Journal of Applied Toxicology

Cover image for Vol. 38 Issue 1

Editor-in-Chief: Philip W. Harvey

Impact Factor: 3.159

ISI Journal Citation Reports © Ranking: 2016: 26/92 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2017, our congratulations go to:

Post Doc Award: Justin Conley, NHREEL, USA (left)

Student Award: Ms. Changqing Zhou, University of Illinois, USA (right)

Justin Conley SOT PhD 2017SOT 2017 Student winner Zhou

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Recently Published Articles

  1. Development of an artificial neural network model for risk assessment of skin sensitization using human cell line activation test, direct peptide reactivity assay, KeratinoSens™ and in silico structure alert parameter

    Morihiko Hirota, Takao Ashikaga and Hirokazu Kouzuki

    Version of Record online: 10 DEC 2017 | DOI: 10.1002/jat.3558

    ANN model for skin sensitization risk using DPRA/KeratinoSens™/h-CLAT/structure alerts.

  2. Comparative proteomic analysis of silver nanoparticle effects in human liver and intestinal cells

    Albert Braeuning, Axel Oberemm, Josephine Görte, Linda Böhmert, Sabine Juling and Alfonso Lampen

    Version of Record online: 7 DEC 2017 | DOI: 10.1002/jat.3568

    Silver nanoparticles and ionic silver exert toxicity in cells. Consumers are orally exposed to silver from food packaging or food additives. Here, a proteomic analysis of effects of AgPURE silver nanoparticles and ionic silver in Hep G2 hepatocarcinoma cells is presented. Data confirm the important role of oxidative stress in silver toxicity. A comparative analysis of silver effects in hepatic and intestinal cells shows how bioinformatic can help to deduce similar biological effects from remarkably differing data sets.

  3. Inhibition of germinal vesicle breakdown in Xenopus oocytes in vitro by a series of substituted glycol ethers

    Douglas J. Fort, Michael B. Mathis, Patrick D. Guiney and John A. Weeks

    Version of Record online: 4 DEC 2017 | DOI: 10.1002/jat.3567

    A 24 hour in vitro Xenopus oocyte maturation assay was used to screen chemicals for endocrine disruption activity. Results suggested, however, that effects substituted GE series might be mediated through the oocyte plasma membrane receptor; the potency of ethylene glycol monophenyl ether may be the result of bimodal inhibition of both the oocyte plasma membrane receptor and androgens via a classical androgen receptor pathways.

  4. Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced-immunosuppressive effects in mouse splenocytes

    Cuiying He, Yuan Song, Takamichi Ichinose, Miao He, Kentaro Morita, Duo Wang, Tamotsu Kanazawa and Yasuhiro Yoshida

    Version of Record online: 29 NOV 2017 | DOI: 10.1002/jat.3554

    Exposure to ambient particulate matter (PM) is associated with serious adverse health effects. We investigated the splenic response in mice administered PM of ≤ 2.5 μ m diameter (PM2.5) with various molecules attached, obtained from different sources. PM2.5 with a low amount of lipopolysaccharide significantly reduced splenocyte mitogen-induced proliferation and cytokine production in mice; this effect was abrogated by antioxidant treatments. Our findings indicate that lipopolysaccharide adhering to PM2.5 modulates the immune response induced by these particles in splenocytes.

  5. Liposomal encapsulation of silver nanoparticles enhances cytotoxicity and causes induction of reactive oxygen species-independent apoptosis

    A. Yusuf, A. Brophy, B. Gorey and A. Casey

    Version of Record online: 27 NOV 2017 | DOI: 10.1002/jat.3566

    A method of encapsulating silver nanoparticles (AgNP) in liposomes (Lipo-AgNP) is described to improve AgNP delivery and enhance its cytotoxicity. Treatment of THP1 cells at low dose of Lipo-AgNP induced a ROS-independent apoptosis due to DNA fragmentation and resulted in the induction of caspase 3/7. The findings indicate that Lipo-AgNP can mediate AgNP cytotoxicity at significantly lower concentrations than standard AgNP.