Journal of Applied Toxicology

Cover image for Vol. 37 Issue 12

Editor-in-Chief: Philip W. Harvey

Impact Factor: 3.159

ISI Journal Citation Reports © Ranking: 2016: 26/92 (Toxicology)

Online ISSN: 1099-1263

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Presented annually at the Society of Toxicology meeting, Journal of Applied Toxicology sponsors achievements in Mixture Toxicology with awards for the best student paper and the best postdoctoral paper. In 2017, our congratulations go to:

Post Doc Award: Justin Conley, NHREEL, USA (left)

Student Award: Ms. Changqing Zhou, University of Illinois, USA (right)

Justin Conley SOT PhD 2017SOT 2017 Student winner Zhou

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Recently Published Articles

  1. Effects of bergenin on methylglyoxal-induced damage in osteoblastic MC3T3-E1 cells

    Kyung Hee Lee and Eun Mi Choi

    Version of Record online: 17 NOV 2017 | DOI: 10.1002/jat.3565

    Pretreating MC3T3-E1 cells with bergenin prevented methylglyoxal (MG)-induced protein adduct formation. Bergenin inhibited MG-induced soluble receptor for AGE, interleukin, ROS, and mitochondrial superoxide production. Additionally bergenin increased glyoxalase I activity, glutathione, heme oxygenase-1, and nuclear factor erythroid 2-related factor 2 levels in the presence of MG. Bergenin reduced MG-induced mitochondrial dysfunction by preventing mitochondrial membrane potential dissipation, loss of ATP, and reduced AMPK.

  2. Metabolic effects of p,p′-DDE on Atlantic salmon hepatocytes

    Pål A. Olsvik and Liv Søfteland

    Version of Record online: 17 NOV 2017 | DOI: 10.1002/jat.3556

    This work aimed to find biomarkers of the major DDT metabolite found in Atlantic salmon aquaculture feeds. Primary hepatocytes were exposed to four concentrations of p,p′-DDE for 48 hours, and endpoints included cytotoxicity, global DNA methylation, targeted transcriptomics and metabolomics profiling. p,p′-DDE exposure was associated with endocrine disruption, impact on carbohydrate and lipid metabolism, and points to possible impact on DNA methylation mechanisms linked to methionine degradation in Atlantic salmon hepatocytes.

  3. Arsenite downregulates H3K4 trimethylation and H3K9 dimethylation during transformation of human bronchial epithelial cells

    Wei Tu, Yin Liu, Chengfeng Xie and Xue Zhou

    Version of Record online: 17 NOV 2017 | DOI: 10.1002/jat.3555

    The aim of this study was to investigate the role of histone methylation in transformation of human bronchial epithelial (BEAS-2B) cells. BEAS-2B cells were transformed by 0.1, 0.5 and 1 μM arsenite at 16 weeks. Both global tri-methylated H3K4 and global di-methylated H3K9 were decreased during cell transformation, which were modulated by reduction of histone methyltransferase activities and/or increase of histone demethylase activities, and also by upregulation of the protein levels of H3K4 demethylase KDM5A for tri-methylated H3K4.

  4. Thirteen week toxicity study of dietary l-tryptophan in rats with a recovery period of 5 weeks

    Yusuke Shibui, Hideki Matsumoto, Yoko Masuzawa, Takumi Ohishi, Tsutomu Fukuwatari, Katsumi Shibata and Ryosei Sakai

    Version of Record online: 16 NOV 2017 | DOI: 10.1002/jat.3562

    We performed a study in rats to determine the oral toxicity of l-tryptophan. Adding 5.0% l-tryptophan to standard rodent chow produced no overt toxicological changes over a 13 week period. Body weight gain and food consumption significantly decreased throughout the experiment, but these changes were reversible. The total no-observed-adverse-effect level of l-tryptophan was 948 mg kg–1 body weight day–1 for males and 1956 mg kg–1 body weight day–1 for females. We conclude that l-tryptophan has a low toxicity profile in terms of human use.

  5. γ-H2AX formation in the urinary bladder of rats treated with two norharman derivatives obtained from o-toluidine and aniline

    T. Toyoda, Y. Totsuka, K. Matsushita, T. Morikawa, N. Miyoshi, K. Wakabayashi and K. Ogawa

    Version of Record online: 16 NOV 2017 | DOI: 10.1002/jat.3560

    To evaluate the role of norharman derivatives in bladder carcinogenesis, we examined γ-H2AX formation in the urinary bladder of male rats treated with aminomethylphenylnorharman (AMPNH) or aminophenylnorharman (APNH) for 4 weeks. γ-H2AX formation in the urothelium was increased in both groups at week 4. After 2 weeks of recovery, γ-H2AX-positive cells remained significantly-high levels in both groups. Thus, AMPNH and APNH showed in vivo genotoxicity in the bladder epithelium, and APNH may be a potent causative agent of bladder carcinogenesis.