Journal of Applied Toxicology

Cover image for Vol. 37 Issue 4

Editor-in-Chief: Philip W. Harvey

Impact Factor: 2.722

ISI Journal Citation Reports © Ranking: 2015: 33/90 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:

Post Doc Award: Justin Conley, USEPA, USA (left)

Student Award: Parker Duffney, Rochester University, USA (right)

SOT Mixtures Award winners 2016

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Recently Published Articles

  1. Development of haemostatic decontaminants for treatment of wounds contaminated with chemical warfare agents. 3: Evaluation of in vitro topical decontamination efficacy using damaged skin

    Helen L. Lydon, Charlotte A. Hall, Christopher H. Dalton, J. Kevin Chipman, John S. Graham and Robert P. Chilcott

    Version of Record online: 20 FEB 2017 | DOI: 10.1002/jat.3446

    This in vitro study assessed three candidate haemostatic products for effectiveness in the decontamination of superficially damaged porcine skin exposed to the radiolabelled CW agents, soman (GD), VX and sulphur mustard (HD). Controlled physical damage (removal of the upper 100 μm skin layer) resulted in significant enhancement of the dermal absorption of all three CW agents. Of the haemostatic products assessed, WoundStat™ was consistently the most effective, being equivalent in performance to a standard military decontaminant (fuller's earth).

  2. Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor

    Zemin Wang, Xilin Li, Qiangen Wu, James C. Lamb IV and James E. Klaunig

    Version of Record online: 20 FEB 2017 | DOI: 10.1002/jat.3445

    The organochlorine pesticide toxaphene has been shown to induce mouse liver tumors following chronic exposure. Experimental evidence supports a nongenotoxic mode of action through nuclear receptor activation, possibly through CAR/PXR. The current study using CAR and/or PXR knock out mice was performed with and without toxaphene treatment. Removal of CAR resulted in an elimination of the key events associated with toxaphene induced mouse liver tumors and therefore demonstrated conclusively that the toxaphene induced mouse liver tumors was mediated by activation of the CAR receptor.

  3. Automated image analysis of intra-tumoral and peripheral endocrine organ vascular bed regression using ‘Fibrelength’ as a novel structural biomarker

    Adam Hargreaves, Alison Bigley, Shirley Price, Jane Kendrew and Simon T. Barry

    Version of Record online: 10 FEB 2017 | DOI: 10.1002/jat.3438

    The study of vascular modulation has received a great deal of attention in recent years. Here we present the generation of a novel structural biomarker, which can be incorporated into a number of contemporary image analysis platforms and used to compare tumour versus systemic host tissue vascularity. By contrasting the measurements obtained, the preclinical efficacy of vascular modulating chemotherapies can be evaluated in light of concomitant systemic vascular toxicity.

  4. Threshold limit values of the cadmium concentration in rice in the development of itai-itai disease using benchmark dose analysis

    Kazuhiro Nogawa, Masaru Sakurai, Masao Ishizaki, Teruhiko Kido, Hideaki Nakagawa and Yasushi Suwazono

    Version of Record online: 10 FEB 2017 | DOI: 10.1002/jat.3444

    The aim of this study was to estimate the lower limit of the benchmark dose (BMDL) as the threshold limit level of the Cd concentration in rice for itai-itai disease and/or suspected disease based upon a logistic regression model. The estimated BMDLs of the Cd concentration in rice for itai-itai disease and/or suspected disease were 0.62–0.76 and 0.27–0.56 mg kg−1 in men and women, respectively. This result provides important information about the worldwide standard for the Cd concentration in rice.

  5. Effects of neonatal 17α-ethinyloestradiol exposure on female-paced mating behaviour in the rat

    Chiaki Komine, Shingo Nakajima, Yasuhiko Kondo, Yasuyuki Horii, Midori Yoshida and Maiko Kawaguchi

    Version of Record online: 8 FEB 2017 | DOI: 10.1002/jat.3449

    Perinatal exposure to xeno-oestrogens can disrupt female sexual development, leading to changes in reproductive behaviour in adulthood, but the effects remain to be fully determined. We examined the effects of a single perinatal exposure to low (0.02 mg kg−1) and high (2.0 mg kg−1) doses of 17α-ethinyloestradiol (EE) on female rats in a paced mating test. The high EE dose, but not the low dose, disrupted females' sexual behaviours in adulthood. Such exposure could pose a risk to reproductive health.

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