Journal of Applied Toxicology
© John Wiley & Sons Ltd
Editor-in-Chief: Philip W. Harvey
Impact Factor: 2.722
ISI Journal Citation Reports © Ranking: 2015: 33/90 (Toxicology)
Online ISSN: 1099-1263
Hot Topics, Unmissable Reviews and News
Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2016, our congratulations go to:
Post Doc Award: Justin Conley, USEPA, USA (left)
Student Award: Parker Duffney, Rochester University, USA (right)
Recently Published Articles
- Prediction of skin sensitization potency using machine learning approaches
Qingda Zang, Michael Paris, David M. Lehmann, Shannon Bell, Nicole Kleinstreuer, David Allen, Joanna Matheson, Abigail Jacobs, Warren Casey and Judy Strickland
Version of Record online: 10 JAN 2017 | DOI: 10.1002/jat.3424
Replacing animal testing for regulatory classification of skin sensitizers is a high priority for US federal agencies. We developed machine learning approaches combining data from three non-animal methods with physicochemical property data to predict three categories of skin sensitization. The top model surpassed the accuracy of a standard animal test for skin sensitization, suggesting that computational models using data from non-animal methods can provide valuable information to assess skin sensitization potency.
- Current sights for mechanisms of deoxynivalenol-induced hepatotoxicity and prospective views for future scientific research: A mini review
Zhao Peng, Liangkai Chen, Andreas K. Nüssler, Liegang Liu and Wei Yang
Version of Record online: 20 DEC 2016 | DOI: 10.1002/jat.3428
In this table, we have shown that DON induced liver damage with positive and negative results in different animal models and cell lines. This mycotoxin can evokes obvious pathological changes in tissue by altering repssions of relative enzymes or oxidative stress. Otherwise, DON can induces expressions of apoptotic proteins thereby producing hepatic fibrosis and other kinds of liver damage.
- Glucose-rich diet aggravates monocrotophos-induced dopaminergic neuronal dysfunction in Caenorhabditis elegans
Chinnu Salim and P. S. Rajini
Version of Record online: 20 DEC 2016 | DOI: 10.1002/jat.3426
Learning and memory were affected by MCP and glucose while basal slowing response of cat-2 worms exposed to MCP and glucose were less affected than N2 of the same treatment. MCP-treated worms showed lesser repulsion to nonanone compared to control worms MCP+ glucose worms showed a greater reduction in repulsion to nonanone. MCP+ glucose worms exhibited a marked reduction in dopamine content BZ555 worms showed a significant degeneration of dopaminergic neurons when exposed to glucose and MCP.
- Genotoxic risk of ethyl-paraben could be related to telomere shortening
F. Finot, A. Kaddour, L. Morat, I. Mouche, N. Zaguia, C. Cuceu, D. Souverville, S. Négrault, O. Cariou, A. Essahli, N. Prigent, J. Saul, F. Paillard, L. Heidingsfelder, P. Lafouge, M. Al Jawhari, W. M. Hempel, M. El May, B. Colicchio, A. Dieterlen, E. Jeandidier, L. Sabatier, J. Clements and R. M'Kacher
Version of Record online: 20 DEC 2016 | DOI: 10.1002/jat.3425
The impact of parabens in human breast tissue remains unclear. We demonstrated a genotoxic effect of ethyl-paraben with and without metabolic activation (S9) and a correlation between telomere dysfunction and increased genotoxic response after ethyl-paraben treatment in studies following OECD guidelines. These data demonstrate genotoxicity and a higher MN frequency of cells with telomere shortening in the presence of ethyl-paraben and could advance our knowledge on the role of paraben in breast cancer cells characterized by drastic telomere shortening.
- In vitro detection of diesel exhaust particles induced human lung carcinoma epithelial cells damage and the effect of resveratrol
Qifei Li, Mingjie Tang and Anhong Zhou
Version of Record online: 9 DEC 2016 | DOI: 10.1002/jat.3423
A combination of two non-invasive techniques (Atomic force microscopy, AFM, and Raman micro-spectroscopy, RM) and other biological instrument tools (flow cytometry and multiplex ELISA) were applied to evaluate the biophysical, biochemical alterations and cytokine, membrane potential and cell cycle of cells with or without resveratrol (RES) pretreatment to different times of diesel exhausted particles (DEPs) exposure to better understand the mechanisms of DEP-induced cell damages and the study of the roles of RES in DEP damaged lung cancer cells.