Journal of Applied Toxicology

Cover image for Vol. 38 Issue 4

Editor-in-Chief: Philip W. Harvey

Impact Factor: 3.159

ISI Journal Citation Reports © Ranking: 2016: 26/92 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2017, our congratulations go to:

Post Doc Award: Justin Conley, NHREEL, USA (left)

Student Award: Ms. Changqing Zhou, University of Illinois, USA (right)

Justin Conley SOT PhD 2017SOT 2017 Student winner Zhou

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Recently Published Articles

  1. Alteration of renal excretion pathways in gentamicin-induced renal injury in rats

    Yan-rong Ma, Xuan Luo, Yan-fang Wu, Tiffany Zhang, Fan Zhang, Guo-qiang Zhang and Xin-an Wu

    Version of Record online: 20 FEB 2018 | DOI: 10.1002/jat.3603

    The exposure of GEN (100 mg kg–1) caused in an acute kidney injury. The negligible tubular injury and increased creatinine level were observed at 50 mg kg–1 dose. GEN (50) did not alter the urinary excretion of inulin, but increased metformin and furosemide excretion. However, GEN (100) resulted in a significant decrease of the urinary excretion of inulin, metformin and p-aminohippurate. These results demonstrated that the function of rOCTs-rMATE1 and rOAT3-rMRPs pathways were significantly upregulated by GEN(50), and glomerular filtration-rOCTs-rMATE1 and -rOAT1-rMRPs pathways were markedly downregulated by GEN(100).

  2. Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty

    Gabriel Adan Araújo Leite, Marciana Sanabria, Marilia Martins Cavariani, Janete Aparecida Anselmo-Franci, Patrícia Fernanda Felipe Pinheiro, Raquel Fantin Domeniconi and Wilma De Grava Kempinas

    Version of Record online: 19 FEB 2018 | DOI: 10.1002/jat.3599

    Prepubertal exposure to rosuvastatin promoted reduced serum follicle-stimulating hormone, luteinizing hormone and testosterone concentrations and increased serum prolactin and estradiol concentrations, leading to a hormonal deregulation on sexual maturity. Furthermore, rosuvastatin-exposed groups exhibited augmented germ cell death, decreased expression of androgen receptors on testis and epididymis and lower expression of aquaporin-9 on epididymal epithelium. In conclusion, administration of rosuvastatin to juvenile male rats impaired male reproduction at adulthood.

  3. Estrogenic and anti-estrogenic activity of butylparaben, butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate and their binary mixtures on two estrogen responsive cell lines (T47D-Kbluc, MCF-7)

    Anca Pop, Tudor Drugan, Arno C. Gutleb, Diana Lupu, Julien Cherfan, Felicia Loghin and Béla Kiss

    Version of Record online: 19 FEB 2018 | DOI: 10.1002/jat.3601

    The estrogenic and anti-estrogenic effects of butylparaben, butylated hydroxyanisole, butylated hydroxytoluene and propyl gallate were evaluated for individual compounds and selected binary mixtures, using two in vitro assays. All compounds displayed estrogenic and/or anti-estrogenic activity in at least one of the assays and there was a good correlation between the individual potencies of compounds and that of binary mixtures. The anti-estrogenic effect of mixtures was predicted by the dose addition model. These results emphasize the importance of a cumulative risk assessment of endocrine disruptors.

  4. Derivation of a no-significant-risk-level for tetrabromobisphenol A based on a threshold non-mutagenic cancer mode of action

    Alison M. Pecquet, Jeanelle M. Martinez, Melissa Vincent, Neeraja Erraguntla and Michael Dourson

    Version of Record online: 13 FEB 2018 | DOI: 10.1002/jat.3594

    A non-mutagenic threshold mode of action for tetrabromobisphenol A was utilized to derive a no-significant-risk-level of 20 mg day–1 for uterine tumors (adenomas, adenocarcinomas, and malignant mixed Müllerian combined) observed in female Wistar Han rats from a National Toxicology Program 2-year bioassay. The most recent available techniques were utilized, including literature review, benchmark dose software, mode of action analysis, and threshold extrapolation. The derived no-significant-risk-level aligns well with other available non-cancer and cancer risk values based on the biology of these tumors.

  5. Environmental mixture with estrogenic activity increases Hsd3b1 expression through estrogen receptors in immature rat granulosa cells

    Dragana Samardzija Nenadov, Kristina Pogrmic-Majkic, Svetlana Fa, Bojana Stanic, Aleksandra Tubic and Nebojsa Andric

    Version of Record online: 13 FEB 2018 | DOI: 10.1002/jat.3596

    Wastewater polar fraction exerting 9 ng EEQ/L of estrogenic activity increased expression of Star and Hsd3b1, but did not alter mRNA level of Cyp19a1 and Lhr. Estrogen receptor inhibitor ICI 182,780 prevented estrogenic mixture-induced increase in Hsd3b1, but not Star mRNA level in immature granulosa cells. These results indicate that environmental chemical mixtures with estrogenic activity exert progesterone disrupting effect in immature rat granulosa cells, which is an effect achieved in part through activation of estrogen receptors.

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