and DCM, alone or combined, in the livers of gpt delta rats. Six-week-old male F344 gpt delta rats were treated with 1,2-DCP, DCM or 1,2-DCP+DCM by oral administration for 4weeks at the dose (200 mg kg−1 body weight 1,2-DCP and 500 mg kg−1 body weight DCM) used in the carcinogenesis study performed by the National Toxicology Program. In vivo mutagenicity was analyzed by gpt mutation/Spi-assays in the livers of rats.

  3. You have full text access to this OnlineOpen article
    Physiologically based pharmacokinetic model for ethyl tertiary-butyl ether and tertiary-butyl alcohol in rats: Contribution of binding to α2u–globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes

    Susan J. Borghoff, Caroline Ring, Marcy I. Banton and Teresa L. Leavens

    Version of Record online: 24 NOV 2016 | DOI: 10.1002/jat.3412

    Inhalation, but not drinking-water exposure, to a high concentration of ethyl tertiary butyl ether was reported to cause liver tumors in male rats. Using a PBPK model for ethyl tertiary butyl ether and its metabolite tertiary butyl alcohol, under cancer bioassay exposure scenarios, showed a shift from linear to nonlinear kinetics at the exposure concentration associated with liver tumors. This suggests that a liver tumor mode of action that occurs under a high exposure concentration is not relevant for assessing human risk.

  4. Immunotoxic effects of in vitro exposure of dolphin lymphocytes to Louisiana sweet crude oil and Corexit™

    Natasha D. White, Celine Godard-Codding, Sarah J. Webb, Gregory D. Bossart and Patricia A. Fair

    Version of Record online: 20 NOV 2016 | DOI: 10.1002/jat.3414

    The immunotoxicity of Louisiana sweet crude oil and the chemical dispersant Corexit™ was examined using lymphocyte proliferation and natural killer cell assays as measures of impact on the adaptive and innate immune response in bottlenose dolphins, respectively. Bottlenose dolphin peripheral blood leukocytes were exposed to Louisiana sweet crude alone and in combination with Corexit. Results observed in this study indicate that exposure to both oil and dispersants causes functional impairment of cells of both the innate and adaptive immune system of bottlenose dolphins at environmentally relevant concentrations.

  5. Effects of oral exposure to the phthalate substitute acetyl tributyl citrate on female reproduction in mice

    Lindsay M. Rasmussen, Nivedita Sen, Xiaosong Liu and Zelieann R. Craig

    Version of Record online: 20 NOV 2016 | DOI: 10.1002/jat.3413

    Acetyl tributyl citrate (ATBC), is a phthalate substitute used in food, toys, cosmetics and medical plastics. Although safe up to 1000 mg kg−1 day−1, its ability to cause reproductive toxicity in females at levels below 50 mg kg−1 day−1 is currently unknown. The effects of lower ATBC exposures on female reproduction were evaluated using mice. Ovaries from ATBC-treated mice had fewer ovarian follicles in the primordial, primary and secondary stages. These findings suggest that low levels of ATBC may be detrimental to the ovary.